Services

Peptide and Peptidomimetic Synthesis

Native peptide synthesis

• Using solid phase synthesis (SPPS) with Fmoc chemistry.
• Peptide length: 2-50 amino acids
• Standard scale: 20 µmol up to 1 mmol
• Small combinatorial libraries (24 or 96 well formate)
• Phosphorylated peptides (pSer, pThr, pTyr)

Labeled Peptides and modified Peptides

• Biotin, dyes (e.g. Fluorescein, Cy3, Cy5, Atto, Tamra etx.), lipids
• Cyclic peptides (e.g. S-S bonds)
• Azide or alkyne modified peptides for click chemistry
• Stapled peptides

Peptide array (600 & 1200 spots)

The SPOT synthesis is a method to generate large numbers of different peptides on cellulose membranes for use in arrays or screening libraries.

Small molecule synthesis

Medicinal Chemistry

• Screening hit resynthesis for further validation. Respectively synthesis of tool compounds described in literature.
• Hit optimization to improve the activity, selectivity etc.
• Synthesis of larger amount of compounds for example for animal studies.
• Targeted protein degradation (TPD) – for example PROTAC

Synthesis of small molecules

• Synthesis of designed molecules for labelling.
• Resynthesis of compounds from literature.
• Combine peptides with synthesized compounds.