Publications

Consensus Guidance for Monitoring Individuals With Islet Autoantibody-Positive Pre-Stage 3 Type 1 Diabetes. Phillip M, Achenbach P, Addala A, Albanese-O'Neill A, Battelino T, Bell KJ, Besser REJ, Bonifacio E, Colhoun HM, Couper JJ, Craig ME, Danne T, de Beaufort C, Dovc K, Driscoll KA, Dutta S, Ebekozien O, Elding Larsson H, Feiten DJ, Frohnert BI, Gabbay RA, Gallagher MP, Greenbaum CJ, Griffin KJ, Hagopian W, Haller MJ, Hendrieckx C, Hendriks E, Holt RIG, Hughes L, Ismail HM, Jacobsen LM, Johnson SB, Kolb LE, Kordonouri O, Lange K, Lash RW, Lernmark Å, Libman I, Lundgren M, Maahs DM, Marcovecchio ML, Mathieu C, Miller KM, O'Donnell HK, Oron T, Patil SP, Pop-Busui R, Rewers MJ, Rich SS, Schatz DA, Schulman-Rosenbaum R, Simmons KM, Sims EK, Skyler JS, Smith LB, Speake C, Steck AK, Thomas NPB, Tonyushkina KN, Veijola R, Wentworth JM, Wherrett DK, Wood JR, Ziegler AG, DiMeglio LA. Diabetes Care. 2024 Jun 24:dci240042. doi: 10.2337/dci24-0042. Online ahead of print. PMID: 38912694

Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes. Phillip M, Achenbach P, Addala A, Albanese-O'Neill A, Battelino T, Bell KJ, Besser REJ, Bonifacio E, Colhoun HM, Couper JJ, Craig ME, Danne T, de Beaufort C, Dovc K, Driscoll KA, Dutta S, Ebekozien O, Larsson HE, Feiten DJ, Frohnert BI, Gabbay RA, Gallagher MP, Greenbaum CJ, Griffin KJ, Hagopian W, Haller MJ, Hendrieckx C, Hendriks E, Holt RIG, Hughes L, Ismail HM, Jacobsen LM, Johnson SB, Kolb LE, Kordonouri O, Lange K, Lash RW, Lernmark Å, Libman I, Lundgren M, Maahs DM, Marcovecchio ML, Mathieu C, Miller KM, O'Donnell HK, Oron T, Patil SP, Pop-Busui R, Rewers MJ, Rich SS, Schatz DA, Schulman-Rosenbaum R, Simmons KM, Sims EK, Skyler JS, Smith LB, Speake C, Steck AK, Thomas NPB, Tonyushkina KN, Veijola R, Wentworth JM, Wherrett DK, Wood JR, Ziegler AG, DiMeglio LA. Diabetologia. 2024 Jun 24. doi: 10.1007/s00125-024-06205-5. Online ahead of print. PMID: 38910151

Infection episodes and islet autoantibodies in children at increased risk for type 1 diabetes before and during the COVID-19 pandemic. Zeller I, Weiss A, Arnolds S, Schütte-Borkovec K, Arabi S, von dem Berge T, Casteels K, Hommel A, Kordonouri O, Larsson HE, Lundgren M, Rochtus A, Snape MD, Szypowka A, Vatish M, Winkler C, Bonifacio E, Ziegler AG; GPPAD Study Group. Infection. 2024 Jun 14. doi: 10.1007/s15010-024-02312-y. Online ahead of print. PMID: 38874748

Effect of population-wide screening for presymptomatic early-stage type 1 diabetes on paediatric clinical care. Bonifacio E, Winkler C, Achenbach P, Ziegler AG. Lancet Diabetes Endocrinol. 2024 Jun;12(6):376-378. doi: 10.1016/S2213-8587(24)00101-3. Epub 2024 May 6. PMID: 38723647 No abstract available.

Caesarean section and risk of type 1 diabetes. Singh T, Weiss A, Vehik K, Krischer J, Rewers M, Toppari J, Lernmark Å, Hagopian W, Akolkar B, Bonifacio E, Ziegler AG, Winkler C; TEDDY Study Group. Diabetologia. 2024 May 31. doi: 10.1007/s00125-024-06176-7. Online ahead of print. PMID: 38819466

Früherkennung von Typ-1-Diabetes durch Inselautoantikörper-Screening – ein Positionspapier der Fr1daPlex-Projektleiter und -Schulungszentren, des BVKJ Bayern und PaedNetz Bayern e.V. Achenbach P, Berner R, Bonifacio E, Brämswig S, Braig S, Dunstheimer D, Ermer U, Ewald D, Gemulla G, Hauer J, Haupt F, Haus G, Hubmann M, Hummel S, Kandler M, Kordonouri O, Lange K, Laub O, Lorrmann A, Nellen-Hellmuth N, Sindichakis M, von dem Berge T, Warncke K, Weber L, Winkler C, Wintermeyer P, Ziegler AG. Gesundheitswesen. 2024 May 6. doi: 10.1055/a-2320-2859. Online ahead of print. PMID: 38710228 German.

Early-childhood body mass index and its association with the COVID-19 pandemic, containment measures and islet autoimmunity in children with increased risk for type 1 diabetes. Hummel S, Rosenberger S, von dem Berge T, Besser REJ, Casteels K, Hommel A, Kordonouri O, Elding Larsson H, Lundgren M, Marcus BA, Oltarzewski M, Rochtus A, Szypowska A, Todd JA, Weiss A, Winkler C, Bonifacio E, Ziegler AG; GPPAD and POInT Study Group. Diabetologia. 2024 Apr;67(4):670-678. doi: 10.1007/s00125-023-06079-z. Epub 2024 Jan 12. PMID: 38214711 Free PMC article.

Clinical care advice for monitoring of islet autoantibody positive individuals with presymptomatic type 1 diabetes. Hendriks AEJ, Marcovecchio ML, Besser REJ, Bonifacio E, Casteels K, Elding Larsson H, Gemulla G, Lundgren M, Kordonouri O, Mallone R, Pociot F, Szypowska A, Toppari J, Berge TVD, Ziegler AG, Mathieu C, Achenbach P; INNODIA consortium, the Fr1da Study Group and the GPPAD Study Group. Diabetes Metab Res Rev. 2024 Feb;40(2):e3777. doi: 10.1002/dmrr.3777. PMID: 38375753

Vitamin D insufficiency in infants with increased risk of developing type 1 diabetes: a secondary analysis of the POInT Study. Jacobs A, Warnants M, Vollmuth V, Winkler C, Weiss A, Ziegler AG, Lundgren M, Elding Larsson H, Kordonouri O, von dem Berge T, Zielmann ML, Bonifacio E, Hommel A, Ołtarzewski M, Szypowska A, Besser R, Todd JA, Casteels K. BMJ Paediatr Open. 2024 Jan 12;8(1):e002212. doi: 10.1136/bmjpo-2023-002212. PMID: 38216311 Free PMC article.

