Publikationen
Chavakis T. Immunometabolism: Where Immunology and Metabolism Meet. J Innate Immun. 2021 Dec 14;14(1):1-3. doi: 10.1159/000521305. Online ahead of print. PMID: 34915503
Watts D, Bechmann N, Meneses A, Poutakidou IK, Kaden D, Conrad C, Krüger A, Stein J, El-Armouche A, Chavakis T, Eisenhofer G, Peitzsch M, Wielockx B. HIF2α regulates the synthesis and release of epinephrine in the adrenal medulla. J Mol Med (Berl). 2021 Nov;99(11):1655-1666. doi: 10.1007/s00109-021-02121-y. Epub 2021 Sep 4. PMID: 34480587
Balaian E, Wobus M, Bornhäuser M, Chavakis T, Sockel K. Myelodysplastic Syndromes and Metabolism. Int J Mol Sci. 2021 Oct 19;22(20):11250. doi: 10.3390/ijms222011250. PMID: 34681910
Jentho E, Ruiz-Moreno C, Novakovic B, Kourtzelis I, Megchelenbrink WL, Martins R, Chavakis T, Soares MP, Kalafati L, Guerra J, Roestel F, Bohm P, Godmann M, Grinenko T, Eugster A, Beretta M, Joosten LAB, Netea MG, Bauer M, Stunnenberg HG, Weis S. Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2102698118. doi: 10.1073/pnas.2102698118. PMID: 34663697
Chavakis T, Wielockx B, Hajishengallis G. Inflammatory Modulation of Hematopoiesis: Linking Trained Immunity and Clonal Hematopoiesis with Chronic Disorders. Annu Rev Physiol. 2021 Oct 6. doi: 10.1146/annurev-physiol-052521-013627. Online ahead of print. PMID: 34614373
Wang H, Li X, Kajikawa T, Shin J, Lim JH, Kourtzelis I, Nagai K, Korostoff JM, Grossklaus S, Naumann R, Chavakis T, Hajishengallis G. Stromal cell-derived DEL-1 inhibits Tfh cell activation and inflammatory arthritis. J Clin Invest. 2021 Oct 1;131(19):e150578. doi: 10.1172/JCI150578. PMID: 34403362
von Bonin M, Jambor HK, Teipel R, Stölzel F, Thiede C, Damm F, Kroschinsky F, Schetelig J, Chavakis T, Bornhäuser M. Clonal hematopoiesis and its emerging effects on cellular therapies. Leukemia. 2021 Oct;35(10):2752-2758. doi: 10.1038/s41375-021-01337-8. Epub 2021 Jul 2. PMID: 34215849
Subramanian P, Gargani S, Palladini A, Chatzimike M, Grzybek M, Peitzsch M, Papanastasiou AD, Pyrina I, Ntafis V, Gercken B, Lesche M, Petzold A, Sinha A, Nati M, Thangapandi VR, Kourtzelis I, Andreadou M, Witt A, Dahl A, Burkhardt R, Haase R, Domingues AMJ, Henry I, Zamboni N, Mirtschink P, Chung KJ, Hampe J, Coskun Ü, Kontoyiannis DL, Chavakis T. The RNA binding protein human antigen R is a gatekeeper of liver homeostasis. Hepatology. 2021 Sep 14. doi: 10.1002/hep.32153. Online ahead of print. PMID: 34519101
Nati M, Chung KJ, Chavakis T. The Role of Innate Immune Cells in Nonalcoholic Fatty Liver Disease. J Innate Immun. 2021 Aug 24:1-11. doi: 10.1159/000518407. Online ahead of print. PMID: 34515137
Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenvoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O'Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG. Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nat Immunol. 2021 Jul;22(7):928. doi: 10.1038/s41590-021-00960-y. PMID: 34017127
Hajishengallis G, Chavakis T. Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nat Rev Immunol. 2021 Jul;21(7):426-440. doi: 10.1038/s41577-020-00488-6. Epub 2021 Jan 28. PMID:
Sormendi S, Deygas M, Sinha A, Bernard M, Krüger A, Kourtzelis I, Le Lay G, Sáez PJ, Gerlach M, Franke K, Meneses A, Kräter M, Palladini A, Guck J, Coskun Ü, Chavakis T, Vargas P, Wielockx B. HIF2α is a direct regulator of neutrophil motility. Blood. 2021 Jun 17;137(24):3416-3427. doi: 10.1182/blood.2020007505. PMID: 33619535
Nording H, Baron L, Haberthür D, Emschermann F, Mezger M, Sauter M, Sauter R, Patzelt J, Knoepp K, Nording A, Meusel M, Meyer-Saraei R, Hlushchuk R, Sedding D, Borst O, Eitel I, Karsten CM, Feil R, Pichler B, Erdmann J, Verschoor A, Chavakis E, Chavakis T, von Hundelshausen P, Köhl J, Gawaz M, Langer HF. The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. Nat Commun. 2021 Jun 7;12(1):3352. doi: 10.1038/s41467-021-23499-w. PMID: 34099640
Hajishengallis G, Chavakis T. DEL-1: a potential therapeutic target in inflammatory and autoimmune disease? Expert Rev Clin Immunol. 2021 Jun;17(6):549-552. doi: 10.1080/1744666X.2021.1915771. Epub 2021 Apr 19. PMID: 33870840
