Publikationen des PLID seit 2013
2025
Perakakis N, Funk AM, Kolb T, Jonas S, Hellerhoff I, Tam FI, Bornstein SR, Chavakis T, Mirtschink P, Ehrlich S. Perturbations in plasma amino acid and lipoprotein subfraction profiles in anorexia nervosa before and after refeeding: A metabolomic cross-sectional and longitudinal analysis. Clin Nutr. 2025 Jan 21;46:107-116. doi: 10.1016/j.clnu.2025.01.014.
Ramachandran A, Nanditha A, Tuomilehto J, Gabriel R, Saboo B, Mohan V, Chawla M, Chawla P, Raghavan A, Gupta A, Joshi S, Agarwal S, Misra A, Sahay R, Tiwaskar MH, Azad Khan AK, Arvind SR, Viswanathan V, Das AK, Makkar BM, Kowlessur S, Yajnik CS, Sriram U, Seshadri KG, Susairaj P, Satheesh K, Duncan BB, Aschner P, Barengo NC, Schwarz PEH, Ceriello A. Call to action for clinicians in the South-East Asian regions on primary prevention of diabetes in people with prediabetes- A consensus statement. Diabetes Res Clin Pract. 2025 Jan 13;221:111997. doi: 10.1016/j.diabres.2025.111997.
Akhtar MN, Hnatiuk A, Delgadillo-Silva L, Geravandi S, Sameith K, Reinhardt S, Bernhardt K, Singh SP, Maedler K, Brusch L, Ninov N. Developmental beta-cell death orchestrates the islet's inflammatory milieu by regulating immune system crosstalk. EMBO J. 2025 Jan 6. doi: 10.1038/s44318-024-00332-w.
Barovic M, Hahn JJ, Heinrich A, Adhikari T, Schwarz P, Mirtschink P, Funk A, Kabisch S, Pfeiffer AFH, Blüher M, Seissler J, Stefan N, Wagner R, Fritsche A, Jumpertz von Schwartzenberg R, Chlamydas S, Harb H, Mantzoros CS, Chavakis T, Schürmann A, Birkenfeld AL, Roden M, Solimena M, Bornstein SR, Perakakis N. Proteomic and Metabolomic Signatures in Prediabetes Progressing to Diabetes or Reversing to Normoglycemia Within 1 Year. Diabetes Care. 2025 Jan 2:dc241412. doi: 10.2337/dc24-1412.
Hummel S, Koeger M, Bonifacio E, Ziegler AG. Dysglycaemia definitions and progression to clinical type 1 diabetes in children with multiple islet autoantibodies. Lancet Diabetes Endocrinol. 2025 Jan;13(1):10-12. doi: 10.1016/S2213-8587(24)00337-1. Epub 2024 Dec 3.
2024
Kopaliani I, Elsaid B, Speier S, Deussen A. Immune and Metabolic Mechanisms of Endothelial Dysfunction. Int J Mol Sci. 2024 Dec 12;25(24):13337. doi: 10.3390/ijms252413337.
Rodionov RN, Jarzebska N, Koay YC, Li M, Kuhn M, Bornstein SR, Martens-Lobenhoffer J, Eslam M, Chen FW, Rubets E, Markov AG, Weiss N, Birkenfeld A, Schwarz P, Bode-Böger SM, Perakakis N, O'Sullivan JF, George J. Symmetric dimethylguanidino valeric acid, a novel single biomarker of hepatic steatosis. iScience. 2024 Nov 13;27(12):111366. doi: 10.1016/j.isci.2024.111366. eCollection 2024 Dec 20.
Siehler J, Bilekova S, Chapouton P, Dema A, Albanese P, Tamara S, Jain C, Sterr M, Enos SJ, Chen C, Malhotra C, Villalba A, Schomann L, Bhattacharya S, Feng J, Akgün Canan M, Ribaudo F, Ansarullah, Burtscher I, Ahlbrecht C, Plettenburg O, Kurth T, Scharfmann R, Speier S, Scheltema RA, Lickert H. Inceptor binds to and directs insulin towards lysosomal degradation in β cells. Nat Metab. 2024 Nov 25. doi: 10.1038/s42255-024-01164-y.
Perakakis N, Mantzoros CS. Evidence from clinical studies of leptin: current and future clinical applications in humans. Metabolism. 2024 Dec;161:156053. doi: 10.1016/j.metabol.2024.156053. Epub 2024 Oct 28.
Perakakis N, Mantzoros CS. Leptin in humans: Evidence from clinical studies and current and future clinical applications. Metabolism. 2024 Oct 26:156053. doi: 10.1016/j.metabol.2024.156053.