Characterisation and clinical outcomes in children and adolescents with diabetes according to newly defined subgroups: a cohort study from the DPV registry. Warncke K, Eckert A, Bonifacio E, Achenbach P, Kordonouri O, Meissner T, Ohlenschläger U, Bonfig W, Ziegler AG, Holl RW. EClinicalMedicine. 2023 Sep 8;64:102208. doi: 10.1016/j.eclinm.2023.102208. eCollection 2023 Oct. PMID: 37731934 Free PMC article.

SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood. Lugar M, Eugster A, Achenbach P, von dem Berge T, Berner R, Besser REJ, Casteels K, Elding Larsson H, Gemulla G, Kordonouri O, Lindner A, Lundgren M, Müller D, Oltarzewski M, Rochtus A, Scholz M, Szypowska A, Todd JA, Ziegler AG, Bonifacio E; GPPAD Study Group. JAMA. 2023 Sep 26;330(12):1151-1160. doi: 10.1001/jama.2023.16348. PMID: 37682551 Free PMC article.

Children diagnosed with presymptomatic type 1 diabetes through public health screening have milder diabetes at clinical manifestation. Hummel S, Carl J, Friedl N, Winkler C, Kick K, Stock J, Reinmüller F, Ramminger C, Schmidt J, Lwowsky D, Braig S, Dunstheimer D, Ermer U, Gerstl EM, Weber L, Nellen-Hellmuth N, Brämswig S, Sindichakis M, Tretter S, Lorrmann A, Bonifacio E, Ziegler AG, Achenbach P; Fr1da Study Group. Diabetologia. 2023 Sep;66(9):1633-1642. doi: 10.1007/s00125-023-05953-0. Epub 2023 Jun 17. PMID: 37329450 Free PMC article.

Type 1 Diabetes Incidence and Risk in Children With a Diagnosis of COVID-19. Weiss A, Donnachie E, Beyerlein A, Ziegler AG, Bonifacio E. JAMA. 2023 Jun 20;329(23):2089-2091. doi: 10.1001/jama.2023.8674. PMID: 37213115 Free PMC article.

Potential of TCR sequencing in graft-versus-host disease. Goel M, Eugster A, Schetelig J, Bonifacio E, Bornhäuser M, Link-Rachner CS. Bone Marrow Transplant. 2023 Mar;58(3):239-246. doi: 10.1038/s41409-022-01885-2. Epub 2022 Dec 7. PMID: 36477111 Free PMC article. Review.

Next Generation Biobanking: Employing a Robotic System for Automated Mononuclear Cell Isolation. Fuchs YF, Brunner J, Weigelt M, Schieferdecker A, Morgenstern R, Sturm A, Winter B, Jambor H, Stölzel F, Ruhnke L, von Bonin M, Rücker-Braun E, Heidenreich F, Fuchs A, Bonifacio E, Bornhäuser M, Poitz DM, Altmann H. Biopreserv Biobank. 2023 Feb;21(1):106-110. doi: 10.1089/bio.2021.0181. Epub 2022 Oct 13. PMID: 36251308 Free PMC article. No abstract available.

Successful integration of newborn genetic testing into UK routine screening using prospective consent to determine eligibility for clinical trials. Bendor-Samuel OM, Wishlade T, Willis L, Aley P, Choi E, Craik R, Mujadidi Y, Mounce G, Roseman F, De La Horra Gozalo A, Bland J, Taj N, Smith I, Ziegler AG, Bonifacio E, Winkler C, Haupt F, Todd JA, Servais L, Snape MD, Vatish M; GPPAD Study Group. Arch Dis Child. 2023 Jan;108(1):26-30. doi: 10.1136/archdischild-2022-324270. Epub 2022 Sep 28. PMID: 36171064 Free PMC article.

Correction to: Progression likelihood score identifies substages of presymptomatic type 1 diabetes in childhood public health screening. Weiss A, Zapardiel-Gonzalo J, Voss F, Jolink M, Stock J, Haupt F, Kick K, Welzhofer T, Heublein A, Winkler C, Achenbach P, Ziegler AG, Bonifacio E; Fr1da-study group. Diabetologia. 2022 Dec;65(12):2175. doi: 10.1007/s00125-022-05798-z. PMID: 36194252 Free PMC article. No abstract available.

Progression likelihood score identifies substages of presymptomatic type 1 diabetes in childhood public health screening. Weiss A, Zapardiel-Gonzalo J, Voss F, Jolink M, Stock J, Haupt F, Kick K, Welzhofer T, Heublein A, Winkler C, Achenbach P, Ziegler AG, Bonifacio E; Fr1da-study group. Diabetologia. 2022 Dec;65(12):2121-2131. doi: 10.1007/s00125-022-05780-9. Epub 2022 Aug 27. PMID: 36028774 Free PMC article.

Corrigendum: A novel type I interferon primed dendritic cell subpopulation in TREX1 mutant chilblain lupus patients. Eugster A, Müller D, Gompf A, Reinhardt S, Lindner A, Ashton M, Zimmermann N, Beissert S, Bonifacio E, Günther C. Front Immunol. 2022 Nov 25;13:1094578. doi: 10.3389/fimmu.2022.1094578. eCollection 2022. PMID: 36518762 Free PMC article.

Elevations in blood glucose before and after the appearance of islet autoantibodies in children. Warncke K, Weiss A, Achenbach P, von dem Berge T, Berner R, Casteels K, Groele L, Hatzikotoulas K, Hommel A, Kordonouri O, Elding Larsson H, Lundgren M, Marcus BA, Snape MD, Szypowska A, Todd JA, Bonifacio E, Ziegler AG; GPPAD and POInT Study Groups. J Clin Invest. 2022 Oct 17;132(20):e162123. doi: 10.1172/JCI162123. PMID: 36250461 Free PMC article.

SARS-CoV-2 Infections and Presymptomatic Type 1 Diabetes Autoimmunity in Children and Adolescents From Colorado, USA, and Bavaria, Germany. Rewers M, Bonifacio E, Ewald D, Geno Rasmussen C, Jia X, Pyle L, Ziegler AG; ASK Study Group and Fr1da Study Group. JAMA. 2022 Sep 27;328(12):1252-1255. doi: 10.1001/jama.2022.14092. PMID: 35930271 Free PMC article.

