Group Members
Head
NameProf. Dr. Michele Solimena
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Administrative Coordinator
NameKatja Pfriem
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Administrative Assistant
NameAline Kalinka
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Scientiffic Coordinator
NameDr. Frank Möller
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Senior Scientist
NameKlaus-Peter Knoch
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Senior Scientist
NameDr. Hassan Mziaut
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Postdoc
NameDr. Inna Kalaidzidis
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Postdoc
NameDr. Andreas Müller
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The aim of my project is the ultrastructural analysis of insulin secretory granules (SGs) of different age. Insulin secretion in pancreatic islets occurs in two phases: a short and rapid first phase followed by a sustained second phase. There is evidence of an age dependent release of SGs, i.e. “older” SGs are less likely to undergo exocytosis relative to “younger” SGs. I will use the latest techniques in fluorescence and electron microscopy to investigate the ultrastructure of SGs of different age and their interaction with the cytoskeleton of the beta cell as well the influence of SG markers on SG aging.
Here is a presentation on one of my projects, which I gave at a symposium celebrating the 100th anniversary of the discovery of insulin at the University of Toronto:
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Postdoc
NameDr. Juha Torkko
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Elevated glucose is the predominant signal to commit beta cells for synthesis of proinsulin and also of other secretory granule associated proteins that undergo regulated processing and maturation for the biogenesis of the secretory-competent insulin granules. The goal of this project is to investigate the role of ICA512/IA-2 and other related factors in the generation and homeostasis of the insulin secretory granule stores.
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Postdoc
NameEsteban Quezada Dulcic PhD
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Predoc
NameOleksandra Topcheva
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PhD student
NamePreethi Kesavan
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Predoc
NameSolange Aurreceochea Duran
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PhD student
NameAbishek Gunasekaran
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MD student
NameSebastian Rummeny
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MD student
NameAntonia Kosok
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MD student
NameLisa-Marie Kretschmar
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MD student
NameNicola Höppner
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Technician
NameKatharina Ganß
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Technician
NameCarla Münster
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Technician
NameAnke Sönmez
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Technician
NameCarolin Eckert
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Technician
NameDaniela Friedland
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