Publications

A. Witt, I. Mateska, A. Palladini, A. Sinha, M. Wölk, A. Harauma, N. Bechmann, C. Pamporaki, A. Dahl, M. Rothe, I. Kopaliani, C. Adolf, A. Riester, B. Wielockx, S.R. Bornstein, M. Kroiss, M. Peitzsch, T. Moriguchi, M. Fedorova, M. Grzybek, T. Chavakis, P. Mirtschink, V.I. Alexaki, Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland. Science Advances. 9 (2023) 1–20. doi:10.1126/sciadv.adf6710.

A. Deussen, I. Kopaliani, Targeting inflammation in hypertension. Current Opinion in Nephrology and Hypertension. 32 (2023) 111–117. doi:10.1097/MNH.0000000000000862.

J. Tolkmitt, H. Brendel, B. Zatschler, S. Brose, C. Brunssen, I. Kopaliani, A. Deussen, K. Matschke, H. Morawietz, Aprotinin does not Impair Vascular Function in Patients Undergoing Coronary Artery Bypass Graft Surgery. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones et Metabolisme. 55 (2023) 65–74. doi:10.1055/A-1984-0255.

A. Hofmann, Y. Khorzom, A. Klimova, S. Wolk, A. Busch, P. Sabarstinski, M. Müglich, D. Egorov, I. Kopaliani, D.M. Poitz, M. Kapalla, B. Hamann, F. Frank, C. Jänichen, C. Brunssen, H. Morawietz, C. Reeps, Associations of Tissue and Soluble LOX-1 with Human Abdominal Aortic Aneurysm. Journal of the American Heart Association. 12 (2023) e027537. doi:10.1161/JAHA.122.027537.

E. Klapproth, A. Witt, P. Klose, J. Wiedemann, N. Vavilthota, S.R. Künzel, S. Kämmerer, M. Günscht, D. Sprott, M. Lesche, F. Rost, A. Dahl, E. Rauch, L. Kattner, S. Weber, P. Mirtschink, I. Kopaliani, K. Guan, K. Lorenz, P. Saftig, M. Wagner, A. El-Armouche, Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction. Nature Communications. 13 (2022) 7648. doi:10.1038/s41467-022-35331-0.

T. Failer, M. Amponsah-Offeh, A. Neuwirth, I. Kourtzelis, P. Subramanian, P. Mirtschink, M. Peitzsch, K. Matschke, S.M. Tugtekin, T. Kajikawa, X. Li, A. Steglich, F. Gembardt, A.C. Wegner, C. Hugo, G. Hajishengallis, T. Chavakis, A. Deussen, V. Todorov, I. Kopaliani, Developmental endothelial locus-1 protects from hypertension-induced cardiovascular remodeling via immunomodulation. Journal of Clinical Investigation. 132 (2022). doi:10.1172/JCI126155.

A. Hofmann, F. Frank, S. Wolk, A. Busch, A. Klimova, P. Sabarstinski, M. Gerlach, D. Egorov, I. Kopaliani, S. Weinert, B. Hamann, D.M. Poitz, C. Brunssen, H. Morawietz, K. Schröder, C. Reeps, NOX4 mRNA correlates with plaque stability in patients with carotid artery stenosis. Redox Biology. 57 (2022) 102473. doi:10.1016/j.redox.2022.102473.

A. Hofmann, M. Müglich, S. Wolk, Y. Khorzom, P. Sabarstinski, I. Kopaliani, D. Egorov, F. Horn, C. Brunssen, S. Giebe, B. Hamann, A. Deussen, H. Morawietz, D.M. Poitz, C. Reeps, Induction of Heme Oxygenase-1 Is Linked to the Severity of Disease in Human Abdominal Aortic Aneurysm. Journal of the American Heart Association. 10 (2021). doi:10.1161/JAHA.121.022747.

I. Kopaliani, N. Jarzebska, S. Billoff, A. Kolouschek, J. Martens-Lobenhoffer, S.R. Bornstein, S.M. Bode-Böger, V.N. Ragavan, N. Weiss, A.A. Mangoni, A. Deussen, R.N. Rodionov, Overexpression of dimethylarginine dimethylaminohydrolase 1 protects from angiotensin II-induced cardiac hypertrophy and vascular remodeling. American Journal of Physiology. Heart and Circulatory Physiology. 321 (2021) H825–H838. doi:10.1152/AJPHEART.00064.2021.