Autoantibodies against ATP4A are a feature of the abundant autoimmunity that develops in first-degree relatives of patients with type 1 diabetes. Zielmann ML, Jolink M, Winkler C, Eugster A, Müller D, Scholz M, Ziegler AG, Bonifacio E. Pediatr Diabetes. 2022 Sep;23(6):714-720. doi: 10.1111/pedi.13361. Epub 2022 May 22. PMID: 35561070

A classification and regression tree analysis identifies subgroups of childhood type 1 diabetes. Achenbach P, Hippich M, Zapardiel-Gonzalo J, Karges B, Holl RW, Petrera A, Bonifacio E, Ziegler AG; DiMelli Study group and DPV Study group. EBioMedicine. 2022 Aug;82:104118. doi: 10.1016/j.ebiom.2022.104118. Epub 2022 Jul 5. PMID: 35803018 Free PMC article.

A Novel Type I Interferon Primed Dendritic Cell Subpopulation in TREX1 Mutant Chilblain Lupus Patients. Eugster A, Müller D, Gompf A, Reinhardt S, Lindner A, Ashton M, Zimmermann N, Beissert S, Bonifacio E, Günther C. Front Immunol. 2022 Jul 13;13:897500. doi: 10.3389/fimmu.2022.897500. eCollection 2022. PMID: 35911727 Free PMC article.

Distinguishing activated T regulatory cell and T conventional cells by single-cell technologies. Reinhardt J, Sharma V, Stavridou A, Lindner A, Reinhardt S, Petzold A, Lesche M, Rost F, Bonifacio E, Eugster A. Immunology. 2022 May;166(1):121-137. doi: 10.1111/imm.13460. Epub 2022 Mar 2. PMID: 35196398 Free PMC article.

Reproducibility of 10x Genomics single cell RNA sequencing method in the immune cell environment. Kraus G, Weigelt M, Reinhardt S, Petzold A, Dahl A, Bonifacio E. J Immunol Methods. 2022 Mar;502:113227. doi: 10.1016/j.jim.2022.113227. Epub 2022 Jan 12. PMID: 35031279

Holthaus L, Sharma V, Brandt D, Ziegler AG, Jastroch M, Bonifacio E. Functional and metabolic fitness of human CD4+ T lymphocytes during metabolic stress. Life Sci Alliance. 2021 Sep 27;4(12):e202101013. doi: 10.26508/lsa.202101013. Print 2021 Dec. PMID: 34580176

Brænne I, Onengut-Gumuscu S, Chen R, Manichaikul AW, Rich SS, Chen WM, Farber CR; TEDDY Study Group. Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes. Sci Rep. 2021 Nov 22;11(1):22651. doi: 10.1038/s41598-021-01840-z. PMID: 34811390

Ziegler AG, Arnolds S, Kölln A, Achenbach P, Berner R, Bonifacio E, Casteels K, Elding Larsson H, Gündert M, Hasford J, Kordonouri O, Lundgren M, Oltarzewski M, Pekalski ML, Pfirrmann M, Snape MD, Szypowska A, Todd JA; GPPAD STUDY GROUP. Supplementation with Bifidobacterium longum subspecies infantis EVC001 for mitigation of type 1 diabetes autoimmunity: the GPPAD-SINT1A randomised controlled trial protocol. BMJ Open. 2021 Nov 9;11(11):e052449. doi: 10.1136/bmjopen-2021-052449. PMID: 34753762

Krämer B, Knoll R, Bonaguro L, ToVinh M, Raabe J, Astaburuaga-García R, Schulte-Schrepping J, Kaiser KM, Rieke GJ, Bischoff J, Monin MB, Hoffmeister C, Schlabe S, De Domenico E, Reusch N, Händler K, Reynolds G, Blüthgen N, Hack G, Finnemann C, Nischalke HD, Strassburg CP, Stephenson E, Su Y, Gardner L, Yuan D, Chen D, Goldman J, Rosenstiel P, Schmidt SV, Latz E, Hrusovsky K, Ball AJ, Johnson JM, Koenig PA, Schmidt FI, Haniffa M, Heath JR, Kümmerer BM, Keitel V, Jensen B, Stubbemann P, Kurth F, Sander LE, Sawitzki B; Deutsche COVID-19 OMICS Initiative (DeCOI), Aschenbrenner AC, Schultze JL, Nattermann J. Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19. Immunity. 2021 Nov 9;54(11):2650-2669.e14. doi: 10.1016/j.immuni.2021.09.002. Epub 2021 Sep 4. PMID: 34592166

von Herrath M, Bonifacio E. How benign autoimmunity becomes detrimental in type 1 diabetes. Proc Natl Acad Sci U S A. 2021 Nov 2;118(44):e2116508118. doi: 10.1073/pnas.2116508118. PMID: 34697240

Watts D, Janßen M, Jaykar M, Palmucci F, Weigelt M, Petzold C, Hommel A, Sparwasser T, Bonifacio E, Kretschmer K. Transient Depletion of Foxp3+ Regulatory T Cells Selectively Promotes Aggressive β Cell Autoimmunity in Genetically Susceptible DEREG Mice. Front Immunol. 2021 Aug 10;12:720133. doi: 10.3389/fimmu.2021.720133. eCollection 2021. PMID: 34447385

Schetelig J, Heidenreich F, Baldauf H, Trost S, Falk B, Hoßbach C, Real R, Roers A, Lindemann D, Dalpke A, Kolditz M, de With K, Bornhäuser M, Bonifacio EE, Rücker-Braun E, Lange V, Markert J, Barth R, Hofmann JA, Sauter J, Bernas SN, Schmidt AH. Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity. Front Immunol. 2021 Jul 26;12:698193. doi: 10.3389/fimmu.2021.698193. eCollection 2021. PMID: 34381451

Wigger L, Barovic M, Brunner AD, Marzetta F, Schöniger E, Mehl F, Kipke N, Friedland D, Burdet F, Kessler C, Lesche M, Thorens B, Bonifacio E, Legido-Quigley C, Barbier Saint Hilaire P, Delerive P, Dahl A, Klose C, Gerl MJ, Simons K, Aust D, Weitz J, Distler M, Schulte AM, Mann M, Ibberson M, Solimena M. Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes. Nat Metab. 2021 Jul;3(7):1017-1031. doi: 10.1038/s42255-021-00420-9. Epub 2021 Jun 28. PMID: 34183850

