Selected Publications

For complete publication record please see Google Scholar

Joubert, P. M. & Poetsch, A. R. Using the DNA language model, GROVER, to parse sequence and epigenetic effects on genome stability. bioRxiv (2025). https://www.biorxiv.org/content/10.1101/2025.07.23.666402

Dang, T. T. V. , Schmaeche, T., Severinov D., Mittne V., Fohgrub J., Baenke F., Stange D. E., and Poetsch A. R..Tumor clone dynamics in gastro-esophageal cancer organoids reveal a non-genetic memory of neoadjuvant chemotherapy via downregulation of NFκB signaling. bioRxiv (2025). https://www.biorxiv.org/content/10.1101/2025.07.29.667467

Sanabria, M., Hirsch, J., Joubert P. M. & Poetsch, A. R. DNA language model GROVER learns sequence context in the human genome. Nature Machine Intelligence 6 (8), 911-923 (2024). https://www.nature.com/articles/s42256-024-00872-0

Sanabria, M., Hirsch, J. & Poetsch, A. R.Distinguishing word identity and sequence context in DNA language models.BMC bioinformatics 25 (1), 301 (2024). https://link.springer.com/article/10.1186/s12859-024-05869-5

Ciotta, G., Singh, S., Gupta, A., Torres, D. C., Fu, J., Choudhury, R., Chu, W. K., Choudhary, C., Gahurova, L., Al-Fatlawi, A., Schroeder, M, Aasland, R, Poetsch, A.R.*, Anastassiadis, K*, Stewart, A. F.* The BOD1L subunit of the mammalian SETD1A complex sustains the expression of DNA damage repair genes despite restraining H3K4 trimethylation. bioRxiv (2023). https://www.biorxiv.org/content/10.1101/2023.04.06.535882.abstract *Corresponding author

Ghodke, I., Remisova, M., Furst, A., Kilic, S., Reina-San-Martin, B., Poetsch, A. R., Altmeyer, M. & Soutoglou, E. AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation. Mol Cell 81, 2596-2610.e7 (2021). https://pubmed.ncbi.nlm.nih.gov/33961796

Kotsantis P, Segura-Bayona S, Margalef P, Marzec P, Ruis P, Hewitt G, Bellelli R, Patel H, Goldstone R, Poetsch AR, Boulton SJ. RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions. Cell Rep. 2020 Dec 22;33(12):108546. doi: 10.1016/j.celrep.2020.108546 . PMID: 33357438 ; PMCID: PMC7773548.

Poetsch A.R. (2020) AP-Seq: A Method to Measure Apurinic Sites and Small Base Adducts Genome-Wide. In: Hancock R. (eds) The Nucleus. Methods in Molecular Biology, vol 2175. Humana, New York, NY.

Poetsch AR. The genomics of oxidative DNA damage, repair, and resulting mutagenesis. CSBJ. (2020) Jan 7;18:207-219.

Chakrabarti AM, Henser-Brownhill T, Monserrat J, Poetsch AR*, Luscombe NM, Scaffidi P*. Target-specific predictability of CRISPR-mediated genome editing. Molecular Cell. (2019) Feb. 21; 73:1–15. * Corresponding author

Poetsch AR*, Boulton SJ, Luscombe NM. Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis. Genome Biology. (2018) Dec. 7; 19:215. doi: 10.1186/s13059-018-1582-2. * Corresponding author