Roeder Lab: Medical systems biology and biometry
The research focus of the Roeder Lab comprises topics from the areas: systems biology / medicine (in particular mathematical modelling and computer simulation), medical biometry / statistics, as well as data integration and study design. A major objective of the research activities in the group is the combination of basic research strategies with clinical applications. This aim leads to a high degree of interdisciplinary, which is reflected by the different research foci listed above. The overarching research theme of the group is the use of theoretical methods and mathematical / statistical modelling approaches to foster evidence-based clinical decision-making and the efficient design and analysis of experimental studies and clinical trials ("model-based medical research“).
Research areas
Systems biology, systems medicine, mathematical modelling
This research focus deals with the development and the application of mathematical models in different areas of the life sciences. Beside basic research questions in biology (e.g. clonal competition at the level of stem cells, stem cell – niche interactions or cell migration), we specifically address topics with an explicit clinical relation (e.g. disease and treatment models of different leukemia types and other malignancies). It is our objective to understand and predict the mechanisms that underlie dynamic physiological and pathophysiological processes by the application of analytic approaches as well as by computer simulation.
Medical Biometry and Bioinformatics
This research area focuses on the development and application of innovative data analysis methods, including the fields of experimental and clinical trial design. Beside methods from “classical” biometry / statistics, we are also working on machine learning and bioinformatics methods including techniques for the integrative analysis of molecular high-throughput data and for the analysis of imaging data.
The scientific focus is complemented by services, which are provided in the context of project-related counselling as well as training offers.
Medical Informatics
Modern diagnostic procedures and/or measurement techniques provide ever-increasing amounts of data (e.g. individual genomic profiles, multi-modal image data, etc.). To use the information contained in these data for the more efficient diagnostics and/or the development of improved therapeutic strategies, a large number of steps are necessary. Beside data safety/integrity, also efficient data storage and data management solutions as well as the integration of different data types are in the focus of current research activities. In our group, we are specifically concerned with the development and implementation of integrated data storage and analysis methods, which allow to extract quantitative information out of clinical trials, to analyse them, and to use the generated knowledge directly for the design of new clinical trials.
Projects
current projects:
- AMR modeling - Modeling of antimicrobial resistance (AMR) based on surveillance data of acute care hospitals in Saxony (SMS)
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DMA/NCT — Different activities concerning data integration, bioinformatic analyses and model-based design of clinical trials within the Core Unit for Data Management and Analytics (NCT/DKFZ)
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ERANET-PLL — Implementation of (epi)genetic and metabolic networks in the targeting of T-cell prolymphocytic leukemia (BMBF, EU - Era-Net / TRANSCAN-2)
- MEDiC —Modellstudiengang Medizin (Bund, Freistaat Sachsen)
finished projects (selection):
- Analysis of cell migration patterns in the zebrafish embryo (TU Dresden)
- CHOICE — Characterization of the osteo-hematopoietic niche during malignant evolution (DKTK)
- Control-T — Mathematical modeling of homeostasis and oncogenesis in mature T cells (DFG, Research group FOR1961)
- HaematoOPT — Model-based optimization and individualization of treatment strategies in hematology (BMBF, e:Med Demonstratoren)
- Mathematical Modelling of Stem Cell / Niche Interactions (TU Dresden)
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Machine Learning-based tumour classification in mass-spectrometry data (TU Dresden, NCT)
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Network-based identification of candidate genes in oligodendroglioma (TU Dresden, NCT)
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prediCt — Mathematical modelling of TKI effects and immune response to predict patient-specific treatment dynamics in CML (BMBF, EU - ERACSysMed)
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Statistical modelling of early engraftment kinetics after stem cell transplantation in AML (TU Dresden)
- SyTASC — Systems-based Therapy of AML Stem Cells (Deutsche Krebshilfe e.V.)
Group leader
© P.Benjamin/NCTDD
Group leader
NameMr Prof. Dr. rer. med. Ingo Röder
Institute Director
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Members of the research group
© Sebastian Gerdes
Research fellow
NameMr Dr. med. Sebastian Gerdes
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© Anna Klimova
Research fellow (external: NCT)
NameMs Dr. Anna Klimova
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© Matthias Kuhn
Research fellow
NameMr Matthias Kuhn M.Sc.
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© Nils Eisfeld
Research fellow
NameMr Dr. rer. nat. René Mauer
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Research fellow
NameMr Dr. rer. nat. Nathan Mikhaylenko
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© Gabriele Müller
Research fellow
NameMs Dipl.-Ing. Gabriele Müller
ZEGV/IMB
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© Anne Riechen
application programmer & web developer
NameMs Anne Pelz M.Sc.
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© Michael Rank
Research fellow
NameMr Michael Rank M.Sc.
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© Konrad Schubert
Research fellow
NameMr Dipl.-Math. Konrad Schubert
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System administration & data management
NameMr Dipl.-Inf. (FH) Silvio Schuster
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© Friedemann Uschner
Research fellow
NameMr Dr. rer. nat. Friedemann Uschner
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© Thomas Zerjatke
Ph.D. student
NameMr Dipl.-Biomath. Thomas Zerjatke
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Students (MD/ Ph.D. students, student assistants)
MD student, research assistant
NameMr Jonas Breidenstein
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© Leonhard Schwager
MD student
NameMr Leonhard Schwager
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© Sebastian Seurig
MD student
NameMr Sebastian Seurig
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Former staff members
© Walter de Back
Research fellow (external: ZIH)
NameMr Dr. Walter de Back
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© Hans Diebner
Research fellow
NameMr Dr. rer. nat. Hans Diebner
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ERASMUS student
NameMs Erika Gaspari B.Sc.
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© Max Griehl
Student assistant
NameMr Max Griehl
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© Maria Herberg
Ph.D. student
NameMs Dr. rer. med. Maria Herberg
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© Helene Hoffmann
Ph.D. student
NameMs Helene Hoffmann M.Sc.
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© Katja Hoffmann
Software developer
NameMs Katja Hoffmann
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© Hendrik Liebscher
MD student
NameMr Hendrik Liebscher
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Ph.D. student
NameMr Adrian Ortiz Cervantes M.Sc.
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© Pirasteh Pahlavan
Research fellow (external: NCT)
NameMs Dr. rer. nat. Pirasteh Pahlavan
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© Mihaela Pricop-Jeckstadt
Research fellow
NameMs Dr. rer. nat. Mihaela Pricop-Jeckstadt
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© Ursula Range
Research fellow
NameMs Dipl.-Math. Ursula Range
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© Thoralf Stange
Research fellow (NCT)
NameMr Dipl.-Inf. Thoralf Stange
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© Konstantin Thierbach
Ph.D. student
NameMr Dipl.-Inf. Konstantin Thierbach
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© Anke Weber
Research fellow
NameMs Dr. med. Anke Weber
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