Hummel S, Weiß A, Bonifacio E, Agardh D, Akolkar B, Aronsson CA, Hagopian WA, Koletzko S, Krischer JP, Lernmark Å, Lynch K, Norris JM, Rewers MJ, She JX, Toppari J, Uusitalo U, Vehik K, Virtanen SM, Beyerlein A, Ziegler AG; TEDDY Study Group. Associations of breastfeeding with childhood autoimmunity, allergies, and overweight: The Environmental Determinants of Diabetes in the Young (TEDDY) study. Am J Clin Nutr. 2021 Jul 1;114(1):134-142. doi: 10.1093/ajcn/nqab065. PMID: 33831944

Warnat-Herresthal S, Schultze H, Shastry KL, Manamohan S, Mukherjee S, Garg V, Sarveswara R, Händler K, Pickkers P, Aziz NA, Ktena S, Tran F, Bitzer M, Ossowski S, Casadei N, Herr C, Petersheim D, Behrends U, Kern F, Fehlmann T, Schommers P, Lehmann C, Augustin M, Rybniker J, Altmüller J, Mishra N, Bernardes JP, Krämer B, Bonaguro L, Schulte-Schrepping J, De Domenico E, Siever C, Kraut M, Desai M, Monnet B, Saridaki M, Siegel CM, Drews A, Nuesch-Germano M, Theis H, Heyckendorf J, Schreiber S, Kim-Hellmuth S; COVID-19 Aachen Study (COVAS), Nattermann J, Skowasch D, Kurth I, Keller A, Bals R, Nürnberg P, Rieß O, Rosenstiel P, Netea MG, Theis F, Mukherjee S, Backes M, Aschenbrenner AC, Ulas T; Deutsche COVID-19 Omics Initiative (DeCOI), Breteler MMB, Giamarellos-Bourboulis EJ, Kox M, Becker M, Cheran S, Woodacre MS, Goh EL, Schultze JL. Swarm Learning for decentralized and confidential clinical machine learning. Nature. 2021 Jun;594(7862):265-270. doi: 10.1038/s41586-021-03583-3. Epub 2021 May 26. PMID: 34040261

Hippich M, Sifft P, Zapardiel-Gonzalo J, Böhmer MM, Lampasona V, Bonifacio E, Ziegler AG. A public health antibody screening indicates a marked increase of SARS-CoV-2 exposure rate in children during the second wave. Med (N Y). 2021 May 14;2(5):571-572. doi: 10.1016/j.medj.2021.03.019. Epub 2021 Apr 3. PMID: 33842906

Assfalg R, Knoop J, Hoffman KL, Pfirrmann M, Zapardiel-Gonzalo JM, Hofelich A, Eugster A, Weigelt M, Matzke C, Reinhardt J, Fuchs Y, Bunk M, Weiss A, Hippich M, Halfter K, Hauck SM, Hasford J, Petrosino JF, Achenbach P, Bonifacio E, Ziegler AG. Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomised controlled trial. Diabetologia. 2021 May;64(5):1079-1092. doi: 10.1007/s00125-020-05376-1. Epub 2021 Jan 30. PMID: 33515070

Xhonneux LP, Knight O, Lernmark Å, Bonifacio E, Hagopian WA, Rewers MJ, She JX, Toppari J, Parikh H, Smith KGC, Ziegler AG, Akolkar B, Krischer JP, McKinney EF. Transcriptional networks in at-risk individuals identify signatures of type 1 diabetes progression. Sci Transl Med. 2021 Mar 31;13(587):eabd5666. doi: 10.1126/scitranslmed.abd5666. PMID: 33790023

Bonifacio E, Weiß A, Winkler C, Hippich M, Rewers MJ, Toppari J, Lernmark Å, She JX, Hagopian WA, Krischer JP, Vehik K, Schatz DA, Akolkar B, Ziegler AG; TEDDY Study Group. An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood. Diabetes Care. 2021 Feb 24:dc202122. doi: 10.2337/dc20-2122. Online ahead of print. PMID: 33627366

Hippich M, Holthaus L, Assfalg R, Zapardiel-Gonzalo J, Kapfelsperger H, Heigermoser M, Haupt F, Ewald DA, Welzhofer TC, Marcus BA, Heck S, Koelln A, Stock J, Voss F, Secchi M, Piemonti L, de la Rosa K, Protzer U, Boehmer M, Achenbach P, Lampasona V, Bonifacio E, Ziegler AG. A Public Health Antibody Screening Indicates a 6-Fold Higher SARS-CoV-2 Exposure Rate than Reported Cases in Children. Med (N Y). 2021 Feb 12;2(2):149-163.e4. doi: 10.1016/j.medj.2020.10.003. Epub 2020 Oct 29. PMID: 33163984

Ziegler AG, Bonifacio E. Shortening the paths to type 1 diabetes mellitus prevention. Nat Rev Endocrinol. 2021 Feb;17(2):73-74. doi: 10.1038/s41574-020-00450-5. PMID: 33257822

Aschenbrenner AC, Mouktaroudi M, Krämer B, Oestreich M, Antonakos N, Nuesch-Germano M, Gkizeli K, Bonaguro L, Reusch N, Baßler K, Saridaki M, Knoll R, Pecht T, Kapellos TS, Doulou S, Kröger C, Herbert M, Holsten L, Horne A, Gemünd ID, Rovina N, Agrawal S, Dahm K, van Uelft M, Drews A, Lenkeit L, Bruse N, Gerretsen J, Gierlich J, Becker M, Händler K, Kraut M, Theis H, Mengiste S, De Domenico E, Schulte-Schrepping J, Seep L, Raabe J, Hoffmeister C, ToVinh M, Keitel V, Rieke G, Talevi V, Skowasch D, Aziz NA, Pickkers P, van de Veerdonk FL, Netea MG, Schultze JL, Kox M, Breteler MMB, Nattermann J, Koutsoukou A, Giamarellos-Bourboulis EJ, Ulas T; German COVID-19 Omics Initiative (DeCOI). Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients. Genome Med. 2021 Jan 13;13(1):7. doi: 10.1186/s13073-020-00823-5. PMID: 33441124

