Publications of the PLID since 2013

Publications 2022

Publications 2023

Publications 2022

2023

Morawietz H, Brendel H, Diaba-Nuhoho P, Catar R, Perakakis N, Wolfrum C, Bornstein SR. Cross-Talk of NADPH Oxidases and Inflammation in Obesity. Antioxidants (Basel). 2023 Aug 9;12(8):1589. doi: 10.3390/antiox12081589.

Beydag-Tasöz BS, D'Costa JV, Hersemann L, Lee BH, Luppino F, Kim YH, Zechner C, Grapin-Botton A. Integrating single-cell imaging and RNA sequencing datasets links differentiation and morphogenetic dynamics of human pancreatic endocrine progenitors. Dev Cell. 2023 Aug 14:S1534-5807(23)00366-0. doi: 10.1016/j.devcel.2023.07.019.

Sandoval-Guzmán T. The axolotl. Nat Methods. 2023 Aug;20(8):1117-1119. doi: 10.1038/s41592-023-01961-5.

Demir M, Bornstein SR, Mantzoros CS, Perakakis N. Liver fat as risk factor of hepatic and cardiometabolic diseases. Obes Rev. 2023 Oct;24(10):e13612. doi: 10.1111/obr.13612.

Malyukov M, Gelfgat E, Ruiz-Babot G, Schmid J, Lehmann S, Spinas G, Beuschlein F, Hantel C, Reisch N, Nawroth PP, Bornstein SR, Steenblock C, Ludwig B. Transplantation of porcine adrenal spheroids for the treatment of adrenal insufficiency. Xenotransplantation. 2023

Perakakis N, Harb H, Hale BG, Varga Z, Steenblock C, Kanczkowski W, Alexaki VI, Ludwig B, Mirtschink P, Solimena M, Toepfner N, Zeissig S, Gado M, Abela IA, Beuschlein F, Spinas GA, Cavelti-Weder C, Gerber PA, Huber M, Trkola A, Puhan MA, Wong WW, Linkermann A, Mohan V, Lehnert H, Nawroth P, Chavakis T, Mingrone G, Wolfrum C, Zinkernagel AS, Bornstein SR. Mechanisms and clinical relevance of the bidirectional relationship of viral infections with metabolic diseases. Lancet Diabetes Endocrinol. 2023

Witt A, Mateska I, Palladini A, Sinha A, Wölk M, Harauma A, Bechmann N, Pamporaki C, Dahl A, Rothe M, Kopaliani I, Adolf C, Riester A, Wielockx B, Bornstein SR, Kroiss M, Peitzsch M, Moriguchi T, Fedorova M, Grzybek M, Chavakis T, Mirtschink P, Alexaki VI. Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland. Sci Adv. 2023

Makhmudova U, Schatz U, Perakakis N, Kassner U, Schumann F, Axthelm C, Stürzebecher P, Sinning DL, Doevelaar A, Rohn B, Westhoff T, Vogt A, Scholl M, Kästner U, Geiling JA, Stach K, Mensch J, Lorenz E, Paitazoglou C, Eitel I, Baessler A, Steinhagen-Thiessen E, Koenig W, Schulze PC, Landmesser U, Laufs U, Weingärtner O; German Inclisiran Network (GIN). High interindividual variability in LDL-cholesterol reductions after inclisiran administration in a real-world multicenter setting in Germany. Clin Res Cardiol. 2023

Semánová C, Szőllősi GJ, Ilyés I, Cardon G, Latomme J, Iotova V, Bazdarska Y, Lindström J, Wikström K, Herrmann S, Schwarz P, Karaglani E, Manios Y, Makrilakis K, Moreno L, González-Gil EM, Rurik I, The Feel Diabetes-Study Group. Differences in Anthropometric Parameters of Children in Six European Countries. Children (Basel). 2023

Hummel S, Carl J, Friedl N, Winkler C, Kick K, Stock J, Reinmüller F, Ramminger C, Schmidt J, Lwowsky D, Braig S, Dunstheimer D, Ermer U, Gerstl EM, Weber L, Nellen-Hellmuth N, Brämswig S, Sindichakis M, Tretter S, Lorrmann A, Bonifacio E, Ziegler AG, Achenbach P; Fr1da Study Group. Children diagnosed with presymptomatic type 1 diabetes through public health screening have milder diabetes at clinical manifestation. Diabetologia. 2023

Williamson A, Norris DM, Yin X, Broadaway KA, Moxley AH, Vadlamudi S, Wilson EP, Jackson AU, Ahuja V, Andersen MK, Arzumanyan Z, Bonnycastle LL, Bornstein SR, Bretschneider MP, Buchanan TA, Chang YC, Chuang LM, Chung RH, Clausen TD, Damm P, Delgado GE, de Mello VD, Dupuis J, Dwivedi OP, Erdos MR, Silva LF, Frayling TM, Gieger C, Goodarzi MO, Guo X, Gustafsson S, Hakaste L, Hammar U, Hatem G, Herrmann S, Højlund K, Horn K, Hsueh WA, Hung YJ, Hwu CM, Jonsson A, Kårhus LL, Kleber ME, Kovacs P, Lakka TA, Lauzon M, Lee IT, Lindgren CM, Lindström J, Linneberg A, Liu CT, Luan J, Aly DM, Mathiesen E, Moissl AP, Morris AP, Narisu N, Perakakis N, Peters A, Prasad RB, Rodionov RN, Roll K, Rundsten CF, Sarnowski C, Savonen K, Scholz M, Sharma S, Stinson SE, Suleman S, Tan J, Taylor KD, Uusitupa M, Vistisen D, Witte DR, Walther R, Wu P, Xiang AH, Zethelius B; Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC); Ahlqvist E, Bergman RN, Chen YI, Collins FS, Fall T, Florez JC, Fritsche A, Grallert H, Groop L, Hansen T, Koistinen HA, Komulainen P, Laakso M, Lind L, Loeffler M, März W, Meigs JB, Raffel LJ, Rauramaa R, Rotter JI, Schwarz PEH, Stumvoll M, Sundström J, Tönjes A, Tuomi T, Tuomilehto J, Wagner R, Barroso I, Walker M, Grarup N, Boehnke M, Wareham NJ, Mohlke KL, Wheeler E, O'Rahilly S, Fazakerley DJ, Langenberg C. Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake. Nat Genet. 2023

Belavgeni A, Maremonti F, Tonnus W, Stadtmüller M, Gavali S, Mallais M, Flade K, Brucker A, Becker JN, Beer K, Tmava M, Stumpf J, Gembardt F, Hugo C, Giacca M, Hale BG, Perakakis N, Sha W, Pratt DA, Schally AV, Bornstein SR, Linkermann A. vPIF-1 is an insulin-like antiferroptotic viral peptide. Proc Natl Acad Sci U S A. 2023

Toledo PL, Vazquez DS, Gianotti AR, Abate MB, Wegbrod C, Torkko JM, Solimena M, Ermácora MR. Condensation of the β-cell secretory granule luminal cargoes pro/insulin and ICA512 RESP18 homology domain. Protein Sci. 2023

Friedrich UA, Bienias M, Zinke C, Prazenicova M, Lohse J, Jahn A, Menzel M, Langanke J, Walter C, Wagener R, Brozou T, Varghese J, Dugas M, Erlacher M, Schröck E, Suttorp M, Borkhardt A, Hauer J, Auer F. A clinical screening tool to detect genetic cancer predisposition in pediatric oncology shows high sensitivity but can miss a substantial percentage of affected children. Genet Med. 2023

Slieker RC, Donnelly LA, Akalestou E, Lopez-Noriega L, Melhem R, Güneş A, Abou Azar F, Efanov A, Georgiadou E, Muniangi-Muhitu H, Sheikh M, Giordano GN, Åkerlund M, Ahlqvist E, Ali A, Banasik K, Brunak S, Barovic M, Bouland GA, Burdet F, Canouil M, Dragan I, Elders PJM, Fernandez C, Festa A, Fitipaldi H, Froguel P, Gudmundsdottir V, Gudnason V, Gerl MJ, van der Heijden AA, Jennings LL, Hansen MK, Kim M, Leclerc I, Klose C, Kuznetsov D, Mansour Aly D, Mehl F, Marek D, Melander O, Niknejad A, Ottosson F, Pavo I, Duffin K, Syed SK, Shaw JL, Cabrera O, Pullen TJ, Simons K, Solimena M, Suvitaival T, Wretlind A, Rossing P, Lyssenko V, Legido Quigley C, Groop L, Thorens B, Franks PW, Lim GE, Estall J, Ibberson M, Beulens JWJ, 't Hart LM, Pearson ER, Rutter GA. Identification of biomarkers for glycaemic deterioration in type 2 diabetes. Nat Commun. 2023

Gado M, Heinrich A, Wiedersich D, Sameith K, Dahl A, Alexaki VI, Swarbrick MM, Baschant U, Grafe I, Perakakis N, Bornstein SR, Rauner M, Hofbauer LC, Henneicke H. Activation of beta-adrenergic receptor signaling prevents glucocorticoid-induced obesity and adipose tissue dysfunction in male mice. Am J Physiol Endocrinol Metab. 2023

Chavakis T, Alexaki VI, Ferrante AW Jr. Macrophage function in adipose tissue homeostasis and metabolic inflammation. Nat Immunol. 2023

Hoffmann C, Schwarz PE, Mantzoros CS, Birkenfeld AL, Wolfrum C, Solimena M, Bornstein SR, Perakakis N. Circulating levels of gastrointestinal hormones in prediabetes reversing to normoglycemia or progressing to diabetes in a year-A cross-sectional and prospective analysis. Diabetes Res Clin Pract. 2023

Steenblock C, Toepfner N, Beuschlein F, Perakakis N, Mohan Anjana R, Mohan V, Mahapatra NR, Bornstein SR. SARS-CoV-2 infection and its effects on the endocrine system. Best Pract Res Clin Endocrinol Metab. 2023

Amponsah-Offeh M, Diaba-Nuhoho P, Speier S, Morawietz H. Oxidative Stress, Antioxidants and Hypertension. Antioxidants (Basel). 2023

Subramanian P, Chavakis T. The complex function of macrophages and their subpopulations in metabolic injury associated fatty liver disease. J Physiol. 2023

Broadaway KA, Yin X, Williamson A, Parsons VA, Wilson EP, Moxley AH, Vadlamudi S, Varshney A, Jackson AU, Ahuja V, Bornstein SR, Corbin LJ, Delgado GE, Dwivedi OP, Silva LF, Frayling TM, Grallert H, Gustafsson S, Hakaste L, Hammar U, Herder C, Herrmann S, Højlund K, Hughes DA, Kleber ME, Lindgren CM, Liu CT, Luan J, Malmberg A, Moissl AP, Morris AP, Perakakis N, Peters A, Petrie JR, Roden M, Schwarz PEH, Sharma S, Silveira A, Strawbridge RJ, Tuomi T, Wood AR, Wu P, Zethelius B, Baldassarre D, Eriksson JG, Fall T, Florez JC, Fritsche A, Gigante B, Hamsten A, Kajantie E, Laakso M, Lahti J, Lawlor DA, Lind L, März W, Meigs JB, Sundström J, Timpson NJ, Wagner R, Walker M, Wareham NJ, Watkins H, Barroso I, O'Rahilly S, Grarup N, Parker SC, Boehnke M, Langenberg C, Wheeler E, Mohlke KL. Loci for insulin processing and secretion provide insight into type 2 diabetes risk. Am J Hum Genet. 2023

Beydag-Tasöz BS, Yennek S, Grapin-Botton A. Towards a better understanding of diabetes mellitus using organoid models. Nat Rev Endocrinol. 2023

Mahmood L, Gonzalez-Gil EM, Makrilakis K, Liatis S, Schwarz P, Herrmann S, Willems R, Cardon G, Latomme J, Rurik I, Radó S, Iotova V, Usheva N, Tankova T, Karaglani E, Manios Y, Moreno LA; Feel4Diabetes-Study Group. Cross-sectional and longitudinal associations between family meals frequency and children's overweight/obesity in families at high risk of type 2 diabetes: The Feel4Diabetes-study. Pediatr Obes. 2023

2022

Eugster A, Müller D, Gompf A, Reinhardt S, Lindner A, Ashton M, Zimmermann N, Beissert S, Bonifacio E, Günther C. Corrigendum: A novel type I interferon primed dendritic cell subpopulation in TREX1 mutant chilblain lupus patients. Front Immunol. 2022 Grapin-Botton A, Kim YH. Pancreas organoid models of development and regeneration. Development. 2022

Katsumoto K, Yennek S, Chen C, Silva LFD, Traikov S, Sever D, Azad A, Shan J, Vainio S, Ninov N, Speier S, Grapin-Botton A. Wnt4 is heterogeneously activated in maturing β-cells to control calcium signaling, metabolism and function. Nat Commun. 2022

Warncke K, Weiss A, Achenbach P, von dem Berge T, Berner R, Casteels K, Groele L, Hatzikotoulas K, Hommel A, Kordonouri O, Elding Larsson H, Lundgren M, Marcus BA, Snape MD, Szypowska A, Todd JA, Bonifacio E, Ziegler AG; GPPAD and POInT Study Groups. Elevations in blood glucose before and after the appearance of islet autoantibodies in children. J Clin Invest. 2022

Riquelme-Guzmán C, Tsai SL, Carreon Paz K, Nguyen C, Oriola D, Schuez M, Brugués J, Currie JD, Sandoval-Guzmán T. Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration. Elife. 2022

Weiss A, Zapardiel-Gonzalo J, Voss F, Jolink M, Stock J, Haupt F, Kick K, Welzhofer T, Heublein A, Winkler C, Achenbach P, Ziegler AG, Bonifacio E; Fr1da-study group. Correction to: Progression likelihood score identifies substages of presymptomatic type 1 diabetes in childhood public health screening. Diabetologia. 2022

Simonetti M, Yilmazer A, Kretschmer K. Genetic Tools for Analyzing Foxp3+ Treg Cells: Fluorochrome-Based Transcriptional Reporters and Genetic Fate-Mapping. Methods Mol Biol. 2022

Tritschler S, Thomas M, Böttcher A, Ludwig B, Schmid J, Schubert U, Kemter E, Wolf E, Lickert H, Theis FJ. A transcriptional cross species map of pancreatic islet cells. Mol Metab. 2022

Tonnus W, Maremonti F, Belavgeni A, Latk M, Kusunoki Y, Brucker A, von Mässenhausen A, Meyer C, Locke S, Gembardt F, Beer K, Hoppenz P, Becker JU, Hugo C, Anders HJ, Bornstein SR, Shao F, Linkermann A. Gasdermin D-deficient mice are hypersensitive to acute kidney injury. Cell Death Dis. 2022

Weiss A, Zapardiel-Gonzalo J, Voss F, Jolink M, Stock J, Haupt F, Kick K, Welzhofer T, Heublein A, Winkler C, Achenbach P, Ziegler AG, Bonifacio E; Fr1da-study group. Progression likelihood score identifies substages of presymptomatic type 1 diabetes in childhood public health screening. Diabetologia. 2022

Ellis JL, Evason KJ, Zhang C, Fourman MN, Liu J, Ninov N, Delous M, Vanhollebeke B, Fiddes I, Otis JP, Houvras Y, Farber SA, Xu X, Lin X, Stainier DYR, Yin C. A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish. Hepatol Commun. 2022

Gloyn AL, Ibberson M, Marchetti P, Powers AC, Rorsman P, Sander M, Solimena M. Every islet matters: improving the impact of human islet research. Nat Metab. 2022

Asplund O, Storm P, Chandra V, Hatem G, Ottosson-Laakso E, Mansour-Aly D, Krus U, Ibrahim H, Ahlqvist E, Tuomi T, Renström E, Korsgren O, Wierup N, Ibberson M, Solimena M, Marchetti P, Wollheim C, Artner I, Mulder H, Hansson O, Otonkoski T, Groop L, Prasad RB. Islet Gene View-a tool to facilitate islet research. Life Sci Alliance. 2022

Perakakis N, Barthel A, Bornstein SR. The Role of Endocrine and Metabolic System in COVID-19 Disease - The Transcampus Experience and Review of Evidence From International Collaborating Groups. Horm Metab Res. 2022

Bakhti M, Bastidas-Ponce A, Tritschler S, Czarnecki O, Tarquis-Medina M, Nedvedova E, Jaki J, Willmann SJ, Scheibner K, Cota P, Salinno C, Boldt K, Horn N, Ueffing M, Burtscher I, Theis FJ, Coskun Ü, Lickert H. Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis. Nat Commun. 2022

Eugster A, Müller D, Gompf A, Reinhardt S, Lindner A, Ashton M, Zimmermann N, Beissert S, Bonifacio E, Günther C. A Novel Type I Interferon Primed Dendritic Cell Subpopulation in TREX1 Mutant Chilblain Lupus Patients. Front Immunol. 2022

Subramanian P, Hampe J, Tacke F, Chavakis T. Fibrogenic Pathways in Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD). Int J Mol Sci. 2022

Duin S, Bhandarkar S, Lehmann S, Kemter E, Wolf E, Gelinsky M, Ludwig B, Lode A. Viability and Functionality of Neonatal Porcine Islet-like Cell Clusters Bioprinted in Alginate-Based Bioinks. Biomedicines. 2022

Patsenker E, Thangapandi VR, Knittelfelder O, Palladini A, Hefti M, Beil-Wagner J, Rogler G, Buch T, Shevchenko A, Hampe J, Stickel F. The PNPLA3 variant I148M reveals protective effects toward hepatocellular carcinoma in mice via restoration of omega-3 polyunsaturated fats. J Nutr Biochem. 2022

Stefan N, Sippel K, Heni M, Fritsche A, Wagner R, Jakob CEM, Preißl H, von Werder A, Khodamoradi Y, Borgmann S, Rüthrich MM, Hanses F, Haselberger M, Piepel C, Hower M, Vom Dahl J, Wille K, Römmele C, Vehreschild J, Stecher M, Solimena M, Roden M, Schürmann A, Gallwitz B, Hrabe de Angelis M, Ludwig DS, Schulze MB, Jensen BEO, Birkenfeld AL. Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry. Front Med (Lausanne). 2022

Rohner M, Schwarz PEH, Bornstein SR. Treating Insulin Resistance with Intermittent Personalized Nutrition to Sustain Metabolic Health and Functioning Immune System for Risk Reduction of Viral Diseases Especially COVID-19 and Long-COVID. Horm Metab Res. 2022

Ludwig S, Distler M, Schubert U, Schmid J, Thies H, Welsch T, Hempel S, Tonn T, Weitz J, Bornstein SR, Ludwig B. Quality of life and metabolic outcomes after total pancreatectomy and simultaneous islet autotransplantation. Commun Med (Lond). 2022

Kübler IC, Kretzschmar J, Brankatschk M, Sandoval-Guzmán T. Local problems need global solutions: The metabolic needs of regenerating organisms. Wound Repair Regen. 2022

Bornstein SR, Ludwig B, Steenblock C. Progress in islet transplantation is more important than ever. Nat Rev Endocrinol. 2022

Bretschneider MP, Klásek J, Karbanová M, Timpel P, Herrmann S, Schwarz PEH. Impact of a Digital Lifestyle Intervention on Diabetes Self-Management: A Pilot Study. Nutrients. 2022

Zielmann ML, Jolink M, Winkler C, Eugster A, Müller D, Scholz M, Ziegler AG, Bonifacio E. Autoantibodies against ATP4A are a feature of the abundant autoimmunity that develops in first-degree relatives of patients with type 1 diabetes. Pediatr Diabetes. 2022

Rehn M, Wenzel A, Frank AK, Schuster MB, Pundhir S, Jørgensen N, Vitting-Seerup K, Ge Y, Jendholm J, Michaut M, Schoof EM, Jensen TL, Rapin N, Sapio RT, Andersen KL, Lund AH, Solimena M, Holzenberger M, Pestov DG, Porse BT. PTBP1 promotes hematopoietic stem cell maintenance and red blood cell development by ensuring sufficient availability of ribosomal constituents. Cell Rep. 2022

Nakamura A, Wong YF, Venturato A, Michaut M, Venkateswaran S, Santra M, Gonçalves C, Larsen M, Leuschner M, Kim YH, Brickman J, Bradley M, Grapin-Botton A. Long-term feeder-free culture of human pancreatic progenitors on fibronectin or matrix-free polymer potentiates β cell differentiation. Stem Cell Reports. 2022

Xiong X, Blakely A, Kim JH, Menting JG, Schäfer IB, Schubert HL, Agrawal R, Gutmann T, Delaine C, Zhang YW, Artik GO, Merriman A, Eckert D, Lawrence MC, Coskun Ü, Fisher SJ, Forbes BE, Safavi-Hemami H, Hill CP, Chou DH. Symmetric and asymmetric receptor conformation continuum induced by a new insulin. Nat Chem Biol. 2022

Belavgeni A, Maremonti F, Stadtmüller M, Bornstein SR, Linkermann A. Schwann cell necroptosis in diabetic neuropathy. Proc Natl Acad Sci U S A. 2022

Grapin-Botton A, Ludwig B. Stem cell-derived β cells go in monkeys. Cell Stem Cell. 2022

Subramanian P, Gargani S, Palladini A, Chatzimike M, Grzybek M, Peitzsch M, Papanastasiou AD, Pyrina I, Ntafis V, Gercken B, Lesche M, Petzold A, Sinha A, Nati M, Thangapandi VR, Kourtzelis I, Andreadou M, Witt A, Dahl A, Burkhardt R, Haase R, Domingues AMJ, Henry I, Zamboni N, Mirtschink P, Chung KJ, Hampe J, Coskun Ü, Kontoyiannis DL, Chavakis T. The RNA binding protein human antigen R is a gatekeeper of liver homeostasis. Hepatology. 2022

Mahmood L, González-Gil EM, Schwarz P, Herrmann S, Karaglani E, Cardon G, De Vylder F, Willems R, Makrilakis K, Liatis S, Iotova V, Tsochev K, Tankova T, Rurik I, Radó S, Moreno LA, Manios Y; Feel4Diabetes-Study Group. Frequency of family meals and food consumption in families at high risk of type 2 diabetes: the Feel4Diabetes-study. Eur J Pediatr. 2022