Kübler IC, Kretzschmar J, Arredondo-Lasso MN, Keeley SD, Rößler LC, Ganss K, Sandoval-Guzmán T, Brankatschk M. Systemic and local lipid adaptations underlie regeneration in Drosophila melanogaster and Ambystoma mexicanum. NPJ Regen Med. 2024 Oct 29;9(1):33. doi: 10.1038/s41536-024-00375-x.
Eugster A, Lorenc A, Kotrulev M, Kamra Y, Goel M, Steinberg-Bains K, Sabbah S, Dietz S, Bonifacio E, Peakman M, Gomez-Tourino I. Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes. Nat Commun. 2024 Oct 29;15(1):9204. doi: 10.1038/s41467-024-53255-9.
Edwards-Jorquera S, Aires R, Ulbricht E, Taubenberger A, Sandoval-Guzmán T. Atomic Force Microscopy Measurements of Cartilage in Intact and Regenerating Axolotl Limbs. J Vis Exp. 2024 Oct 11;(212). doi: 10.3791/66946.
Müller A, Klena N, Pang S, Garcia LEG, Topcheva O, Aurrecoechea Duran S, Sulaymankhil D, Seliskar M, Mziaut H, Schöniger E, Friedland D, Kipke N, Kretschmar S, Münster C, Weitz J, Distler M, Kurth T, Schmidt D, Hess HF, Xu CS, Pigino G, Solimena M. Structure, interaction and nervous connectivity of beta cell primary cilia. Nat Commun. 2024 Oct 24;15(1):9168. doi: 10.1038/s41467-024-53348-5.
Aljani B, Garbe AI, Sedlmeier EM, Lickert R, Rost F, Ziegler AG, Bonifacio E, Eugster A. Gene expression profiles in placenta and their association with anesthesia, delivery mode and maternal diabetes. Placenta. 2024 Oct 15;158:126-135. doi: 10.1016/j.placenta.2024.10.008.
Huber E, Singh T, Bunk M, Hebel M, Kick K, Weiß A, Kohls M, Köger M, Hergl M, Zapardiel Gonzalo JM, Bonifacio E, Ziegler AG. Discrimination and precision of Continuous Glucose Monitoring in staging children with presymptomatic type 1 diabetes. J Clin Endocrinol Metab. 2024 Oct 16:dgae691. doi: 10.1210/clinem/dgae691. Kögel A, Keidel A, Loukeri MJ, Kuhn CC, Langer LM, Schäfer IB, Conti E. Structural basis of mRNA decay by the human exosome-ribosome supercomplex. Nature. 2024 Oct 9. doi: 10.1038/s41586-024-08015-6.
Kögel A, Keidel A, Loukeri MJ, Kuhn CC, Langer LM, Schäfer IB, Conti E. Structural basis of mRNA decay by the human exosome-ribosome supercomplex. Nature. 2024 Oct 9. doi: 10.1038/s41586-024-08015-6.
Castells-Nobau A, Moreno-Navarrete JM, de la Vega-Correa L, Puig I, Federici M, Sun J, Burcelin R, Guzylack-Piriou L, Gourdy P, Cazals L, Arnoriaga-Rodríguez M, Frühbeck G, Seoane LM, López-Miranda J, Tinahones FJ, Dieguez C, Dumas ME, Pérez-Brocal V, Moya A, Perakakis N, Mingrone G, Bornstein S, Rodriguez Hermosa JI, Castro E, Fernández-Real JM, Mayneris-Perxachs J. Multiomics of the intestine-liver-adipose axis in multiple studies unveils a consistent link of the gut microbiota and the antiviral response with systemic glucose metabolism. Gut. 2024 Oct 2:gutjnl-2024-332602. doi: 10.1136/gutjnl-2024-332602.
Phillip M, Achenbach P, Addala A, Albanese-O'Neill A, Battelino T, Bell KJ, Besser REJ, Bonifacio E, Colhoun HM, Couper JJ, Craig ME, Danne T, de Beaufort C, Dovc K, Driscoll KA, Dutta S, Ebekozien O, Larsson HE, Feiten DJ, Frohnert BI, Gabbay RA, Gallagher MP, Greenbaum CJ, Griffin KJ, Hagopian W, Haller MJ, Hendrieckx C, Hendriks E, Holt RIG, Hughes L, Ismail HM, Jacobsen LM, Johnson SB, Kolb LE, Kordonouri O, Lange K, Lash RW, Lernmark Å, Libman I, Lundgren M, Maahs DM, Marcovecchio ML, Mathieu C, Miller KM, O'Donnell HK, Oron T, Patil SP, Pop-Busui R, Rewers MJ, Rich SS, Schatz DA, Schulman-Rosenbaum R, Simmons KM, Sims EK, Skyler JS, Smith LB, Speake C, Steck AK, Thomas NPB, Tonyushkina KN, Veijola R, Wentworth JM, Wherrett DK, Wood JR, Ziegler AG, DiMeglio LA. Correction to: Consensus guidance for monitoring individuals with islet autoantibody‑positive pre‑stage 3 type 1 diabetes. Diabetologia. 2024 Sep;67(9):2012-2014. doi: 10.1007/s00125-024-06266-6.