Bernardes JP, Mishra N, Tran F, Bahmer T, Best L, Blase JI, Bordoni D, Franzenburg J, Geisen U, Josephs-Spaulding J, Köhler P, Künstner A, Rosati E, Aschenbrenner AC, Bacher P, Baran N, Boysen T, Brandt B, Bruse N, Dörr J, Dräger A, Elke G, Ellinghaus D, Fischer J, Forster M, Franke A, Franzenburg S, Frey N, Friedrichs A, Fuß J, Glück A, Hamm J, Hinrichsen F, Hoeppner MP, Imm S, Junker R, Kaiser S, Kan YH, Knoll R, Lange C, Laue G, Lier C, Lindner M, Marinos G, Markewitz R, Nattermann J, Noth R, Pickkers P, Rabe KF, Renz A, Röcken C, Rupp J, Schaffarzyk A, Scheffold A, Schulte-Schrepping J, Schunk D, Skowasch D, Ulas T, Wandinger KP, Wittig M, Zimmermann J, Busch H, Hoyer BF, Kaleta C, Heyckendorf J, Kox M, Rybniker J, Schreiber S, Schultze JL, Rosenstiel P; HCA Lung Biological Network; Deutsche COVID-19 Omics Initiative (DeCOI). Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19. Immunity. 2020 Dec 15;53(6):1296-1314.e9. doi: 10.1016/j.immuni.2020.11.017. Epub 2020 Nov 26. PMID: 33296687

Hollstein T, Schulte DM, Schulz J, Glück A, Ziegler AG, Bonifacio E, Wendorff M, Franke A, Schreiber S, Bornstein SR, Laudes M. Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report. Nat Metab. 2020 Oct;2(10):1021-1024. doi: 10.1038/s42255-020-00281-8. Epub 2020 Sep 2. PMID: 32879473

Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu CJ, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim KM, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk HD, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, Vinh MT, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Händler K, Schultze JL, Aschenbrenner AC, Li Y, Nattermann J, Sawitzki B, Saliba AE, Sander LE; Deutsche COVID-19 OMICS Initiative (DeCOI). Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell. 2020 Sep 17;182(6):1419-1440.e23. doi: 10.1016/j.cell.2020.08.001. Epub 2020 Aug 5. PMID: 32810438

Vehik K, Bonifacio E, Lernmark Å, Yu L, Williams A, Schatz D, Rewers M, She JX, Toppari J, Hagopian W, Akolkar B, Ziegler AG, Krischer JP; TEDDY Study Group. Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2020 Sep;43(9):2066-2073. doi: 10.2337/dc19-2547. Epub 2020 Jul 8. PMID: 32641373

Ferrat LA, Vehik K, Sharp SA, Lernmark Å, Rewers MJ, She JX, Ziegler AG, Toppari J, Akolkar B, Krischer JP, Weedon MN, Oram RA, Hagopian WA; TEDDY Study Group; Committees. A combined risk score enhances prediction of type 1 diabetes among susceptible children. Nat Med. 2020 Aug;26(8):1247-1255. doi: 10.1038/s41591-020-0930-4. Epub 2020 Aug 7. PMID: 32770166

Ziegler AG, Bonifacio E. Why is the presence of autoantibodies against GAD associated with a relatively slow progression to clinical diabetes? Diabetologia. 2020 Aug;63(8):1665-1666. doi: 10.1007/s00125-020-05175-8. Epub 2020 May 26. PMID: 32451571

Lindfors K, Lin J, Lee HS, Hyöty H, Nykter M, Kurppa K, Liu E, Koletzko S, Rewers M, Hagopian W, Toppari J, Ziegler AG, Akolkar B, Krischer JP, Petrosino JF, Lloyd RE, Agardh D; TEDDY Study Group. Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study. Gut. 2020 Aug;69(8):1416-1422. doi: 10.1136/gutjnl-2019-319809. Epub 2019 Nov 19. PMID: 31744911

Syed F, Tersey SA, Turatsinze JV, Felton JL, Kang NJ, Nelson JB, Sims EK, Defrance M, Bizet M, Fuks F, Cnop M, Bugliani M, Marchetti P, Ziegler AG, Bonifacio E, Webb-Robertson BJ, Balamurugan AN, Evans-Molina C, Eizirik DL, Mather KJ, Arslanian S, Mirmira RG. Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes. Clin Epigenetics. 2020 Jul 31;12(1):116. doi: 10.1186/s13148-020-00906-5. PMID: 32736653

Monti P, Vignali D, Ziegler AG, Bonifacio E. Soluble IL-7 receptor alpha concentration in cord blood is linked to sex and maternal diabetes, but not with subsequent development of type 1 diabetes. Eur J Immunol. 2020 Jun;50(6):903-905. doi: 10.1002/eji.201948447. Epub 2020 Apr 9. PMID: 32056201

Knoop J, Eugster A, Gavrisan A, Lickert R, Sedlmeier EM, Dietz S, Lindner A, Warncke K, Hummel N, Ziegler AG, Bonifacio E. Maternal Type 1 Diabetes Reduces Autoantigen-Responsive CD4+ T Cells in Offspring. Diabetes. 2020 Apr;69(4):661-669. doi: 10.2337/db19-0751. Epub 2020 Jan 2. PMID: 31896551

Li Q, Parikh H, Butterworth MD, Lernmark Å, Hagopian W, Rewers M, She JX, Toppari J, Ziegler AG, Akolkar B, Fiehn O, Fan S, Krischer JP; TEDDY Study Group. Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study. Diabetes. 2020 Mar;69(3):465-476. doi: 10.2337/db19-0756. Epub 2020 Feb 6. PMID:

Liu X, Vehik K, Huang Y, Elding Larsson H, Toppari J, Ziegler AG, She JX, Rewers M, Hagopian WA, Akolkar B, Krischer JP; TEDDY Study Group. Distinct Growth Phases in Early Life Associated With the Risk of Type 1 Diabetes: The TEDDY Study. Diabetes Care. 2020 Mar;43(3):556-562. doi: 10.2337/dc19-1670. Epub 2020 Jan 2. PMID: 31896601

Ziegler AG, Kick K, Bonifacio E, Haupt F, Hippich M, Dunstheimer D, Lang M, Laub O, Warncke K, Lange K, Assfalg R, Jolink M, Winkler C, Achenbach P; Fr1da Study Group. Yield of a Public Health Screening of Children for Islet Autoantibodies in Bavaria, Germany. JAMA. 2020 Jan 28;323(4):339-351. doi: 10.1001/jama.2019.21565. PMID: 31990315

Bonifacio E, Achenbach P. Birth and coming of age of islet autoantibodies. Clin Exp Immunol. 2019 Dec;198(3):294-305. doi: 10.1111/cei.13360. Epub 2019 Sep 12. Review. PubMed PMID: 31397889.

Lindfors K, Lin J, Lee HS, Hyöty H, Nykter M, Kurppa K, Liu E, Koletzko S, Rewers M, Hagopian W, Toppari J, Ziegler AG, Akolkar B, Krischer JP, Petrosino JF, Lloyd RE, Agardh D; TEDDY Study Group. Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study. Gut. 2019 Nov 19. pii: gutjnl-2019-319809. doi: 10.1136/gutjnl-2019-319809. [Epub ahead of print] PubMed PMID: 31744911.