Pazur K, Giannios I, Lesche M, Rodriguez-Aznar E, Gavalas A. Hoxb1 Regulates Distinct Signaling Pathways in Neuromesodermal and Hindbrain Progenitors to Promote Cell Survival and Specification. Stem Cells. 2022

Tonnus W, Locke S, Meyer C, Maremonti F, Eggert L, von Mässenhausen A, Bornstein SR, Green DR, Linkermann A. Rubicon-deficiency sensitizes mice to mixed lineage kinase domain-like (MLKL)-mediated kidney ischemia-reperfusion injury. Cell Death Dis. 2022

Kraus G, Weigelt M, Reinhardt S, Petzold A, Dahl A, Bonifacio E. Reproducibility of 10x Genomics single cell RNA sequencing method in the immune cell environment. J Immunol Methods. 2022

Reinhardt J, Sharma V, Stavridou A, Lindner A, Reinhardt S, Petzold A, Lesche M, Rost F, Bonifacio E, Eugster A. Distinguishing activated T regulatory cell and T conventional cells by single-cell technologies. Immunology. 2022

Fritsche L, Hummel J, Wagner R, Löffler D, Hartkopf J, Machann J, Hilberath J, Kantartzis K, Jakubowski P, Pauluschke-Fröhlich J, Brucker S, Hörber S, Häring HU, Roden M, Schürmann A, Solimena M, de Angelis MH, Peter A, Birkenfeld AL, Preissl H, Fritsche A, Heni M. The German Gestational Diabetes Study (PREG), a prospective multicentre cohort study: rationale, methodology and design. BMJ Open. 2022

von Mässenhausen A, Zamora Gonzalez N, Maremonti F, Belavgeni A, Tonnus W, Meyer C, Beer K, Hannani MT, Lau A, Peitzsch M, Hoppenz P, Locke S, Chavakis T, Kramann R, Muruve DA, Hugo C, Bornstein SR, Linkermann A. Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion. Sci Adv. 2022

Hempel S, Oehme F, Ehehalt F, Solimena M, Kolbinger FR, Bogner A, Welsch T, Weitz J, Distler M. The Impact of Pancreatic Head Resection on Blood Glucose Homeostasis in Patients with Chronic Pancreatitis. J Clin Med. 2022

Singh SP, Chawla P, Hnatiuk A, Kamel M, Silva LD, Spanjaard B, Eski SE, Janjuha S, Olivares-Chauvet P, Kayisoglu O, Rost F, Bläsche J, Kränkel A, Petzold A, Kurth T, Reinhardt S, Junker JP, Ninov N. A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish. Development. 2022

Steenblock C, Schwarz PEH, Perakakis N, Brajshori N, Beqiri P, Bornstein SR. The interface of COVID-19, diabetes, and depression. Discov Ment Health. 2022

2021

Ziegler AG, Danne T, Daniel C, Bonifacio E. 100 Years of Insulin: Lifesaver, immune target, and potential remedy for prevention. Med (N Y). 2021

Goveas N, Waskow C, Arndt K, Heuberger J, Zhang Q, Alexopoulou D, Dahl A, Birchmeier W, Anastassiadis K, Stewart AF, Kranz A. MLL1 is required for maintenance of intestinal stem cells. PLoS Genet. 2021

Reinhardt G, Timpel P, Schwarz PEH, Harst L. Long-Term Effects of a Video-Based Smartphone App ("VIDEA Bewegt") to Increase the Physical Activity of German Adults: A Single-Armed Observational Follow-Up Study. Nutrients. 2021

Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV Jr, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF. Publisher Correction: An open-access volume electron microscopy atlas of whole cells and tissues. Nature. 2021

von Herrath M, Bonifacio E. How benign autoimmunity becomes detrimental in type 1 diabetes. Proc Natl Acad Sci U S A. 2021

Wagner R, Eckstein SS, Yamazaki H, Gerst F, Machann J, Jaghutriz BA, Schürmann A, Solimena M, Singer S, Königsrainer A, Birkenfeld AL, Häring HU, Fritsche A, Ullrich S, Heni M. Metabolic implications of pancreatic fat accumulation. Nat Rev Endocrinol. 2021

Delgadillo-Silva LF, Akhtar MN, Taşöz E, Ninov N. Simultaneous Calcium Imaging and Glucose Stimulation in Living Zebrafish to Investigate In Vivo β-Cell Function. J Vis Exp. 2021

Steenblock C, Schwarz PEH, Ludwig B, Linkermann A, Zimmet P, Kulebyakin K, Tkachuk VA, Markov AG, Lehnert H, de Angelis MH, Rietzsch H, Rodionov RN, Khunti K, Hopkins D, Birkenfeld AL, Boehm B, Holt RIG, Skyler JS, DeVries JH, Renard E, Eckel RH, Alberti KGMM, Geloneze B, Chan JC, Mbanya JC, Onyegbutulem HC, Ramachandran A, Basit A, Hassanein M, Bewick G, Spinas GA, Beuschlein F, Landgraf R, Rubino F, Mingrone G, Bornstein SR. COVID-19 and metabolic disease: mechanisms and clinical management. Lancet Diabetes Endocrinol. 2021

Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV Jr, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF. An open-access volume electron microscopy atlas of whole cells and tissues. Nature. 2021

Holthaus L, Sharma V, Brandt D, Ziegler AG, Jastroch M, Bonifacio E. Functional and metabolic fitness of human CD4+ T lymphocytes during metabolic stress. Life Sci Alliance. 2021

Pinter A, Schwarz P, Gerdes S, Simon JC, Saalbach A, Rush J, Melzer N, Kramps T, Häberle B, Reinhardt M. Biologic Treatment in Combination with Lifestyle Intervention in Moderate to Severe Plaque Psoriasis and Concomitant Metabolic Syndrome: Rationale and Methodology of the METABOLyx Randomized Controlled Clinical Trial. Nutrients. 2021

Subramanian P, Gargani S, Palladini A, Chatzimike M, Grzybek M, Peitzsch M, Papanastasiou AD, Pyrina I, Ntafis V, Gercken B, Lesche M, Petzold A, Sinha A, Nati M, Thangapandi VR, Kourtzelis I, Andreadou M, Witt A, Dahl A, Burkhardt R, Haase R, Domingues AMJ, Henry I, Zamboni N, Mirtschink P, Chung KJ, Hampe J, Coskun Ü, Kontoyiannis DL, Chavakis T. The RNA binding protein HuR is a gatekeeper of liver homeostasis. Hepatology. 2021

Nati M, Chung KJ, Chavakis T. The Role of Innate Immune Cells in Nonalcoholic Fatty Liver Disease. J Innate Immun. 2021

Kemter E, Müller A, Neukam M, Ivanova A, Klymiuk N, Renner S, Yang K, Broichhagen J, Kurome M, Zakhartchenko V, Kessler B, Knoch KP, Bickle M, Ludwig B, Johnsson K, Lickert H, Kurth T, Wolf E, Solimena M. Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs. Proc Natl Acad Sci U S A. 2021

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Lechner K, Lechner B, Crispin A, Schwarz PEH, von Bibra H. Waist-to-height ratio and metabolic phenotype compared to the Matsuda index for the prediction of insulin resistance. Sci Rep. 2021

Huber MK, Drotar DM, Hiller H, Beery ML, Joseph P, Kusmartseva I, Speier S, Atkinson MA, Mathews CE, Phelps EA. Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices. J Vis Exp. 2021

Hippich M, Sifft P, Zapardiel-Gonzalo J, Böhmer MM, Lampasona V, Bonifacio E, Ziegler AG. A Public Health Antibody Screening Indicates a Marked Increase of SARS-CoV-2 Exposure Rate in Children during the Second Wave. Med (N Y). 2021

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Henke C, Haufe S, Ziehl D, Bornstein SR, Schulz-Menger J, Heni M, Engeli S, Jordan J, Birkenfeld AL. Low-fat hypocaloric diet reduces neprilysin in overweight and obese human subjects. ESC Heart Fail. 2021

Bornstein SR, Rubino F, Ludwig B, Rietzsch H, Schwarz PEH, Rodionov RN, Khunti K, Hopkins D, Birkenfeld AL, Boehm B, Amiel S, Holt RIG, Skyler JS, DeVries JH, Renard E, Eckel RH, Zimmet P, Alberti KG, Geloneze B, Chan JC, Mbanya JC, Onyegbutulem HC, Ramachandran A, Basit A, Hassanein M, Spinas GA, Beuschlein F, Mingrone G. Consequences of the COVID-19 pandemic for patients with metabolic diseases. Nat Metab. 2021

Bonifacio E, Weiß A, Winkler C, Hippich M, Rewers MJ, Toppari J, Lernmark Å, She JX, Hagopian WA, Krischer JP, Vehik K, Schatz DA, Akolkar B, Ziegler AG; TEDDY Study Group. An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood. Diabetes Care. 2021

Sormendi S, Deygas M, Sinha A, Bernard MLM, Krüger A, Koutzelis I, Le Lay GM, Sáez PJ, Gerlach M, Franke K, Meneses A, Kräter M, Palladini A, Guck J, Coskun Ü, Chavakis T, Vargas P, Wielockx B. HIF2α is a Direct Regulator of Neutrophil Motility. Blood. 2021

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Hu M, Cebola I, Carrat G, Jiang S, Nawaz S, Khamis A, Canouil M, Froguel P, Schulte A, Solimena M, Ibberson M, Marchetti P, Cardenas-Diaz FL, Gadue PJ, Hastoy B, Alemeida-Souza L, McMahon H, Rutter GA. Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion. Cell Rep. 2021

Müller A, Schmidt D, Xu CS, Pang S, D'Costa JV, Kretschmar S, Münster C, Kurth T, Jug F, Weigert M, Hess HF, Solimena M. 3D FIB-SEM reconstruction of microtubule-organelle interaction in whole primary mouse β cells. J Cell Biol. 2021

Ziegler AG, Bonifacio E. Shortening the paths to type 1 diabetes mellitus prevention. Nat Rev Endocrinol. 2021

Assfalg R, Knoop J, Hoffman KL, Pfirrmann M, Zapardiel-Gonzalo JM, Hofelich A, Eugster A, Weigelt M, Matzke C, Reinhardt J, Fuchs Y, Bunk M, Weiss A, Hippich M, Halfter K, Hauck SM, Hasford J, Petrosino JF, Achenbach P, Bonifacio E, Ziegler AG. Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomised controlled trial. Diabetologia. 2021

Ansarullah, Jain C, Far FF, Homberg S, Wißmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenländer L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Müller TD, Meier M, Tschöp MH, Coskun Ü, Lickert H. Inceptor counteracts insulin signalling in β-cells to control glycaemia. Nature. 2021

Willmes DM, Daniels M, Kurzbach A, Lieske S, Bechmann N, Schumann T, Henke C, El-Agroudy NN, Da Costa Goncalves AC, Peitzsch M, Hofmann A, Kanczkowski W, Kräker K, Müller DN, Morawietz H, Deussen A, Wagner M, El-Armouche A, Helfand SL, Bornstein SR, de Cabo R, Bernier M, Eisenhofer G, Tank J, Jordan J, Birkenfeld AL. The longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms. JCI Insight. 2021

Hazini A, Dieringer B, Pryshliak M, Knoch KP, Heimann L, Tolksdorf B, Pappritz K, El-Shafeey M, Solimena M, Beling A, Kurreck J, Klingel K, Fechner H. miR-375- and miR-1-Regulated Coxsackievirus B3 Has No Pancreas and Heart Toxicity But Strong Antitumor Efficiency in Colorectal Carcinomas. Hum Gene Ther. 2021

Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D, Jansen R, Min JL, Dimas AS, Ulrich A, Zudina L, Gådin JR, Jiang L, Faggian A, Bonnefond A, Fadista J, Stathopoulou MG, Isaacs A, Willems SM, Navarro P, Tanaka T, Jackson AU, Montasser ME, O'Connell JR, Bielak LF, Webster RJ, Saxena R, Stafford JM, Pourcain BS, Timpson NJ, Salo P, Shin SY, Amin N, Smith AV, Li G, Verweij N, Goel A, Ford I, Johnson PCD, Johnson T, Kapur K, Thorleifsson G, Strawbridge RJ, Rasmussen-Torvik LJ, Esko T, Mihailov E, Fall T, Fraser RM, Mahajan A, Kanoni S, Giedraitis V, Kleber ME, Silbernagel G, Meyer J, Müller-Nurasyid M, Ganna A, Sarin AP, Yengo L, Shungin D, Luan J, Horikoshi M, An P, Sanna S, Boettcher Y, Rayner NW, Nolte IM, Zemunik T, Iperen EV, Kovacs P, Hastie ND, Wild SH, McLachlan S, Campbell S, Polasek O, Carlson O, Egan J, Kiess W, Willemsen G, Kuusisto J, Laakso M, Dimitriou M, Hicks AA, Rauramaa R, Bandinelli S, Thorand B, Liu Y, Miljkovic I, Lind L, Doney A, Perola M, Hingorani A, Kivimaki M, Kumari M, Bennett AJ, Groves CJ, Herder C, Koistinen HA, Kinnunen L, Faire U, Bakker SJL, Uusitupa M, Palmer CNA, Jukema JW, Sattar N, Pouta A, Snieder H, Boerwinkle E, Pankow JS, Magnusson PK, Krus U, Scapoli C, de Geus EJCN, Blüher M, Wolffenbuttel BHR, Province MA, Abecasis GR, Meigs JB, Hovingh GK, Lindström J, Wilson JF, Wright AF, Dedoussis GV, Bornstein SR, Schwarz PEH, Tönjes A, Winkelmann BR, Boehm BO, März W, Metspalu A, Price JF, Deloukas P, Körner A, Lakka TA, Keinanen-Kiukaanniemi SM, Saaristo TE, Bergman RN, Tuomilehto J, Wareham NJ, Langenberg C, Männistö S, Franks PW, Hayward C, Vitart V, Kaprio J, Visvikis-Siest S, Balkau B, Altshuler D, Rudan I, Stumvoll M, Campbell H, van Duijn CM, Gieger C, Illig T, Ferrucci L, Pedersen NL, Pramstaller PP, Boehnke M, Frayling TM, Shuldiner AR, Peyser PA, Kardia SLR, Palmer LJ, Penninx BW, Meneton P, Harris TB, Navis G, Harst PV, Smith GD, Forouhi NG, Loos RJF, Salomaa V, Soranzo N, Boomsma DI, Groop L, Tuomi T, Hofman A, Munroe PB, Gudnason V, Siscovick DS, Watkins H, Lecoeur C, Vollenweider P, Franco-Cereceda A, Eriksson P, Jarvelin MR, Stefansson K, Hamsten A, Nicholson G, Karpe F, Dermitzakis ET, Lindgren CM, McCarthy MI, Froguel P, Kaakinen MA, Lyssenko V, Watanabe RM, Ingelsson E, Florez JC, Dupuis J, Barroso I, Morris AP, Prokopenko I; Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC). Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Nat Commun. 2021

2020

Tang X, Kusmartseva I, Kulkarni S, Posgai A, Speier S, Schatz DA, Haller MJ, Campbell-Thompson M, Wasserfall CH, Roep BO, Kaddis JS, Atkinson MA. Image-Based Machine Learning Algorithms for Disease Characterization in the Human Type 1 Diabetes Pancreas. Am J Pathol. 2020

Peitzsch C, Gorodetska I, Klusa D, Shi Q, Alves TC, Pantel K, Dubrovska A. Metabolic regulation of prostate cancer heterogeneity and plasticity. Semin Cancer Biol. 2020

Marselli L, Piron A, Suleiman M, Colli ML, Yi X, Khamis A, Carrat GR, Rutter GA, Bugliani M, Giusti L, Ronci M, Ibberson M, Turatsinze JV, Boggi U, De Simone P, De Tata V, Lopes M, Nasteska D, De Luca C, Tesi M, Bosi E, Singh P, Campani D, Schulte AM, Solimena M, Hecht P, Rady B, Bakaj I, Pocai A, Norquay L, Thorens B, Canouil M, Froguel P, Eizirik DL, Cnop M, Marchetti P. Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes. Cell Rep. 2020

Ziegler AG, Bonifacio E. Shortening the paths to type 1 diabetes mellitus prevention. Nat Rev Endocrinol. 2020

Noseda ACD, Rodrigues LS, Targa ADS, Ilkiw JL, Fagotti J, Dos Santos PD, Cecon E, Markus RP, Solimena M, Jockers R, Lima MMS. MT2 melatonin receptors expressed in the olfactory bulb modulate depressive-like behavior and olfaction in the 6-OHDA model of Parkinson's disease. Eur J Pharmacol. 2020

Hippich M, Holthaus L, Assfalg R, Zapardiel Gonzalo JM, Kapfelsperger H, Heigermoser M, Haupt F, Ewald DA, Welzhofer TC, Marcus BA, Heck S, Koelln A, Stock J, Voss F, Secchi M, Piemonti L, Rosa K, Protzer U, Boehmer M, Achenbach P, Lampasona V, Bonifacio E, Ziegler AG. Public health antibody screening indicates a six-fold higher SARS-CoV-2 exposure rate than reported cases in children. Med (N Y). 2020

Imam A, Winnebeck EC, Buchholz N, Froguel P, Bonnefond A, Solimena M, Ivanova A, Bouvier M, Plouffe B, Charpentier G, Karamitri A, Jockers R, Roenneberg T, Vetter C. Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study. Front Physiol. 2020

Chen C, Rawat D, Samikannu B, Bender M, Preissner KT, Linn T. Platelet Glycoprotein VI dependent Thrombus Stabilization is Essential for the Intraportal Engraftment of Pancreatic Islets. Am J Transplant. 2020

Chwastek G, Surma MA, Rizk S, Grosser D, Lavrynenko O, Rucińska M, Jambor H, Sáenz J. Principles of Membrane Adaptation Revealed through Environmentally Induced Bacterial Lipidome Remodeling. Cell Rep. 2020

Stazi M, Negro S, Megighian A, D'Este G, Solimena M, Jockers R, Lista F, Montecucco C, Rigoni M. Melatonin promotes regeneration of injured motor axons via MT1 receptors. J Pineal Res. 2020

Kaptan D, Penkov S, Zhang X, Gade VR, Raghuraman BK, Galli R, Sampaio JL, Haase R, Koch E, Shevchenko A, Zaburdaev V, Kurzchalia TV. Exogenous ethanol induces a metabolic switch that prolongs the survival of Caenorhabditis elegans dauer larva and enhances its resistance to desiccation. Aging Cell. 2020

Vasiljević J, Torkko JM, Knoch KP, Solimena M. The making of insulin in health and disease. Diabetologia. 2020

Höfner L, Luther AM, Palladini A, Fröhlich T, Waberski D. Tolerance of Stored Boar Spermatozoa to Autologous Seminal Plasma: A Proteomic and Lipidomic Approach. Int J Mol Sci. 2020

Hollstein T, Schulte DM, Schulz J, Glück A, Ziegler AG, Bonifacio E, Wendorff M, Franke A, Schreiber S, Bornstein SR, Laudes M. Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report. Nat Metab. 2020

Buitinga M, Cohrs CM, Eter WA, Claessens-Joosten L, Frielink C, Bos D, Sandker G, Brom M, Speier S, Gotthardt M. Non-Invasive Monitoring of Glycemia-Induced Regulation Of GLP-1R Expression in Murine and Human Islets of Langerhans. Diabetes. 2020

Stefanovic S, Laforest B, Desvignes JP, Lescroart F, Argiro L, Maurel-Zaffran C, Salgado D, Plaindoux E, De Bono C, Pazur K, Théveniau-Ruissy M, Béroud C, Puceat M, Gavalas A, Kelly RG, Zaffran S. Hox-dependent coordination of mouse cardiac progenitor cell patterning and differentiation. Elife. 2020

Bornstein SR, Zimmet P, Rubino F, Ludwig B. Management of diabetes in patients with COVID-19 - Authors' reply. Lancet Diabetes Endocrinol. 2020

Bornstein SR, Malyukov M, Heller C, Ziegler CG, Ruiz-Babot G, Schedl A, Ludwig B, Steenblock C. New Horizons: Novel Adrenal Regenerative Therapies. J Clin Endocrinol Metab.

