Extraordinary Life Sciences seminar with Dr. Thomas Theil, University of Edinburgh

Title: "Studying the role of primary cilia in human corticogenesis using organoids"

Hosts: Catherina Becker (CRTD) & Thomas Becker (CRTD)

Please see the Zoom-details here:

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https://tu-dresden.zoom.us/j/2481651371?pwd=ekNBdlVLYUp6TXFDNHhNWUxRTlNmdz09

Meeting ID: 248 165 1371

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Meeting ID: 248 165 1371

Passcode: 428542

Abstract:

Defects in primary cilia, cellular antennas that control multiple intracellular signalling pathways, underlie several neurodevelopmental disorders, but how cilia control essential steps in human brain formation remains elusive. We are investigating ciliary roles using human cortical organoids that provide unprecedented opportunities to model brain development and disease. We determined that cilia are regulating critical steps in forebrain development such as dorsal/ventral patterning and neuronal differentiation. Our findings also have implications for our understanding of the pathogenesis of neurodevelopmental disorders including autism spectrum disorders.

Everybody is very welcome!