Fuchs YF, Sharma V, Eugster A, Kraus G, Morgenstern R, Dahl A, Reinhardt S,Petzold A, Lindner A, Löbel D, Bonifacio E. Gene Expression-Based Identification of Antigen-Responsive CD8(+) T Cells on a Single-Cell Level. Front Immunol. 2019 Nov 6;10:2568. doi: 10.3389/fimmu.2019.02568. eCollection 2019. PubMed PMID: 31781096; PubMed Central PMCID: PMC6851025.

Johnson RK, Vanderlinden L, DeFelice BC, Kechris K, Uusitalo U, Fiehn O, Sontag M, Crume T, Beyerlein A, Lernmark Ä, Toppari J, Ziegler AG, She JX, Hagopian W, Rewers M, Akolkar B, Krischer J, Virtanen SM, Norris JM; TEDDY Study Group. Metabolite-related dietary patterns and the development of islet autoimmunity. Sci Rep. 2019 Oct 15;9(1):14819. doi: 10.1038/s41598-019-51251-4. PubMed PMID: 31616039; PubMed Central PMCID: PMC6794249.

Frank NM, Lynch KF, Uusitalo U, Yang J, Lönnrot M, Virtanen SM, Hyöty H, Norris JM; TEDDY Study Group. The relationship between breastfeeding and reported respiratory and gastrointestinal infection rates in young children. BMC Pediatr. 2019 Sep 18;19(1):339. doi: 10.1186/s12887-019-1693-2. PubMed PMID: 31533753; PubMed Central PMCID: PMC6749679.

Winkler C, Jolink M, Knopff A, Kwarteng NA, Achenbach P, Bonifacio E, Ziegler AG. Age, HLA, and Sex Define a Marked Risk of Organ-Specific Autoimmunity in First-Degree Relatives of Patients With Type 1 Diabetes. Diabetes Care. 2019 Sep;42(9):1684-1691. doi: 10.2337/dc19-0315. Epub 2019 Jun 18. PubMed PMID: 31213469.

Beyerlein A, Bonifacio E, Vehik K, Hippich M, Winkler C, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Ä, Rewers MJ, She JX, Toppari J, Akolkar B, Rich SS, Ziegler AG; TEDDY Study Group. Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study. J Med Genet. 2019 Sep;56(9):602-605. doi: 10.1136/jmedgenet-2018-105532. Epub 2018 Oct 4. PubMed PMID: 30287597; PubMed Central PMCID: PMC6690814.

Winkler C, Haupt F, Heigermoser M, Zapardiel-Gonzalo J, Ohli J, Faure T, Kalideri E, Hommel A, Delivani P, Berner R, Kordonouri O, Roloff F, von dem Berge T, Lange K, Oltarzewski M, Glab R, Szypowska A, Snape MD, Vatish M, Todd JA, Larsson HE, Ramelius A, Kördel JÄ, Casteels K, Paulus J, Ziegler AG, Bonifacio E; GPPAD Study Group. Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials-GPPAD-02 study design and first results. Pediatr Diabetes. 2019 Sep;20(6):720-727. doi: 10.1111/pedi.12870. Epub 2019 Jun 13. PubMed PMID: 31192505; PubMed Central PMCID: PMC6851563.

Hoffmann VS, Weiß A, Winkler C, Knopff A, Jolink M, Bonifacio E, Ziegler AG. Landmark models to define the age-adjusted risk of developing stage 1 type 1 diabetes across childhood and adolescence. BMC Med. 2019 Jul 9;17(1):125. doi: 10.1186/s12916-019-1360-3. PubMed PMID: 31286933; PubMed Central PMCID: PMC6615150.

Ziegler AG, Achenbach P, Berner R, Casteels K, Danne T, Gündert M, Hasford J, Hoffmann VS, Kordonouri O, Lange K, Elding Larsson H, Lundgren M, Snape MD, Szypowska A, Todd JA, Bonifacio E; and the GPPAD Study group. Oral insulin therapy for primary prevention of type 1 diabetes in infants with high genetic risk: the GPPAD-POInT (global platform for the prevention of autoimmune diabetes primary oral insulin trial) study protocol. BMJ Open. 2019 Jun 28;9(6):e028578. doi: 10.1136/bmjopen-2018-028578. PubMed PMID: 31256036; PubMed Central PMCID: PMC6609035.

Krischer JP, Liu X, Vehik K, Akolkar B, Hagopian WA, Rewers MJ, She JX, Toppari J, Ziegler AG, Lernmark Ä; TEDDY Study Group. Predicting Islet Cell Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress Report. Diabetes Care. 2019 Jun;42(6):1051-1060. doi: 10.2337/dc18-2282. Epub 2019 Apr 9. PubMed PMID: 30967432; PubMed Central PMCID: PMC6609953.

Peplow C, Assfalg R, Beyerlein A, Hasford J, Bonifacio E, Ziegler AG. Blood draws up to 3% of blood volume in clinical trials are safe in children. Acta Paediatr. 2019 May;108(5):940-944. doi: 10.1111/apa.14607. Epub 2018 Oct 30. PubMed PMID: 30291644; PubMed Central PMCID: PMC6587985.

Ashton MP, Eugster A, Dietz S, Loebel D, Lindner A, Kuehn D, Taranko AE, Heschel B, Gavrisan A, Ziegler AG, Aringer M, Bonifacio E. Association of Dendritic Cell Signatures With Autoimmune Inflammation Revealed by Single-Cell Profiling. Arthritis Rheumatol. 2019 May;71(5):817-828. doi: 10.1002/art.40793. Epub 2019 Apr 6. PubMed PMID: 30511817.

Eugster A, Kraus G, Lidzba V, Müller D, Jolink M, Ziegler AG, Bonifacio E. Cytoplasmic ends of tetraspanin 7 harbour epitopes recognised by autoantibodies in type 1 diabetes. Diabetologia. 2019 May;62(5):805-810. doi: 10.1007/s00125-019-4832-2. Epub 2019 Feb 21. PubMed PMID: 30789994.

Ziegler AG, Hoffmann GF, Hasford J, Larsson HE, Danne T, Berner R, Penno M, Koralova A, Dunne J, Bonifacio E. Screening for asymptomatic beta cell autoimmunity in young children. Lancet Child Adolesc Health. 2019 May;3(5):288-290. doi: 10.1016/S2352-4642(19)30028-8. Epub 2019 Feb 10. PubMed PMID: 30745054.

