Prof. Ingo Roeder, Ph.D.
© P.Benjamin/NCTDD
Chair for Medical Biometry and Statistics
NameMr Prof. Dr. rer. med. Ingo Röder
Institute Director
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Prof. Ingo Roeder is Head of the Institute for Medical Informatics and Biometry. He is a member of the Carl Gustav Carus Medical Faculty at the Technische Universität Dresden. In particular, he holds the Chair for Medical Statistics and Biometry. Since 2015 Prof. Roeder has been scientific head of the Core Unit for Data Management and Analytics (DMA) at the National Centre for Tumor Diseases (NCT) at the partner site Dresden. Between 2014 and 2018 he acted as CIO of the TU Dresden School of Medicine. Since 2018 he ihas been dean of studies at the Faculty of Medicine.
Prof. Roeder’s research focus covers the following areas:
Theoretical Biology/System medicine:
- Application of mathematical models in the context of treatment optimisation/model-based experimental/study design (e.g. regarding CML, AML, T-PLL)
- Dynamics of molecular regulation networks
- Theoretical concepts of stem cell organisation (theoretical setm cell biology)
- Clonal competition phenomena and stem cell/niche interactions
Biostatistics/Bioinformatics:
- Statistical modelling (e.g. mixed-effect models)
- Analysis of cellular genealogies
- Analysis of single cell tracking data
- Model-based trial design
- Integrative analysis of molecular data (e.g. NGS-based)
Medical Informatics:
- Data integration models
- „Big Data“ in oncology
- Integration of model predictions in processes of clinical decision-making
Publications
2022
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RNAi-Mediated Screen of Primary AML Cells Nominates MDM4 as a Therapeutic Target in NK-AML with DNMT3A Mutations, 2 Mar 2022, In: Cells. 11, 5, 854Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Comparative Gene Expression Analysis Reveals Similarities and Differences of Chronic Myeloid Leukemia Phases, 5 Jan 2022, In: Cancers. 14, 1, 256Electronic (full-text) versionResearch output: Contribution to journal > Research article
2021
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How to predict relapse in leukemia using time series data: A comparative in silico study, Nov 2021, In: PloS one. 16, 11, e0256585Electronic (full-text) versionResearch output: Contribution to journal > Research article
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linus: Conveniently explore, share, and present large-scale biological trajectory data in a web browser, Nov 2021, In: PLOS computational biology. 17, 11, e1009503Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Overlooking the obvious?: On the potential of treatment alterations to predict patient-specific therapy response, Feb 2021, In: Experimental hematology. 94, p. 26-30, 5 p.Electronic (full-text) versionResearch output: Contribution to journal > Review article
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TraCurate: Efficiently curating cell tracks, Jan 2021, In: SoftwareX. 13, 100656Electronic (full-text) versionResearch output: Contribution to journal > Research article
2020
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Noncanonical effector functions of the T-memory–like T-PLL cell are shaped by cooperative TCL1A and TCR signaling, 10 Dec 2020, In: Blood. 136, 24, p. 2786-2802, 17 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Differential response to cytotoxic therapy explains treatment dynamics of acute myeloid leukaemia patients: Insights from a mathematical modelling approach: Differential response to cytotoxic therapy explains treatment dynamics of acute myeloid leukaemia patients: Insights from a mathematical modelling approach, 1 Sep 2020, In: Journal of the Royal Society interface. 17, 170, 20200091Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Mathematical basis for the assessment of antibiotic resistance and administrative counter-strategies, Sep 2020, In: PloS one. 15, 9 September, e0238692Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Analysis of chronic myeloid leukaemia during deep molecular response by genomic PCR: a traffic light stratification model with impact on treatment-free remission, Aug 2020, In: Leukemia. 34, 8, p. 2113-2124, 12 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article