B3 - Aging and Dopamine Modulation
Project Aims
This is a subproject of the CRC940, which is a DFG-funded Collaborative Research Centre. We aim at investigating the role of neuromodulatory systems in regulating the balance between complementary control processes and how these neuromodulatory effects are further moderated by individual differences during adult development.
Leveraging aging-related decline in dopamine modulation, project B3 during the second funding period investigated interactions between a pharmacological dopamine intervention and aging on the prioritization of model-based vs. model-free control during spatial navigation and sequential decision making. Current analyses of data from the 2nd funding phase so far indicate age-related differences in the prioritization between different modes of control in several domains of functions.
> For further details on B3 during the 2nd funding period (B3/2) click here.
Extending our focus on control prioritization, in the 3rd funding period we are examining the effects of dopamine intervention and aging on underlying processes of meta-control during situations that require forward planning and the selection of optimal control policies under uncertainty.
> For further details on B3 during the 3rd funding period (B3/3) click here.
Principal Investigators
Prof. Dr. med. Michael N. Smolka (Chair of Systems Neuroscience, TUD)
Staff (Lifespan Developmental Neuroscience)
Collaborators
Dr. Nicolas Schuck (Head of NeuroCode, MPIB Berlin)
M.Sc. Christoph Koch (NeuroCode, MPIB Berlin)
Selected Publications
Baeuchl, C., Chen, H.-Y., Su, Y.-S., Hämmerer, D., Klados, M., & Li, S.-C. (2019). Interactive effects of dopamine transporter genotype and aging on resting-state functional networks. PLOS ONE, 4(5): e0215849. doi:10.1371/journal.pone.0215849
Beste, C., Adelhöfer, N., Gohil, K., Passow, S., Roessner, V., & Li, S.-C. (2018). Dopamine modulates the efficiency of sensory evidence accumulation during perceptual decision making. International Journal of Neuropsychopharmacology, 21, 649-655. doi:10.1093/ijnp/pyy019
Thurm F., Schuck N. W., Fauser M., Doeller C. F., Stankevich Y., Evens, R., ... Li, S.-C. (2016). Dopamine modulation of spatial memory performance in parkinson’s disease. Neurobiology of Aging, 38, 93-103. doi:10.1016/j.neurobiolaging.2015.10.019
Li, S.-C., & Rieckmann, A. (2014). Neuromodulation and aging: Implications of aging neuronal gain control on cognition. Current Opinion in Neurobiology, 29, 148-158. doi:10.1016/j.conb.2014.07.009