Publikationen
Li, W., Luo, X., Strano, A., Arun, S., Gamm, O., Poetsch, M.S., Hasse, M., Steiner, R.-P., Fischer, K., Pöche, J., Ulbricht, Y., Lesche, M., Trimaglio, G., El-Armouche, A., Dahl, A., Mirtschink, P., Guan, K.#, Schubert, M.#, 2025. Comprehensive promotion of iPSC-CM maturation by integrating metabolic medium with nanopatterning and electrostimulation. Nat Commun. 16, 2785. https://doi.org/10.1038/s41467-025-58044-6. #shared correspondence.
Künzel, S.R., Klapproth, E., Zimmermann, N., Kämmerer, S., Schubert, M., Künzel, K., Hoffmann, M., Drukewitz, S., Vehlow, A., Eitler, J., Arriens, M., Thiel, J., Kronstein-Wiedemann, R., Tietze, M., Beissert, S., Renner, B., El-Armouche, A., Günther, C., 2024. Radiation-induced morphea of the breast - characterization and treatment of fibroblast dysfunction with repurposed mesalazine. Sci Rep. 14, 26132. https://doi.org/10.1038/s41598-024-74206-w
Pavlaki, N., Froese, A., Li, W., De Jong, K.A., Geertz, B., Subramanian, H., Mohagaonkar, S., Luo, X., Schubert, M., Wiegmann, R., Margaria, J.P., Ghigo, A., Kämmerer, S., Hirsch, E., El-Armouche, A., Guan, K., Nikolaev, V.O., 2024. Gene therapy with phosphodiesterases 2A and 4B ameliorates heart failure and arrhythmias by improving subcellular cAMP compartmentation. Cardiovascular Research. 120, 1011–1023. https://doi.org/10.1093/cvr/cvae094
Hannemann, J., Wasser, K., Mileva, Y., Kleinsang, F., Schubert, M., Schwedhelm, E., Guan, K., Wachter, R., Böger, R., 2024. Symmetric Dimethylarginine Predicts Previously Undetected Atrial Fibrillation in Patients With Ischemic Stroke. J Am Heart Assoc. 13, e034994. https://doi.org/10.1161/JAHA.124.034994
Schmidt, S., Li, W., Schubert, M., Binnewerg, B., Prönnecke, C., Zitzmann, F.D., Bulst, M., Wegner, S., Meier, M., Guan, K., Jahnke, H.-G., 2024. Novel high-dense microelectrode array based multimodal bioelectronic monitoring system for cardiac arrhythmia re-entry analysis. Biosens Bioelectron. 252, 116120. https://doi.org/10.1016/j.bios.2024.116120
Cachorro, E.*, Günscht, M.*, Schubert, M.*, Sadek, M.S., Siegert, J., Dutt, F., Bauermeister, C., Quickert, S., Berning, H., Nowakowski, F., Lämmle, S., Firneburg, R., Luo, X., Künzel, S.R., Klapproth, E., Mirtschink, P., Mayr, M., Dewenter, M., Vettel, C., Heijman, J., Lorenz, K., Guan, K., El-Armouche, A., Wagner, M., Kämmerer, S. 2023. CNP promotes antiarrhythmic effects via phosphodiesterase 2. Circ Res. 132(4):400-414. doi: 10.1161/CIRCRESAHA.122.322031. *contributed equally.
Li, W., Luo, X., Poetsch, M.S., Oertel, R., Nichani, K., Schneider, M., Strano, A., Hasse, M., Steiner, R.P., Cyganek, L., Hettwer, K., Uhlig, S., Simon, K., Guan, K.#, Schubert, M.#. 2022. Synergistic Adverse Effects of Azithromycin and Hydroxychloroquine on Human Cardiomyocytes at a Clinically Relevant Treatment Duration. Pharmaceuticals. 15(2):220. doi: 10.3390/ph15020220. #shared last authorship.
Hoffmann, M., Kant, T.A., Emig, R., Rausch, J.S.E., Newe, M., Schubert, M., Künzel, K., Winter, L., Klapproth, E., Peyronnet, R., Ravens, U., El-Armouche, A., Künzel, S.R., 2021. Repurposing mesalazine against cardiac fibrosis in vitro. Naunyn-Schmiedeberg’s Arch Pharmacol. 394, 533-543. doi: 10.1007/s00210-020-01998-9.
Schüß, C.*, Vu, O.*, Schubert, M.*, Du, Y., Mishra, N.M., Tough, I.R., Stichel, J., Weaver, C.D., Emmitte, K.A., Cox, H.M., Meiler, J., Beck-Sickinger, A.G. 2021. Highly Selective Y4 Receptor Antagonist Binds in an Allosteric Binding Pocket. J Med Chem. 64(5):2801-2814. doi: 10.1021/acs.jmedchem.0c02000. *contributed equally.
Li, W., Stauske, M., Luo, X., Wagner, S., Vollrath, M., Mehnert, C.S., Schubert, M., Cyganek, L., Chen, S., Hasheminasab, S.-M., Wulf, G., El-Armouche, A., Maier, L.S., Hasenfuss, G., Guan, K., 2020. Disease Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes From Brugada Syndrome Patients With a Loss-of-Function SCN5A Mutation. Front Cell Dev Biol. 8, 1181. doi: 10.3389/fcell.2020.592893.
