Group Members

Administration

Administrative Coordinator

Katja Pfriem

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work Tel.: +49 351 796-36612
fax Fax: +49 351 796-36698

katja.pfriem@tu-dresden.de

Administration

Dana Krüger

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work Tel.: +49 351 796-36618
fax Fax: +49 351 796-36699

dana.krueger@tu-dresden.de

Administrative Assistance

Annika Hutschreuther-Azizi

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work Tel.: +49 351 796-36610
fax Fax: +49 351 796-36698

annika.hutschreuther-azizi@tu-dresden.de

Scientific Coordinator

Scientiffic Coordinator

Dr. Frank Möller

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work Tel.: +49 351 796-5634
fax Fax: +49 351 796-36698

frank.moeller@tu-dresden.de

Senior Scientists

Senior Scientist

Klaus-Peter Knoch

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work Tel.: +49 351 796-36619
fax Fax: +49 351 463-36698

klaus.knoch@mailbox.tu-dresden.de

Senior Scientist

Dr. Hassan Mziaut

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work Tel.: +49 351 796-36613
fax Fax: +49 351 796-36698

Hassan.Mziaut@tu-dresden.de

Postdoc

Dr. Inna Kalaidzidis

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work Tel.: +49 351 796-36608
fax Fax: +49 351 796-36698

inna.kalaidzidis@helmholtz-muenchen.de

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Postdoc

Dr. Andreas Müller

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work Tel.: +49 351 796-36607
fax Fax: +49 351 796-36698

Andreas.Mueller8@mailbox.tu-dresden.de

The aim of my project is the ultrastructural analysis of insulin secretory granules (SGs) of different age. Insulin secretion in pancreatic islets occurs in two phases: a short and rapid first phase followed by a sustained second phase. There is evidence of an age dependent release of SGs, i.e. “older” SGs are less likely to undergo exocytosis relative to “younger” SGs. I will use the latest techniques in fluorescence and electron microscopy to investigate the ultrastructure of SGs of different age and their interaction with the cytoskeleton of the beta cell as well the influence of SG markers on SG aging.

Here is a presentation on one of my projects, which I gave at a symposium celebrating the 100th anniversary of the discovery of insulin at the University of Toronto:

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Postdoc

Dr. Juha Torkko

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work Tel.: +49 351 796-36604
fax Fax: +49 351 796-36698

juha.torkko@mailbox.tu-dresden.de

Elevated glucose is the predominant signal to commit beta cells for synthesis of proinsulin and also of other secretory granule associated proteins that undergo regulated processing and maturation for the biogenesis of the secretory-competent insulin granules. The goal of this project is to investigate the role of ICA512/IA-2 and other related factors in the generation and homeostasis of the insulin secretory granule stores.

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Postdoc

Dr. Jovana Vasiljevic

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work Tel.: +49 351 796-36608
fax Fax: +49 351 796-36698

Jovana.Dinic@mailbox.tu-dresden.de

Post-transcriptional regulation is largely responsible for glucose-stimulated proinsulin biosynthesis in beta-cells. A number of RNA-binding proteins, such as PTBP1 and hnRNP K, mediate the glucose-dependent increase in insulin mRNA stability and translation. However, many of the RNA-protein interactions in beta cells are still unknown. My work focuses on identifying the proteins that bind to insulin mRNA in beta cells and investigating their role in insulin expression. Elucidating the composition and activity of protein-RNA complexes is key for a better understanding of the post-transcriptional mechanisms involved in insulin biosynthesis and secretory granule biogenesis.

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Predoc

Dr. Martin Neukam

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