Laimighofer M, Lickert R, Fuerst R, Theis FJ, Winkler C, Bonifacio E, Ziegler AG, Krumsiek J. Common patterns of gene regulation associated with Cesarean section and the development of islet autoimmunity - indications of immune cell activation. Sci Rep. 2019 Apr 18;9(1):6250. doi: 10.1038/s41598-019-42750-5. PubMed PMID: 31000755; PubMed Central PMCID: PMC6472354.

Schreiber M, Weigelt M, Karasinsky A, Anastassiadis K, Schallenberg S, Petzold
C, Bonifacio E, Kretschmer K, Hommel A. Inducible IL-7 Hyperexpression Influences
Lymphocyte Homeostasis and Function and Increases Allograft Rejection. Front
Immunol. 2019 Apr 10;10:742. doi: 10.3389/fimmu.2019.00742. eCollection 2019.
PubMed PMID: 31024566; PubMed Central PMCID: PMC6467976.

Laimighofer M, Lickert R, Fuerst R, Theis FJ, Winkler C, Bonifacio E, Ziegler
AG, Krumsiek J. Common patterns of gene regulation associated with Cesarean
section and the development of islet autoimmunity - indications of immune cell
activation. Sci Rep. 2019 Apr 18;9(1):6250. doi: 10.1038/s41598-019-42750-5.
PubMed PMID: 31000755; PubMed Central PMCID: PMC6472354.

Krischer JP, Liu X, Vehik K, Akolkar B, Hagopian WA, Rewers MJ, She JX,
Toppari J, Ziegler AG, Lernmark Å; TEDDY Study Group. Predicting Islet Cell
Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress Report. Diabetes
Care. 2019 Apr 9. pii: dc182282. doi: 10.2337/dc18-2282. [Epub ahead of print]
PubMed PMID: 30967432.

Eugster A, Kraus G, Lidzba V, Müller D, Jolink M, Ziegler AG, Bonifacio E.
Cytoplasmic ends of tetraspanin 7 harbour epitopes recognised by autoantibodies
in type 1 diabetes. Diabetologia. 2019 May;62(5):805-810. doi:
10.1007/s00125-019-4832-2. Epub 2019 Feb 21. PubMed PMID: 30789994.

Marín Morales JM, Münch N, Peter K, Freund D, Oelschlägel U, Hölig K, Böhm T,
Flach AC, Keßler J, Bonifacio E, Bornhäuser M, Fuchs A. Automated Clinical Grade
Expansion of Regulatory T Cells in a Fully Closed System. Front Immunol. 2019 Feb
1;10:38. doi: 10.3389/fimmu.2019.00038. eCollection 2019. PubMed PMID: 30778344;
PubMed Central PMCID: PMC6369367.

Ziegler AG, Hoffmann GF, Hasford J, Larsson HE, Danne T, Berner R, Penno M,
Koralova A, Dunne J, Bonifacio E. Screening for asymptomatic β-cell autoimmunity
in young children. Lancet Child Adolesc Health. 2019 Feb 8. pii:
S2352-4642(19)30028-8. doi: 10.1016/S2352-4642(19)30028-8. [Epub ahead of print]
PubMed PMID: 30745054.

Albert S, Koristka S, Gerbaulet A, Cartellieri M, Arndt C, Feldmann A, Berndt
N, Loureiro LR, von Bonin M, Ehninger G, Eugster A, Bonifacio E, Bornhäuser M,
Bachmann MP, Ehninger A. Tonic Signaling and Its Effects on Lymphopoiesis of
CAR-Armed Hematopoietic Stem and Progenitor Cells. J Immunol. 2019 Feb 6. pii:
ji1801004. doi: 10.4049/jimmunol.1801004. [Epub ahead of print] PubMed PMID:
30728213.

Hippich M, Beyerlein A, Hagopian WA, Krischer JP, Vehik K, Knoop J, Winker C,
Toppari J, Lernmark Å, Rewers MJ, Steck AK, She JX, Akolkar B, Robertson CC,
Onengut-Gumuscu S, Rich SS, Bonifacio E, Ziegler AG; TEDDY Study Group. Genetic
Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the
General Population and Children From Affected Families. Diabetes. 2019 Jan 17.
pii: db180882. doi: 10.2337/db18-0882. [Epub ahead of print] PubMed PMID:
30655385.

Ashton MP, Eugster A, Dietz S, Loebel D, Lindner A, Kuehn D, Taranko AE,
Heschel B, Gavrisan A, Ziegler AG, Aringer M, Bonifacio E. Single-cell profiling
reveals dendritic cell signatures associated with autoimmune inflammation.
Arthritis Rheumatol. 2018 Dec 4. doi: 10.1002/art.40793. [Epub ahead of print]
PubMed PMID: 30511817.

Endesfelder D, Zu Castell W, Bonifacio E, Rewers M, Hagopian WA, She JX,
Lernmark Å, Toppari J, Vehik K, Williams AJK, Yu L, Akolkar B, Krischer JP,
Ziegler AG, Achenbach P; TEDDY Study Group. Time-Resolved Autoantibody Profiling
Facilitates Stratification of Preclinical Type 1 Diabetes in Children. Diabetes.
2019 Jan;68(1):119-130. doi: 10.2337/db18-0594. Epub 2018 Oct 10. PubMed PMID:
30305370; PubMed Central PMCID: PMC6302536.

Peplow C, Assfalg R, Beyerlein A, Hasford J, Bonifacio E, Ziegler AG. Blood
draws up to 3% of blood volume in clinical trials are safe in children. Acta
Paediatr. 2018 Oct 6. doi: 10.1111/apa.14607. [Epub ahead of print] PubMed PMID:
30291644.

Beyerlein A, Bonifacio E, Vehik K, Hippich M, Winkler C, Frohnert BI, Steck
AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar
B, Rich SS, Ziegler AG; TEDDY Study Group. Progression from islet autoimmunity to
clinical type 1 diabetes is influenced by genetic factors: results from the
prospective TEDDY study. J Med Genet. 2018 Oct 4. pii: jmedgenet-2018-105532.
doi: 10.1136/jmedgenet-2018-105532. [Epub ahead of print] PubMed PMID: 30287597.

Link-Rachner CS, Eugster A, Rücker-Braun E, Heidenreich F, Oelschlägel U, Dahl
A, Klesse C, Kuhn M, Middeke JM, Bornhäuser M, Bonifacio E, Schetelig J. T cell
receptor alpha repertoire of CD8+ T cells following allogeneic stem cell
transplantation using next-generation sequencing. Haematologica. 2018 Sep 27.
pii: haematol.2018.199802. doi: 10.3324/haematol.2018.199802. [Epub ahead of
print] PubMed PMID: 30262565.

