Publications
Mameishvili E, Serafimidis I, Iwaszkiewicz S, Lesche M, Reinhardt S, Bölicke N, Büttner M, Stellas D, Papadimitropoulou A, Szabolcs M, Anastassiadis K, Dahl A, Theis F, Efstratiadis A, Gavalas A. Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer. Proc Natl Acad Sci U S A. 2019 Sep 23. pii: 201901075. doi: 10.1073/pnas.1901075116. [Epub ahead of print]
Giannios I, Serafimidis I, Anastasiou V, Pezzolla D, Lesche M, Andree C, Bickle M, Gavalas A. 2019. Protein Methyltransferase Inhibition Decreases Endocrine Specification Through the Upregulation of Aldh1b1 Expression. Stem Cells. Jan 25. doi: 10.1002/stem.2979.
Serafimidis, I., Rodriguez-Aznar, E., Lesche, M., Yoshioka, K., Takuwa, Y., Dahl, A., Pan, D., Gavalas, A., 2017. Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling. PLoS Biol 15, e2000949.
Anastasiou, V., Ninou, E., Alexopoulou, D., Stertmann, J., Muller, A., Dahl, A., Solimena, M., Speier, S., Serafimidis, I., Gavalas, A., 2016. Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice. Diabetologia 59, 139-150.
Ioannou, M., Serafimidis, I., Arnes, L., Sussel, L., Singh, S., Vasiliou, V., Gavalas, A., 2013. ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools. Developmental biology 374, 153-163.
Serafimidis, I., Heximer, S., Beis, D., Gavalas, A., 2011. GPCR signaling and S1P play a phylogenetically conserved role in endocrine pancreas morphogenesis. Mol Cell Biol.
Gouti, M., Briscoe, J., Gavalas, A., 2011. Anterior Hox genes interact with components of the neural crest specification network to induce neural crest fates. Stem Cells 29, 858-870.
Jacob, J., Ferri, A.L., Milton, C., Prin, F., Pla, P., Lin, W., Gavalas, A., Ang, S.L., Briscoe, J., 2007. Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis. Nat Neurosci 10, 1433-1439.
Serafimidis, I., Rakatzi, I., Episkopou, V., Gouti, M., Gavalas, A., 2008. Novel effectors of directed and Ngn3-mediated differentiation of mouse embryonic stem cells into endocrine pancreas progenitors. Stem Cells 26, 3-16.
Gouti, M., Gavalas, A., 2008. Hoxb1 controls cell fate specification and proliferative capacity of neural stem and progenitor cells. Stem Cells 26, 1985-1997.
Gavalas, A., Ruhrberg, C., Livet, J., Henderson, C.E., Krumlauf, R., 2003. Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes. Development 130, 5663-5679.
Gavalas, A., 2002. ArRAnging the hindbrain. Trends Neurosci 25, 61-64.
Gavalas, A., Trainor, P., Ariza-McNaughton, L., Krumlauf, R., 2001. Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest. Development 128, 3017-3027.
Gavalas, A., Krumlauf, R., 2000. Retinoid signalling and hindbrain patterning. Curr Opin Genet Dev 10, 380-386.
Gavalas, A., Studer, M., Lumsden, A., Rijli, F.M., Krumlauf, R., Chambon, P., 1998. Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch. Development 125, 1123-1136.
Studer, M., Gavalas, A., Marshall, H., Ariza-McNaughton, L., Rijli, F.M., Chambon, P., Krumlauf, R., 1998. Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning. Development 125, 1025-1036.
Gavalas, A., Davenne, M., Lumsden, A., Chambon, P., Rijli, F.M., 1997. Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning. Development 124, 3693-3702.