Thangapandi VR, Knittelfelder O, Brosch M, Patsenker E, Vvedenskaya O, Buch S, Hinz S, Hendricks A, Nati M, Herrmann A, Rekhade DR, Berg T, Matz-Soja M, Huse K, Klipp E, Pauling JK, Wodke JA, Miranda Ackerman J, Bonin MV, Aigner E, Datz C, von Schönfels W, Nehring S, Zeissig S, Röcken C, Dahl A, Chavakis T, Stickel F, Shevchenko A, Schafmayer C, Hampe J, Subramanian P. Loss of hepatic Mboat7 leads to liver fibrosis. Gut. 2021 May;70(5):940-950. doi: 10.1136/gutjnl-2020-320853. Epub 2020 Jun 26. PMID: 32591434
Watts D, Stein J, Meneses A, Bechmann N, Neuwirth A, Kaden D, Krüger A, Sinha A, Alexaki VI, Luis Gustavo Perez-Rivas, Kircher S, Martinez A, Theodoropoulou M, Eisenhofer G, Peitzsch M, El-Armouche A, Chavakis T, Wielockx B. HIF1α is a direct regulator of steroidogenesis in the adrenal gland. Cell Mol Life Sci. 2021 Apr;78(7):3577-3590. doi: 10.1007/s00018-020-03750-1. Epub 2021 Jan 19. PMID: 33464382
Moustakas II, Katsarou A, Legaki AI, Pyrina I, Ntostoglou K, Papatheodoridi AM, Gercken B, Pateras IS, Gorgoulis VG, Koutsilieris M, Chavakis T, Chatzigeorgiou A. Hepatic Senescence Accompanies the Development of NAFLD in Non-Aged Mice Independently of Obesity. Int J Mol Sci. 2021 Mar 26;22(7):3446. doi: 10.3390/ijms22073446. PMID: 33810566
Dudeck J, Kotrba J, Immler R, Hoffmann A, Voss M, Alexaki VI, Morton L, Jahn SR, Katsoulis-Dimitriou K, Winzer S, Kollias G, Fischer T, Nedospasov SA, Dunay IR, Chavakis T, Müller AJ, Schraven B, Sperandio M, Dudeck A. Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation. Immunity. 2021 Mar 9;54(3):468-483.e5. doi: 10.1016/j.immuni.2020.12.017. Epub 2021 Jan 22. PMID: 33484643
Ziogas A, Sajib MS, Lim JH, Alves TC, Das A, Witt A, Hagag E, Androulaki N, Grossklaus S, Gerlach M, Noll T, Grinenko T, Mirtschink P, Hajishengallis G, Chavakis T, Mikelis CM, Sprott D. Glycolysis is integral to histamine-induced endothelial hyperpermeability. FASEB J. 2021 Mar;35(3):e21425. doi: 10.1096/fj.202001634R. PMID: 33566443
Južnić L, Peuker K, Strigli A, Brosch M, Herrmann A, Häsler R, Koch M, Matthiesen L, Zeissig Y, Löscher BS, Nuber A, Schotta G, Neumeister V, Chavakis T, Kurth T, Lesche M, Dahl A, von Mässenhausen A, Linkermann A, Schreiber S, Aden K, Rosenstiel PC, Franke A, Hampe J, Zeissig S. SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation. Gut. 2021 Mar;70(3):485-498. doi: 10.1136/gutjnl-2020-321339. Epub 2020 Jun 5. PMID: 32503845
Gaete D, Rodriguez D, Watts D, Sormendi S, Chavakis T, Wielockx B. HIF-Prolyl Hydroxylase Domain Proteins (PHDs) in Cancer-Potential Targets for Anti-Tumor Therapy? Cancers (Basel). 2021 Feb 27;13(5):988. doi: 10.3390/cancers13050988. PMID: 33673417
Hajishengallis G, Li X, Chavakis T. Immunometabolic control of hematopoiesis. Mol Aspects Med. 2021 Feb;77:100923. doi: 10.1016/j.mam.2020.100923. Epub 2020 Nov 5. PMID: 33160640
Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenvoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O'Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG. Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nat Immunol. 2021 Jan;22(1):2-6. doi: 10.1038/s41590-020-00845-6. PMID: 33293712
Mitroulis I, Hajishengallis G, Chavakis T. Trained Immunity and Cardiometabolic Disease: The Role of Bone Marrow. Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):48-54. doi: 10.1161/ATVBAHA.120.314215. Epub 2020 Nov 19. PMID: 33207931
Kalafati L, Mitroulis I, Verginis P, Chavakis T, Kourtzelis I. Neutrophils as Orchestrators in Tumor Development and Metastasis Formation. Front Oncol. 2020 Dec 10;10:581457. doi: 10.3389/fonc.2020.581457. eCollection 2020. PMID: 33363012
Kalafati L, Chavakis T. Hematopoietic stem and progenitor cells take the route through the bone marrow endothelium. Haematologica. 2020 Dec 1;105(12):2700-2701. doi: 10.3324/haematol.2020.262113. PMID: 33256368
Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourão A, Blanchet X, Wichapong K, Aslani M, Brunßen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen MJAP, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, Hundelshausen PV, Steffens S, Duchêne J, Megens RTA, Sattler M, Weber C. Autophagy unleashes noncanonical microRNA functions. Autophagy. 2020 Dec;16(12):2294-2296. doi: 10.1080/15548627.2020.1830523. Epub 2020 Oct 15. PMID: 33054575
Li X, Colamatteo A, Kalafati L, Kajikawa T, Wang H, Lim JH, Bdeir K, Chung KJ, Yu X, Fusco C, Porcellini A, De Simone S, Matarese G, Chavakis T, De Rosa V, Hajishengallis G. The DEL-1/β3 integrin axis promotes regulatory T cell responses during inflammation resolution. J Clin Invest. 2020 Dec 1;130(12):6261-6277. doi: 10.1172/JCI137530. PMID: 32817592