F. Kessel, A. Steglich, T. Tschongov, F. Gembardt, L. Ruhnke, J. Stumpf, R. Behrendt, C. Cohrs, I. Kopaliani, V. Todorov, M. Gerlach, C. Hugo, New automatic quantification method of immunofluorescence and histochemistry in whole histological sections. Cellular Signalling. 62 (2019) 109335. doi:10.1016/j.cellsig.2019.05.020.

K. Riedel, A.J. Deussen, J. Tolkmitt, S. Weber, P. Schlinkert, B. Zatschler, C. Friebel, B. Müller, A. El-Armouche, H. Morawietz, K. Matschke, I. Kopaliani, Estrogen determines sex differences in adrenergic vessel tone by regulation of endothelial β-adrenoceptor expression. American Journal of Physiology-Heart and Circulatory Physiology. 317 (2019) H243–H254. doi:10.1152/ajpheart.00456.2018.

S. Al-Gburi, A. Deussen, B. Zatschler, S. Weber, S. Künzel, A. El-Armouche, K. Lorenz, M. Cybularz, H. Morawietz, I. Kopaliani, Sex-difference in expression and function of beta-adrenoceptors in macrovessels: role of the endothelium. Basic Research in Cardiology. 112 (2017) 29. doi:10.1007/s00395-017-0617-2.

S. Khedr, A. Deussen, I. Kopaliani, B. Zatschler, M. Martin, Effects of tryptophan-containing peptides on angiotensin-converting enzyme activity and vessel tone ex vivo and in vivo. European Journal of Nutrition. (2017). doi:10.1007/s00394-016-1374-y.

S. Al-Gburi, A.J. Deussen, R. Galli, M.H. Muders, B. Zatschler, A. Neisser, B. Müller, I. Kopaliani, Sex-specific differences in age-dependent progression of aortic dysfunction and related cardiac remodeling in spontaneously hypertensive rats. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. (2017) ajpregu.00231.2016. doi:10.1152/ajpregu.00231.2016.

R.P. Brandes, S. Harenkamp, C. Schürmann, I. Josipovic, B. Rashid, F. Rezende, O. Löwe, F. Moll, J. Epah, J. Eresch, A. Nayak, I. Kopaliani, C. Penski, M. Mittelbronn, N. Weissmann, K. Schröder, The Cytosolic NADPH Oxidase Subunit NoxO1 Promotes an Endothelial Stalk Cell Phenotype. Arteriosclerosis, Thrombosis, and Vascular Biology. (2016). doi:10.1161/ATVBAHA.116.307132.

I. Kopaliani, M. Martin, B. Zatschler, B. Müller, A. Deussen, Data of the natural and pharmaceutical angiotensin-converting enzyme inhibitor isoleucine-tryptophan as a potent blocker of matrix metalloproteinase-2 expression in rat aorta. Data in Brief. 8 (2016) 958–962. doi:10.1016/j.dib.2016.06.059.

S. Otto, A. Deussen, B. Zatschler, B. Müller, A. Neisser, K. Barth, H. Morawietz, I. Kopaliani, A novel role of endothelium in activation of latent pro-membrane type 1 MMP and pro-MMP-2 in rat aorta., Cardiovascular Research. 109 (2016) 409–18. doi:10.1093/cvr/cvv256.

I. Kopaliani, M. Martin, B. Zatschler, B. Müller, A. Deussen, Whey peptide Isoleucine-Tryptophan inhibits expression and activity of matrix metalloproteinase-2 in rat aorta. Peptides. 82 (2016) 52–59. doi:10.1016/j.peptides.2016.05.009.

M. Martin, I. Kopaliani, A. Jannasch, C. Mund, V. Todorov, T. Henle, A. Deussen, Antihypertensive and cardioprotective effects of the dipeptide isoleucine-tryptophan and whey protein hydrolysate. Acta Physiologica (Oxford, England). (2015). doi:10.1111/apha.12578.

I. Kopaliani, M. Martin, B. Zatschler, K. Bortlik, B. Müller, A. Deussen, Cell-specific and endothelium-dependent regulations of matrix metalloproteinase-2 in rat aorta. Basic Research in Cardiology. 109 (2014) 419. doi:10.1007/s00395-014-0419-8.