Advanced Cellular Therapeutics
Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for life-threatening hematopoietic disorders such as leukemia and lymphoma. However, despite improved conditioning regimens, graft-versus-host disease (GvHD) – an attack of patient tissue by immune cells within the graft -remains a major complication affecting every second transplanted patient. Frequent resistance to current treatment options makes GvHD the leading cause of premature non-relapse mortality in HSC recipients followed by infection. Our group develops novel individualized cell-based therapeutics to combat the unmet clinical need for efficient treatment of GvHD and viral infection after HSCT. We work in close collaboration with the Good Manufacturing Practice (GMP) facility of the Center for Regenerative Therapies Dresden (CRTD).
Current research of our group shows that re-balancing tolerance in the new immune-system with an additional dose of stem cell donor-derived immune cells (Regulatory T cells, “Tregs”) can alleviate chronic GvHD-complications after transplantation. Generating this advanced therapy medicinal product (ATMP) is laborious and involves a second blood cell donation (“apheresis”), isolation and expansion of the cells under “Good Manufacturing practice (GMP)” conditions. Recently our group established a novel smart Treg manufacturing protocol based on an automated closed system that simplifies this procedure.
- A randomized phase II clinical trial to test smart-produced Treg cells in early chronic GvHD
- Automated GMP production of antigen-specific T cells to treat viral infections in immune-compromised patients
- Adaptation of the smart manufacturing strategy to other immune cells used in cancer therapies
- Deep immunomonitoring of patients including flow- and mass cytometry (CyTOF), T cell receptor sequencing and single cell and RNA sequencing
Lab members:
© Friederike Braun
Group leader
NameDr. Anke Fuchs (née Theil)
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POSITIONS |
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|---|---|
| since 07/2019 | Mildred-Scheel-Nachwuchszentrum (MSNZ) and Center for Regenerative Therapies Dresden (CRTD) Research group leader |
| from 2015 |
Project leader Clinical Translation CRTD/Medical Clinic I, University Hospital Dresden |
| Head of Quality control according to German drug law (§13 AMG), GMP facility, CRTD | |
| 2013-2014 | Postdoctoral scientist, CRTD (Group Ezio Bonifacio; Topic: autoimmunity, type 1 diabetes) |
| 2007 | Industrial Placement at R&D department, Proimmune, Oxford, UK |
| EDUCATION | |
|---|---|
| 2008-2012 | Doctorate (PhD) (Group Ezio Bonifacio), Dresden within the DIGS-BB |
| 2001-2008 | Technical Biology Studies at University of Stuttgart |
| 2005-2006 | Undergraduate Thesis, Auckland Cancer Society Research Center, New Zealand |
| HONORS | |
|---|---|
| 2017/2018 | Fellow of the Maria-Reiche Mentoring Programe for female scientists, TU Dresden |
| 2017 | Young Investigator Award of the International Society of Cellular Therapy (ISCT) |
| 2012 | Best dissertation award, CRTD |
| 2005/2006 | Stipend from the Landesstiftung foundation of the federal state Baden-Württemberg for for a research stay at the University of Auckland, New Zealand |
MEMBERSHIPS
International Society Cell and Gene Therapy (ISCT)
Deutsche Gesellschaft für Gentherapy e.V. (DG-GT)
Action to Focus and Accelerate Cell-based Tolerance-inducing Therapies (AFACTT)
FUNDINGS
2020 MeDDrive "Deep immune profiling after T regulatory cell therapy in chronic graft-versus-host disease"
LINKS
© Marie Brombach
José Manuel Marín Morales
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© M. Gonciarz
PhD student
NameKavitha Lakshmi K. Krishnakumar
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Samikshya Santosh Nirmala M.Sc.
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Selected publications:
Marín Morales JM, Münch N, Peter K, Freund D, Oelschlägel U, Hölig K, Böhm T, Flach AC, Keßler J, Bonifacio E, Bornhäuser M, Fuchs A. Automated Clinical Grade Expansion of Regulatory T Cells in a Fully Closed System. Front Immunol. 2019;10:38. PMID: 30778344
Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Gołab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grześ D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization. Front Immunol. 2018; 15;8. PMID:29379498
Theil A,Wilhelm C, Kuhn M, Petzold A, Tuve S, Oelschlägel U, Dahl A, Bornhäuser M, Bonifacio E, Eugster A. T cell receptor repertoires after adoptive transfer of expanded allogeneic regulatory T cells. Clin Exp Immunol. 2016;187(2):316–24. PMID: 27774628
Theil A, Tuve S, Oelschlägel U, Maiwald A, Döhler D, Oßmann D, Zenkel A, Wilhelm C, Middeke JM, Shayegi N, Trautmann-Grill K, von Bonin M, Platzbecker U, Ehninger G, Bonifacio E, Bornhäuser M. Adoptive transfer of allogeneic regulatory T cells into patients with chronic graft-versus-host disease. Cytotherapy 2015;17(4):473–86. PMID: 25573333
News/activities:
Das CRTD begrüßt MSNZ Kollegiatin Anke Fuchs als Gruppenleiterin
CRTD Forscher bringen Innovation ans Krankenbett
Contact:
© Magdalena Gonciarz
Fuchs Lab
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Besuchsadresse:
CRTD / DFG Center for Regenerative Therapies at the TU Dresden, 1.131 Fetscherstrasse 105
01307 Dresden
Postadresse:
Technische Universität Dresden CRTD / DFG Center for Regenerative Therapies at the TU Dresden Dr. Anke Fuchs Fetscherstrasse 105
01307 Dresden