Moorlag SJCFM, Rodriguez-Rosales YA, Gillard J, Fanucchi S, Theunissen K, Novakovic B, de Bont CM, Negishi Y, Fok ET, Kalafati L, Verginis P, Mourits VP, Koeken VACM, de Bree LCJ, Pruijn GJM, Fenwick C, van Crevel R, Joosten LAB, Joosten I, Koenen H, Mhlanga MM, Diavatopoulos DA, Chavakis T, Netea MG. BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils. Cell Rep. 2020 Nov 17;33(7):108387. doi: 10.1016/j.celrep.2020.108387. PMID: 33207187
Kajikawa T, Wang B, Li X, Wang H, Chavakis T, Moutsopoulos NM, Hajishengallis G. Frontline Science: Activation of metabolic nuclear receptors restores periodontal tissue homeostasis in mice with leukocyte adhesion deficiency-1. J Leukoc Biol. 2020 Nov;108(5):1501-1514. doi: 10.1002/JLB.5HI0420-648R. Epub 2020 May 18. PMID: 32421906
Kalafati L, Kourtzelis I, Schulte-Schrepping J, Li X, Hatzioannou A, Grinenko T, Hagag E, Sinha A, Has C, Dietz S, de Jesus Domingues AM, Nati M, Sormendi S, Neuwirth A, Chatzigeorgiou A, Ziogas A, Lesche M, Dahl A, Henry I, Subramanian P, Wielockx B, Murray P, Mirtschink P, Chung KJ, Schultze JL, Netea MG, Hajishengallis G, Verginis P, Mitroulis I, Chavakis T. Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity. Cell. 2020 Oct 29;183(3):771-785.e12. doi: 10.1016/j.cell.2020.09.058. PMID: 33125892
Alissafi T, Kalafati L, Lazari M, Filia A, Kloukina I, Manifava M, Lim JH, Alexaki VI, Ktistakis NT, Doskas T, Garinis GA, Chavakis T, Boumpas DT, Verginis P. Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity. Cell Metab. 2020 Oct 6;32(4):591-604.e7. doi: 10.1016/j.cmet.2020.07.001. Epub 2020 Jul 31. PMID: 32738205.
Hajishengallis G, Chavakis T, Lambris JD. Current understanding of periodontal disease pathogenesis and targets for host-modulation therapy. Periodontol 2000. 2020 Oct;84(1):14-34. doi: 10.1111/prd.12331. PMID: 32844416
Nagai K, Ideguchi H, Kajikawa T, Li X, Chavakis T, Cheng J, Messersmith PB, Heber-Katz E, Hajishengallis G. An injectable hydrogel-formulated inhibitor of prolyl-4-hydroxylase promotes T regulatory cell recruitment and enhances alveolar bone regeneration during resolution of experimental periodontitis. FASEB J. 2020 Oct;34(10):13726-13740. doi: 10.1096/fj.202001248R. Epub 2020 Aug 19. PMID: 32812255
Kronstein-Wiedemann R, Nowakowska P, Milanov P, Gubbe K, Seifried E, Bugert P, Chavakis T, Tonn T. Regulation of ABO blood group antigen expression by miR-331-3p and miR-1908-5p during hematopoietic stem cell differentiation. Stem Cells. 2020 Oct 1;38(10):1348-1362. doi: 10.1002/stem.3251. Epub 2020 Jul 4. PMID: 32621650
Maekawa T, Tamura H, Domon H, Hiyoshi T, Isono T, Yonezawa D, Hayashi N, Takahashi N, Tabeta K, Maeda T, Oda M, Ziogas A, Alexaki VI, Chavakis T, Terao Y, Hajishengallis G. Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-1. JCI Insight. 2020 Aug 6;5(15):e136706. doi: 10.1172/jci.insight.136706. PMID: 32603314
Mitroulis I, Kalafati L, Bornhäuser M, Hajishengallis G, Chavakis T. Regulation of the Bone Marrow Niche by Inflammation. Front Immunol. 2020 Jul 21;11:1540. doi: 10.3389/fimmu.2020.01540. eCollection 2020. PMID: 32849521
Pyrina I, Chung KJ, Michailidou Z, Koutsilieris M, Chavakis T, Chatzigeorgiou A. Fate of Adipose Progenitor Cells in Obesity-Related Chronic Inflammation. Front Cell Dev Biol. 2020 Jul 14;8:644. doi: 10.3389/fcell.2020.00644. eCollection 2020. PMID: 32760729
Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourão A, Blanchet X, Wichapong K, Aslani M, Brunßen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen MJAP, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, von Hundelshausen P, Steffens S, Duchêne J, Megens RTA, Sattler M, Weber C. Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis. Sci Transl Med. 2020 Jun 3;12(546):eaaz2294. doi: 10.1126/scitranslmed.aaz2294. PMID: 32493793
Netea MG, Domínguez-Andrés J, Barreiro LB, Chavakis T, Divangahi M, Fuchs E, Joosten LAB, van der Meer JWM, Mhlanga MM, Mulder WJM, Riksen NP, Schlitzer A, Schultze JL, Stabell Benn C, Sun JC, Xavier RJ, Latz E. Defining trained immunity and its role in health and disease. Nat Rev Immunol. 2020 Jun;20(6):375-388. doi: 10.1038/s41577-020-0285-6. Epub 2020 Mar 4. PMID: 32132681
Mirea AM, Stienstra R, Kanneganti TD, Tack CJ, Chavakis T, Toonen EJM, Joosten LAB. Mice Deficient in the IL-1β Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD. Inflammation. 2020 Jun;43(3):1054-1064. doi: 10.1007/s10753-020-01190-4. PMID: 32002713
