Kretschmer Group
In a healthy organism, regulatory T (Treg) cells expressing the transcription factor Foxp3 suppress fatal immune responses against self, thereby preventing catastrophic autoimmunity. Understanding the biology of Foxp3+ Treg cells will help to harness their potent suppressor function against unwanted immune responses underlying autoimmune diseases or the destruction of transplanted hematopoietic stem cells.
© Karsten Kretschmer
Future projects and goals
o Define molecular circuits governing Foxp3⁺ Treg cell fate, stability, and tissue adaptation, including signaling, transcriptional, and epigenetic mechanisms.
o Elucidate Treg cell heterogeneity and lineage specialization across immune and metabolic tissues.
o Develop targeted strategies to enhance Treg cell function and promote antigen-specific, tissue-adapted immune tolerance.
If you have any questions regarding our research or if your are interested in a scientific collaboration please contact us.
© CRTD
Prof. Dr. Karsten Kretschmer
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