Pinkert S, Pryshliak M, Pappritz K, Knoch K, Hazini A, Dieringer B, Schaar K, Dong F, Hinze L, Lin J, Lassner D, Klopfleisch R, Solimena M, Tschöpe C, Kaya Z, El-Shafeey M, Beling A, Kurreck J, Van Linthout S, Klingel K, Fechner H. Development of a new mouse model for coxsackievirus-induced myocarditis by attenuating coxsackievirus B3 virulence in the pancreas. Cardiovasc Res. 2020

Qadir MMF, Álvarez-Cubela S, Weitz J, Panzer JK, Klein D, Moreno-Hernández Y, Cechin S, Tamayo A, Almaça J, Hiller H, Beery M, Kusmartseva I, Atkinson M, Speier S, Ricordi C, Pugliese A, Caicedo A, Fraker CA, Pastori RL, Domínguez-Bendala J. Publisher Correction: Long-term culture of human pancreatic slices as a model to study real-time islet regeneration. Nat Commun. 2020

Henke C, Töllner K, van Dijk RM, Miljanovic N, Cordes T, Twele F, Bröer S, Ziesak V, Rohde M, Hauck SM, Vogel C, Welzel L, Schumann T, Willmes DM, Kurzbach A, El-Agroudy NN, Bornstein SR, Schneider SA, Jordan J, Potschka H, Metallo CM, Köhling R, Birkenfeld AL, Löscher W. Disruption of the sodium-dependent citrate transporter SLC13A5 in mice causes alterations in brain citrate levels and neuronal network excitability in the hippocampus. Neurobiol Dis. 2020

Pyrina I, Chung KJ, Michailidou Z, Koutsilieris M, Chavakis T, Chatzigeorgiou A. Fate of Adipose Progenitor Cells in Obesity-Related Chronic Inflammation. Front Cell Dev Biol. 2020

Sharma V, Hecker N, Walther F, Stuckas H, Hiller M. Convergent Losses of TLR5 Suggest Altered Extracellular Flagellin Detection in Four Mammalian Lineages. Mol Biol Evol. 2020

Qadir MMF, Álvarez-Cubela S, Weitz J, Panzer JK, Klein D, Moreno-Hernández Y, Cechin S, Tamayo A, Almaça J, Hiller H, Beery M, Kusmartseva I, Atkinson M, Speier S, Ricordi C, Pugliese A, Caicedo A, Fraker CA, Pastori RL, Domínguez-Bendala J. Long-term culture of human pancreatic slices as a model to study real-time islet regeneration. Nat Commun. 2020

Thangapandi VR, Knittelfelder O, Brosch M, Patsenker E, Vvedenskaya O, Buch S, Hinz S, Hendricks A, Nati M, Herrmann A, Rekhade DR, Berg T, Matz-Soja M, Huse K, Klipp E, Pauling JK, Wodke JA, Miranda Ackerman J, Bonin MV, Aigner E, Datz C, von Schönfels W, Nehring S, Zeissig S, Röcken C, Dahl A, Chavakis T, Stickel F, Shevchenko A, Schafmayer C, Hampe J, Subramanian P. Loss of hepatic Mboat7 leads to liver fibrosis. Gut. 2020

Mirea AM, Stienstra R, Kanneganti TD, Tack CJ, Chavakis T, Toonen EJM, Joosten LAB. Mice Deficient in the IL-1β Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD. Inflammation. 2020

Ziegler AG, Bonifacio E. Why is the presence of autoantibodies against GAD associated with a relatively slow progression to clinical diabetes? Diabetologia. 2020

Carrat GR, Haythorne E, Tomas A, Haataja L, Müller A, Arvan P, Piunti A, Cheng K, Huang M, Pullen TJ, Georgiadou E, Stylianides T, Amirruddin NS, Salem V, Distaso W, Cakebread A, Heesom KJ, Lewis PA, Hodson DJ, Briant LJ, Fung ACH, Sessions RB, Alpy F, Kong APS, Benke PI, Torta F, Teo AKK, Leclerc I, Solimena M, Wigley DB, Rutter GA. The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis. Mol Metab. 2020

Rubino F, Cohen RV, Mingrone G, le Roux CW, Mechanick JI, Arterburn DE, Vidal J, Alberti G, Amiel SA, Batterham RL, Bornstein S, Chamseddine G, Del Prato S, Dixon JB, Eckel RH, Hopkins D, McGowan BM, Pan A, Patel A, Pattou F, Schauer PR, Zimmet PZ, Cummings DE. Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery. Lancet Diabetes Endocrinol. 2020

Kabeza CB, Harst L, Schwarz PEH, Timpel P. A qualitative study of users' experiences after 3 months: the first Rwandan diabetes self-management Smartphone application "Kir'App". Ther Adv Endocrinol Metab. 2020

Bornstein SR, Rubino F, Khunti K, Mingrone G, Hopkins D, Birkenfeld AL, Boehm B, Amiel S, Holt RI, Skyler JS, DeVries JH, Renard E, Eckel RH, Zimmet P, Alberti KG, Vidal J, Geloneze B, Chan JC, Ji L, Ludwig B. Practical recommendations for the management of diabetes in patients with COVID-19. Lancet Diabetes Endocrinol. 2020

Panzer JK, Hiller H, Cohrs CM, Almaça J, Enos SJ, Beery M, Cechin S, Drotar DM, Weitz JR, Santini J, Huber MK, Muhammad Fahd Qadir M, Pastori RL, Domínguez-Bendala J, Phelps EA, Atkinson MA, Pugliese A, Caicedo A, Kusmartseva I, Speier S. Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis. JCI Insight. 2020

Timpel P, Lang C, Wens J, Contel JC, Schwarz PEH; MANAGE CARE Study Group. The Manage Care Model - Developing an Evidence-Based and Expert-Driven Chronic Care Management Model for Patients with Diabetes. Int J Integr Care. 2020

Cohrs CM, Panzer JK, Drotar DM, Enos SJ, Kipke N, Chen C, Bozsak R, Schöniger E, Ehehalt F, Distler M, Brennand A, Bornstein SR, Weitz J, Solimena M, Speier S. Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis. Cell Rep. 2020

Fischer T, Stumpf P, Reinhardt G, Schwarz PEH, Timpel P. Video-based smartphone app ('VIDEA bewegt') for physical activity support in German adults: a study protocol for a single-armed observational study. BMJ Open. 2020

Schuhmacher M, Grasskamp AT, Barahtjan P, Wagner N, Lombardot B, Schuhmacher JS, Sala P, Lohmann A, Henry I, Shevchenko A, Coskun Ü, Walter AM, Nadler A. Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities. Proc Natl Acad Sci U S A. 2020

Penkov S, Raghuraman BK, Erkut C, Oertel J, Galli R, Ackerman EJM, Vorkel D, Verbavatz JM, Koch E, Fahmy K, Shevchenko A, Kurzchalia TV. A metabolic switch regulates the transition between growth and diapause in C. elegans. BMC Biol. 2020

Timpel P, Oswald S, Schwarz PEH, Harst L. Mapping the Evidence on the Effectiveness of Telemedicine Interventions in Diabetes, Dyslipidemia, and Hypertension: An Umbrella Review of Systematic Reviews and Meta-Analyses. J Med Internet Res. 2020

Willems R, Pil L, Lambrinou CP, Kivelä J, Wikström K, Gonzalez-Gil EM, De Miguel-Etayo P, Nánási A, Semánová C, Van Stappen V, Cardon G, Tsochev K, Iotova V, Chakarova N, Makrilakis K, Dafoulas G, Timpel P, Schwarz P, Manios Y, Annemans L; Feel4Diabetes research group. Methodology of the health economic evaluation of the Feel4Diabetes-study. BMC Endocr Disord. 2020

Kyrou I, Tsigos C, Mavrogianni C, Cardon G, Van Stappen V, Latomme J, Kivelä J, Wikström K, Tsochev K, Nanasi A, Semanova C, Mateo-Gallego R, Lamiquiz-Moneo I, Dafoulas G, Timpel P, Schwarz PEH, Iotova V, Tankova T, Makrilakis K, Manios Y; Feel4Diabetes-study Group. Sociodemographic and lifestyle-related risk factors for identifying vulnerable groups for type 2 diabetes: a narrative review with emphasis on data from Europe. BMC Endocr Disord. 2020

Angelini G, Castagneto Gissey L, Corpo GD, Giordano C, Cerbelli B, Severino A, Manco M, Basso N, Birkenfeld AL, Bornstein SR, Genco A, Mingrone G, Casella G. Publisher Correction: New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery. Sci Rep. 2020

Mirea AM, Stienstra R, Kanneganti TD, Tack CJ, Chavakis T, Toonen EJM, Joosten LAB. Mice Deficient in the IL-1β Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD. Inflammation. 2020

Ziegler AG, Kick K, Bonifacio E, Haupt F, Hippich M, Dunstheimer D, Lang M, Laub O, Warncke K, Lange K, Assfalg R, Jolink M, Winkler C, Achenbach P; Fr1da Study Group. Yield of a Public Health Screening of Children for Islet Autoantibodies in Bavaria, Germany. JAMA. 2020

Troullinaki M, Chen LS, Witt A, Pyrina I, Phieler J, Kourtzelis I, Chmelar J, Sprott D, Gercken B, Koutsilieris M, Chavakis T, Chatzigeorgiou A. Robo4-mediated pancreatic endothelial integrity decreases inflammation and islet destruction in autoimmune diabetes. FASEB J. 2020

Gutmann T, Schäfer IB, Poojari C, Brankatschk B, Vattulainen I, Strauss M, Coskun Ü. Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain. J Cell Biol. 2020

Knoop J, Eugster A, Gavrisan A, Lickert R, Sedlmeier EM, Dietz S, Lindner A, Warncke K, Hummel N, Ziegler AG, Bonifacio E. Maternal Type 1 Diabetes Reduces Autoantigen-Responsive CD4+ T Cells in Offspring. Diabetes. 2020

Panzer JK, Cohrs CM, Speier S. Using Pancreas Tissue Slices for the Study of Islet Physiology. Methods Mol Biol. 2020

Singh SP, Ninov N. Multicolor Labeling and Tracing of Pancreatic Beta-Cell Proliferation in Zebrafish. Methods Mol Biol. 2020

Cohrs CM, Chen C, Speier S. Transplantation of Islets of Langerhans into the Anterior Chamber of the Eye for Longitudinal In Vivo Imaging. Methods Mol Biol. 2020

Ludwig B, Wolf E, Schönmann U, Ludwig S. Large Animal Models of Diabetes. Methods Mol Biol. 2020

Schumann T, König J, Henke C, Willmes DM, Bornstein SR, Jordan J, Fromm MF, Birkenfeld AL. Solute Carrier Transporters as Potential Targets for the Treatment of Metabolic Disease. Pharmacol Rev. 2020

Mziaut H, Henniger G, Ganss K, Hempel S, Wolk S, McChord J, Chowdhury K, Ravassard P, Knoch KP, Krautz C, Weitz J, Grützmann R, Pilarsky C, Solimena M, Kersting S. MiR-132 controls pancreatic beta cell proliferation and survival through Pten/Akt/Foxo3 signaling. Mol Metab. 2020

Pryshliak M, Hazini A, Knoch K, Dieringer B, Tolksdorf B, Solimena M, Kurreck J, Pinkert S, Fechner H. MiR-375-mediated suppression of engineered coxsackievirus B3 in pancreatic cells. FEBS Lett. 2020

Kahl S, Gancheva S, Straßburger K, Herder C, Machann J, Katsuyama H, Kabisch S, Henkel E, Kopf S, Lagerpusch M, Kantartzis K, Kupriyanova Y, Markgraf D, van Gemert T, Knebel B, Wolkersdorfer MF, Kuss O, Hwang JH, Bornstein SR, Kasperk C, Stefan N, Pfeiffer A, Birkenfeld AL, Roden M. Empagliflozin Effectively Lowers Liver Fat Content in Well-Controlled Type 2 Diabetes: A Randomized, Double-Blind, Phase 4, Placebo-Controlled Trial. Diabetes Care. 2020

Capristo E, Panunzi S, De Gaetano A, Raffaelli M, Guidone C, Iaconelli A, L'Abbate L, Birkenfeld AL, Bellantone R, Bornstein S, Mingrone G. Corrigendum to "Intensive lifestyle modifications with or without liraglutide 3mg vs. sleeve gastrectomy: A three-arm non-randomised, controlled, pilot study" [Diabetes Metab. 44 (2018) 235-242]. Diabetes Metab. 2020

2019

Bonifacio E, Achenbach P. Birth and coming of age of islet autoantibodies. Clin Exp Immunol. (2019)

Goldman O, Puchinsky D, Durlacher K, Sancho R, Ludwig B, Kugelmeier P, Heller C, Kunicher N, Bornstein SR, Treves AJ. Lung Based Engineered Micro-Pancreas Sustains Human Beta Cell Survival and Functionality. Horm Metab Res. (2019)

Fuchs YF, Sharma V, Eugster A, Kraus G, Morgenstern R, Dahl A, Reinhardt S, Petzold A, Lindner A, Löbel D, Bonifacio E. Gene Expression-Based Identification of Antigen-Responsive CD8(+) T Cells on a Single-Cell Level. Front Immunol. (2019)

Angelini G, Gissey LC, Del Corpo G, Giordano C, Cerbelli B, Severino A, Manco M, Basso N, Birkenfeld AL, Bornstein SR, Genco A, Mingrone G, Casella G. New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery. Sci Rep. (2019)

Trautenberg LC, Prince E, Maas C, Beier N, Honold F, Grzybek M, Brankatschk M. Selective Phosphorylation of Akt/Protein-Kinase B Isoforms in Response to Dietary Cues. Front Cell Dev Biol. (2019)

Pinkert S, Pryshliak M, Pappritz K, Knoch K, Hazini A, Dieringer B, Schaar K, Dong F, Hinze L, Lin J, Lassner D, Klopfleisch R, Solimena M, Tschöpe C, Kaya Z, Beling A, Kurreck J, van Linthout S, Klingel K, Fechner H. Development of a New Mouse Model for Coxsackievirus-Induced Myocarditis by Attenuating Coxsackievirus B3 Virulence in the Pancreas. Cardiovasc Res. (2019)

Mameishvili E, Serafimidis I, Iwaszkiewicz S, Lesche M, Reinhardt S, Bölicke N, Büttner M, Stellas D, Papadimitropoulou A, Szabolcs M, Anastassiadis K, Dahl A, Theis F, Efstratiadis A, Gavalas A. Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer. Proc Natl Acad Sci U S A. (2019)

Kabisch S, Meyer NMT, Honsek C, Gerbracht C, Dambeck U, Kemper M, Osterhoff MA, Birkenfeld AL, Arafat AM, Hjorth MF, Weickert MO, Pfeiffer AFH. Fasting Glucose State Determines Metabolic Response to Supplementation with Insoluble Cereal Fibre: A Secondary Analysis of the Optimal Fibre Trial (OptiFiT). Nutrients. (2019)

Binger KJ, Neukam M, Tattikota SG, Qadri F, Puchkov D, Willmes DM, Wurmsee S, Geisberger S, Dechend R, Raile K, Kurth T, Nguyen G, Poy MN, Solimena M, Muller DN, Birkenfeld AL. Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic β cells. Proc Natl Acad Sci U S A. (2019)

Barovic M, Distler M, Schöniger E, Radisch N, Aust D, Weitz J, Ibberson M, Schulte AM, Solimena M. Metabolically phenotyped pancreatectomized patients as living donors for the study of islets in health and diabetes. Mol Metab. (2019)

Timpel P, Harst L, Reifegerste D, Weihrauch-Blüher S, Schwarz PEH. What should governments be doing to prevent diabetes throughout the life course? Diabetologia. (2019)

El-Agroudy NN, Kurzbach A, Rodionov RN, O'Sullivan J, Roden M, Birkenfeld AL, Pesta DH. Are Lifestyle Therapies Effective for NAFLD Treatment? Trends Endocrinol Metab. (2019)

Bonifacio E, Achenbach P. Birth and coming of age of islet autoantibodies. Clin Exp Immunol. (2019)

Straube R, Voit-Bak K, Gor A, Steinmeier T, Chrousos GP, Boehm BO, Birkenfeld AL, Barbir M, Balanzew W, Bornstein SR. Correction: Lipid Profiles in Lyme Borreliosis: A Potential Role for Apheresis? Horm Metab Res. (2019)

Hoffmann VS, Weiß A, Winkler C, Knopff A, Jolink M, Bonifacio E, Ziegler AG. Landmark models to define the age-adjusted risk of developing stage 1 type 1 diabetes across childhood and adolescence. BMC Med. (2019)

Jendle J, Birkenfeld AL, Polonsky WH, Silver R, Uusinarkaus K, Hansen T,
Håkan-Bloch J, Tadayon S, Davies MJ. Improved treatment satisfaction in patients
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Winkler C, Jolink M, Knopff A, Kwarteng NA, Achenbach P, Bonifacio E, Ziegler
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Marchetti P, Schulte AM, Marselli L, Schoniger E, Bugliani M, Kramer W,
Overbergh L, Ullrich S, Gloyn AL, Ibberson M, Rutter G, Froguel P, Groop L,
McCarthy MI, Dotta F, Scharfmann R, Magnan C, Eizirik DL, Mathieu C, Cnop M,
Thorens B, Solimena M. Fostering improved human islet research: a European
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Husain M, Birkenfeld AL, Donsmark M, Dungan K, Eliaschewitz FG, Franco DR,
Jeppesen OK, Lingvay I, Mosenzon O, Pedersen SD, Tack CJ, Thomsen M, Vilsbøll T,
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Backman M, Flenkenthaler F, Blutke A, Dahlhoff M, Ländström E, Renner S,
Philippou-Massier J, Krebs S, Rathkolb B, Prehn C, Grzybek M, Coskun Ü, Rothe M,
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Kessel F, Steglich A, Tschongov T, Gembardt F, Ruhnke L, Stumpf J, Behrendt R,
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Khamis A, Canouil M, Siddiq A, Crouch H, Falchi M, Bulow MV, Ehehalt F,
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Toledo PL, Torkko JM, Müller A, Wegbrod C, Sönmez A, Solimena M, Ermácora MR.
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Meydan S, Marks J, Klepacki D, Sharma V, Baranov PV, Firth AE, Margus T, Kefi
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Mirea AM, Toonen EJM, van den Munckhof I, Munsterman ID, Tjwa ETTL, Jaeger M,
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Eugster A, Kraus G, Lidzba V, Müller D, Jolink M, Ziegler AG, Bonifacio E.
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Straube R, Voit-Bak K, Gor A, Steinmeier T, Chrousos GP, Boehm BO, Birkenfeld
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Dudeck J, Froebel J, Kotrba J, Lehmann CHK, Dudziak D, Speier S, Nedospasov
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Giannios I, Serafimidis I, Anastasiou V, Pezzolla D, Lesche M, Andree C,
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Laimighofer M, Lickert R, Fuerst R, Theis FJ, Winkler C, Bonifacio E, Ziegler
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Schreiber M, Weigelt M, Karasinsky A, Anastassiadis K, Schallenberg S,
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Duin S, Schütz K, Ahlfeld T, Lehmann S, Lode A, Ludwig B, Gelinsky M. 3D
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Grzybek M, Palladini A, Alexaki VI, Surma MA, Simons K, Chavakis T, Klose C,
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Rosenstock J, Allison D, Birkenfeld AL, Blicher TM, Deenadayalan S, Jacobsen
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Capristo E, Panunzi S, De Gaetano A, Raffaelli M, Guidone C, Iaconelli A,
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Capristo E, Panunzi S, De Gaetano A, Spuntarelli V, Bellantone R,
Giustacchini P, Birkenfeld AL, Amiel S, Bornstein SR, Raffaelli M, Mingrone G.
Response to Letter to the Editor: "Incidence of Hypoglycemia After Gastric Bypass
vs Sleeve Gastrectomy: A Randomized Trial". J Clin Endocrinol Metab. (2019)

Cecon E, Ivanova A, Luka M, Gbahou F, Friederich A, Guillaume JL, Keller P,
Knoch K, Ahmad R, Delagrange P, Solimena M, Jockers R. Detection of recombinant
and endogenous mouse melatonin receptors by monoclonal antibodies targeting the
C-terminal domain. J Pineal Res. (2019)

Weihrauch-Blüher S, Schwarz P, Klusmann JH. Childhood obesity: increased risk
for cardiometabolic disease and cancer in adulthood. Metabolism. (2019)

Dickmeis T, Feng Y, Mione MC, Ninov N, Santoro M, Spaink HP, Gut P.
Nano-Sampling and Reporter Tools to Study Metabolic Regulation in Zebrafish.
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Birkenfeld AL, Jordan J, Dworak M, Merkel T, Burnstock G. Myocardial
metabolism in heart failure: Purinergic signalling and other metabolic concepts.
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Delgadillo-Silva LF, Tsakmaki A, Akhtar N, Franklin ZJ, Konantz J, Bewick GA,
Ninov N. Modelling pancreatic β-cell inflammation in zebrafish identifies the
natural product wedelolactone for human islet protection. Dis Model Mech. (2019)

Endesfelder D, Zu Castell W, Bonifacio E, Rewers M, Hagopian WA, She JX,
Lernmark Å, Toppari J, Vehik K, Williams AJK, Yu L, Akolkar B, Krischer JP,
Ziegler AG, Achenbach P; TEDDY Study Group. Time-Resolved Autoantibody Profiling
Facilitates Stratification of Preclinical Type 1 Diabetes in Children. Diabetes.
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Schott M, R Bornstein S, A Stratakis C. Hormone and Metabolic Research: 50
Years of Research. Horm Metab Res. (2019)

Sharma V, Hiller M. Coding Exon-Structure Aware Realigner (CESAR): Utilizing
Genome Alignments for Comparative Gene Annotation. Methods Mol Biol.
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Bornstein SR, Steenblock C, Chrousos GP, Schally AV, Beuschlein F, Kline G,
Krone NP, Licinio J, Wong ML, Ullmann E, Ruiz-Babot G, Boehm BO, Behrens A,
Brennand A, Santambrogio A, Berger I, Werdermann M, Sancho R, Linkermann A,
Lenders JW, Eisenhofer G, Andoniadou CL. Stress-inducible-stem cells: a new view
on endocrine, metabolic and mental disease? Mol Psychiatry. (2019)

Kourtzelis I, Li X, Mitroulis I, Grosser D, Kajikawa T, Wang B, Grzybek M,
von Renesse J, Czogalla A, Troullinaki M, Ferreira A, Doreth C, Ruppova K, Chen
LS, Hosur K, Lim JH, Chung KJ, Grossklaus S, Tausche AK, Joosten LAB,
Moutsopoulos NM, Wielockx B, Castrillo A, Korostoff JM, Coskun Ü, Hajishengallis
G, Chavakis T. DEL-1 promotes macrophage efferocytosis and clearance of
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Penkov S, Mitroulis I, Hajishengallis G, Chavakis T. Immunometabolic
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2018

Steenblock C, Rubin de Celis MF, Delgadillo Silva LF, Pawolski V, Brennand A, Werdermann M, Berger I, Santambrogio A, Peitzsch M, Andoniadou CL, Schally AV, Bornstein SR. Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress. Proc Natl Acad Sci U S A. (2018)

Schwarz PEH, Timpel P, Harst L, Greaves CJ, Ali MK, Lambert J, Weber MB, Almedawar MM, Morawietz H. Reprint of: Blood Sugar Regulation for Cardiovascular Health Promotion and Disease Prevention: JACC Health Promotion Series. J Am Coll Cardiol. (2018)

Ashton MP, Eugster A, Dietz S, Loebel D, Lindner A, Kuehn D, Taranko AE, Heschel B, Gavrisan A, Ziegler AG, Aringer M, Bonifacio E. Single-cell profiling reveals dendritic cell signatures associated with autoimmune inflammation. Arthritis Rheumatol. (2018)

Weigert M, Schmidt U, Boothe T, Müller A, Dibrov A, Jain A, Wilhelm B, Schmidt D, Broaddus C, Culley S, Rocha-Martins M, Segovia-Miranda F, Norden C, Henriques R, Zerial M, Solimena M, Rink J, Tomancak P, Royer L, Jug F, Myers EW. Content-aware image restoration: pushing the limits of fluorescence microscopy. Nat Methods. (2018)