Mathieu C, Lahesmaa R, Bonifacio E, Achenbach P, Tree T. Immunological
biomarkers for the development and progression of type 1 diabetes. Diabetologia.
2018 Nov;61(11):2252-2258. doi: 10.1007/s00125-018-4726-8. Epub 2018 Sep 12.
Review. PubMed PMID: 30209538.

Holthaus L, Lamp D, Gavrisan A, Sharma V, Ziegler AG, Jastroch M, Bonifacio
E. CD4(+) T cell activation, function, and metabolism are inhibited by low
concentrations of DMSO. J Immunol Methods. 2018 Dec;463:54-60. doi:
10.1016/j.jim.2018.09.004. Epub 2018 Sep 7. PubMed PMID: 30201392.

Müller D, Telieps T, Eugster A, Weinzierl C, Jolink M, Ziegler AG, Bonifacio
E. Novel minor HLA DR associated antigens in type 1 diabetes. Clin Immunol. 2018
Sep;194:87-91. doi: 10.1016/j.clim.2018.07.001. Epub 2018 Jul 7. PubMed PMID:
29990590.

Hippich M, Oleynik A, Jain K, Winkler C, Ferreira RC, Bonifacio E, Ziegler
AG, Briese T. Searching peripheral blood mononuclear cells of children with viral
respiratory tract infections preceding islet autoimmunity for viruses by
high-throughput sequencing. Acta Diabetol. 2018 Aug;55(8):881-884. doi:
10.1007/s00592-018-1138-7. Epub 2018 Apr 23. PubMed PMID: 29687279.

Achenbach P, Hawa MI, Krause S, Lampasona V, Jerram ST, Williams AJK,
Bonifacio E, Ziegler AG, Leslie RD; Action LADA consortium. Autoantibodies to
N-terminally truncated GAD improve clinical phenotyping of individuals with
adult-onset diabetes: Action LADA 12. Diabetologia. 2018 Jul;61(7):1644-1649.
doi: 10.1007/s00125-018-4605-3. Epub 2018 Apr 4. PubMed PMID: 29619531.

Bonifacio E, Beyerlein A, Hippich M, Winkler C, Vehik K, Weedon MN,
Laimighofer M, Hattersley AT, Krumsiek J, Frohnert BI, Steck AK, Hagopian WA,
Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Oram RA, Rich
SS, Ziegler AG; TEDDY Study Group. Genetic scores to stratify risk of developing
multiple islet autoantibodies and type 1 diabetes: A prospective study in
children. PLoS Med. 2018 Apr 3;15(4):e1002548. doi: 10.1371/journal.pmed.1002548.
eCollection 2018 Apr. PubMed PMID: 29614081; PubMed Central PMCID: PMC5882115.

Mehdi AM, Hamilton-Williams EE, Cristino A, Ziegler A, Bonifacio E, Le Cao
KA, Harris M, Thomas R. A peripheral blood transcriptomic signature predicts
autoantibody development in infants at risk of type 1 diabetes. JCI Insight. 2018
Mar 8;3(5). pii: 98212. doi: 10.1172/jci.insight.98212. [Epub ahead of print]
PubMed PMID: 29515040; PubMed Central PMCID: PMC5922278.

Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda
K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren JE, Ladell K, Larger E,
Beressi JP, Lissina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio
E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R;
ImMaDiab Study Group. Islet-reactive CD8(+) T cell frequencies in the pancreas,
but not in blood, distinguish type 1 diabetic patients from healthy donors. Sci
Immunol. 2018 Feb 2;3(20). pii: eaao4013. doi: 10.1126/sciimmunol.aao4013. PubMed
PMID: 29429978; PubMed Central PMCID: PMC5874133.

Kindt ASD, Fuerst RW, Knoop J, Laimighofer M, Telieps T, Hippich M, Woerheide MA, Wahl S, Wilson R, Sedlmeier EM, Hommel A, Todd JA, Krumsiek J, Ziegler AG, Bonifacio E. Allele-specific methylation of type 1 diabetes susceptibility genes. J Autoimmun. 2017 Dec 7 [Epub ahead of print]

Heninger, A.K., Eugster, A., Kuehn, D., Buettner, F., Kuhn, M., Lindner, A., Dietz, S., Jergens, S., Wilhelm, C., Beyerlein, A., Ziegler, A.G., and Bonifacio, E. A Divergent Population of Autoantigen-Responsive CD4+ T Cells in Infants Prior to β Cell Autoimmunity. Science Translational Medicine, 9 (2017)

Bonifacio, E., Ziegler, A.G., Klingensmith, G., Schober, E., Bingley, P.J., Rottenkolber, M., Theil, A., Eugster, A., Puff, R., Peplow, C., Buettner, F., Lange, K., Eisenbarth, G., Hasford, J., and Achenbach, P. Effects of high-dose oral insulin on immune responses in children at high risk for type 1 diabetes: the Pre-POINT randomized clinical trial. JAMA 313, 1541-1549. (2015)

Ziegler, A.G., Rewers, M., Simell, O., Simell, T., Lempainen, J., Steck, A., Winkler, C., Ilonen, J., Veijola, R., Knip, M., Bonifacio, E., and Eisenbarth, G.S. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 309, 2473-2479. (2013)

Heninger, A.K., Monti, P., Wilhelm, C., Schwaiger, P., Kuehn, D., Ziegler, A.G., and Bonifacio, E. Activation of islet autoreactive naive T cells in infants is influenced by homeostatic mechanisms and antigen-presenting capacity. Diabetes 62, 2059-2066. (2013)

Heninger AK, Theil A, Wilhelm C, Petzold C, Huebel N, Kretschmer K, Bonifacio E, Monti P. IL-7 abrogates suppressive activity of human CD4+CD25+FOXP3+regulatory T cells and allows expansion of alloreactive and autoreactive T cells. J Immunol. Dec 15;189(12):5649-58. (2012)

Monti, P., Scirpoli, M., Maffi, P., Ghidoli, N., De Taddeo, F., Bertuzzi, F., Piemonti, L., Falcone, M., Secchi, A., and Bonifacio, E. Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells. J Clin Invest 118, 1806-1814. (2008)

Achenbach, P., Koczwara, K., Knopff, A., Naserke, H., Ziegler, A.G., and Bonifacio, E. Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes. J Clin Invest 114, 589-597.(2004)

Ziegler, A.G., Schmid, S., Huber, D., Hummel, M., and Bonifacio, E. Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. JAMA 290, 1721-1728. (2003)

Bonifacio, E., Bingley, P.J., Shattock, M., Dean, B.M., Dunger, D., Gale, E.A., and Bottazzo, G.F. Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes. Lancet 335, 147-149. (1990)