Luo, X., Li, W., Künzel, K., Henze, S., Cyganek, L., Strano, A., Poetsch, M.S., Schubert, M., Guan, K., 2020. IP3R-Mediated Compensatory Mechanism for Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes With Cardiac Ryanodine Receptor Deficiency. Front Cell Dev Biol. 8, 772. https://doi.org/10.3389/fcell.2020.00772.
Schubert, M., Hansen, S., Leefmann, J., Guan, K., 2020. Repurposing Antidiabetic Drugs for Cardiovascular Disease. Front Physiol. 11, 1168. https://doi.org/10.3389/fphys.2020.568632.
Kolanowski, T.J*., Busek, M.*, Schubert, M.*, Dmitrieva, A., Binnewerg, B., Pöche, J., Fisher, K., Schmieder, F., Grünzner, S., Hansen, S., Richter, A., El-Armouche, A., Sonntag, F., Guan, K., 2020. Enhanced structural maturation of human induced pluripotent stem cell-derived cardiomyocytes under a controlled microenvironment in a microfluidic system. Acta Biomater. 102, 273–286. *contributed equally. https://doi.org/10.1016/j.actbio.2019.11.044.
Schubert, M.*, Binnewerg, B.*, Voronkina, A., Muzychka, L., Wysokowski, M., Petrenko, I., Kovalchuk, V., Tsurkan, M., Martinovic, R., Bechmann, N., Ivanenko, V.N., Fursov, A., Smolii, O.B., Fromont, J., Joseph, Y., Bornstein, S.R., Giovine, M., Erpenbeck, D., Guan, K., Ehrlich, H., 2019. Naturally Prefabricated Marine Biomaterials: Isolation and Applications of Flat Chitinous 3D Scaffolds from Ianthella labyrinthus (Demospongiae: Verongiida). Int J Mol Sci. 20, 5105. *contributed equally. https://doi.org/10.3390/ijms20205105.
Binnewerg, B*., Schubert, M*., Voronkina, A., Muzychka, L., Wysokowski, M., Petrenko, I., Djurović, M., Kovalchuk, V., Tsurkan, M., Martinovic, R., Bechmann, N., Fursov, A., Ivanenko, V.N., Tabachnick, K.R., Smolii, O.B., Joseph, Y., Giovine, M., Bornstein, S.R., Stelling, A.L., Tunger, A., Schmitz, M., Taniya, O.S., Kovalev, I.S., Zyryanov, G.V., Guan, K., Ehrlich, H., 2020. Marine biomaterials: Biomimetic and pharmacological potential of cultivated Aplysina aerophoba marine demosponge. Materials Science and Engineering. 109, 110566. *contributed equally. https://doi.org/10.1016/j.msec.2019.110566.
Kovalchuk, V., Voronkina, A., Binnewerg, B., Schubert, M., Muzychka, L., Wysokowski, M., Tsurkan, M.V., Bechmann, N., Petrenko, I., Fursov, A., Martinovic, R., Ivanenko, V.N., Fromont, J., Smolii, O.B., Joseph, Y., Giovine, M., Erpenbeck, D., Gelinsky, M., Springer, A., Guan, K., Bornstein, S.R., Ehrlich, H., 2019. Naturally Drug-Loaded Chitin: Isolation and Applications. Mar Drugs. 17, 574.
Machałowski, T., Wysokowski, M., Żółtowska-Aksamitowska, S., Bechmann, N., Binnewerg, B., Schubert, M., Guan, K., Bornstein, S.R., Czaczyk, K., Pokrovsky, O., Kraft, M., Bertau, M., Schimpf, C., Rafaja, D., Tsurkan, M., Galli, R., Meissner, H., Petrenko, I., Fursov, A., Voronkina, A., Figlerowicz, M., Joseph, Y., Jesionowski, T., Ehrlich, H., 2019. Spider Chitin. The biomimetic potential and applications of Caribena versicolor tubular chitin. Carbohydr Polym. 226, 115301. https://doi.org/10.3390/md17100574.
Kaiser, A., Hempel, C., Wanka, L., Schubert, M., Hamm, H.E., Beck-Sickinger, A.G., 2018. G Protein Preassembly Rescues Efficacy of W6.48 Toggle Mutations in Neuropeptide Y2 Receptor. Mol. Pharmacol. 93, 387–401. https://doi.org/10.1124/mol.117.110544.
Schubert, M., Stichel, J., Du, Y., Tough, I.R., Sliwoski, G., Meiler, J., Cox, H.M., Weaver, C.D., Beck-Sickinger, A.G., 2017. Identification and Characterization of the First Selective Y4 Receptor Positive Allosteric Modulator. J. Med. Chem. 60, 7605–7612. https://doi.org/10.1021/acs.jmedchem.7b00976.
Sliwoski, G.*, Schubert, M.*, Stichel, J.*, Weaver, D., Beck-Sickinger, A.G., Meiler, J., 2016. Discovery of Small-Molecule Modulators of the Human Y4 Receptor. PLOS ONE. 11, e0157146. *contributed equally. https://doi.org/10.1371/journal.pone.0157146.