Cecon E, Ivanova A, Luka M, Gbahou F, Friederich A, Guillaume JL, Keller P, Knoch K, Ahmad R, Delagrange P, Solimena M, Jockers R. Detection of recombinant and endogenous mouse melatonin receptors by monoclonal antibodies targeting the C-terminal domain. J Pineal Res. (2018)

Singh SP, Janjuha S, Chaudhuri S, Reinhardt S, Kränkel A, Dietz S, Eugster A, Bilgin H, Korkmaz S, Zararsız G, Ninov N, Reid JE. Machine learning based classification of cells into chronological stages using single-cell transcriptomics. Sci Rep. (2018)

Kourtzelis I, Li X, Mitroulis I, Grosser D, Kajikawa T, Wang B, Grzybek M, von Renesse J, Czogalla A, Troullinaki M, Ferreira A, Doreth C, Ruppova K, Chen LS, Hosur K, Lim JH, Chung KJ, Grossklaus S, Tausche AK, Joosten LAB, Moutsopoulos NM, Wielockx B, Castrillo A, Korostoff JM, Coskun Ü, Hajishengallis G, Chavakis T. DEL-1 promotes macrophage efferocytosis and clearance of inflammation. Nat Immunol. (2018)

Dudeck J, Froebel J, Kotrba J, Lehmann CHK, Dudziak D, Speier S, Nedospasov SA, Schraven B, Dudeck A. Engulfment of mast cell secretory granules on skin inflammation boosts dendritic cell migration and priming efficiency. J Allergy Clin Immunol. (2018)

Endesfelder D, Castell WZ, Bonifacio E, Rewers M, Hagopian WA, She JX, Lernmark Å, Toppari J, Vehik K, Williams AJK, Yu L, Akolkar B, Krischer JP, Ziegler AG, Achenbach P; TEDDY Study Group. Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children. Diabetes.(2018)

von Loeffelholz C, Thomas-Rüddel D, Bauer M, Birkenfeld A. Effect of Magnesium Loading Dose on Insulin Resistance in Patients With Stress-Induced Hyperglycemia: A Randomized Clinical Trial. J Intensive Care Med. (2018)

Schwarz PEH, Timpel P, Harst L, Greaves CJ, Ali MK, Lambert J, Weber MB, Almedawar MM, Morawietz H. Blood Sugar Regulation for Cardiovascular Health Promotion and Disease Prevention: JACC Health Promotion Series. J Am Coll Cardiol. (2018)

Capristo E, Panunzi S, De Gaetano A, Spuntarelli V, Bellantone R, Giustacchini P, Birkenfeld AL, Amiel S, Bornstein SR, Raffaelli M, Mingrone G. Response to letter: Incidence of Hypoglycemia After Gastric Bypass vs Sleeve Gastrectomy: A Randomized Trial. J Clin Endocrinol Metab. (2018)

Brankatschk M, Gutmann T, Knittelfelder O, Palladini A, Prince E, Grzybek M, Brankatschk B, Shevchenko A, Coskun Ü, Eaton S. A Temperature-Dependent Switch in Feeding Preference Improves Drosophila Development and Survival in the Cold. Dev Cell. (2018)

Bornstein SR, Steenblock C, Chrousos GP, Schally AV, Beuschlein F, Kline G, Krone NP, Licinio J, Wong ML, Ullmann E, Ruiz-Babot G, Boehm BO, Behrens A, Brennand A, Santambrogio A, Berger I, Werdermann M, Sancho R, Linkermann A, Lenders JW, Eisenhofer G, Andoniadou CL. Stress-inducible-stem cells: a new view on endocrine, metabolic and mental disease? Mol Psychiatry. (2018)

Nieto-Garai JA, Glass B, Bunn C, Giese M, Jennings G, Brankatschk B, Agarwal S, Börner K, Contreras FX, Knölker HJ, Zankl C, Simons K, Schroeder C, Lorizate M, Kräusslich HG. Lipidomimetic Compounds Act as HIV-1 Entry Inhibitors by Altering Viral Membrane Structure. Front Immunol. (2018)

Mathieu C, Lahesmaa R, Bonifacio E, Achenbach P, Tree T. Immunological biomarkers for the development and progression of type 1 diabetes. Diabetologia. (2018)

Holthaus L, Lamp D, Gavrisan A, Sharma V, Ziegler AG, Jastroch M, Bonifacio E. CD4(+) T cell activation, function, and metabolism are inhibited by low concentrations of DMSO. J Immunol Methods. (2018)

Birkenfeld AL, Jordan J, Dworak M, Merkel T, Burnstock G. Myocardial metabolism in heart failure: Purinergic signalling and other metabolic concepts. Pharmacol Ther. (2018)

Tabansky I, Keskin DB, Watts D, Petzold C, Funaro M, Sands W, Wright P, Yunis EJ, Najjar S, Diamond B, Cao Y, Mooney D, Kretschmer K, Stern JNH. Targeting DEC-205(-)DCIR2(+) dendritic cells promotes immunological tolerance in proteolipid protein-induced experimental autoimmune encephalomyelitis. Mol Med. (2018)

Nikolakopoulou P, Chatzigeorgiou A, Kourtzelis I, Toutouna L, Masjkur J, Arps-Forker C, Poser SW, Rozman J, Rathkolb B, Aguilar-Pimentel JA; German Mouse Clinic Consortium, Wolf E, Klingenspor M, Ollert M, Schmidt-Weber C, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Tsata V, Monasor LS, Troullinaki M, Witt A, Anastasiou V, Chrousos G, Yi CX, García-Cáceres C, Tschöp MH, Bornstein SR, Androutsellis-Theotokis A. Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain. Sci Rep. (2018)

Selch S, Chafai A, Sticht H, Birkenfeld AL, Fromm MF, König J. Analysis of naturally occurring mutations in the human uptake transporter NaCT important for bone and brain development and energy metabolism. Sci Rep. (2018)

Janjuha S, Pal Singh S, Ninov N. Analysis of Beta-cell Function Using Single-cell Resolution Calcium Imaging in Zebrafish Islets. J Vis Exp. (2018)

Tauscher S, Nakagawa H, Völker K, Werner F, Krebes L, Potapenko T, Doose S, Birkenfeld AL, Baba HA, Kuhn M. β Cell-specific deletion of guanylyl cyclase A, the receptor for atrial natriuretic peptide, accelerates obesity-induced glucose intolerance in mice. Cardiovasc Diabetol. (2018)

Müller D, Telieps T, Eugster A, Weinzierl C, Jolink M, Ziegler AG, Bonifacio E. Novel minor HLA DR associated antigens in type 1 diabetes. Clin Immunol. (2018)

Jordan J, Birkenfeld AL, Melander O, Moro C. Natriuretic Peptides in Cardiovascular and Metabolic Crosstalk: Implications for Hypertension Management. Hypertension. (2018)

Chung KJ, Nati M, Chavakis T, Chatzigeorgiou A. Innate immune cells in the adipose tissue. Rev Endocr Metab Disord. (2018)

von Loeffelholz C, Gissey LC, Schumann T, Henke C, Kurzbach A, Struck J, Bergmann A, Hanefeld M, Schatz U, Bornstein SR, Casella G, Mingrone G, Birkenfeld AL. The anorexigenic peptide neurotensin relates to insulin sensitivity in obese patients after BPD or RYGB metabolic surgery. Int J Obes (Lond). (2018)

Tofte N, Lindhardt M, Adamova K, Beige J, Beulens JWJ, Birkenfeld AL, Currie G, Delles C, Dimos I, Francová L, Frimodt-Møller M, Girman P, Göke R, Havrdova T, Kooy A, Mischak H, Navis G, Nijpels G, Noutsou M, Ortiz A, Parvanova A, Persson F, Ruggenenti PL, Rutters F, Rychlík I, Spasovski G, Speeckaert M, Trillini M, von der Leyen H, Rossing P. Characteristics of high- and low-risk individuals in the PRIORITY study: urinary proteomics and mineralocorticoid receptor antagonism for prevention of diabetic nephropathy in Type 2 diabetes. Diabet Med. (2018)

Hippich M, Oleynik A, Jain K, Winkler C, Ferreira RC, Bonifacio E, Ziegler AG, Briese T. Searching peripheral blood mononuclear cells of children with viral respiratory tract infections preceding islet autoimmunity for viruses by high-throughput sequencing. Acta Diabetol. (2018)

Janjuha S, Singh SP, Tsakmaki A, Mousavy Gharavy SN, Murawala P, Konantz J, Birke S, Hodson DJ, Rutter GA, Bewick GA, Ninov N. Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish. Elife. (2018)

Achenbach P, Hawa MI, Krause S, Lampasona V, Jerram ST, Williams AJK, Bonifacio E, Ziegler AG, Leslie RD; Action LADA consortium. Autoantibodies to N-terminally truncated GAD improve clinical phenotyping of individuals with adult-onset diabetes: Action LADA 12. Diabetologia. (2018)

Schallenberg S, Kretschmer K. New insight into type 1 diabetes development: resolving early diabetogenic CD4(+) T cell responses that precede seroconversion. Ann Transl Med. (2018)

Balyura M, Gelfgat E, Steenblock C, Androutsellis-Theotokis A, Ruiz-Babot G, Guasti L, Werdermann M, Ludwig B, Bornstein T, Schally AV, Brennand A, Bornstein SR. Expression of progenitor markers is associated with the functionality of a bioartificial adrenal cortex. PLoS One. (2018)

Capristo E, Panunzi S, De Gaetano A, Spuntarelli V, Bellantone R, Giustacchini P, Birkenfeld AL, Amiel S, Bornstein SR, Raffaelli M, Mingrone G. Incidence of Hypoglycemia After Gastric Bypass vs Sleeve Gastrectomy: A Randomized Trial. J Clin Endocrinol Metab. (2018)

Gilis-Januszewska A, Barengo NC, Lindström J, Wójtowicz E, Acosta T, Tuomilehto J, Schwarz PEH, Piwońska-Solska B, Szybiński Z, Windak A, Hubalewska-Dydejczyk A. Predictors of long term weight loss maintenance in patients at high risk of type 2 diabetes participating in a lifestyle intervention program in primary health care: The DE-PLAN study. PLoS One. (2018)

Honsek C, Kabisch S, Kemper M, Gerbracht C, Arafat AM, Birkenfeld AL, Dambeck U, Osterhoff MA, Weickert MO, Pfeiffer AFH. Fibre supplementation for the prevention of type 2 diabetes and improvement of glucose metabolism: the randomised controlled Optimal Fibre Trial (OptiFiT). Diabetologia. (2018)

Freudenberg K, Lindner N, Dohnke S, Garbe AI, Schallenberg S, Kretschmer K. Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation. Front Immunol. (2018)

Gutmann T, Kim KH, Grzybek M, Walz T, Coskun Ü. Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor. J Cell Biol. (2018)

Oshima M, Knoch KP, Diedisheim M, Petzold A, Cattan P, Bugliani M, Marchetti P, Choudhary P, Huang GC, Bornstein SR, Solimena M, Albagli-Curiel O, Scharfmann R. Virus-like infection induces human β cell dedifferentiation. JCI Insight. (2018)

Capristo E, Panunzi S, De Gaetano A, Raffaelli M, Guidone C, Iaconelli A, L'Abbate L, Birkenfeld AL, Bellantone R, Bornstein SR, Mingrone G. Intensive lifestyle modifications with or without liraglutide 3mg vs. sleeve gastrectomy: A three-arm non-randomised, controlled, pilot study. Diabetes Metab. (2018)

Ruiz-Babot G, Balyura M, Hadjidemetriou I, Ajodha SJ, Taylor DR, Ghataore L, Taylor NF, Schubert U, Ziegler CG, Storr HL, Druce MR, Gevers EF, Drake WM, Srirangalingam U, Conway GS, King PJ, Metherell LA, Bornstein SR, Guasti L. Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells. Cell Rep. (2018)

Gilis-Januszewska A, Lindström J, Barengo NC, Tuomilehto J, Schwarz PE, Wójtowicz E, Piwońska-Solska B, Szybiński Z, Windak A, Hubalewska-Dydejczyk A. Predictors of completing a primary health care diabetes prevention intervention programme in people at high risk of type 2 diabetes: Experiences of the DE-PLAN project. Medicine (Baltimore). (2018)

Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Gołab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grześ D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P. Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization. Front Immunol. (2018)

Monzón-Casanova E, Screen M, Díaz-Muñoz MD, Coulson RMR, Bell SE, Lamers G, Solimena M, Smith CWJ, Turner M. The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers. Nat Immunol. (2018)

Toepfner N, Herold C, Otto O, Rosendahl P, Jacobi A, Kräter M, Stächele J, Menschner L, Herbig M, Ciuffreda L, Ranford-Cartwright L, Grzybek M, Coskun Ü, Reithuber E, Garriss G, Mellroth P, Henriques-Normark B, Tregay N, Suttorp M, Bornhäuser M, Chilvers ER, Berner R, Guck J. Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood. Elife. (2018)

Mitroulis I, Ruppova K, Wang B, Chen LS, Grzybek M, Grinenko T, Eugster A, Troullinaki M, Palladini A, Kourtzelis I, Chatzigeorgiou A, Schlitzer A, Beyer M, Joosten LAB, Isermann B, Lesche M, Petzold A, Simons K, Henry I, Dahl A, Schultze JL, Wielockx B, Zamboni N, Mirtschink P, Coskun Ü, Hajishengallis G, Netea MG, Chavakis T. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell. (2018)

Solimena M, Schulte AM, Marselli L, Ehehalt F, Richter D, Kleeberg M, Mziaut H, Knoch KP, Parnis J, Bugliani M, Siddiq A, Jörns A, Burdet F, Liechti R, Suleiman M, Margerie D, Syed F, Distler M, Grützmann R, Petretto E, Moreno-Moral A, Wegbrod C, Sönmez A, Pfriem K, Friedrich A, Meinel J, Wollheim CB, Baretton GB, Scharfmann R, Nogoceke E, Bonifacio E, Sturm D, Meyer-Puttlitz B, Boggi U, Saeger HD, Filipponi F, Lesche M, Meda P, Dahl A, Wigger L, Xenarios I, Falchi M, Thorens B, Weitz J, Bokvist K, Lenzen S, Rutter GA, Froguel P, von Bülow M, Ibberson M, Marchetti P. Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes. Diabetologia. (2018)

Balyura M, Gelfgat E, Ullmann E, Ludwig B, Barnea ER, Bornstein SR. PreImplantation Factor (PIF*) Regulates Stress-Induced Adrenal Steroidogenesis and Anti-Inflammatory Cytokines: Potential Application for Bioartificial Adrenal Transplant. Horm Metab Res. (2018)

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Willmes DM, Kurzbach A, Henke C, Schumann T, Zahn G, Heifetz A, Jordan J, Helfand SL, Birkenfeld AL. The longevity gene INDY (I'm Not Dead Yet) in metabolic control: Potential as pharmacological target. Pharmacol Ther. (2018)

Weitz JR, Makhmutova M, Almaça J, Stertmann J, Aamodt K, Brissova M, Speier S, Rodriguez-Diaz R, Caicedo A. Mouse pancreatic islet macrophages use locally released ATP to monitor beta cell activity. Diabetologia. (2018)

von Loeffelholz C, Birkenfeld A. The Role of Non-exercise Activity Thermogenesis in Human Obesity. In: De Groot LJ et al. Endotext (2018)

2017

Alfar, E.A. ; Kirova, D. ; Konantz, J. ; Birke, S. ; Mansfeld, J. ; Ninov, N. Distinct levels of reactive oxygen species coordinate metabolic activity with beta-cell mass plasticity. Sci. Rep. 7 (2017)

Anitei, M. ; Stange, C. ; Czupalla, C. ; Niehage, C. ; Schuhmann, K. ; Sala, P. ; Czogalla, A. ; Pursche, T. ; Coskun, Ü. ; Shevchenko, A. ; Hoflack, B. Spatiotemporal control of lipid conversion, actin-based mechanical forces, and curvature sensors during clathrin/AP-1-coated vesicle biogenesis. Cell Rep. 20, 2087-2099 (2017)

Bilkova, E. ; Pleskot, R. ; Rissanen, S. ; Sun, S. ; Czogalla, A. ; Cwiklik, L. ; Róg, T. ; Vattulainen, I. ; Cremer, P.S. ; Jungwirth, P. ; Coskun, Ü. Calcium directly regulates phosphatidylinositol 4,5-Bbsphosphate headgroup conformation and recognition. J. Am. Chem. Soc. 139, 4019-4024 (2017)

Blutke, A. ; Renner, S. ; Flenkenthaler, F. ; Backman, M. ; Haesner, S. ; Kemter, E. ; Ländström, E. ; Braun-Reichhart, C. ; Albl, B. ; Streckel, E. ; Rathkolb, B. ; Prehn, C. ; Palladini, A. ; Grzybek, M. ; Krebs, S. ; Bauersachs, S. ; Bähr, A. ; Brühschwein, A. ; Deeg, C.A. ; De Monte, E. ; Dmochewitz, M. ; Eberle, C. ; Emrich, D. ; Fux, R. ; Groth, F. ; Gumbert, S. ; Heitmann, A. ; Hinrichs, A.S. ; Keßler, B. ; Kurome, M. ; Leipig-Rudolph, M. ; Matiasek, K. ; Öztürk, H. ; Otzdorff, C. ; Reichenbach, M. ; Reichenbach, H.D. ; Rieger, A. ; Rieseberg, B. ; Rosati, M. ; Saucedo, M.N. ; Schleicher, A. ; Schneider, M.R. ; Simmet, K. ; Steinmetz, J. ; Übel, N. ; Zehetmaier, P. ; Jung, A. ; Adamski, J. ; Coskun, Ü. ; Hrabě de Angelis, M. ; Simmet, C. ; Ritzmann, M. ; Meyer-Lindenberg, A. ; Blum, H. ; Arnold, G.J. ; Fröhlich, T. ; Wanke, R. ; Wolf, E. The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes. Mol. Metab. 6, 931-940 (2017)

Brunssen, C. ; Hofmann, A. ; Peitzsch, M. ; Frenzel, A. ; Ziegler, C.G. ; Brown, N.F. ; Weldon, S.M. ; Eisenhofer, G. ; Willenberg, H.S. ; Bornstein, S.R. ; Morawietz, H. Impact of aldosterone synthase inhibitor FAD286 on steroid hormone profile in human adrenocortical cells. Horm. Metab. Res. 49, 701-706 (2017)

Carrat, G.R. ; Hu, M. ; Nguyen-Tu, M. ; Chabosseau, P. ; Gaulton, K.J. ; van de Bunt, M. ; Siddiq, A. ; Falchi, M. ; Thurner, M. ; Canouil, M. ; Pattou, F. ; Leclerc, I. ; Pullen, T.J. ; Cane, M.C. ; Prabhala, P. ; Greenwald, W. ; Schulte, A. ; Marchetti, P. ; Ibberson, M. ; MacDonald, P.E. ; Fox, J.E.M. ; Gloyn, A.L. ; Froguel, P. ; Solimena, M. ; McCarthy, M.I. ; Rutter, G.A. Decreased STARD10 expression is associated with defective insulin secretion in humans and mice. Am. J. Hum. Genet. 100, 238-256 (2017)

Chen, C. ; Cohrs, C.M. ; Stertmann, J. ; Bozsak, R. ; Speier, S. Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis. Mol. Metab. (2017)

Chung, K.-J. ; Chatzigeorgiou, A. ; Economopoulou, M. ; Garcia-Martin, R. ; Alexaki, V.I. ; Mitroulis, I. ; Nati, M. ; Gebler, J. ; Ziemssen, T. ; Goelz, S.E. ; Phieler, J. ; Lim, J.H. ; Karalis, K.P. ; Papayannopoulou, T. ; Blueher, M. ; Hajishengallis, G. ; Chavakis, T. A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity. Nat. Immunol. 18, 654-664 (2017)

Cohrs, C.M. ; Chen, C. ; Jahn, S. ; Stertmann, J. ; Chmelova, H. ; Weitz, J. ; Bähr, A. ; Klymiuk, N. ; Steffen, A. ; Ludwig, B. ; Kamvissi, V. ; Wolf, E. ; Bornstein, S.R. ; Solimena, M. ; Speier, S. Vessel network architecture of adult human islets promotes distinct cell-cell interactions in situ and is altered after transplantation. Endocrinology 158, 1-13 (2017)

Dudeck, J. ; Medyukhina, A. ; Fröbel, J. ; Svensson, C.M. ; Kotrba, J. ; Gerlach, M. ; Gradtke, A.C. ; Schröder, B. ; Speier, S. ; Figge, M.T. ; Dudeck, A. Mast cells acquire MHC II from dendritic cells during skin inflammation. J. Exp. Med. 214, 3791-3811 (2017)

Fuchs, Y.F. ; Eugster, A. ; Dietz, S. ; Sebelefsky, C. ; Kühn, D. ; Wilhelm, C. ; Lindner, A. ; Gavrisan, A. ; Knoop, J. ; Dahl, A. ; Ziegler, A.-G. ; Bonifacio, E. CD8+ T cells specific for the islet autoantigen IGRP are restricted in their T cell receptor chain usage. Sci. Rep. 7:44661 (2017)

Hanefeld, M. ; Engelmann, K. ; Appelt, D. ; Sandner, D. ; Weigmann, I. ; Ganz, X. ; Pistrosch, F. ; Koehler, C.M. ; Gasparic, A. ; Birkenfeld, A.L. Intra-individual variability and circadian rhythm of vascular endothelial growth factors in subjects with normal glucose tolerance and type 2 diabetes. PLoS ONE 12:e0184234 (2017)

Heidenreich, S. ; Witte, N. ; Weber, P. ; Goehring, I. ; Tolkachov, A. ; von Loeffelholz, C. ; Doecke, S. ; Bauer, M. ; Stockmann, M. ; Pfeiffer, A.F.H. ; Birkenfeld, A.L. ; Pietzke, M. ; Kempa, S. ; Muenzner, M. ; Schupp, M. Retinol saturase coordinates liver metabolism by regulating ChREBP activity. Nat. Commun. 8:384 (2017)

