Research topics

Preparative methods

• Modular systems for regioselective immobilization of biologically active molecules on biomaterial surfaces
• Coating of biomaterials with trace element-enriched calcium phosphate phases to improve osseointegration as well as implementation of antibacterial properties
• Nanostructuring of titanium-based materials by means of electrochemical-based processes

• Immobilization of anti-adhesive polymers in titanium-based dental implant materials to minimize biofilm formation (in cooperation with Prof. Kuckling, University of Paderborn)

Analytical methods

Characterization of biofunctionalized surfaces:

• microscopy: scanning electron microscopy, atomic force microscopy
• physicochemical: determination of flat band potential, donor density, corrosion resistance by using different electrochemical methods (potentiodynamic measurements and electrochemical impedance spectroscopy)
• cell biological: interaction of human cells with surfaces or released components (osteoblasts, osteoclasts, fibroblasts, endothelial cells) by means of static or dynamic cell culture

• characterization of the angiogenic potential of released compounds by 2D and 3D angiogenesis assays
• microbiological: in situ- haracterization of biofilm formation by fluorescently labeled E. coli (SM2029) in static and dynamic bacterial culture

• Determination of the "cleanability" of innovative surfaces by reproducible application of different prophylactic cleaning methods to avoid mature bacterial biofilms on dental implant materials (in cooperation with Jun-Prof. Paula Korn, Clinic for Oral and Maxillofacial Surgery, University Hospital Dresden)