Group Members

Head

Prof. Dr. Michele Solimena

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Administration

Administrative Coordinator

Katja Pfriem

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Administration

Dana Krüger

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Administrative Assistance

Annika Hutschreuther-Azizi

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Scientific Coordinator

Scientiffic Coordinator

Dr. Frank Möller

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Senior Scientists

Senior Scientist

Klaus-Peter Knoch

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Senior Scientist

Dr. Hassan Mziaut

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Postdoc

Dr. Inna Kalaidzidis

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Postdoc

Dr. Andreas Müller

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The aim of my project is the ultrastructural analysis of insulin secretory granules (SGs) of different age. Insulin secretion in pancreatic islets occurs in two phases: a short and rapid first phase followed by a sustained second phase. There is evidence of an age dependent release of SGs, i.e. “older” SGs are less likely to undergo exocytosis relative to “younger” SGs. I will use the latest techniques in fluorescence and electron microscopy to investigate the ultrastructure of SGs of different age and their interaction with the cytoskeleton of the beta cell as well the influence of SG markers on SG aging.

Here is a presentation on one of my projects, which I gave at a symposium celebrating the 100th anniversary of the discovery of insulin at the University of Toronto:

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Postdoc

Dr. Juha Torkko

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Elevated glucose is the predominant signal to commit beta cells for synthesis of proinsulin and also of other secretory granule associated proteins that undergo regulated processing and maturation for the biogenesis of the secretory-competent insulin granules. The goal of this project is to investigate the role of ICA512/IA-2 and other related factors in the generation and homeostasis of the insulin secretory granule stores.

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PhD students