Kretschmer Group
In a healthy organism, regulatory T (Treg) cells expressing the transcription factor Foxp3 suppress fatal immune responses against self, thereby preventing catastrophic autoimmunity. Understanding the biology of Foxp3+ Treg cells will help to harness their potent suppressor function against unwanted immune responses underlying autoimmune diseases or the destruction of transplanted hematopoietic stem cells.
![future projects](https://tu-dresden.de/cmcb/crtd/forschungsgruppen/crtd-forschungsgruppen/kretschmer/resources/bilder/Picture1-1.png/@@images/d6163915-b8a2-42f8-aec9-83b67ae430f8.png)
Future projects and goals
- Identify molecular pathways that govern the biology of Foxp3+ Treg cells, including cell signaling, gene transcription, and epigenetic regulation.
- Dissect Foxp3+ Treg cell heterogeneity, with an emphasis on immune and non-immune functions of developmental sublineages.
- Establish approaches to enhance Foxp3+ Treg cell activity for promoting antigen-specific immune tolerance in autoimmune diseases.