Publikationen
L. Jarc, M. Bandral, E. Zanfrini, M. Lesche, V. Kufrin, R. Sendra, D. Pezzolla, I. Giannios, S. Khattak, K. Neumann, B. Ludwig and A. Gavalas. Regulation of multiple signaling pathways promotes the consistent expansion of human pancreatic progenitors in defined conditions (2024). Elife, Jan 5;12, RP89962 doi: 10.7554/eLife.89962.
K. Pazur, I. Giannios, M. Lesche, E. Rodriguez-Aznar and A. Gavalas. Hoxb1 regulates distinct signaling pathways in neuromesodermal and hindbrain progenitors to promote cell survival and specification (2022). Stem Cells 40 175-189 doi: 10.1093/stmcls/sxab014.
E. Spears, I. Serafimidis, A. C. Powers, and A. Gavalas. Proliferation Versus Progenitor Differentiation and Transdifferentiation in Restoring Beta Cell Mass (2021). Front. Endocrinology 12 722250 doi: 10.3389/fendo.2021.722250.
S. Stefanovic, B. Laforest, J.P. Desvignes, F. Lescroart, L. Argiro, C. Maurel-Zaffran, D.Salgado, E. Plaindoux, C. De Bono, K. Pazur, M. Theveniau-Ruissy, C. Beroud, M. Puceat, A. Gavalas, R.G. Kelly and S. Zaffran. Hox-dependent coordination of mouse cardiac progenitor cell patterning and differentiation (2020). Elife 9 55124 doi: 10.7554/eLife.55124.
E. Mameishvili, I. Serafimidis, S. Iwaszkiewicz, M. Lesche, S. Reinhardt, N. Bölicke, M. Büttner, D. Stellas, A. Papadimitropoulou, M. Szabolcs, K. Anastassiadis, A. Dahl, F. Theis, A. Efstratiadis and A. Gavalas. Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for K-ras induced pancreatic cancer (2019). PNAS 116 20679-20688 doi: 10.1073/pnas.1901075116.
I. Giannios, I. Serafimidis, V. Anastasiou, D. Pezzola, M. Lesche, C. Andree, M. Bickle, and A. Gavalas. Protein methyltransferase inhibition decreases endocrine specification through the upregulation of Aldh1b1 expression (2019). Stem Cells, 37 640-651 doi:10.1002/stem.2979.
I. Serafimidis, E. Rodriguez-Aznar, M. Lesche, K. Yoshioka, Y. Takuwa, A. Dahl, D. Pan and A. Gavalas. Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signaling (2017). PLOS Biology, 15 e2000949 doi: 10.1371/journal.pbio.2000949.
V. Anastasiou, E. Ninou, D. Alexopoulou, J Stertmann, A. Müller, A. Dahl, M. Solimena, S. Speier, I. Serafimidis and A. Gavalas. Aldehyde dehydrogenase activity is necessary for β cell development and functionality (2016). Diabetologia, 59 139-150 doi: 10.1007/s00125-015-3784-4.
M. Ioannou, I. Serafimidis, L. Sussel, L. Arnes, Singh S., V. Vasiliou and A. Gavalas. ALDH1B1 is a potential stem / progenitor marker for multiple pancreas progenitor pools (2013). Dev. Biol. 374 153-63 doi: 10.1016/j.ydbio.2012.10.030.
I. Serafimidis, S. Heximer, D. Beis and A. Gavalas. GPCR signaling and S1P play a phylogenetically conserved role in endocrine pancreas morphogenesis (2011). Mol. Cell. Biol. 31 4442-53 doi: 10.1128/MCB.05702-11.
M. Bami, V. Episkopou, A. Gavalas and M. Gouti. Directed neural differentiation of mouse embryonic stem cells is a sensitive system for the identification of novel Hox gene effectors (2011). PLOS One, 6, e20197 doi: 10.1371/journal.pone.0020197.
M. Gouti, J. Briscoe and A. Gavalas. Anterior Hox genes interact with components of the neural crest specification network to induce neural crest fates (2011). Stem Cells, 29, 858-70 doi: 10.1002/stem.630.