Kamel, M. ; Ninov, N. Catching new targets in metabolic disease with a zebrafish. Curr. Opin. Pharmacol. 37, 41-50 (2017)

Ludwig, B. ; Ludwig, S. ; Steffen, A. ; Knauf, Y. ; Zimerman, B. ; Heinke, S. ; Lehmann, S. ; Schubert, U. ; Schmid, J. ; Bleyer, M. ; Schoenmann, U. ; Colton, C.K. ; Bonifacio, E. ; Solimena, M. ; Reichel, A. ; Schally, A.V. ; Rotem, A. ; Barkai, U. ; Grinberg-Rashi, H. ; Kaup, F. ; Avni, Y. ; Jones, P. ; Bornstein, S.R. Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes. Proc. Natl. Acad. Sci. U.S.A. 114, 11745-11750 (2017)

Müller, A. ; Neukam, M. ; Ivanova, A. ; Sönmez, A. ; Münster, C. ; Kretschmar, S. ; Kalaidzidis, Y. ; Kurth, T. ; Verbavatz, J.-M. ; Solimena, M. A global approach for quantitative super resolution and electron microscopy on cryo and epoxy sections using self-labeling protein tags. Sci. Rep. 7:23 (2017)

Müller, A. ; Mziaut, H. ; Neukam, M. ; Knoch, K.-P. ; Solimena, M. A 4D view on insulin secretory granule turnover in the β-cell. Diabetes Obes. Metab. 19, 107-114 (2017)

Rathjen, T. ; Yan, X. ; Kononenko, N.L. ; Ku, M.C. ; Song, K. ; Ferrarese, L. ; Tarallo, V. ; Puchkov, D. ; Kochlamazashvili, G. ; Brachs, S. ; Varela, L. ; Szigeti-Buck, K. ; Yi, C.-X. ; Schriever, S.C. ; Tattikota, S.G. ; Carlo, A.S. ; Moroni, M. ; Siemens, J. ; Heuser, A. ; van der Weyden, L. ; Birkenfeld, A.L. ; Niendorf, T. ; Poulet, J.F.A. ; Horvath, T.L. ; Tschöp, M. ; Heinig, M. ; Trajkovski, M. ; Haucke, V. ; Poy, M.N. Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1. Nat. Neurosci. 20, 1096-1103 (2017)

Rissanen, S. ; Grzybek, M. ; Orlowski, A. ; Róg, T. ; Cramariuc, O. ; Levental, I. ; Eggeling, C. ; Sezgin, E. ; Vattulainen, I. Phase partitioning of GM1 and its bodipy-labeled analog determine their different binding to Cholera Toxin. Front. Physiol. 8:252 (2017)

Schuhmann, K. ; Srzentić, K. ; Nagornov, K.O. ; Thomas, H. ; Gutmann, T. ; Coskun, Ü. ; Tsybin, Y.O. ; Shevchenko, A. Monitoring membrane lipidome turnover by metabolic15N labeling and shotgun ultra-high-resolution orbitrap fourier transform mass spectrometry. Anal. Chem. 89, 12857-12865 (2017)

Serafimidis, I. ; Rodriguez-Aznar, E. ; Lesche, M. ; Yoshioka, K. ; Takuwa, Y. ; Dahl, A. ; Pan, D. ; Gavalas, A. Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling. PLoS Biol. 15:e2000949 (2017)

Singh, S.P. ; Janjuha, S. ; Hartmann, T. ; Kayisoglu, O. ; Konantz, J. ; Birke, S. ; Murawala, P. ; Alfar, E.A. ; Murata, K. ; Eugster, A. ; Tsuji, N. ; Morrissey, E.R. ; Brand, M. ; Ninov, N. Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth. Nat. Commun. 8:664 (2017)

Solimena, M. ; Schulte, A.M. ; Marselli, L. ; Ehehalt, F. ; Richter, D. ; Kleeberg, M. ; Mziaut, H. ; Knoch, K.-P. ; Parnis, J. ; Bugliani, M. ; Siddiq, A. ; Jörns, A. ; Burdet, F. ; Liechti, R. ; Suleiman, M. ; Margerie, D. ; Syed, F. ; Distler, M. ; Grützmann, R. ; Petretto, E. ; Moreno-Moral, A. ; Wegbrod, C. ; Sönmez, A. ; Pfriem, K. ; Friedrich, A. ; Meinel, J. ; Wollheim, C.B. ; Baretton, G.B. ; Scharfmann, R. ; Nogoceke, E. ; Bonifacio, E. ; Sturm, D. ; Meyer-Puttlitz, B. ; Boggi, U. ; Saeger, H.-D. ; Filipponi, F. ; Lesche, M. ; Meda, P. ; Dahl, A. ; Wigger, L. ; Xenarios, I. ; Falchi, M. ; Thorens, B. ; Weitz, J. ; Bokvist, K. ; Lenzen, S. ; Rutter, G.A. ; Froguel, P. ; von Bülow, M. ; Ibberson, M. ; Marchetti, P. Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes. Diabetologia, 1-17 (2017)

Stefanko, A. ; Thiede, C. ; Ehninger, G. ; Simons, K. ; Grzybek, M. Lipidomic approach for stratification of acute myeloid leukemia patients. PLoS ONE 12:e0168781 (2017)

Steffen, A. ; Kiss, T. ; Schmid, J. ; Schubert, U. ; Heinke, S. ; Lehmann, S. ; Bornstein, S.R. ; Ludwig, B. ; Ludwig, S. Production of high-quality islets from goettingen minipigs: Choice of organ preservation solution, donor pool, and optimal cold ischemia time. Xenotransplantation 24:e12284 (2017)

Steringer, J.P. ; Lange, S. ; Čujová, S. ; Šachl, R. ; Poojari, C. ; Lolicato, F. ; Beutel, O. ; Müller, H.M. ; Unger, S. ; Coskun, Ü. ; Honigmann, A. ; Vattulainen, I. ; Hof, M. ; Freund, C. ; Nickel, W. Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components. eLife 6:e28985 (2017)

von Bibra, H. ; Saha, S. ; Hapfelmeier, A. ; Mueller, G. ; Schwarz, P.E. Impact of the triglyceride/high-density lipoprotein cholesterol ratio and the hypertriglyceremic-waist phenotype to predict the metabolic syndrome and insulin resistance. Horm. Metab. Res. 49, 542-549 (2017)

von Loeffelholz, C. ; Lieske, S. ; Neuschäfer-Rube, F. ; Willmes, D.M. ; Raschzok, N. ; Sauer, I.M. ; König, J. ; Fromm, M. ; Horn, P. ; Chatzigeorgiou, A. ; Pathe-Neuschäfer-Rube, A. ; Jordan, J. ; Pfeiffer, A.F.H. ; Mingrone, G. ; Bornstein, S.R. ; Ströhle, P. ; Harms, C. ; Wunderlich, F.T. ; Helfand, S.L. ; Bernier, M. ; de Cabo, R. ; Shulman, G.I. ; Chavakis, T. ; Püschel, G.P. ; Birkenfeld, A.L. The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism. Hepatology 66, 616-630 (2017)

Weitz, J.R. ; Makhmutova, M. ; Almaça, J. ; Stertmann, J. ; Aamodt, K. ; Brissova, M. ; Speier, S. ; Rodriguez-Diaz, R. ; Caicedo, A. Mouse pancreatic islet macrophages use locally released ATP to monitor beta cell activity. Diabetologia 61, 1-11 (2017)

Willmes, D.M. ; Kurzbach, A. ; Henke, C. ; Zahn, G. ; Heifetz, A. ; Jordan, J. ; Helfand, S.L. ; Birkenfeld, A.L. The longevity gene INDY (I'm Not Dead Yet) in metabolic control: Potential as pharmacological target. Pharmacol. Ther., DOI: 10.1016/j.pharmthera.2017.10.003 (2017)

2016

Alexaki, V.I. ; Chavakis, T. The role of innate immunity in the regulation of brown and beige adipogenesis. Rev. Endocr. Metab. Disord. 17, 41-49 (2016)

Anastasiou, V. ; Ninou, E. ; Alexopoulou, D. ; Stertmann, J. ; Müller, A. ; Dahl, A. ; Solimena, M. ; Speier, S. ; Serafimidis, I. ; Gavalas, A. Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice. Diabetologia 59, 139-150 (2016)

Bader, E. ; Migliorini, A. ; Gegg, M. ; Moruzzi, N. ; Gerdes, J.M. ; Roscioni, S. ; Bakhti, M. ; Brandl, E. ; Irmler, M. ; Beckers, J. ; Aichler, M. ; Feuchtinger, A. ; Leitzinger, C. ; Zischka, H. ; Wang-Sattler, R. ; Jastroch, M. ; Tschöp, M. ; Machicao, F. ; Staiger, H. ; Häring, H.-U. ; Chmelova, H. ; Chouinard, J.A. ; Oskolkov, N. ; Korsgren, O. ; Speier, S. ; Lickert, H. Identification of proliferative and mature β-cells in the islets of Langerhans. Nature 535, 430-434 (2016)

Catani, M. ; Walther, D. ; Christie, M.R. ; McLaughlin, K.A. ; Bonifacio, E. ; Eugster, A. Isolation of human monoclonal autoantibodies derived from pancreatic lymph node and peripheral blood B cells of islet autoantibody-positive patients. Diabetologia 59, 294-298 (2016)

Chen, C. ; Chmelova, H. ; Cohrs, C.M. ; Chouinard, J.A. ; Jahn, S. ; Stertmann, J. ; Uphues, I. ; Speier, S. Alterations in β-cell calcium dynamics and efficacy outweigh islet mass adaptation in compensation of insulin resistance and prediabetes onset. Diabetes 65, 2676-2685 (2016)

Chmelar, J. ; Chatzigeorgiou, A. ; Chung, K.-J. ; Prucnal, M. ; Voehringer, D. ; Roers, A. ; Chavakis, T. No role for mast cells in obesity-related metabolic dysregulation. Front. Immunol. 7:524 (2016)

Daniels, M.A. ; Kan, C. ; Willmes, D.M. ; Ismail, K. ; Pistrosch, F. ; Hopkins, D. ; Mingrone, G. ; Bornstein, S.R. ; Birkenfeld, A.L. Pharmacogenomics in type 2 diabetes: Oral antidiabetic drugs. Pharmacogenomics J. 16, 399-410 (2016)

Ehret, G.B. ; Ferreira, T. ; Chasman, D.I. ; Jackson, A.U. ; Schmidt, E.M. ; Johnson, T. ; Thorleifsson, G. ; Luan, J. ; Donnelly, L.A. ; Kanoni, S. ; Petersen, A.-K. ; Pihur, V. ; Strawbridge, R.J. ; Shungin, D. ; Hughes, M.F. ; Meirelles, O. ; Kaakinen, M. ; Bouatia-Naji, N. ; Kristiansson, K. ; Shah, S. ; Kleber, M.E. ; Guo, X. ; Lyytikäinen, L.P. ; Fava, C. ; Eriksson, N. ; Nolte, I.M. ; Magnusson, P.K. ; Salfati, E.L. ; Rallidis, L.S. ; Theusch, E. ; Smith, A.J. ; Folkersen, L. ; Witkowska, K. ; Pers, T.H. ; Joehanes, R. ; Kim, S.K. ; Lataniotis, L. ; Jansen, R. ; Johnson, A.D. ; Warren, H. ; Kim, Y.J. ; Zhao, W. ; Wu, Y. ; Tayo, B.O. ; Bochud, M. ; Absher, D. ; Adair, L.S. ; Amin, N. ; Arking, D.E. ; Axelsson, T. ; Baldassarre, D. ; Balkau, B. ; Bandinelli, S. ; Barnes, M.R. ; Barroso, I. ; Bevan, S. ; Bis, J.C. ; Bjornsdottir, G. ; Boehnke, M. ; Boerwinkle, E. ; Bonnycastle, L.L. ; Boomsma, D.I. ; Bornstein, S. ; Brown, M.J. ; Burnier, M. ; Cabrera, C.P. ; Chambers, J.C. ; Chang, I.S. ; Cheng, C.Y. ; Chines, P.S. ; Chung, R.H. ; Collins, F.S. ; Connell, J.M. ; Döring, A. ; Dallongeville, J. ; Danesh, J. ; de Faire, U. ; Delgado, G. ; Dominiczak, A.F. ; Doney, A.S. ; Drenos, F. ; Edkins, S. ; Eicher, J.D. ; Elosua, R. ; Enroth, S. ; Erdmann, J. ; Eriksson, P. ; Esko, T. ; Evangelou, E. ; Evans, A. ; Fall, T. ; Farrall, M. ; Felix, J.F. ; Ferrieres, J. ; Ferrucci, L. ; Fornage, M. ; Forrester, T. ; Franceschini, N. ; Franco, O.H. ; Franco-Cereceda, A. ; Fraser, R.M. ; Ganesh, S.K. ; Gao, H. ; Gertow, K. ; Gianfagna, F. ; Gigante, B. ; Giulianini, F. ; Goel, A. ; Goodall, A.H. ; Goodarzi, M.O. ; Gorski, M. ; Gräßler, J. ; Groves, C.J. ; Gudnason, V. ; Gyllensten, U. ; Hallmans, G. ; Hartikainen, A.L. ; Hassinen, M. ; Havulinna, A.S. ; Hayward, C. ; Hercberg, S. ; Herzig, K.H. ; Hicks, A.A. ; Hingorani, A.D. ; Hirschhorn, J.N. ; Hofman, A. ; Holmen, J. ; Holmen, O.L. ; Hottenga, J.J. ; Howard, P. ; Hsiung, C.A. ; Hunt, S.C. ; Ikram, M.A. ; Illig, T. ; Iribarren, C. ; Jensen, R.A. ; Kähönen, M. ; Kang, H.M. ; Kathiresan, S. ; Keating, B.J. ; Khaw, K.T. ; Kim, Y.K. ; Kim, E. ; Kivimaki, M. ; Klopp, N. ; Kolovou, G. ; Komulainen, P. ; Kooner, J.S. ; Kosova, G. ; Krauss, R.M. ; Kuh, D. ; Kutalik, Z. ; Kuusisto, J. ; Kvaløy, K. ; Lakka, T.A. ; Lee, N.R. ; Lee, I.T. ; Lee, W.J. ; Levy, D. ; Li, X. ; Liang, K.W. ; Lin, H. ; Lin, L. ; Lindstrom, J. ; Lobbens, S. ; Männisto, S. ; Müller, G. ; Müller-Nurasyid, M. ; Mach, F. ; Markus, H.S. ; Marouli, E. ; McCarthy, M.I. ; McKenzie, C.A. ; Meneton, P. ; Menni, C. ; Metspalu, A. ; Mijatovic, V. ; Moilanen, L. ; Montasser, M.E. ; Morris, A.D. ; Morrison, A.C. ; Mulas, A. ; Nagaraja, R. ; Narisu, N. ; Nikus, K. ; O'Donnell, C.J. ; O'Reilly, P.F. ; Ong, K.K. ; Paccaud, F. ; Palmer, C.D. ; Parsa, A. ; Pedersen, N.L. ; Penninx, B.W. ; Perola, M. ; Peters, A. ; Poulter, N. ; Pramstaller, P.P. ; Psaty, B.M. ; Quertermous, T. ; Rao, D.C. ; Rasheed, A. ; Rayner, N.W. ; Renström, F. ; Rettig, R. ; Rice, K.M. ; Roberts, R. ; Rose, L.M. ; Rossouw, J. ; Samani, N.J. ; Sanna, S. ; Saramies, J. ; Schunkert, H. ; Sebert, S. ; Sheu, W.H. ; Shin, Y.A. ; Sim, X. ; Smit, J.H. ; Smith, A.V. ; Sosa, M.X. ; Spector, T.D. ; Stancáková, A. ; Stanton, A.V. ; Stirrups, K.E. ; Stringham, H.M. ; Sundström, J. ; Swift, A.J. ; Syvanen, A.C. ; Tai, E.S. ; Tanaka, T. ; Tarasov, K.V. ; Teumer, A. ; Thorsteinsdottir, U. ; Tobin, M.D. ; Tremoli, E. ; Uitterlinden, A.G. ; Uusitupa, M. ; Vaez, A. ; Vaidya, D. ; van Duijn, C.M. ; van Iperen, E.P. ; Vasan, R.S. ; Verwoert, G.C. ; Virtamo, J. ; Vitart, V. ; Voight, B.F. ; Vollenweider, P. ; Wagner, A. ; Wain, L.V. ; Wareham, N.J. ; Watkins, H. ; Weder, A.B. ; Westra, H.J. ; Wilks, R.J. ; Wilsgaard, T. ; Wilson, J.F. ; Wong, T.Y. ; Yang, T.P. ; Yao, J. ; Yengo, L. ; Zhang, W. ; Zhao, J.H. ; Zhu, X. ; Bovet, P. ; Cooper, R.S. ; Mohlke, K.L. ; Saleheen, D. ; Lee, J.Y. ; Elliott, P. ; Gierman, H.J. ; Willer, C.J. ; Franke, L. ; Hovingh, G.K. ; Taylor, K.D. ; Dedoussis, G. ; Sever, P. ; Wong, A. ; Lind, L. ; Assimes, T.L. ; Njølstad, I. ; Schwarz, P.E.H. ; Langenberg, C. ; Snieder, H. ; Caulfield, M.J. ; Melander, O. ; Laakso, M. ; Saltevo, J. ; Rauramaa, R. ; Tuomilehto, J. ; Ingelsson, E. ; Lehtimäki, T. ; Hveem, K. ; Palmas, W. ; Marz, W. ; Kumari, M. ; Salomaa, V. ; Chen, Y.I. ; Rotter, J.I. ; Froguel, P. ; Jarvelin, M.R. ; Lakatta, E.G. ; Kuulasmaa, K. ; Franks, P.W. ; Hamsten, A. ; CHARGE-EchoGen Consortium (Wichmann, H.-E. ; Meitinger, T.) ; Palmer, C.N. ; Stefansson, K. ; Ridker, P.M. ; Loos, R.J. ; Chakravarti, A. ; Deloukas, P. ; Morris, A.P. ; Newton-Cheh, C. ; Munroe, P.B. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat. Genet. 48, 1171-1184 (2016)

Garcia-Martin, R. ; Alexaki, V.I. ; Qin, N. ; Rubin de Celis, M.F. ; Economopoulou, M. ; Ziogas, A. ; Gercken, B. ; Kotlabova, K. ; Phieler, J. ; Ehrhart-Bornstein, M. ; Bornstein, S.R. ; Eisenhofer, G. ; Breier, G. ; Blueher, M. ; Hampe, J. ; El-Armouche, A. ; Chatzigeorgiou, A. ; Chung, K.-J. ; Chavakis, T. Adipocyte-specific hypoxia-inducible factor 2α deficiency exacerbates obesity-induced brown adipose tissue dysfunction and metabolic dysregulation. Mol. Cell. Biol. 36, 376-393 (2016)

Gruetzmann, R. ; Ludwig, B. ; Weitz, J. ; Ludwig, S. Totale Pankreatektomie und Isletautotransplantation bei einem Kind mit chronisch rezidivierender Pankreatitis. Zentralbl. Chir. 141, 17-20 (2016)

Hanefeld, M. ; Pistrosch, F. ; Bornstein, S.R. ; Birkenfeld, A.L. The metabolic vascular syndrome - guide to an individualized treatment. Rev. Endocr. Metab. Disord. 17, 5-17 (2016)

Heinke, S. ; Ludwig, B. ; Schubert, U. ; Schmid, J. ; Kiss, T. ; Steffen, A. ; Bornstein, S.R. ; Ludwig, S. Diabetes induction by total pancreatectomy in minipigs with simultaneous splenectomy: A feasible approach for advanced diabetes research. Xenotransplantation 23, 405-413 (2016)

Klose, C. ; Coskun, Ü. Shotgun Lipidomics in der biomedizinischen und klinischen Forschung: Hochdurchsatzscreening. BIOspektrum 22, 617-619 (2016)

Kourtzelis, I. ; Kotlabova, K. ; Lim, J.H. ; Mitroulis, I. ; Ferreira, A. ; Chen, L. ; Gercken, B. ; Steffen, A. ; Kemter, E. ; Klotzsche-von Ameln, A. ; Waskow, C. ; Hosur, K. ; Chatzigeorgiou, A. ; Ludwig, B. ; Wolf, E. ; Hajishengallis, G. ; Chavakis, T. Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation. Thromb. Haemost. 115, 781-788 (2016)

Kragl, M. ; Schubert, R. ; Karsjens, H. ; Otter, S. ; Bartosinska, B. ; Jeruschke, K. ; Weiss, J. ; Chen, C. ; Alsteens, D. ; Kuss, O. ; Speier, S. ; Eberhard, D. ; Müller, D.J. ; Lammert, E. The biomechanical properties of an epithelial tissue determine the location of its vasculature. Nat. Commun. 7:13560 (2016)

Liikanen, I. ; Tahtinen, S. ; Guse, K. ; Gutmann, T. ; Savola, P. ; Oksanen, M. ; Kanerva, A. ; Hemminki, A. Oncolytic adenovirus expressing monoclonal antibody trastuzumab for treatment of HER2-positive cancer. Mol. Cancer Ther. 15, 2259-2269 (2016)

Markmann, J.F. ; Bartlett, S.T. ; Johnson, P. ; Korsgren, O. ; Hering, B.J. ; Scharp, D. ; Kay, T.W. ; Bromberg, J. ; Odorico, J.S. ; Weir, G.C. ; Bridges, N.D. ; Kandaswamy, R. ; Stock, P. ; Friend, P. ; Gotoh, M. ; Cooper, D.K. ; Park, C.G. ; OʼConnell, P.J. ; Stäbler, C. ; Matsumoto, S. ; Ludwig, B. ; Choudhary, P. ; Khovatchev, B. ; Rickels, M.R. ; Sykes, M. ; Wood, K. ; Kraemer, K. ; Hwa, A. ; Stanley, E. ; Ricordi, C. ; Zimmerman, M. ; Greenstein, J. ; Montanya, E. ; Otonkoski, T. Executive summary of IPITA-TTS opinion leaders report on the future of β-cell replacement. Transplantation 100, E25-E31 (2016)