Yuh DY, Maekawa T, Li X, Kajikawa T, Bdeir K, Chavakis T, Hajishengallis G. The secreted protein DEL-1 activates a β3 integrin-FAK-ERK1/2-RUNX2 pathway and promotes osteogenic differentiation and bone regeneration. J Biol Chem. 2020 May 22;295(21):7261-7273. doi: 10.1074/jbc.RA120.013024. Epub 2020 Apr 12. PMID: 32280065
Heinzmann D, Noethel M, Ungern-Sternberg SV, Mitroulis I, Gawaz M, Chavakis T, May AE, Seizer P. CD147 is a Novel Interaction Partner of Integrin αMβ2 Mediating Leukocyte and Platelet Adhesion. Biomolecules. 2020 Apr 2;10(4):541. doi: 10.3390/biom10040541. PMID: 32252487
Kourtzelis I, Hajishengallis G, Chavakis T. Phagocytosis of Apoptotic Cells in Resolution of Inflammation. Front Immunol. 2020 Mar 31;11:553. doi: 10.3389/fimmu.2020.00553. eCollection 2020. PMID: 32296442
Ziogas A, Maekawa T, Wiessner JR, Le TT, Sprott D, Troullinaki M, Neuwirth A, Anastasopoulou V, Grossklaus S, Chung KJ, Sperandio M, Chavakis T, Hajishengallis G, Alexaki VI. DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1. J Immunol. 2020 Mar 1;204(5):1214-1224. doi: 10.4049/jimmunol.1900746. Epub 2020 Jan 24. PMID: 31980574
Troullinaki M, Chen LS, Witt A, Pyrina I, Phieler J, Kourtzelis I, Chmelar J, Sprott D, Gercken B, Koutsilieris M, Chavakis T, Chatzigeorgiou A. Robo4-mediated pancreatic endothelial integrity decreases inflammation and islet destruction in autoimmune diabetes. FASEB J. 2020 Feb;34(2):3336-3346. doi: 10.1096/fj.201900125RR. Epub 2020 Jan 9. PMID: 31916652
Hatzioannou A, Banos A, Sakelaropoulos T, Fedonidis C, Vidali MS, Köhne M, Händler K, Boon L, Henriques A, Koliaraki V, Georgiadis P, Zoidakis J, Termentzi A, Beyer M, Chavakis T, Boumpas D, Tsirigos A, Verginis P. An intrinsic role of IL-33 in Treg cell-mediated tumor immunoevasion. Nat Immunol. 2020 Jan;21(1):75-85. doi: 10.1038/s41590-019-0555-2. Epub 2019 Dec 16. PMID: 31844326
Yilmaz C, Karali K, Fodelianaki G, Gravanis A, Chavakis T, Charalampopoulos I, Alexaki VI. Neurosteroids as regulators of neuroinflammation. Front Neuroendocrinol. 2019 Oct;55:100788. doi: 10.1016/j.yfrne.2019.100788. Epub 2019 Sep 9. Review. PubMed PMID: 31513776.
Ramasz B, Krüger A, Reinhardt J, Sinha A, Gerlach M, Gerbaulet A, Reinhardt S, Dahl A, Chavakis T, Wielockx B, Grinenko T. Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases. Blood. 2019 Sep 26;134(13):1046-1058. doi: 10.1182/blood.2019000721. Epub 2019 Aug 21. PubMed PMID: 31434705.
Chavakis T, Mitroulis I, Hajishengallis G. Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation. Nat Immunol. 2019 Jul;20(7):802-811. doi: 10.1038/s41590-019-0402-5. Epub 2019 Jun 18. Review. PubMed PMID: 31213716; PubMed Central PMCID: PMC6709414.
Sprott D, Poitz DM, Korovina I, Ziogas A, Phieler J, Chatzigeorgiou A,
Mitroulis I, Deussen A, Chavakis T, Klotzsche-von Ameln A. Endothelial-Specific
Deficiency of ATG5 (Autophagy Protein 5) Attenuates Ischemia-Related
Angiogenesis. Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1137-1148. doi:
10.1161/ATVBAHA.119.309973. PubMed PMID: 31070476.
Mirea AM, Toonen EJM, van den Munckhof I, Munsterman ID, Tjwa ETTL, Jaeger M,
Oosting M, Schraa K, Rutten JHW, van der Graaf M, Riksen NP, de Graaf J, Netea
MG, Tack CJ, Chavakis T, Joosten LAB. Increased proteinase 3 and neutrophil
elastase plasma concentrations are associated with non-alcoholic fatty liver
disease (NAFLD) and type 2 diabetes. Mol Med. 2019 May 2;25(1):16. doi:
10.1186/s10020-019-0084-3. PubMed PMID: 31046673.
Hajishengallis G, Chavakis T. DEL-1-Regulated Immune Plasticity and
Inflammatory Disorders. Trends Mol Med. 2019 May;25(5):444-459. doi:
10.1016/j.molmed.2019.02.010. Epub 2019 Mar 15. Review. PubMed PMID: 30885428;
PubMed Central PMCID: PMC6488420.
Fodelianaki G, Lansing F, Bhattarai P, Troullinaki M, Zeballos MA,
Charalampopoulos I, Gravanis A, Mirtschink P, Chavakis T, Alexaki VI. Nerve
Growth Factor modulates LPS - induced microglial glycolysis and inflammatory
responses. Exp Cell Res. 2019 Apr 15;377(1-2):10-16. doi:
10.1016/j.yexcr.2019.02.023. Epub 2019 Feb 25. PubMed PMID: 30817930.
Wielockx B, Grinenko T, Mirtschink P, Chavakis T. Hypoxia Pathway Proteins in
Normal and Malignant Hematopoiesis. Cells. 2019 Feb 13;8(2). pii: E155. doi:
10.3390/cells8020155. Review. PubMed PMID: 30781787.
