Seminar (SS 2019)
Mathematics of tumor progression
Objective
Tumour progression results from ecological and evolutionary processes at the cell level. Pheno- and genotypically heterogeneous tumour cells interact with each other, adapt to and remodel their microenvironment and invade distant spatial regions by exploiting fitness trade-offs between proliferation and migration. Mathematical models can yield insights into the spatio-temporal dynamics of tumour progression. The main focus of the seminar is the introduction of mathematical models (including game theory, Moran and cellular automaton models) addressing key steps of tumour progression by means of oral presentations and discussions. The final seminar program results from the kickoff meeting.
The seminar is intended for undergraduate/graduate students and researchers in mathematics, physics, biology, medicine, and computer science who are interested in this highly interdisciplinary research area. Each participant is expected to give a 30 min presentation centered around a recent high-impact scientific publication.
Time and Location
- Time: 4 Friday mornings 10.00-13:00: May 3, 10, 24, and June 7
Location: APB-1096, Faculty of Computer Science, TU Dresden, Nöthnitzer Str. 46 - Kickoff meeting and distribution of talks: April 9, 14.00-15.00, APB-E054
- Program will be finalized after the Kickoff meeting
- To download material and papers please proceed here
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- Flyer with the objective of the seminar.
Program
| Date | Speakers | Title |
|---|---|---|
| May 3 |
Day I: Model types |
|
| Robert Walter |
Branching processes |
|
| Anurag Trivedi | Moran model | |
| Franziska Keidel | Spatial Moran model | |
| May 10 | Day II: Cancer risk and incidance rates | |
| Robert Müller | Peto's paradox | |
| Julian Rode | Tissue-specific risk | |
| Josué Nava-Sedeno | Early mutations | |
| May 24 | Day III: Spatial progression | |
| Sia Hranova | Impact of tissue structure on cancer evolution | |
| Henrik Stolzmann | Evolutionary cell dynamics in human epidermis | |
| Tom Paulat | Tumor evolution with spatial dispersal | |
| June 7 | Day IV: Data-driven models | |
| N.N. | Quantifying cell divisions in human cancers | |
| Bianca Güttner | Impacts of dispersal and cell turnover on intratumor heterogeneity | |
| Marcus Krellner | Spatial structure governs the mode of tumor evolution | |
Organizers:
Thomas Buder1,2, Andreas Deutsch1, Simon Syga1, Anja Voß-Böhme1,2
1. ZIH, TU Dresden, 2. Hochschule für Technik und Wirtschaft Dresden
Contact:
Andreas Deutsch, Tel. 463-31943