Morozov, V.A. ; Ludwig, S. ; Ludwig, B. ; Rotem, A. ; Barkai, U. ; Bornstein, S.R. ; Denner, J. Islet cell transplantation from Gottingen minipigs to cynomolgus monkeys: Analysis of virus safety. Xenotransplantation 23, 320-327 (2016)

Mziaut, H. ; Mulligan, B. ; Hoboth, P. ; Otto, O. ; Ivanova, A. ; Herbig, M. ; Schumann, D. ; Hildebrandt, T.B. ; Dehghany, J. ; Sönmez, A. ; Münster, C. ; Meyer-Hermann, M. ; Guck, J. ; Kalaidzidis, Y. ; Solimena, M. The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512. Mol. Metab. 5, 656-68 (2016)

Nati, M. ; Haddad, D. ; Birkenfeld, A.L. ; Koch, C.A. ; Chavakis, T. ; Chatzigeorgiou, A. The role of immune cells in metabolism-related liver inflammation and development of Non-Alcoholic Steatohepatitis (NASH). Rev. Endocr. Metab. Disord. 17, 29-39 (2016)

Raab, J. ; Haupt, F. ; Scholz, M. ; Matzke, C. ; Warncke, K. ; Lange, K. ; Assfalg, R. ; Weininger, K. ; Wittich, S. ; Löbner, S. ; Beyerlein, A. ; Nennstiel-Ratzel, U. ; Lang, M. ; Laub, O. ; Dunstheimer, D. ; Bonifacio, E. ; Achenbach, P. ; Winkler, C. ; Ziegler, A.-G. Capillary blood islet autoantibody screening for identifying pre-type 1 diabetes in the general population: Design and initial results of the Fr1da study. BMJ Open 6:e011144 (2016)

Richter, K. ; Barthel, A. ; Bornstein, S.R. ; El-Armouche, A. ; Wagner, M. PCSK9-Inhibitoren – Durchbruch bei der LDL-Cholesterin-Senkung? Dtsch. Med. Wochenschr. 141, 863-869 (2016)

Simons, K. ; Coskun, Ü. Membrane lipid galore. J. Mol. Biol. 428, 4737-4738 (2016)

Sosa, L. ; Torkko, J.M. ; Primo, M.E. ; Llovera, R.E. ; Toledo, P.L. ; Rios, A.S. ; Gonzalez Flecha, F.L. ; Trabucchi, A. ; Valdez, S.N. ; Poskus, E. ; Solimena, M. ; Ermácora, M.R. Biochemical, biophysical, and functional properties of ICA512/IA-2 RESP18 homology domain. Biochim. Biophys. Acta-Proteins Proteom. 1864, 511-522 (2016)

Struecker, B. ; Ludwig, S. ; Schmelzle, M. ; Ludwig, B. Cell transplantation for regeneration and function recovery before and after oncological resections. Onkologe 22, 478-487 (2016)

Ullrich, M. ; Bergmann, R. ; Peitzsch, M. ; Zenker, E.F. ; Cartellieri, M. ; Bachmann, M. ; Ehrhart-Bornstein, M. ; Block, N.L. ; Schally, A.V. ; Eisenhofer, G. ; Bornstein, S.R. ; Pietzsch, J. ; Ziegler, C.G. Multimodal somatostatin receptor theranostics using [64Cu]Cu-/[177Lu]Lu-DOTA-(Tyr3)octreotate and AN-238 in a mouse pheochromocytoma model. Theranostics 6, 650-665 (2016)

Ziegler, A.-G. ; Haupt, F. ; Scholz, M. ; Weininger, K. ; Wittich, S. ; Löbner, S. ; Matzke, C. ; Gezginci, C. ; Riethausen, S. ; Beyerlein, A. ; Zillmer, S. ; Amoroso, M. ; Coles, R. ; Powell, M. ; Furmaniak, J. ; Rees Smith, B. ; Winkler, C. ; Bonifacio, E. ; Achenbach, P. 3 screen ELISA for high-throughput detection of beta cell autoantibodies in capillary blood. Diabetes Technol. Ther. 18, 687-693 (2016)

2015

Balyura, M. ; Gelfgat, E. ; Ehrhart-Bornstein, M. ; Ludwig, B. ; Gendler, Z. ; Barkai, U. ; Zimerman, B. ; Rotem, A. ; Block, N.L. ; Schally, A.V. ; Bornstein, S.R. Transplantation of bovine adrenocortical cells encapsulated in alginate. Proc. Natl. Acad. Sci. U.S.A. 112, 2527-2532 (2015)

Benazra, M. ; Lecomte, M.J. ; Colace, C. ; Müller, A. ; Machado, C. ; Pechberty, S. ; Bricout-Neveu, E. ; Grenier-Godard, M. ; Solimena, M. ; Scharfmann, R. ; Czernichow, P. ; Ravassard, P. A human beta cell line with drug inducible excision of immortalizing transgenes. Mol. Metab. 4, 916-925 (2015)

Bergmann, A. ; Schwarz, P.E. Dem Diabetes davonlaufen, den Diabetes wegessen. Diabetes akt. 13, 3 (2015)

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Beutel, O. ; Roder, F. ; Birkholz, O. ; Rickert, C. ; Steinhoff, H. ; Grzybek, M. ; Coskun, Ü. ; Piehler, J. Two-dimensional trap for ultrasensitive quantification of transient protein interactions. ACS Nano 9, 9783-9791 (2015)

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Xie, T.Y. ; Ngo, S.T. ; Veldhuis, J.D. ; Jeffery, P.L. ; Chopin, L.K. ; Tschöp, M. ; Waters, M.J. ; Tolle, V. ; Epelbaum, J. ; Chen, C.C. ; Steyn, F.J. Effect of deletion of ghrelin-o-acyltransferase on the pulsatile release of growth hormone in mice. J. Neuroendocrinol. 27, 872-886 (2015)

Yang, C. ; Rahbari, N.N. ; Mees, S.T. ; Schaab, F. ; Koch, M. ; Weitz, J. ; Reissfelder, C. Staged resection of bilobar colorectal liver metastases: Surgical strategies. Langenbecks Arch. Surg. 400, 633-640 (2015)

Zhao, M. ; Choudhary, P. ; Srinivasan, P. ; Tang, H. ; Heaton, N. ; Fung, M. ; Barthel, A. ; Bornstein, S.R. ; Amiel, S.A. ; Huang, G.C. Modification of human islet preparation: An effective approach to improve graft outcome after islet transplantation? Horm. Metab. Res. 47, 72-77 (2015)

2014

Abe, T. ; Shin, J.T. ; Hosur, K. ; Udey, M.C. ; Chavakis, T. ; Hajishengallis, G. Regulation of osteoclast homeostasis and inflammatory bone loss by MFG-E8. J. Immunol. 193, 1383-1391 (2014)

Ansurudeen, I. ; Kopf, P.G. ; Gauthier, K.M. ; Bornstein, S.R. ; Cowley, A.W. ; Campbell, W.B. Aldosterone secretagogues increase adrenal blood flow in male rats. Endocrinology 155, 127-132 (2014)

Baessler, A. ; Lamounier-Zepter, V. ; Fenk, S. ; Strack, C. ; Lahmann, C. ; Loew, T. ; Schmitz, G. ; Blüher, M. ; Bornstein, S.R. ; Fischer, M. Adipocyte fatty acid-binding protein levels are associated with left ventricular diastolic dysfunction in morbidly obese subjects. Nutr. Diabetes 4:e106 (2014)

Ban, R.H. ; Kamvissi, V. ; Schulte, K.M. ; Bornstein, S.R. ; Rubino, F. ; Graessler, J. Lipidomic profiling at the interface of metabolic surgery and cardiovascular disease. Curr. Atheroscler. Rep. 16:455 (2014)

Bellemann, N. ; Sommer, C.M. ; Mokry, T. ; Kortes, N. ; Gnutzmann, D. ; Gockner, T. ; Schmitz, A. ; Weitz, J. ; Kauczor, H.U. ; Radeleff, B. ; Stampfl, U. Hepatic artery stent-grafts for the emergency treatment of acute bleeding. Eur. J. Radiol. 83, 1799-1803 (2014)

Beyerlein, A. ; Chmiel, R. ; Hummel, S. ; Winkler, C. ; Bonifacio, E. ; Ziegler, A.-G. Timing of gluten introduction and islet autoimmunity in young children: Updated results from the BABYDIET study. Diabetes Care 37, e194-e195 (2014)

Birkenfeld, A.L. ; Shulman, G.I. Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology 59, 713-723 (2014)

Bogusławska, D.M. ; Machnicka, B. ; Hryniewicz-Jankowska, A. ; Czogalla, A. Spectrin and phospholipids - the current picture of their fascinating interplay. Cell. Mol. Biol. Lett. 19, 158-179 (2014)

Bonifacio, E. ; Krumsiek, J. ; Winkler, C. ; Theis, F.J. ; Ziegler, A.-G. A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion. Acta Diabetol. 51, 403-411 (2014)

Borg, D.J. ; Weigelt, M. ; Wilhelm, C. ; Gerlach, M. ; Bickle, M. ; Speier, S. ; Bonifacio, E. ; Hommel, A. Mesenchymal stromal cells improve transplanted islet survival and islet function in a syngeneic mouse model. Diabetologia 57, 522-531 (2014)

Bork, U. ; Grützmann, R. ; Rahbari, N.N. ; Schölch, S. ; Distler, M. ; Reissfelder, C. ; Koch, M. ; Weitz, J. Prognostic relevance of minimal residual disease in colorectal cancer. World J. Gastroenterol. 20, 10296-10304 (2014)

Bornstein, S.R. ; Amiel, S.A. ; Rubino, F. ; Mingrone, G. ; Kamvissi, V. ; Solimena, M. ; Bonifacio, E. ; Jones, P. ; Schwarz, P. ; Birkenfeld, A.L. ; Behrens, A. ; Barthel, A. ; Lechler, R. ; Peakman, M. Creating a "Transcampus" in diabetes research between King's College London and the Technische Universität Dresden: Update on islet biology and transplantation. Horm. Metab. Res. 47, DOI: 10.1055/s-0034-1396842 (2014)

Chatzigeorgiou, A. ; Chung, K.-J. ; Garcia-Martin, R. ; Alexaki, V.I. ; Klotzsche-von Ameln, A. ; Phieler, J. ; Sprott, D. ; Kanczkowski, W. ; Tzanavari, T. ; Bdeir, M. ; Bergmann, S. ; Cartellieri, M. ; Bachmann, M. ; Nikolakopoulou, P. ; Androutsellis-Theotokis, A. ; Siegert, G. ; Bornstein, S.R. ; Muders, M.H. ; Boon, L. ; Karalis, K.P. ; Lutgens, E. ; Chavakis, T. Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation. Hepatology 60, 1196-1210 (2014)

Chatzigeorgiou, A. ; Seijkens, T. ; Zarzycka, B. ; Engel, D. ; Poggi, M. ; van den Berg, S. ; Soehnlein, O. ; Winkels, H. ; Beckers, L. ; Lievens, D. ; Driessen, A. ; Kusters, P. ; Biessen, E. ; Garcia-Martin, R. ; Klotzsche-von Ameln, A. ; Gijbels, M.J. ; Noelle, R. ; Boon, L. ; Hackeng, T.M. ; Schulte, K.M. ; Schulte, K. ; Xu, A. ; Vriend, G. ; Nabuurs, S.B. ; Chung, K.-J. ; Willems van Dijk, K. ; Rensen, P.C. ; Gerdes, N. ; de Winther, M.P. ; Block, N.L. ; Schally, A.V. ; Weber, C. ; Bornstein, S.R. ; Nicolaes, G.A.F. ; Chavakis, T. ; Lutgens, E. Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc. Natl. Acad. Sci. U.S.A. 111, 2686-2691 (2014)

Choi, T.Y. ; Ninov, N. ; Stainier, D.Y. ; Shin, D. Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish. Gastroenterology 146, 776-788 (2014)

Chung, K.-J. ; Mitroulis, I. ; Wiessner, J.R. ; Zheng, Y.Y. ; Siegert, G. ; Sperandio, M. ; Chavakis, T. A novel pathway of rapid TLR-triggered activation of integrin-dependent leukocyte adhesion that requires Rap1 GTPase. Mol. Biol. Cell 25, 2948-2955 (2014)

Czogalla, A. ; Grzybek, M. ; Jones, W. ; Coskun, Ü. Validity and applicability of membrane model systems for studying interactions of peripheral membrane proteins with lipids. Biochim. Biophys. Acta-Mol. Cell Biol. Lipids 1841, 1049-1059 (2014)

Därr, R. ; Pamporaki, C. ; Peitzsch, M. ; Miehle, K. ; Prejbisz, A. ; Peczkowska, M. ; Weismann, D. ; Beuschlein, F. ; Sinnott, R. ; Bornstein, S.R. ; Neumann, H.P. ; Januszewicz, A. ; Lenders, J.W. ; Eisenhofer, G. Biochemical diagnosis of phaeochromocytoma using plasma-free normetanephrine, metanephrine and methoxytyramine: Importance of supine sampling under fasting conditions. Clin. Endocrinol. 80, 478-486 (2014)

Distler, M. ; Kersting, S. ; Rückert, F. ; Kross, P. ; Saeger, H.-D. ; Weitz, J. ; Grützmann, R. Chronic pancreatitis of the pancreatic remnant is an independent risk factor for pancreatic fistula after distal pancreatectomy. BMC Surg. 14:54 (2014)

Distler, M. ; Aust, D. ; Weitz, J. ; Pilarsky, C. ; Grützmann, R. Precursor lesions for sporadic pancreatic cancer: PanIN, IPMN, and MCN. Biomed Res. Int. 2014:474905 (2014)

Economopoulou, M. ; Masjkur, J. ; Raiskup, F. ; Ebermann, D. ; Saha, S. ; Karl, M.O. ; Funk, R. ; Jaszai, J. ; Chavakis, T. ; Ehrhart-Bornstein, M. ; Pillunat, L.E. ; Kunz-Schughart, L.A. ; Kurth, I. ; Dubrovska, A. ; Androutsellis-Theotokis, A. Expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium. Int. J. Radiat. Biol. 90, 700-709 (2014)

Elding Larsson, H. ; Vehik, K. ; Gesualdo, P. ; Akolkar, B. ; Hagopian, W. ; Krischer, J.P. ; Lernmark, A. ; Rewers, M. ; Simell, O. ; She, J.-X. ; Ziegler, A.-G. ; Haller, M.J. ; TEDDY Study Group (Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Hummel, S. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Roth, R. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.) Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease. Pediatr. Diabetes 15, 118-126 (2014)

Endesfelder, D. ; zu Castell, W. ; Ardissone, A. ; Davis-Richardson, A.G. ; Achenbach, P. ; Hagen, M. ; Pflueger, M. ; Gano, K.A. ; Fagen, J.R. ; Drew, J.C. ; Brown, C.T. ; Kolaczkowski, B. ; Atkinson, M.J. ; Schatz, D. ; Bonifacio, E. ; Triplett, E.W. ; Ziegler, A.-G. Compromised gut microbiota networks in children with anti-islet cell autoimmunity. Diabetes 63, 2006-2014 (2014)

Ferreira, R.C. ; Guo, H. ; Coulson, R.M. ; Smyth, D.J. ; Pekalski, M.L. ; Burren, O.S. ; Cutler, A.J. ; Doecke, J.D. ; Flint, S. ; McKinney, E.F. ; Lyons, P.A. ; Smith, K.G. ; Achenbach, P. ; Beyerlein, A. ; Dunger, D.B. ; Wicker, L.S. ; Todd, J.A. ; Bonifacio, E. ; Wallace, C. ; Ziegler, A.-G. A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk of type 1 diabetes. Diabetes 63, 2538-2550 (2014)

Folprecht, G. ; Gruenberger, T. ; Bechstein, W. ; Raab, H.R. ; Weitz, J. ; Lordick, F. ; Hartmann, J.T. ; Stoehlmacher-Williams, J. ; Lang, H. ; Trarbach, T. ; Liersch, T. ; Ockert, D. ; Jaeger, D. ; Steger, U. ; Suedhoff, T. ; Rentsch, A. ; Köhne, C.H. Survival of patients with initially unresectable colorectal liver metastases treated with FOLFOX/cetuximab or FOLFIRI/cetuximab in a multidisciplinary concept (CELIM study). Ann. Oncol. 25, 1018-1025 (2014)

Folprecht, G. ; Weitz, J. ; Hoffmann, R.T. CT-morphologische Evaluation neoadjuvanter Chemotherapie. Chirurg 85, 31-36 (2014)

Franquelim, H.G. ; Linko, V. ; Czogalla, A. ; Dietz, H. ; Schwille, P. Synthetic membrane curvature-inducing DNA origami scaffolds. Biophys. J. 106:617a (2014)

Fuchs, Y.F. ; Adler, K. ; Lindner, A. ; Karasinsky, A. ; Wilhelm, C. ; Weigelt, M. ; Balke, H. ; Förtsch, K. ; Mortler-Hildebrandt, L.F. ; Harlan, D.M. ; Pechhold, K. ; Ziegler, A.-G. ; Bonifacio, E. Igrp and insulin vaccination induce CD8+ T cell mediated autoimmune diabetes in the RIP-CD80GP mouse. Clin. Exp. Immunol. 176, 199-206 (2014)

Gattu, A.K. ; Birkenfeld, A.L. ; Iwakiri, Y. ; Jay, S. ; Saltzman, M. ; Doll, J. ; Protiva, P. ; Samuel, V.T. ; Crawford, S.E. ; Chung, C. Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. Endocrinology 155, 1373-1385 (2014)

Gerl, M.J. ; Sachsenheimer, T. ; Grzybek, M. ; Coskun, Ü. ; Wieland, F.T. ; Brügger, B. Analysis of transmembrane domains and lipid modified peptides with matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. Anal. Chem. 86, 3722-3726 (2014)

Graessler, J. ; Bornstein, T.D. ; Goel, D. ; Bhalla, V.P. ; Lohmann, T. ; Wolf, T. ; Koch, M. ; Qin, Y. ; Licinio, J. ; Wong, M.L. ; Chavakis, T. ; Xu, A. ; Shevchenko, A. ; Schuhmann, K. ; Schwarz, P.E. ; Schulte, K.M. ; Patel, A. ; Bornstein, S.R. Lipidomic profiling before and after Roux-en-Y gastric bypass in obese patients with diabetes. Pharmacogenomics J. 14, 201-207 (2014)

Grützmann, R. ; Kersting, S. ; Distler, M. ; Weitz, J. Arterielle Rekonstruktion beim duktalen Pankreaskarzinom – Darstellung chirurgischer Techniken. Zentralbl. Chir. 139, 261-264 (2014)

Hackert, T. ; Weitz, J. ; Büchler, M.W. Splenic artery use for arterial reconstruction in pancreatic surgery. Langenbecks Arch. Surg. 399, 667-671 (2014)

Hajishengallis, G. ; Chavakis, T. ; Hajishengallis, E. ; Lambris, J.D. Neutrophil homeostasis and inflammation: Novel paradigms from studying periodontitis. J. Leukoc. Biol., DOI: 10.1189/jlb.3VMR1014-468R (2014)

Hanefeld, M. ; Bornstein, S.R. ; Barthel, A. Moderne medikamentöse Therapie des Typ-2-Diabetes. Dtsch. Med. Wochenschr. 139, 2494-2497 (2014)

Hummel, S. ; Vehik, K. ; Uusitalo, U. ; McLeod, W. ; Aronsson, C.A. ; Frank, N. ; Gesualdo, P. ; Yang, J. ; Norris, J.M. ; Virtanen, S.M. ; TEDDY Study Group (Ziegler, A.-G. ; Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Roth, R. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.) Infant feeding patterns in families with a diabetes history - observations from The Environmental Determinants of Diabetes in the Young (TEDDY) birth cohort study. Public Health Nutr. 17, 2853-2862 (2014)

Kahlert, C. ; Fiala, M. ; Musso, G. ; Halama, N. ; Keim, S. ; Mazzone, M. ; Lasitschka, F. ; Pecqueux, M. ; Klupp, F. ; Schmidt, T. ; Rahbari, N.N. ; Schölch, S. ; Pilarsky, C. ; Ulrich, A. ; Schneider, M. ; Weitz, J. ; Koch, M. Prognostic impact of a compartment-specific angiogenic marker profile in patients with pancreatic cancer. Oncotarget 5, 12978-12989 (2014)

Kahlert, C. ; Melo, S.A. ; Protopopov, A. ; Tang, J. ; Seth, S. ; Koch, M. ; Zhang, J. ; Weitz, J. ; Chin, L. ; Futreal, A. ; Kalluri, R. Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer. J. Biol. Chem. 289, 3869-3875 (2014)

Kibbey, R.G. ; Choi, C.S. ; Lee, H.Y. ; Cabrera, O. ; Pongratz, R.L. ; Zhao, X. ; Birkenfeld, A.L. ; Li, C. ; Berggren, P.O. ; Stanley, C. ; Shulman, G.I. Mitochondrial GTP insensitivity contributes to hypoglycemia in hyperinsulinemia hyperammonemia by inhibiting glucagon release. Diabetes 63, 4218-4229 (2014)

Kirchberg, J. ; Weitz, J. Minimalinvasive Chirurgie primärer und sekundärer Lebertumoren. Chirurg 85, 689-695 (2014)

Knoch, K.P. ; Nath-Sain, S. ; Petzold, A. ; Schneider, H. ; Beck, M. ; Wegbrod, C. ; Sönmez, A. ; Münster, C. ; Friedrich, A. ; Roivainen, M. ; Solimena, M. PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells. Mol. Metab. 3, 518-530 (2014)

Krause, S. ; Landherr, U. ; Agardh, C.-D. ; Hausmann, S. ; Link, K. ; Hansen, J.M. ; Lynch, K.F. ; Powell, M. ; Furmaniak, J. ; Rees-Smith, B. ; Bonifacio, E. ; Ziegler, A.-G. ; Lernmark, A. ; Achenbach, P. GAD autoantibody affinity in adult patients with latent autoimmune diabetes, the study participants of a GAD65 vaccination trial. Diabetes Care 37, 1675-1680 (2014)

