Group Functional Biomaterials
The Functional Biomaterials group at the Max Bergmann Center for Biomaterials works on artificial extracellular matrices (aECM) for defined communication with cells and the binding/release of biological mediator proteins in the field of matrix engineering. The research focus is on elucidating the underlying molecular mechanisms with which chemically modified glycosaminoglycans (GAG) influence biological mediator proteins, such as growth factors. Further, we deal with the design and characterization of multiparametric defined, cellular microenvironments and in particular with the resulting biological reactions.
© Christiane Heinemann
Research Profile
- Tissue-specific two- and three-dimensional artificial extracellular matrices (aEZM) made from natural polymer materials as defined, adjustable microenvironments for controlling cellular behavior
- aEZM with defined action profiles, including the influencing of mediator proteins present in vivo (growth factors, cytokines) to actively support the regeneration of bone and skin tissue, particularly for older patients with limited healing capacity
- Elucidation of the structure-property relationships of glycosaminoglycan (GAG) derivatives in their interaction with healing-relevant mediator proteins and their receptors
Fields of research
- Artificial extracellular matrices based on collagen and glycosaminoglycan derivatives
- Surface coating
- Multiparametric hydrogels
- Biochemical and biophysical interaction analysis (ELISA, SPR)
- Cell culture with human mesenchymal stem cells // Cell lines
- Mechanical testing