Forschung
Der Bereich befasst sich mit der Erforschung der Angiogenese (Neubildung von Blutgefäßen) sowie der Rolle von Zelladhäsionsproteinen in Tumoren.
Ausgewählte Publikationen
Nachfolgend finden Sie eine Auswahl von Publikationen, die im Arbeitsbereich oder in Kooperation mit anderen Arbeitsgruppen entstanden sind. Eine ausführliche Auflistung unserer Publikationen finden Sie in Pubmed, im Web of Science und bei Google Scholar.
Patejdl R, Demir IE, Frieling T, Goebel-Stengel M, Günther L, Keller J, Niesler B, Stengel A, Neckel PH. Curricular representation of neurogastroenterology: A survey among medical students in Germany. Neurogastroenterol Motil 2023 Mar 9:e14557
Steiner G, Galli R, Preusse G, Michen S, Meinhardt M, Temme A, Sobottka SB, Juratli TA, Koch E, Schackert G, Kirsch M, Uckermann O. A new approach for clinical translation of infrared spectroscopy: exploitation of the signature of glioblastoma for general brain tumor recognition. J Neurooncol 2023;161(1):57-66
Brock T, Boudriot E, Klawitter A, Großer M, Nguyen TTP, Giebe S, Klapproth E, Temme A, El-Armouche A, Breier G. The Influence of VE-Cadherin on Adhesion and Incorporation of Breast Cancer Cells into Vascular Endothelium. Int J Mol Sci 2021;22:6049
Dinger TF, Chen O, Dittfeld C, Hetze L, Hüther M, Wondrak M, Löck S, Eicheler W, Breier G, Kunz-Schughart LA. Microenvironmentally-driven Plasticity of CD44 isoform expression determines Engraftment and Stem-like Phenotype in CRC cell lines. Theranostics 2020;10:7599
Egners A, Rezaei M, Kuzmanov A, Poitz DM, Streichert D, Müller-Reichert T, Wielockx B, Breier G. PHD3 Acts as Tumor Suppressor in Mouse Osteosarcoma and Influences Tumor Vascularization via PDGF-C Signaling. Cancers 2018;10:496
Rezaei M, Cao J, Friedrich K, Kemper B, Brendel O, Grosser M, Adrian M, Baretton G, Breier G, Schnittler HJ. The expression of VE-cadherin in breast cancer cells modulates cell dynamics as a function of tumor differentiation and promotes tumor-endothelial cell interactions. Histochem Cell Biol 2018;149:15
Breier G, Grosser M, Rezaei M. Endothelial cadherins in cancer. Cell Tiss Res 2014; 355:523
Nakayama M, Nakayama A, van Lessen M, Yamamoto H, Hoffmann S, Drexler HC, Itoh N, Hirose T, Breier G, Vestweber D, Cooper JA, Ohno S, Kaibuchi K, Adams RH. Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol 2013;15:249-60
Rezaei M, Friedrich K, Wielockx B, Kuzmanov A, Kettelhake A, Labelle M, Schnittler H, Baretton G, Breier G. Interplay between neural-cadherin and vascular endothelial-cadherin in breast cancer progression. Breast Cancer Res 2012; 14:R154
Klotzsche-von Ameln A, Muschter A, Mamlouk S, Kalucka J, Prade I, Franke K, Rezaei M, Poitz DM, Breier G, Wielockx B. Inhibition of HIF Prolyl Hydroxylase-2 Blocks Tumor Growth through the Anti-Proliferative Activity of TGF-beta. Cancer Res 2011; 71: 3306-16
Labelle M, Schnittler HJ, Aust DE, Friedrich K, Baretton G, Vestweber D, Breier G. Vascular endothelial cadherin promotes breast cancer progression via transforming growth factor-beta signaling. Cancer Res 2008; 68:1388
Raab S, Beck H, Gaumann A, Yuce A, Gerber HP, Plate KH, Hammes HP, Ferrara N, Breier G. Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor. Thromb Haemost 2004; 91:595
Vajkoczy P, Farhadi M, Gaumann A, Heidenreich R, Erber R, Wunder A, Tonn JC, Menger MD, Breier G. Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF-receptor-2, and angiopoietin-2. J Clin Invest 2002; 109:777
Kappel A, Rönicke V, Damert A, Flamme I, Risau W, Breier G. Identification of VEGF receptor-2 (Flk-1) promoter/enhancer sequences sufficient for angioblast and endothelial cell-specific transcription in transgenic mice. Blood 1999; 93:4284
Breier G, Breviario F, Caveda L, Berthier R, Schnürch H, Gotsch U, Vestweber D, Risau W, Dejana E. Molecular cloning and expression of murine vascular endothelial cadherin in early stage development of cardiovascular system. Blood 1996; 87:630-41
Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declerq C, Pawling J, Moons L, Collen D, Risau W, Nagy A. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996; 380:435-9
Plate KH, Breier G, Weich HA, Risau W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 1992; 359:845-8.
Breier G, Albrecht U, Sterrer S, Risau W. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 1992; 114:521-32