Grzybek M, Palladini A, Alexaki VI, Surma MA, Simons K, Chavakis T, Klose C,
Coskun Ü. Comprehensive and quantitative analysis of white and brown adipose
tissue by shotgun lipidomics. Mol Metab. 2019 Jan 30. pii: S2212-8778(18)31114-1.
doi: 10.1016/j.molmet.2019.01.009. [Epub ahead of print] PubMed PMID: 30777728.
Wang B, Lim JH, Kajikawa T, Li X, Vallance BA, Moutsopoulos NM, Chavakis T,
Hajishengallis G. Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect
from Lethal Citrobacter rodentium-Induced Colitis. Cell Rep. 2019 Feb
5;26(6):1614-1626.e5. doi: 10.1016/j.celrep.2019.01.054. PubMed PMID: 30726742.
Troullinaki M, Alexaki VI, Mitroulis I, Witt A, Klotzsche-von Ameln A, Chung
KJ, Chavakis T, Economopoulou M. Nerve growth factor regulates endothelial cell
survival and pathological retinal angiogenesis. J Cell Mol Med. 2019 Jan 24. doi:
10.1111/jcmm.14002. [Epub ahead of print] PubMed PMID: 30680928.
Troullinaki M, Garcia-Martin R, Sprott D, Klotzsche-von Ameln A, Grossklaus S,
Mitroulis I, Chavakis T, Economopoulou M. 53BP1 Deficiency Promotes Pathological
Neovascularization in Proliferative Retinopathy. Thromb Haemost. 2019 Jan 8. doi:
10.1055/s-0038-1676966. [Epub ahead of print] PubMed PMID: 30620991.
Penkov S, Mitroulis I, Hajishengallis G, Chavakis T. Immunometabolic
Crosstalk: An Ancestral Principle of Trained Immunity? Trends Immunol. 2019
Jan;40(1):1-11. doi: 10.1016/j.it.2018.11.002. Epub 2018 Nov 29. Review. PubMed
PMID: 30503793; PubMed Central PMCID: PMC6312479.
Kourtzelis I, Li X, Mitroulis I, Grosser D, Kajikawa T, Wang B, Grzybek M, von
Renesse J, Czogalla A, Troullinaki M, Ferreira A, Doreth C, Ruppova K, Chen LS,
Hosur K, Lim JH, Chung KJ, Grossklaus S, Tausche AK, Joosten LAB, Moutsopoulos
NM, Wielockx B, Castrillo A, Korostoff JM, Coskun Ü, Hajishengallis G, Chavakis
T. DEL-1 promotes macrophage efferocytosis and clearance of inflammation. Nat
Immunol. 2019 Jan;20(1):40-49. doi: 10.1038/s41590-018-0249-1. Epub 2018 Nov 19.
PubMed PMID: 30455459; PubMed Central PMCID: PMC6291356.
Poultsidi A, Dimopoulos Y, He TF, Chavakis T, Saloustros E, Lee PP, Petrovas
C. Lymph Node Cellular Dynamics in Cancer and HIV: What Can We Learn for the
Follicular CD4 (Tfh) Cells? Front Immunol. 2018 Sep 27;9:2233. doi:
10.3389/fimmu.2018.02233. eCollection 2018. Review. PubMed PMID: 30319664; PubMed
Central PMCID: PMC6170630.
Mirtschink P, Chavakis T. Stabilin-1-Mediated Efferocytosis Protects against
Vascular Leakage in Sepsis: A Novel Therapeutic Approach? Thromb Haemost. 2018
Nov;118(11):1852-1853. doi: 10.1055/s-0038-1673688. Epub 2018 Oct 12. PubMed
PMID: 30312979.
Korovina I, Neuwirth A, Sprott D, Weber S, Sardar Pasha SPB, Gercken B,
Breier G, El-Armouche A, Deussen A, Karl MO, Wielockx B, Chavakis T,
Klotzsche-von Ameln A. Hematopoietic hypoxia-inducible factor 2α deficiency
ameliorates pathological retinal neovascularization via modulation of endothelial
cell apoptosis. FASEB J. 2019 Feb;33(2):1758-1770. doi: 10.1096/fj.201800430R.
Epub 2018 Aug 29. PubMed PMID: 30156910.
Göbel K, Eichler S, Wiendl H, Chavakis T, Kleinschnitz C, Meuth SG. The
Coagulation Factors Fibrinogen, Thrombin, and Factor XII in Inflammatory
Disorders-A Systematic Review. Front Immunol. 2018 Jul 26;9:1731. doi:
10.3389/fimmu.2018.01731. eCollection 2018. PubMed PMID: 30105021; PubMed Central
PMCID: PMC6077258.
Chung KJ, Nati M, Chavakis T, Chatzigeorgiou A. Innate immune cells in the
adipose tissue. Rev Endocr Metab Disord. 2018 Dec;19(4):283-292. doi:
10.1007/s11154-018-9451-6. Review. PubMed PMID: 29922964.
Mitroulis I, Kalafati L, Hajishengallis G, Chavakis T. Myelopoiesis in the
Context of Innate Immunity. J Innate Immun. 2018;10(5-6):365-372. doi:
10.1159/000489406. Epub 2018 Jun 6. Review. PubMed PMID: 29874678; PubMed Central
PMCID: PMC6281852.
Grinenko T, Eugster A, Thielecke L, Ramasz B, Krüger A, Dietz S, Glauche I,
Gerbaulet A, von Bonin M, Basak O, Clevers H, Chavakis T, Wielockx B.
