Serviceleistungen
Peptide and Peptidomimetic Synthesis
Native peptide synthesis
- Using solid phase synthesis (SPPS) with Fmoc chemistry.
- Peptide length: 2-50 amino acids
- Standard scale: 20 µmol up to 1 mmol
- Small combinatorial libraries (24 or 96 well formate)
- Phosphorylated peptides (pSer, pThr, pTyr)
Labeled Peptides and modified Peptides
- Biotin, dyes (e.g. Fluorescein, Cy3, Cy5, Atto, Tamra etx.), lipids
- Cyclic peptides (e.g. S-S bonds)
- Azide or alkyne modified peptides for click chemistry
- Stapled peptides
Peptide array (600 & 1200 spots)
The SPOT synthesis is a method to generate large numbers of different peptides on cellulose membranes for use in arrays or screening libraries.
Small molecule synthesis
Medicinal Chemistry
- Screening hit resynthesis for further validation. Respectively synthesis of tool compounds described in literature.
- Hit optimization to improve the activity, selectivity etc.
- Synthesis of larger amount of compounds for example for animal studies.
- Targeted protein degradation (TPD) – for example PROTAC
Synthesis of small molecules
- Synthesis of designed molecules for labelling.
- Resynthesis of compounds from literature.
- Combine peptides with synthesized compounds.