Krause, S. ; Beyerlein, A. ; Winkler, C. ; Gavrisan, A. ; Kayser, C. ; Puff, R. ; Bonifacio, E. ; Ziegler, A.-G. ; Achenbach, P. Soluble interleukin-2 receptor alpha in preclinical type 1 diabetes. Acta Diabetol. 51, 517-518 (2014)

Krautz, C. ; Kuithan, F. ; Dobroschke, J. ; Nagel, I. ; Hartmann, S. ; Aust, D.E. ; Baretton, G. ; Weitz, J. ; Reissfelder, C. Peritoneal dissemination of a gastric API2-MALT1-positive MALT lymphoma. J. Clin. Pathol. 67, 746-748 (2014)

Lee, H.S. ; Burkhardt, B.R. ; McLeod, W. ; Smith, S. ; Eberhard, C. ; Lynch, K. ; Hadley, D. ; Rewers, M. ; Simell, O. ; She, J.X. ; Hagopian, B. ; Lernmark, A. ; Akolkar, B. ; Ziegler, A.-G. ; Krischer, J.P. ; TEDDY Study Group (Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Hummel, S. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Roth, R. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.) Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Diabetes Metab. Res. Rev. 30, 424-434 (2014)

Lee, H.Y. ; Gattu, A.K. ; Camporez, J.P. ; Kanda, S. ; Guigni, B. ; Kahn, M. ; Zhang, D. ; Galbo, T. ; Birkenfeld, A.L. ; Jornayvaz, F.R. ; Jurczak, M.J. ; Choi, C.S. ; Yan, Z. ; Williams, R.S. ; Shulman, G.I. ; Samuel, V.T. Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice. Diabetologia 57, 1232-1241 (2014)

Liang, Q. ; Zhong, L. ; Zhang, J. ; Wang, Y. ; Bornstein, S.R. ; Triggle, C.R. ; Ding, H. ; Lam, K.S. ; Xu, A. FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting. Diabetes 63, 4064-4075 (2014)

Liu, E. ; Lee, H.S. ; Aronsson, C.A. ; Hagopian, W.A. ; Koletzko, S. ; Rewers, M.J. ; Eisenbarth, G.S. ; Bingley, P.J. ; Bonifacio, E. ; Simell, V. ; Agardh, D. ; TEDDY Study Group (Ziegler, A.-G. ; Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Hummel, S. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Roth, R. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.) Risk of pediatric celiac disease according to HLA haplotype and country. N. Engl. J. Med. 371, 42-49 (2014)

Ludwig, B. ; Barthel, A. ; Reichel, A. ; Block, N.L. ; Ludwig, S. ; Schally, A.V. ; Bornstein, S.R. Modulation of the pancreatic islet-stress axis as a novel potential therapeutic target in diabetes mellitus. Vitam. Horm. 95, 195-222 (2014)

Machnicka, B. ; Czogalla, A. ; Hryniewicz-Jankowska, A. ; Bogusławska, D.M. ; Grochowalska, R. ; Heger, E. ; Sikorski, A.F. Spectrins: A structural platform for stabilization and activation of membrane channels, receptors and transporters. Biochim. Biophys. Acta-Biomembr. 1838, 620-634 (2014)

Masjkur, J. ; Arps-Forker, C. ; Poser, S.W. ; Nikolakopoulou, P. ; Toutouna, L. ; Chenna, R. ; Chavakis, T. ; Chatzigeorgiou, A. ; Chen, L.S. ; Dubrovska, A. ; Choudhary, P. ; Uphues, I. ; Mark, M. ; Bornstein, S.R. ; Androutsellis-Theotokis, A. Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release. J. Biol. Chem. 289, 35503-35516 (2014)

Masjkur, J. ; Levenfus, I. ; Lange, S. ; Arps-Forker, C. ; Poser, S.W. ; Qin, N. ; Vukicevic, V. ; Chavakis, T. ; Eisenhofer, G. ; Bornstein, S.R. ; Ehrhart-Bornstein, M. ; Androutsellis-Theotokis, A. A defined, controlled culture system for primary bovine chromaffin progenitors reveals novel biomarkers and modulators. Stem Cells Trans. Med. 3, 801-808 (2014)

Mayer, C.T. ; Lahl, K. ; Milanez-Almeida, P. ; Watts, D. ; Dittmer, U. ; Fyhrquist, N. ; Huehn, J. ; Kopf, M. ; Kretschmer, K. ; Rouse, B. ; Sparwasser, T. Advantages of Foxp3+ regulatory T cell depletion using DEREG mice. Immun. Inflamm. Dis. 2, 162-165 (2014)

Mitroulis, I. ; Kang, Y.Y. ; Gahmberg, C.G. ; Siegert, G. ; Hajishengallis, G. ; Chavakis, T. ; Choi, E.Y. Developmental endothelial locus-1 attenuates complement-dependent phagocytosis through inhibition of Mac-1-integrin. Thromb. Haemost. 111, 1004-1006 (2014)

Moutsopoulos, N.M. ; Konkel, J. ; Sarmadi, M. ; Eskan, M.A. ; Wild, T. ; Dutzan, N. ; Abusleme, L. ; Zenobia, C. ; Hosur, K.B. ; Abe, T. ; Uzel, G. ; Chen, W. ; Chavakis, T. ; Holland, S.M. ; Hajishengallis, G. Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss. Sci. Transl. Med. 6:229ra40 (2014)

Neuschäfer-Rube, F. ; Lieske, S. ; Kuna, M. ; Henkel, J. ; Perry, R.J. ; Erion, D.M. ; Pesta, D. ; Willmes, D.M. ; Brachs, S. ; von Loeffelholz, C. ; Tolkachov, A. ; Schupp, M. ; Pathe-Neuschäfer-Rube, A. ; Pfeiffer, A.F. ; Shulman, G.I. ; Püschel, G.P. ; Birkenfeld, A.L. The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes. Diabetes 63, 1048-1057 (2014)

Niebling, J. ; Rünker, A. ; Schallenberg, S. ; Kretschmer, K. ; Kempermann, G. Myelin-specific T helper 17 cells promote adult hippocampal neurogenesis through indirect mechanisms. F1000Res. 3:169 (2014)

Pamporaki, C. ; Bursztyn, M. ; Reimann, M. ; Ziemssen, T. ; Bornstein, S.R. ; Sweep, F.C. ; Timmers, H. ; Lenders, J.W. ; Eisenhofer, G. Seasonal variation in plasma free normetanephrine concentrations: Implications for biochemical diagnosis of pheochromocytoma. Eur. J. Endocrinol. 170, 349-357 (2014)

Parfentyeva, E. ; Saha, S. ; Hjellset, V.T. ; Kopprasch, S. ; Schwarz, P.E. Assessment of small C-fiber status for screening of oxidative stress in patients at risk of diabetes. Horm. Metab. Res. 46, 360-364 (2014)

Petrov, E.P. ; Czogalla, A. ; Kauert, D.J. ; Seidel, R. ; Schwille, P. Diffusion and freezing transition of rod-like DNA origami on freestanding lipid membranes. Biophys. J. 106:701a (2014)

Petzold, C. ; Steinbronn, N. ; Gereke, M. ; Strasser, R.H. ; Sparwasser, T. ; Bruder, D. ; Geffers, R. ; Schallenberg, S. ; Kretschmer, K. Fluorochrome-based definition of naturally occurring Foxp3+ regulatory T cells of intra- and extrathymic origin. Eur. J. Immunol. 44, 3632-3645 (2014)

Qin, N. ; de Cubas, A.A. ; Garcia-Martin, R. ; Richter, S. ; Peitzsch, M. ; Menschikowski, M. ; Lenders, J.W. ; Timmers, H.J. ; Mannelli, M. ; Opocher, G. ; Economopoulou, M. ; Siegert, G. ; Chavakis, T. ; Pacak, K. ; Robledo, M. ; Eisenhofer, G. Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X. Int. J. Cancer 135, 2054-2064 (2014)

Rahbari, N.N. ; Reissfelder, C. ; Schulze-Bergkamen, H. ; Jäger, D. ; Büchler, M.W. ; Weitz, J. ; Koch, M. Adjuvant therapy after resection of colorectal liver metastases: the predictive value of the MSKCC clinical risk score in the era of modern chemotherapy. BMC Cancer 14:174 (2014)

Rahbari, N.N. ; Elbers, H. ; Koch, M. ; Vogler, P. ; Striebel, F. ; Bruckner, T. ; Mehrabi, A. ; Schemmer, P. ; Büchler, M.W. ; Weitz, J. Randomized clinical trial of stapler versus clamp-crushing transection in elective liver resection. Br. J. Surg. 101, 200-207 (2014)

Reissfelder, C. ; Brand, K. ; Sobiegalla, J. ; Rahbari, N.N. ; Bork, U. ; Schirmacher, P. ; Büchler, M.W. ; Weitz, J. ; Koch, M. Chemotherapy-associated liver injury and its influence on outcome after resection of colorectal liver metastases. Surgery 155, 245-254 (2014)

Reißfelder, C. ; Kirchberg, J. ; Weitz, J. Nervenschonende offene tiefe anteriore Rektumresektion beim Rektumkarzinom. Zentralbl. Chir. 139, 381-383 (2014)

Roth, R. ; Lynch, K. ; Lernmark, B. ; Baxter, J. ; Simell, T. ; Smith, L. ; Swartling, U. ; Ziegler, A.-G. ; Johnson, S.B. ; TEDDY Study Group (Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Hummel, S. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.) Maternal anxiety about a child's diabetes risk in the TEDDY study: The potential role of life stress, postpartum depression, and risk perception. Pediatr. Diabetes 16, 287-298 (2014)

Schlottmann, I. ; Ehrhart-Bornstein, M. ; Wabitsch, M. ; Bornstein, S.R. ; Lamounier-Zepter, V. Calcium-dependent release of adipocyte fatty acid binding protein from human adipocytes. Int. J. Obes. 38, 1221-1227 (2014)

Schlueter, N. ; de Sterke, A. ; Willmes, D.M. ; Spranger, J. ; Jordan, J. ; Birkenfeld, A.L. Metabolic actions of natriuretic peptides and therapeutic potential in the metabolic syndrome. Pharmacol. Ther. 144, 12-27 (2014)

Schulte, K.M. ; Talat, N. ; Galata, G. ; Aylwin, S. ; Izatt, L. ; Eisenhofer, G. ; Barthel, A. ; Bornstein, S.R. Genetics and the clinical approach to paragangliomas. Horm. Metab. Res. 46, 964-973 (2014)

Schulte, K.M. ; Talat, N. ; Galata, G. ; Gilbert, J. ; Miell, J. ; Hofbauer, L.C. ; Barthel, A. ; Diaz-Cano, S. ; Bornstein, S.R. Oncologic resection achieving r0 margins improves disease-free survival in parathyroid cancer. Ann. Surg. Oncol. 21, 1891-1897 (2014)

Seijkens, T. ; Kusters, P. ; Chatzigeorgiou, A. ; Chavakis, T. ; Lutgens, E. Immune cell crosstalk in obesity: A key role for costimulation? Diabetes 63, 3982-3991 (2014)

Steinert, G. ; Schölch, S. ; Niemietz, T. ; Iwata, N. ; García, S.A. ; Behrens, B. ; Voigt, A. ; Kloor, M. ; Benner, A. ; Bork, U. ; Rahbari, N.N. ; Büchler, M.W. ; Stoecklein, N.H. ; Weitz, J. ; Koch, M. Immune escape and survival mechanisms in circulating tumor cells of colorectal cancer. Cancer Res. 74, 1694-1704 (2014)

Stumpp, C. ; Beyerlein, A. ; Ziegler, A.-G. ; Bonifacio, E. Neonatal and infant beta cell hormone concentrations in relation to type 1 diabetes risk. Pediatr. Diabetes 15, 528-533 (2014)

Tsourdi, E. ; Heidrich, F.M. ; Winzer, M. ; Röllig, C. ; Kirsch, C.M. ; Meinel, J. ; Baretton, G.B. ; Bornstein, S.R. ; Hofbauer, L.C. An exotic cause of exudative enteropathy. Am. J. Case Rep. 15, 226-229 (2014)

Tsuji, N. ; Ninov, N. ; Delawary, M. ; Osman, S. ; Roh, A.S. ; Gut, P. ; Stainier, D.Y. Whole organism high content screening identifies stimulators of pancreatic beta-cell proliferation. PLoS ONE 9:e104112 (2014)

Ullrich, M. ; Bergmann, R. ; Peitzsch, M. ; Cartellieri, M. ; Qin, N. ; Ehrhart-Bornstein, M. ; Block, N.L. ; Schally, A.V. ; Pietzsch, J. ; Eisenhofer, G. ; Bornstein, S.R. ; Ziegler, C.G. In vivo fluorescence imaging and urinary monoamines as surrogate biomarkers of disease progression in a mouse model of pheochromocytoma. Endocrinology 155, 4149-4156 (2014)

Vahl, J.C. ; Drees, C. ; Heger, K. ; Heink, S. ; Fischer, J.C. ; Nedjic, J. ; Ohkura, N. ; Morikawa, H. ; Poeck, H. ; Schallenberg, S. ; Rieß, D. ; Hein, M.Y. ; Buch, T. ; Polic, B. ; Schönle, A. ; Zeiser, R. ; Schmitt-Gräff, A. ; Kretschmer, K. ; Klein, L. ; Korn, T. ; Sakaguchi, S. ; Schmidt-Supprian, M. Continuous T cell receptor signals maintain a functional regulatory T cell pool. Immunity 41, 722-736 (2014)

van Noort, V. ; Schölch, S. ; Iskar, M. ; Zeller, G. ; Ostertag, K. ; Schweitzer, C. ; Werner, K. ; Weitz, J. ; Koch, M. ; Bork, P. Novel drug candidates for the treatment of metastatic colorectal cancer through global inverse gene-expression profiling. Cancer Res. 74, 5690-5699 (2014)

Volk, A. ; Rahbari, N.N. ; Koch, M. ; Weitz, J. Leistenhernienversorgung nach Lichtenstein. Zentralbl. Chir. 139, 581-582 (2014)

Walter, U. ; Kohlert, T. ; Rahbari, N.N. ; Weitz, J. ; Welsch, T. Impact of preoperative diabetes on long-term survival after curative resection of pancreatic adenocarcinoma: A systematic review and meta-analysis. Ann. Surg. Oncol. 21, 1082-1089 (2014)

Wang, Y. ; Xiao, Y. ; Zhong, L. ; Ye, D. ; Zhang, J. ; Tu, Y. ; Bornstein, S.R. ; Zhou, Z. ; Lam, K.S. ; Xu, A. Increased neutrophil elastase and proteinase 3 and augmented NETosis are closely associated with β-cell autoimmunity in patients with type 1 diabetes. Diabetes 63, 4239-4248 (2014)

Wieduwild, R. ; Lin, W. ; Boden, A. ; Kretschmer, K. ; Zhang, Y. A repertoire of peptide tags for controlled drug release from injectable noncovalent hydrogel. Biomacromolecules 15, 2058-2066 (2014)

Winkler, C. ; Krumsiek, J. ; Buettner, F. ; Angermüller, C. ; Giannopoulou, E.Z. ; Theis, F.J. ; Ziegler, A.-G. ; Bonifacio, E. Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes. Diabetologia 57, 2521-2529 (2014)

Xiao, S. ; Yosef, N. ; Yang, J. ; Wang, Y. ; Zhou, L. ; Zhu, C. ; Wu, C. ; Baloglu, E. ; Schmidt, D. ; Ramesh, R. ; Lobera, M. ; Sundrud, M.S. ; Tsai, P.Y. ; Xiang, Z. ; Wang, J. ; Xu, Y. ; Lin, X. ; Kretschmer, K. ; Rahl, P.B. ; Young, R.A. ; Zhong, Z. ; Hafler, D.A. ; Regev, A. ; Ghosh, S. ; Marson, A. ; Kuchroo, V.K. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity 40, 477-489 (2014)

Yang, J. ; Lernmark, A. ; Uusitalo, U.M. ; Lynch, K.F. ; Veijola, R. ; Winkler, C. ; Larsson, H.E. ; Rewers, M. ; She, J.X. ; Ziegler, A.-G. ; Simell, O.G. ; Hagopian, W.A. ; Akolkar, B. ; Krischer, J.P. ; Vehik, K. ; TEDDY Study Group (Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Hummel, S. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Roth, R. ; Stock, J. ; Strauss, E. ; Warncke, K.) Prevalence of obesity was related to HLA-DQ in 2-4 year old children at genetic risk for type 1 diabetes. Int. J. Obes. 38, 1491-1496 (2014)

2013

Barkai, U. ; Weir, G.C. ; Colton, C.K. ; Ludwig, B. ; Bornstein, S.R. ; Brendel, M.D. ; Neufeld, T.P. ; Bremer, C. ; Leon, A. ; Evron, Y. ; Yavriyants, K. ; Azarov, D. ; Zimermann, B. ; Maimon, S. ; Shabtay, N. ; Balyura, M. ; Rozenshtein, T. ; Vardi, P. ; Bloch, K. ; de Vos, P. ; Rotem, A. Enhanced oxygen supply improves islet viability in a new bioartificial pancreas. Cell Transplant. 22, 1463-1476 (2013)

Bauer, K. ; Nelius, N. ; Reuschenbach, M. ; Koch, M. ; Weitz, J. ; Steinert, G. ; Kopitz, J. ; Beckhove, P. ; Tariverdian, M. ; von Knebel Doeberitz, M. ; Kloor, M. T cell responses against microsatellite instability-induced frameshift peptides and influence of regulatory T cells in colorectal cancer. Cancer Immunol. Immunother. 62, 27-37 (2013)

Bonifacio, E. Targeting innate immunity in type 1 diabetes: Strike one. Lancet 381, 1880-1881 (2013)

Calvet, J.H. ; Dupin, J. ; Winiecki, H. ; Schwarz, P.E. Assessment of small fiber neuropathy through a quick, simple and non-invasive method in a German diabetes outpatient clinic. Exp. Clin. Endocrinol. Diabet. 121, 80-83 (2013)

Chatzigeorgiou, A. ; Phieler, J. ; Gebler, J. ; Bornstein, S.R. ; Chavakis, T. CD40L stimulates the crosstalk between adipocytes and inflammatory cells. Horm. Metab. Res. 45, 741-747 (2013)

Chavakis, T. ; Ehrhart-Bornstein, M. The adrenal gland in the center. Horm. Metab. Res. 45, 79-80 (2013)

Chmelar, J. ; Chung, K.-J. ; Chavakis, T. The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance. Thromb. Haemost. 109, 399-406 (2013)

Czogalla, A. ; Petrov, E.P. ; Kauert, D.J. ; Uzunova, V. ; Zhang, Y. ; Seidel, R. ; Schwille, P. Switchable domain partitioning and diffusion of DNA origami rods on membranes. Faraday Discuss. 161, 31-43 (2013)

Dekkers, T. ; Deinum, J. ; Schultzekool, L.J. ; Blondin, D. ; Vonend, O. ; Hermus, A.R. ; Peitzsch, M. ; Rump, L.C. ; Antoch, G. ; Sweep, F.C. ; Bornstein, S.R. ; Lenders, J.W. ; Willenberg, H.S. ; Eisenhofer, G. Plasma metanephrine for assessing the selectivity of adrenal venous sampling. Hypertension 62, 1152-1157 (2013)

Döcke, S. ; Lock, J.F. ; Birkenfeld, A.L. ; Hoppe, S. ; Lieske, S. ; Rieger, A. ; Raschzok, N. ; Sauer, I.M. ; Florian, S. ; Osterhoff, M.A. ; Heller, R. ; Herrmann, K. ; Lindenmüller, S. ; Horn, P. ; Bauer, M. ; Weickert, M.O. ; Neuhaus, P. ; Stockmann, M. ; Möhlig, M. ; Pfeiffer, A.F. ; von Loeffelholz, C. Elevated hepatic chemerin mRNA expression in human non-alcoholic fatty liver disease. Eur. J. Endocrinol. 169, 547-557 (2013)

Eugster, A. ; Lindner, A. ; Heninger, A.K. ; Wilhelm, C. ; Dietz, S. ; Ziegler, A.-G. ; Bonifacio, E. Measuring T cell receptor and T cell gene expression diversity in antigen-responsive human CD4+ T cells. J. Immunol. Methods 400-401, 13-22 (2013)

Ferraz, C. ; Lorenz, S. ; Wojtas, B. ; Bornstein, S.R. ; Paschke, R. ; Eszlinger, M. Inverse correlation of miRNA and cell cycle-associated genes suggests influence of miRNA on benign thyroid nodule tumorigenesis. J. Clin. Endocrinol. Metab. 98, 8-16 (2013)

Franke, K. ; Kalucka, J. ; Mamlouk, S. ; Singh, R.P. ; Muschter, A. ; Weidemann, A. ; Iyengar, V. ; Jahn, S. ; Wieczorek, K. ; Geiger, K. ; Muders, M.H. ; Sykes, A.M. ; Poitz, D.M. ; Ripich, T. ; Otto, T. ; Bergmann, S. ; Breier, G. ; Baretton, G. ; Fong, G.H. ; Greaves, D.R. ; Bornstein, S. ; Chavakis, T. ; Fandrey, J. ; Gassmann, M. ; Wielockx, B. HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis. Blood 121, 1436-1445 (2013)

Gavalas, A. ; Lan, T.H. ; Liu, Q. ; Corrêa, I.R. ; Javitch, J.A. ; Lambert, N.A. Segregation of family A G protein-coupled receptor protomers in the plasma membrane. Mol. Pharmacol. 84, 346-352 (2013)

Graessler, J. ; Qin, Y. ; Zhong, H. ; Zhang, J. ; Licinio, J. ; Wong, M.L. ; Xu, A. ; Chavakis, T. ; Bornstein, A.B. ; Ehrhart-Bornstein, M. ; Lamounier-Zepter, V. ; Lohmann, T. ; Wolf, T. ; Bornstein, S.R. Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: Correlation with inflammatory and metabolic parameters. Pharmacogenomics J. 13, 514-522 (2013)

Gräßler, J. ; Blüher, M. ; Chavakis, T. Adipositas und Inflammation. Dtsch. Med. Wochenschr. 138, 172-175 (2013)