Hematopoietic stem cells can differentiate into restricted myeloid progenitors
before cell division in mice. Nat Commun. 2018 May 15;9(1):1898. doi:
10.1038/s41467-018-04188-7. PubMed PMID: 29765026; PubMed Central PMCID:
PMC5954009.
Singh RP, Grinenko T, Ramasz B, Franke K, Lesche M, Dahl A, Gassmann M,
Chavakis T, Henry I, Wielockx B. Hematopoietic Stem Cells but Not Multipotent
Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO
Transgenic Mice. Stem Cell Reports. 2018 Jun 5;10(6):1908-1919. doi:
10.1016/j.stemcr.2018.04.012. Epub 2018 May 10. PubMed PMID: 29754961; PubMed
Central PMCID: PMC5989815.
Mirea AM, Tack CJ, Chavakis T, Joosten LAB, Toonen EJM. IL-1 Family Cytokine
Pathways Underlying NAFLD: Towards New Treatment Strategies. Trends Mol Med. 2018 May;24(5):458-471. doi: 10.1016/j.molmed.2018.03.005. Epub 2018 Apr 14. Review.
PubMed PMID: 29665983; PubMed Central PMCID: PMC5939989.
Mirtschink P, Chavakis T. The Missed Notch to Bring Down Diabetes. Trends
Endocrinol Metab. 2018 Jul;29(7):448-450. doi: 10.1016/j.tem.2018.03.011. Epub
2018 Mar 29. PubMed PMID: 29606343.
Moysidou M, Karaliota S, Kodela E, Salagianni M, Koutmani Y, Katsouda A,
Kodella K, Tsakanikas P, Ourailidou S, Andreakos E, Kostomitsopoulos N, Skokos D,
Chatzigeorgiou A, Chung KJ, Bornstein S, Sleeman MW, Chavakis T, Karalis KP. CD8+
T cells in beige adipogenesis and energy homeostasis. JCI Insight. 2018 Mar
8;3(5). pii: 95456. doi: 10.1172/jci.insight.95456. [Epub ahead of print] PubMed
PMID: 29515042; PubMed Central PMCID: PMC5922290.
Chen LS, Kourtzelis I, Singh RP, Grossklaus S, Wielockx B, Hajishengallis G,
Chavakis T, Mitroulis I. Endothelial Cell-Specific Overexpression of Del-1 Drives
Expansion of Haematopoietic Progenitor Cells in the Bone Marrow. Thromb Haemost.
2018 Feb 7. doi: 10.1055/s-0038-1624582. [Epub ahead of print] PubMed PMID:
29415284; PubMed Central PMCID: PMC6081267.
Mitroulis I, Ruppova K, Wang B, Chen LS, Grzybek M, Grinenko T, Eugster A, Troullinaki M, Palladini A, Kourtzelis I, Chatzigeorgiou A, Schlitzer A, Beyer M, Joosten LAB, Isermann B, Lesche M, Petzold A, Simons K, Henry I, Dahl A, Schultze JL, Wielockx B, Zamboni N, Mirtschink P, Coskun Ü, Hajishengallis G, Netea MG and Chavakis T. Modulation of myelopoiesis progenitors is an integral component of trained immunity. CELL, 2018, 172:147-161.
Subramanian P, Prucnal M, Gercken B, Economopoulou M, Hagishengallis G, Chavakis T. Endothelial cell-specific overexpression of Developmental endothelial locus-1 does not influence atherosclerosis development in ApoE-/- mice. Thromb Haemost. 2017; 117:2003-2005.
Madhusudhan T, Wang H, Ghosh S, Dong W, Kumar V, Al-Dabet MM, Manoharan J, Nazir S, Elwakiel A, Bock F, Kohli S, Marquardt A, Sögüt I, Shahzad K, Müller AJ, Esmon CT, Nawroth PP, Reiser J, Chavakis T, Ruf W, Isermann B. Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin like function. Blood. 2017; 130:1445-1455.
Alissafi T, Banos A, Boon L, Sparwasser T, Ghigo A, Wing K, Vassilopoulos D, Boumpas D, Chavakis T, Cadwell K, Verginis P. Tregs restrain dendritic cell autophagy to ameliorate autoimmunity. J Clin Invest. 2017; 127:2789-2804.
Chung KJ, Chatzigeorgiou A, Economopoulou M, Garcia-Martin R, Alexaki VI, Mitroulis I, Nati M, Gebler J, Ziemssen T, Goelz SE, Phieler J, Lim JH, Karalis KP, Papayannopoulou T, Blüher M, Hajishengallis G, Chavakis T. A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity. Nat Immunol. 2017; 18:654-664.