M. Poulou, D. Bell, K. Bozonelos, M. Alexiou, A. Gavalas, R. Lovell-Badge and E. Remboutsika. Development of a chromosomally integrated metabolite-inducible Leu3p-alpha-IPM "off-on" gene switch. (2010). PLOS One, 5, e12488 doi: 10.1371/journal.pone.0012488.
M. Kapasa, I. Serafimidis, A. Gavalas* and S. Kossida*. Identification of phylogenetically conserved enhancer elements implicated in pancreas development in the WISP1 and CTGF orthologs (2008). Genomics 92, 301-308 doi: 10.1016/j.ygeno.2008.06.003 (* joint corresponding authors).
M. Gouti and A. Gavalas. Hoxb1 controls cell fate specification and proliferative capacity of neural stem and progenitor cells (2008). Stem Cells 26, 1985-1997 doi: 10.1634/stemcells.2008-0182.
I. Serafimidis, I. Rakatzi, V. Episkopou, M. Gouti and A. Gavalas. Novel Effectors of Directed and ngn3 Mediated Differentiation of Mouse Embryonic Stem Cells into Endocrine Pancreas Progenitors (2008). Stem Cells 26, 3-16 doi: 10.1634/stemcells.2007-0194.
J. Jacob, A.L. Ferri, C. Milton, F. Prin, P. Pla, W. Lin, A. Gavalas, S.L. Ang and J. Briscoe. Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis (2007). Nat. Neurosci. 10, 1433-9 doi: 10.1038/nn1985.
S. Remacle, L. Abbas, O. d. Backer, N. Pacico, A. Gavalas, F. Gofflot, J. J. Picard, and R. Rezsöhazy. Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo. (2004). Mol. Cell. Biol. 24, 8567-8575 doi: 10.1128/MCB.24.19.8567-8575.2004.
A. Gavalas, C. Ruhrberg, J. Livet, C. Henderson and R. Krumlauf. Neurogenesis defects in the hindbrain of Hox mutants reflect regulatory interactions among Hox genes (2003). Development 130, 5663-5679 doi: 10.1242/dev.00802.
A. Gavalas. arRAnging the hindbrain (2002). Trends in Neurosciences, 25, 59-6 doi: 10.1016/s0166-2236(02)02067-2.
A. Gavalas, P. Trainor, L. Ariza-McNaughton, and R. Krumlauf. Synergy between Hoxa1 and Hoxb1: The relationship between arch patterning and the generation of cranial neural crest (2001). Development 128, 3017-3027 doi: 10.1242/dev.128.15.3017.
G. DiRocco, A. Gavalas, H. Popperl, R.Krumlauf, F. Mavilio and V. Zappavigna. The HOXB1 transcriptional activation domain and the recruitment of a SOX/OCT complex control the cell context-dependent activity of the Hoxb1 autoregulatory enhancer (2001). J. Biol. Chem. 276, 20506-20515 doi: 10.1074/jbc.M011175200.
A. Gavalas and R. Krumlauf. Retinoid signalling and hindbrain patterning (2000). Current Opinion in Genetics & Development 10, 380-386 doi: 10.1016/s0959-437x(00)00100-3.
F.M. Rijli, A. Gavalas and P. Chambon. Segmentation and specification in the branchial region of the head: the role of the Hox selector genes (1998). Int. J. Dev. Biology 42, 393-401.
A. Gavalas, M. Studer, A. Lumsden, F.M. Rijli, R. Krumlauf and P. Chambon. Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch (1998). Development 125, 1123-1136 doi: 10.1242/dev.125.6.1123.
M. Studer, A. Gavalas, H. Marshall, L. Ariza McNaughton, F.M. Rijli, P. Chambon and R. Krumlauf. Genetic interactions betweenHoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning (1998). Development 125, 1025-1036 doi: 10.1242/dev.125.6.1025.
A. Gavalas, M. Davenne, A. Lumsden, P. Chambon and F.M. Rijli. Control of axon guidance and rostral hindbrain patterning by Hoxa-2. (1997). Development, 124, 3693-3702 doi: 10.1242/dev.124.19.3693.