Gräßler, J. ; Kopprasch, S. ; Passauer, J. ; Fischer, S. ; Schuhmann, K. ; Bergmann, S. ; Siegert, G. ; Shevchenko, A. ; Bornstein, S.R. ; Julius, U. Differential effects of lipoprotein apheresis by lipidfiltration or dextran sulfate adsorption on lipidomic profile. Atherosclerosis 14, 151-155 (2013)

Hajishengallis, G. ; Chavakis, T. Endogenous modulators of inflammatory cell recruitment. Trends Immunol. 34, 1-6 (2013)

Haufe, S. ; Haas, V. ; Utz, W. ; Birkenfeld, A.L. ; Jeran, S. ; Böhnke, J. ; Mähler, A. ; Luft, F.C. ; Schulz-Menger, J. ; Boschmann, M. ; Jordan, J. ; Engeli, S. Long-lasting improvements in liver fat and metabolism despite body weight regain after dietary weight loss. Diabetes Care 36, 3786-3792 (2013)

Heninger, A.K. ; Monti, P. ; Wilhelm, C. ; Schwaiger, P. ; Kuehn, D. ; Ziegler, A.-G. ; Bonifacio, E. Activation of islet autoreactive naive T cells in infants is influenced by homeostatic mechanisms and antigen presenting capacity. Diabetes 62, 2059-2066 (2013)

Hohenstein, B. ; Bornstein, S.R. ; Aringer, M. Immunoadsorption for connective tissue disease. Atherosclerosis 14, 185-189 (2013)

Ilegems, E. ; Dicker, A. ; Speier, S. ; Sharma, A. ; Bahow, A. ; Edlund, P.K. ; Leibiger, I.B. ; Berggren, P.O. Reporter islets in the eye reveal the plasticity of the endocrine pancreas. Proc. Natl. Acad. Sci. U.S.A. 110, 20581-20586 (2013)

Ioannou, M. ; Serafimidis, I. ; Arnes, L. ; Sussel, L. ; Singh, S. ; Vasiliou, V. ; Gavalas, A. ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools. Dev. Biol. 374, 153-163 (2013)

Ivanova, A. ; Kalaidzidis, Y. ; Dirkx, R. ; Sarov, M. ; Gerlach, M. ; Schroth-Diez, B. ; Müller, A. ; Liu, Y. ; Andree, C. ; Mulligan, B. ; Münster, C. ; Kurth, T. ; Bickle, M. ; Speier, S. ; Anastassiadis, K. ; Solimena, M. Age-dependent labeling and imaging of insulin secretory granules. Diabetes 62, 3687-3696 (2013)

Julius, U. ; Taseva, K. ; Fischer, S. ; Passauer, J. ; Bornstein, S.R. Current situation of lipoprotein apheresis in Saxony. Atherosclerosis 14, 51-55 (2013)

Kanczkowski, W. ; Alexaki, V.I. ; Tran, N. ; Großklaus, S. ; Zacharowski, K. ; Martinez, A. ; Popovics, P. ; Block, N.L. ; Chavakis, T. ; Schally, A.V. ; Bornstein, S.R. Hypothalamo-pituitary and immune-dependent adrenal regulation during systemic inflammation. Proc. Natl. Acad. Sci. U.S.A. 110, 14801-14806 (2013)

Kanczkowski, W. ; Chatzigeorgiou, A. ; Grossklaus, S. ; Sprott, D. ; Bornstein, S.R. ; Chavakis, T. Role of the endothelial-derived endogenous anti-inflammatory factor Del-1 in inflammation-mediated adrenal gland dysfunction. Endocrinology 154, 1181-1189 (2013)

Kanczkowski, W. ; Chatzigeorgiou, A. ; Samus, M. ; Tran, N. ; Zacharowski, K. ; Chavakis, T. ; Bornstein, S.R. Characterization of the LPS-induced inflammation of the adrenal gland in mice. Mol. Cell. Endocrinol. 371, 228-235 (2013)

Klotzsche-von Ameln, A. ; Prade, I. ; Grosser, M. ; Kettelhake, A. ; Rezaei, M. ; Chavakis, T. ; Flamme, I. ; Wielockx, B. ; Breier, G. PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-α. Mol. Cancer Res. 11, 1337-1348 (2013)

Kopprasch, S. ; Bornstein, S.R. ; Schwarz, P.E. ; Bergmann, S. ; Julius, U. ; Graessler, J. Single whole blood dextran sulfate adsorption favorably affects systemic oxidative balance in lipoprotein apheresis patients. Atherosclerosis 14, 157-160 (2013)

Korten, S. ; Brunssen, C. ; Poitz, D.M. ; Großklaus, S. ; Brux, M. ; Schnittler, H.J. ; Strasser, R.H. ; Bornstein, S.R. ; Morawietz, H. ; Goettsch, W. Impact of Hey2 and COUP-TFII on genes involved in arteriovenous differentiation in primary human arterial and venous endothelial cells. Basic Res. Cardiol. 108:362 (2013)

Krautz, C. ; Wolk, S. ; Steffen, A. ; Knoch, K.P. ; Ceglarek, U. ; Thiery, J. ; Bornstein, S. ; Saeger, H.-D. ; Solimena, M. ; Kersting, S. Effects of immunosuppression on alpha and beta cell renewal in transplanted mouse islets. Diabetologia 56, 1596-1604 (2013)

Kumashiro, N. ; Beddow, S.A. ; Vatner, D.F. ; Majumdar, S.K. ; Cantley, J.L. ; Guebre-Egziabher, F. ; Fat, I. ; Guigni, B. ; Jurczak, M.J. ; Birkenfeld, A.L. ; Kahn, M. ; Perler, B.K. ; Puchowicz, M.A. ; Manchem, V.P. ; Bhanot, S. ; Still, C.D. ; Gerhard, G.S. ; Petersen, K.F. ; Cline, G.W. ; Shulman, G.I. ; Samuel, V.T. Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance. Diabetes 62, 2183-2194 (2013)

Lamounier-Zepter, V. ; Look, C. ; Ehrhart-Bornstein, M. ; Bornstein, S.R. ; Fischer, S. ; Julius, U. Lipoprotein apheresis reduces adipocyte fatty acid-binding protein serum levels. Atherosclerosis 14, 129-134 (2013)

Langer, H.F. ; Chavakis, T. Platelets and neurovascular inflammation. Thromb. Haemost. 110, 888-893 (2013)

Lee, H.S. ; Briese, T. ; Winkler, C. ; Rewers, M. ; Bonifacio, E. ; Hyoty, H. ; Pflueger, M. ; Simell, O. ; She, J.X. ; Hagopian, W. ; Lernmark, A. ; Akolkar, B. ; Krischer, J.P. ; Ziegler, A.-G. ; TEDDY Study Group Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes. Diabetologia 56, 1705-1711 (2013)

Leinster, D.A. ; Colom, B. ; Whiteford, J.R. ; Ennis, D.P. ; Lockley, M. ; McNeish, I.A. ; Aurrand-Lions, M. ; Chavakis, T. ; Imhof, B.A. ; Balkwill, F.R. ; Nourshargh, S. Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer. FASEB J. 27, 4244-4253 (2013)

Lin, Z. ; Tian, H. ; Lam, K.S. ; Lin, S. ; Hoo, R.C. ; Konishi, M. ; Itoh, N. ; Wang, Y. ; Bornstein, S.R. ; Xu, A. ; Li, X. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab. 17, 779-789 (2013)

Löffler, M.G. ; Birkenfeld, A.L. ; Philbrick, K.M. ; Belman, J.P. ; Habtemichael, E.N. ; Booth, C.J. ; Castorena, C.M. ; Choi, C.S. ; Jornayvaz, F.R. ; Gassaway, B.M. ; Lee, H.Y. ; Cartee, G.D. ; Philbrick, W. ; Shulman, G.I. ; Samuel, V.T. ; Bogan, J.S. Enhanced fasting glucose turnover in mice with disrupted action of TUG protein in skeletal muscle. J. Biol. Chem. 288, 20135-20150 (2013)

Ludwig, B. ; Reichel, A. ; Steffen, A. ; Zimerman, B. ; Schally, A.V. ; Block, N.L. ; Colton, C.K. ; Ludwig, S. ; Kersting, S. ; Bonifacio, E. ; Solimena, M. ; Gendler, Z. ; Rotem, A. ; Barkai, U. ; Bornstein, S.R. Transplantation of human islets without immunosuppression. Proc. Natl. Acad. Sci. U.S.A. 110, 19054-19058 (2013)

Magro, M.G. ; Solimena, M. Regulation of β-cell function by RNA-binding proteins. Mol. Metab. 2, 348-355 (2013)

Maliga, Z. ; Junqueira, M. ; Toyoda, Y. ; Ettinger, A. ; Mora-Bermudez, F. ; Klemm, R.W. ; Vasilj, A. ; Guhr, E. ; Ibarlucea-Benitez, I. ; Poser, I. ; Bonifacio, E. ; Huttner, W.B. ; Shevchenko, A. ; Hyman, A.A. A genomic toolkit to investigate kinesin and myosin motor function in cells. Nat. Cell Biol. 15, 325-334 (2013)

Marciniak, A. ; Selck, C. ; Friedrich, B. ; Speier, S. Mouse pancreas tissue slice culture facilitates long-term studies of exocrine and endocrine cell physiology in situ. PLoS ONE 8:e78706 (2013)

Monti, P. ; Brigatti, C. ; Krasmann, M. ; Ziegler, A.-G. ; Bonifacio, E. Concentration and activity of the soluble form of the interleukin-7 receptor α in type I diabetes identifies an interplay between hyperglycemia and immune function. Diabetes 62, 2500-2508 (2013)

Morawietz, H. ; Goettsch, W. ; Brux, M. ; Reimann, M. ; Bornstein, S.R. ; Julius, U. ; Ziemssen, T. Lipoprotein apheresis of hypercholesterolemic patients mediates vasoprotective gene expression in human endothelial cells. Atherosclerosis 14, 107-113 (2013)

Müller, G. ; Parfentyeva, E. ; Olschewsky, J. ; Bornstein, S.R. ; Schwarz, P.E. Assessment of small fiber neuropathy to predict future risk of type 2 diabetes. Prim. Care Diabetes 7, 269-273 (2013)

Müller, G. ; Weser, G. ; Schwarz, P.E. The European perspective of diabetes prevention: The need for individualization of diabetes prevention. J. Endocrinol. Invest. 36, 352-357 (2013)

Neufeld, T.P. ; Ludwig, B. ; Barkai, U. ; Weir, G.C. ; Colton, C.K. ; Evron, Y. ; Balyura, M. ; Yavriyants, K. ; Zimermann, B. ; Azarov, D. ; Maimon, S. ; Shabtay, N. ; Rozenshtein, T. ; Lorber, D. ; Steffen, A. ; Willenz, U. ; Bloch, K. ; Vardi, P. ; Taube, R. ; de Vos, P. ; Lewis, E.C. ; Bornstein, S.R. ; Rotem, A. The efficacy of an immunoisolating membrane system for islet xenotransplantation in minipigs. PLoS ONE 8:e70150 (2013)

Ninov, N. ; Hesselson, D. ; Gut, P. ; Zhou, A. ; Fidelin, K. ; Stainier, D.Y. Metabolic regulation of cellular plasticity in the pancreas. Curr. Biol. 23, 1242-1250 (2013)

Palm, W. ; Swierczynska, M.M. ; Kumari, V. ; Ehrhart-Bornstein, M. ; Bornstein, S.R. ; Eaton, S. Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals. PLoS Biol. 11:e1001505 (2013)

Pamporaki, C. ; Därr, R. ; Bursztyn, M. ; Glöckner, S. ; Bornstein, S.R. ; Lenders, J.W. ; Pacak, K. ; Krinner, A. ; Eisenhofer, G. Plasma-free vs deconjugated metanephrines for diagnosis of phaeochromocytoma. Clin. Endocrinol. 79, 476-483 (2013)

Petrowski, K. ; Wintermann, G.B. ; Schaarschmidt, M. ; Bornstein, S.R. ; Kirschbaum, C. Blunted salivary and plasma cortisol response in patients with panic disorder under psychosocial stress. Int. J. Psychophysiol. 88, 35-39 (2013)

Petzold, C. ; Riewaldt, J. ; Watts, D. ; Sparwasser, T. ; Schallenberg, S. ; Kretschmer, K. Foxp3+ regulatory T cells in mouse models of type 1 diabetes. J. Diabetes Res. 2013:940710 (2013)

Phieler, J. ; Chung, K.-J. ; Chatzigeorgiou, A. ; Klotzsche-von Ameln, A. ; Garcia-Martin, R. ; Sprott, D. ; Moisidou, M. ; Tzanavari, T. ; Ludwig, B. ; Baraban, E. ; Ehrhart-Bornstein, M. ; Bornstein, S.R. ; Mziaut, H. ; Solimena, M. ; Karalis, K.P. ; Economopoulou, M. ; Lambris, J.D. ; Chavakis, T. The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance. J. Immunol. 191, 4367-4374 (2013)

Phieler, J. ; Garcia-Martin, R. ; Lambris, J.D. ; Chavakis, T. The role of the complement system in metabolic organs and metabolic diseases. Semin. Immunol. 25, 47-53 (2013)

Piemonti, L. ; Everly, M.J. ; Maffi, P. ; Scavini, M. ; Poli, F. ; Nano, R. ; Cardillo, M. ; Melzi, R. ; Mercalli, A. ; Sordi, V. ; Lampasona, V. ; Espadas de Arias, A. ; Scalamogna, M. ; Bosi, E. ; Bonifacio, E. ; Secchi, A. ; Terasaki, P.I. Alloantibody and autoantibody monitoring predicts islet transplantation outcome in human type 1 diabetes. Diabetes 62, 1656-1664 (2013)

Reichel, A. ; Rietzsch, H. ; Ludwig, B. ; Röthig, K. ; Moritz, A. ; Bornstein, S.R. Self-adjustment of insulin dose using graphically depicted self-monitoring of blood glucose measurements in patients with type 1 diabetes mellitus. J. Diabetes Sci. Technol. 7, 156-162 (2013)

Reimann, M. ; Julius, U. ; Bornstein, S.R. ; Fischer, S. ; Reichmann, H. ; Rüdiger, H. ; Ziemssen, T. Regular lipoprotein apheresis maintains residual cardiovascular and microvascular function in patients with advanced atherosclerotic disease. Atherosclerosis 14, 135-141 (2013)

Ringers, J. ; van der Torren, C.R. ; van de Linde, P. ; van der Boog, P.J. ; Mallat, M.J. ; Bonifacio, E. ; Roep, B.O. ; de Fijter, J.W. Pretransplantation GAD-autoantibody status to guide prophylactic antibody induction therapy in simultaneous pancreas and kidney transplantation. Transplantation 96, 745-752 (2013)

Ritter, P.S. ; Kretschmer, K. ; Pfennig, A. ; Soltmann, B. Disturbed sleep in bipolar disorder is related to an elevation of IL-6 in peripheral monocytes. Med. Hypotheses 81, 1031-1033 (2013)

Saha, S. ; Graessler, J. ; Bornstein, S.R. ; Schwarz, P.E. ; Kopprasch, S. Stimulation of phagocyte adhesion to endothelial cells by modified VLDL and HDL requires scavenger receptor BI. Mol. Cell. Biochem. 383, 21-28 (2013)

Saha, S. ; Schwarz, P.E. ; Bergmann, S. ; Bornstein, S.R. ; Graessler, J. ; Kopprasch, S. Circulating very-low-density lipoprotein from subjects with impaired glucose tolerance accelerates adrenocortical cortisol and aldosterone synthesis. Horm. Metab. Res. 45, 169-172 (2013)

Schatz, U. ; Arneth, B. ; Siegert, G. ; Siegels, D. ; Fischer, S. ; Julius, U. ; Bornstein, S.R. Iron deficiency and its management in patients undergoing lipoprotein apheresis. Comparison of two parenteral iron formulations. Atherosclerosis 14, 115-122 (2013)

Schöfl, C. ; Franz, H. ; Grussendorf, M. ; Honegger, J. ; Jaursch-Hancke, C. ; Mayr, B. ; Schopohl, J. Long-term outcome in patients with acromegaly: Analysis of 1344 patients from the German Acromegaly Register. Eur. J. Endocrinol. 168, 39-47 (2013)

Schubert, U. ; Schmid, J. ; Lehmann, S. ; Zhang, X.Y. ; Morawietz, H. ; Block, N.L. ; Kanczkowski, W. ; Schally, A.V. ; Bornstein, S.R. ; Ludwig, B. Transplantation of pancreatic islets to adrenal gland is promoted by agonists of growth-hormone-releasing hormone. Proc. Natl. Acad. Sci. U.S.A. 110, 2288-2293 (2013)

Schwarz, P.E. ; Gallein, G. ; Ebermann, D. ; Müller, A. ; Lindner, A. ; Rothe, U. ; Nebel, I.T. ; Müller, G. Global Diabetes Survey - an annual report on quality of diabetes care. Diabetes Res. Clin. Pract. 100, 11-18 (2013)

Shin, J.T. ; Hosur, K.B. ; Pyaram, K. ; Jotwani, R. ; Liang, S. ; Chavakis, T. ; Hajishengallis, G. Expression and function of the homeostatic molecule Del-1 in endothelial cells and the periodontal tissue. Clin. Dev. Immunol. 2013:617809 (2013)

Singh, R.P. ; Franke, K. ; Kalucka, J. ; Mamlouk, S. ; Muschter, A. ; Gembarska, A. ; Grinenko, T. ; Willam, C. ; Naumann, R. ; Anastassiadis, K. ; Stewart, A.F. ; Bornstein, S.R. ; Chavakis, T. ; Breier, G. ; Waskow, C. ; Wielockx, B. HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress. Blood 121, 5158-5166 (2013)

Stalder, T. ; Kirschbaum, C. ; Alexander, N. ; Bornstein, S.R. ; Gao, W. ; Miller, R. ; Stark, S. ; Bosch, J.A. ; Fischer, J.E. Cortisol in hair and the metabolic syndrome. J. Clin. Endocrinol. Metab. 98, 2573-2580 (2013)

Sturm, D. ; Marselli, L. ; Ehehalt, F. ; Richter, D. ; Distler, M. ; Kersting, S. ; Grützmann, R. ; Bokvist, K. ; Froguel, P. ; Liechti, R. ; Jörns, A. ; Meda, P. ; Baretton, G.B. ; Saeger, H.-D. ; Schulte, A.M. ; Marchetti, P. ; Solimena, M. Improved protocol for laser microdissection of human pancreatic islets from surgical specimens. J. Vis. Exp. 71:e50231 (2013)

Swierczynska, M.M. ; Lamounier-Zepter, V. ; Bornstein, S.R. ; Eaton, S. Lipoproteins and Hedgehog signalling - possible implications for the adrenal gland function. Eur. J. Clin. Invest. 43, 1178-1183 (2013)

Taseva, K. ; Fischer, S. ; Passauer, J. ; Weiss, N. ; Bornstein, S.R. ; Julius, U. Factors inducing cardiovascular events in patients treated by lipoprotein apheresis. Atherosclerosis 14, 45-50 (2013)

Tausche, A.K. ; Gehrisch, S. ; Panzner, I. ; Winzer, M. ; Range, U. ; Bornstein, S.R. ; Siegert, G. ; Wunderlich, C. ; Aringer, M. A 3-day delay in synovial fluid crystal identification did not hinder the reliable detection of monosodium urate and calcium pyrophosphate crystals. J. Clin. Rheumatol. 19, 241-245 (2013)

Toker, A. ; Engelbert, D. ; Garg, G. ; Polansky, J.K. ; Floess, S. ; Miyao, T. ; Baron, U. ; Düber, S. ; Geffers, R. ; Giehr, P. ; Schallenberg, S. ; Kretschmer, K. ; Olek, S. ; Walter, J. ; Weiss, S. ; Hori, S. ; Hamann, A. ; Huehn, J. Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus. J. Immunol. 190, 3180-3188 (2013)

Toporkiewicz, M. ; Grzybek, M. ; Meissner, J. ; Michalczyk, I. ; Dubielecka, P.M. ; Korycka, J. ; Seweryn, E. ; Sikorski, A.F. Release of an ~55kDa fragment containing the actin-binding domain of β-spectrin by caspase-8 during FND-induced apoptosis depends on the presence of protein 4.1. Arch. Biochem. Biophys. 535, 205-213 (2013)

Tsourdi, E. ; Barthel, A. ; Rietzsch, H. ; Reichel, A. ; Bornstein, S.R. Current aspects in the pathophysiology and treatment of chronic wounds in diabetes mellitus. Biomed Res. Int. 2013:385641 (2013)

Ullmann, E. ; Barthel, A. ; Licinio, J. ; Petrowski, K. ; Bornstein, S.R. ; Strauß, B. Increased rate of depression and psychosomatic symptoms in Jewish migrants from the post-Soviet-Union to Germany in the 3rd generation after the Shoa. Transl. Psychiatry 3:e241 (2013)

von Dryander, M. ; Fischer, S. ; Passauer, J. ; Müller, G. ; Bornstein, S.R. ; Julius, U. Differences in the atherogenic risk of patients treated by lipoprotein apheresis according to their lipid pattern. Atherosclerosis 14, 39-44 (2013)

Willmes, D.M. ; Birkenfeld, A.L. The role of INDY in metabolic regulation. Comp. Struc. Biotech. J. 6:e201303020 (2013)

Ziegler, A.-G. ; Rewers, M. ; Simell, O. ; Simell, T. ; Lempainen, J. ; Steck, A. ; Winkler, C. ; Ilonen, J. ; Veijola, R. ; Knip, M. ; Bonifacio, E. ; Eisenbarth, G.S. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 309, 2473-2479 (2013)

Ziegler, C.G. ; Ullrich, M. ; Schally, A.V. ; Bergmann, R. ; Pietzsch, J. ; Gebauer, L. ; Gondek, K. ; Qin, N. ; Pacak, K. ; Ehrhart-Bornstein, M. ; Eisenhofer, G. ; Bornstein, S.R. Anti-tumor effects of peptide analogs targeting neuropeptide hormone receptors on mouse pheochromocytoma cells. Mol. Cell. Endocrinol. 371, 189-194 (2013)