Chmelar J, Chatzigeorgiou A, Chung KJ, Prucnal M, Voehringer D, Roers A and Chavakis T. No role for mast cells in obesity-related metabolic dysregulation. Front Immunol. 2016, Nov 7:524
Teufel A, Itzel T, Erhart W, Brosch M, Wang XY, Kim YO, von Schönfels W, Herrmann A, Brückner S, Stickel F, Dufour JF, Chavakis T, Hellerbrand C, Spang R, Maass T, Becker T, Schreiber S, Schafmayer C, Schuppan D, Hampe J. Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues from Patients. Gastroenterology 2016, 151:513-25
Toonen EJ, Mirea AM, Tack CJ, Stienstra R, Ballak DB, van Diepen JA, Hijmans A, Chavakis T, Dokter WH, Pham CT, Netea MG, Dinarello CA, Joosten LA. Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance. Mol Medicine 2016 doi: 10.2119/molmed.2016.00033
Kourtzelis K, Kotlabova K, Lim JH, Mitroulis I, Ferreira A, Chen LS, Gercken B, Steffen A, Kemter E, Klotzsche-von Ameln A, Waskow C, Hosur K, Chatzigeorgiou A, Ludwig B, Wolf E, Hajishengallis G, Chavakis T. Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation. Thrombosis Haemostasis, 2016, 115:781-8
García-Martín R, Alexaki VI, Qin N, Rubín de Celis MF, Economopoulou M, Ziogas A, Gercken B, Kotlabova K, Phieler J, Ehrhart-Bornstein M, Bornstein SR, Eisenhofer G, Breier G, Blüher M, Hampe J, El-Armouche A, Chatzigeorgiou A, Chung KJ, Chavakis T. Adipocyte-specific HIF2α deficiency exacerbates obesity-induced brwon adipose tissue dysfunction and metabolic dysregulation. Mol Cell Biol., 2015, 36:376-93
Maekawa T, Kavita Hosur K, Abe T, Kantarci A, Ziogas A, Wang B, Van Dyke TE, Chavakis T*, Hajishengallis G* Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β–C/EBPβ pathway. Nature Communications, 2015 Sep 16;6:8272. *contributed equally as senior author to the work
Economopoulou M, Avramovic N, Klotzsche-von Ameln A, Korovina I, Sprott D, Samus M, Gercken B, Troullinaki M, Grossklaus S, Funk RH, Li X, Imhof B, Orlova VV, Chavakis T. Endothelial-specific deficiency of Junctional Adhesion Molecule-C promotes vessel normalization in the course of proliferative retinopathy. Thromb Haemost. 2015, 114:1241-9
Colom B, Bodkin JV, Beyrau M, Woodfin A, Ody C, Rourke C, Chavakis T, Brohi K, Imhof BA, Nourshargh S. Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial cell Migration In Vivo Immunity. 2015, 42:1075-86
Pruenster M, Kurz AR, Chung KJ, Cao-Ehlker X, Bieber S, Nussbaum CF, Bierschenk S, Eggersmann TK, Rohwedder I, Heinig K, Immler R, Moser M, Koedel U, Gran S, McEver RP, Vestweber D, Verschoor A, Leandersson T, Chavakis T, Roth J, Vogl T and Sperandio M. Extracellular MRP8/14 is a regulator of β2 integrin dependent neutrophil slow rolling and adhesion in vivo. Nature Communications, 2015, Apr 20;6:6915
Madhusudhan T, Wang H, Dong W, Ghosh S, Bock F, Thangapandi VR, Ranjan S, Wolter J, Kohli S, Shahzad K, Heidel F, Krueger M, Schwenger V, Moeller M, Kalinski T, Reiser J, Chavakis T and Berend Isermann. Defective podocyte insulin signaling through p85-XBP1 promotes ATF6 dependent maladaptive ER-stress response in diabetic nephropathy. Nature Communications, 2015, Mar 10;6:6496
Weber GF, Chousterman BG, He S, Fenn AM, Nairz M, Anzai A, Brenner T, Uhle F, Iwamoto Y, Robbins CS, Noiret L, Maier SL, Zönnchen T, Rahbari NN, Schölch S, Klotzsche-von Ameln A, Chavakis T, Weitz J, Hofer S, Weigand MA, Nahrendorf M, Weissleder R, Swirski FK. Interleukin-3 amplifies acute inflammation and is apotential therapeutic target in sepsis. Science 2015, 347:1260-5
van den Berg SM, Seijkens TT, Kusters PJ, Zarzycka B, Beckers L, den Toom M, Gijbels MJ, Chatzigeorgiou A, Weber C, de Winther MP, Chavakis T, Nicolaes GA, Lutgens E. Blocking CD40-Traf6 interactions by small molecule inhibitor 6860766 ameliorates the complications of diet induced obesity in mice. Int J Obes (Lond). 2015, 39:782-90
Chatzigeorgiou A, Chung KJ, Garcia-Martin R, Alexaki I, Klotzsche-von Ameln A, Phieler J, Sprott D, Kanczkowski W, Tzanavari T, Bdeir M, Bergmann S, Cartellieri M, Bachmann M, Nikolakopoulou P, Androutsellis-Theotokis A, Siegert G, Bornstein SR, Muders MH, Boon L, Karalis KP, Lutgens E, and Chavakis T. Dual role of B7 costimulation in obesity-related non-alcoholic steatohepatitis (NASH) and metabolic dysregulation. Hepatology, 60:1196-2010, 2014
Chatzigeorgiou A, Seijkens T, Zarzycka B, Engel D, Poggi M, van den Berg S, van den Berg S, Soehnlein O, Winkels H, Beckers L, Lievens D, Driessen A, Kusters P, Biessen E, Garcia- Martin R, Klotzsche-von Ameln A, Gijbels M, Noelle R, Boon L, Hackeng T, Schulte K, Xu A, Vriend G, Nabuurs S, Chung KJ, Willems van Dijk K, Rensen PC, Gerdes N, de Winther M, Block NL, Schally AV, Weber C, Bornstein SR, Nicolaes G, Chavakis T*, Lutgens E*. Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc Natl Acad Sci U S A. 111:2686-91, 2014 *contributed equally as senior author to the work
Phieler J, Chung KJ, Chatzigeorgiou A, Klotzsche-von Ameln A, Garcia-Martin R, Sprott D, Moisidou M, Tzanavari T, Ludwig B, Baraban E, Ehrhart-Bornstein M, Bornstein SR, Mziaut H, Solimena M, Karalis KP, Economopoulou M, Lambris JD, Chavakis T. The complement anaphylatoxin c5a receptor contributes to obese adipose tissue inflammation and insulin resistance. J Immunol. 191: 4367-74, 2013
Eskan, M.A., Jotwani, R., Abe, T., Chmelar, J., Lim, J.H., Liang, S., Ciero, P., Krauss, J., Li, F., Rauner, M., Hofbauer, L.C., Choi, E.Y., Chung, K.J., Hashim, A., Curtis, M., Chavakis, T.*, Hajishengallis, G.* 2012. The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss. Nature Immunology, 13: 465-473, 2012 *contributed equally as senior authors to the work
Woodfin, A., Voisin, M.B., Bauer, M., Colom, B., Caille, D., Diapouli, F.M., Nash, G.B., Chavakis, T., Albelda, S., Rainger, G.E., Meda, P., Imhof, B.A. and Nourshargh, S. Junctional adhesion molecule-C (JAM-C) is a key regulator of polarized neutrophil transendothelial cell migration in vivo. Nature Immunology, 12:761-9, 2011
Langer, H.F., Chung, K.J., Orlova, V.V., Choi, E.Y., Kaul, K., Kruhlak, M.J., Alatsatianos, M., DeAngelis, R.A., Roche, P.A., Magotti, P., Li, X., Economopoulou, M., Rafail, S., Lambris, J.D., and Chavakis, T. Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis. BLOOD, 116:4395-403.2010.
Economopoulou, M., Langer, H.F., Celeste, A., Orlova, V.V., Choi, E.Y., Ma, M., Vassilopoulos, A., Callen, E., Deng, C., Bassing, C.H., Boehm, M., Nussenzweig, A. and Chavakis, T. Histone H2AX is integral to hypoxia-driven neovascularisation. Nature Med., 15:553-8, 2009.
Choi. E.Y., Chavakis, E., Czabanka, M.A., Langer, H., Fraemohs, L., Economopoulou, M., Kundu, R.K., Orlandi, A., Zheng, Y.Y., Prieto, D.A., Ballantyne, C.M., Constant, S.L., Aird, W., Papayannopoulou, T., Gahmberg, C.G., Udey, M.C., Vajkoczy, P., Quertermous, T., Dimmeler, S., Weber, C., and Chavakis, T. Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment. Science, 2008, 322:1101-04.
Isermann, B., Vinnikov, I., Madhusudhan, T., Herzog, S., Huntscha, S., Blausitz, J., Corrat, M., Buender, R., Zeier, M., Blessing, E., Chavakis, T., Esmon, C., Weiler, H., Bierhaus, A., Nawroth, P.P. The thrombomodulin protein C system protects against endothelial dysfunction and diabetic nephropathy by inhibiting glucose induced apoptosis. Nature Medicine, 13:1349-58, 2007.
Orlova, V., Economopoulou, M., Lupu, F., Santoso, S. and Chavakis, T. Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin-mediated cell-cell contacts. J Exp Med. 203:2703-14, 2006.
Santoso, S., Sachs, U.J., Kroll, H., Linder, M, Preissner, K.T., and Chavakis, T.: The Junctional Adhesion Molecule-3 on human platelets is a counter-receptor for the leukocyte integrin Mac-1. J Exp Med. 196:679-691, 2002.
Reviews
Breier G*, Chavakis T*, Hirsch E*. Angiogenesis in metabolic-vascular disease. Thromb Haemost. 2017; 117:1289-1295 * authors contributed equally
Kourtzelis I, Mitroulis I, von Renesse J, Hajishengallis G, Chavakis T. From leukocyte recruitment to resolution of inflammation: the cardinal role of integrins. J Leukoc Biol. 2017 Epub ahead of print; doi: 10.1189/jlb.3MR0117-024R.
Alexaki VI and Chavakis T. The role of innate immunity in the regulation of brown and beige adipogenesis. Rev Endocr Metab Disor 2016, 17:41-9
Nati M, Haddad D, Birkenfeld A, Koch C, Chavakis T* and Chatzigeorgiou A*. The role of immune cells inmetabolism-related liver inflammation 5 and development of non-alcoholic steatohepatitis (NASH). Rev Endocr Metab Disor, 2016, 17:29-39 *contributed equally as senior author to the work
Norata GD, Caligiuri G, Chavakis T, Matarese G, Netea MG, Nicoletti A, O'Neill LA, Marelli-Berg FM. The Cellular and Molecular Basis of Translational Immunometabolism. Immunity. 2015, 43:421-34
Kourtzelis I, Magnusson PU, Kotlabova K, Lambris JD, Chavakis T. Regulation of instant blood mediated inflammatory reaction (IBMIR) in pancreatic islet xeno-transplantation: Points for therapeutic interventions. Adv Exp Med Biol. 2015, 865:171-88
Seijkens T, Kusters P, Chatzigeorgiou A, Chavakis T, Lutgens E. Immune cell crosstalk in obesity: a key role for co-stimulation? Diabetes, 2014, 63:3982-91
Mitroulis I, Alexaki VI, Kourtzelis I, Ziogas A, Hajishengallis G, Chavakis T. Leukocyte integrins: Role in leukocyte recruitment and as therapeutic targets in inflammatory disease. Pharmacology and Therapeutics, 2015, 147:123-35
Phieler J, Garcia-Martin R, Lambris J and Chavakis T. The role of the complement system in metabolic organs and metabolic diseases. Seminars in Immunology, 25: 47-53, 2013
Chmelar J, Chung KJ, Chavakis T. The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance. Thromb Haemost. 109:399-406, 2013
Hajishengallis G and Chavakis T. Endogenous modulators of inflammatory cell recruitment. Trends Immunol, 34:1-6, 2013
Chatzigeorgiou A, Karalis KP, Bornstein SR, Chavakis T. Lymphocytes in obesity-related adipose tissue inflammation. Diabetologia. 55: 2583-92, 2012