Wang R, Gomez Salazar M, Pruñonosa Cervera I, Coutts A, French K, Pinto MM, Gohlke S, García-Martín R, Blüher M, Schofield CJ, Kourtzelis I, Stimson RH, Bénézech C, Christian M, Schulz TJ, Gudmundsson EF, Jennings LL, Gudnason VG, Chavakis T, Morton NM, Emilsson V, Michailidou Z. Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality. Nat Commun. 2024 Aug 29;15(1):7483. doi: 10.1038/s41467-024-51718-7.
Kramer J, Aires R, Keeley SD, Schröder TA, Lauer G, Sandoval-Guzmán T. Axolotl mandible regeneration occurs through mechanical gap closure and a shared regenerative program with the limb. Dis Model Mech. 2024 Sep 1;17(9):dmm050743. doi: 10.1242/dmm.050743. Epub 2024 Sep 27.
Zanfrini E, Bandral M, Jarc L, Ramirez-Torres MA, Pezzolla D, Kufrin V, Rodriguez-Aznar E, Avila AKM, Cohrs C, Speier S, Neumann K, Gavalas A. Generation and application of novel hES cell reporter lines for the differentiation and maturation of hPS cell-derived islet-like clusters. Sci Rep. 2024 Aug 27;14(1):19863. doi: 10.1038/s41598-024-69645-4.
Perez-Frances M, Bru-Tari E, Cohrs C, Abate MV, van Gurp L, Furuyama K, Speier S, Thorel F, Herrera PL. Regulated and adaptive in vivo insulin secretion from islets only containing β-cells. Nat Metab. 2024 Sep;6(9):1791-1806. doi: 10.1038/s42255-024-01114-8. Epub 2024 Aug 21.
Aljani B, Lindner A, Weigelt M, Zhao M, Sharma V, Bonifacio E, Jones P, Eugster A. Small RNA-Seq and real time rt-qPCR reveal islet miRNA released under stress conditions. Islets. 2024 Dec 31;16(1):2392343. doi: 10.1080/19382014.2024.2392343.
Arold D, Bornstein SR, Perakakis N, Ehrlich S, Bernardoni F. Regional gray matter changes in steatotic liver disease provide a neurobiological link to depression: A cross-sectional UK biobank cohort study. Metabolism. 2024 Jul 30:155983. doi: 10.1016/j.metabol.2024.155983.
Maremonti F, Tonnus W, Gavali S, Bornstein S, Shah A, Giacca M, Linkermann A. Ferroptosis-based advanced therapies as treatment approaches for metabolic and cardiovascular diseases. Cell Death Differ. 2024 Jul 27. doi: 10.1038/s41418-024-01350-1.
Delgadillo-Silva LF, Tasöz E, Singh SP, Chawla P, Georgiadou E, Gompf A, Rutter GA, Ninov N. Optogenetic β cell interrogation in vivo reveals a functional hierarchy directing the Ca2+ response to glucose supported by vitamin B6. Sci Adv. 2024 Jun 28;10(26):eado4513. doi: 10.1126/sciadv.ado4513. Epub 2024 Jun 26.
Drotar DM, Mojica-Avila AK, Bloss DT, Cohrs CM, Manson CT, Posgai AL, Williams MD, Brusko MA, Phelps EA, Wasserfall CH, Speier S, Atkinson MA. Impaired islet function and normal exocrine enzyme secretion occur with low inter-regional variation in type 1 diabetes. Cell Rep. 2024 Jun 25;43(6):114346. doi: 10.1016/j.celrep.2024.114346. Epub 2024 Jun 7.
Phillip M, Achenbach P, Addala A, Albanese-O'Neill A, Battelino T, Bell KJ, Besser REJ, Bonifacio E, Colhoun HM, Couper JJ, Craig ME, Danne T, de Beaufort C, Dovc K, Driscoll KA, Dutta S, Ebekozien O, Elding Larsson H, Feiten DJ, Frohnert BI, Gabbay RA, Gallagher MP, Greenbaum CJ, Griffin KJ, Hagopian W, Haller MJ, Hendrieckx C, Hendriks E, Holt RIG, Hughes L, Ismail HM, Jacobsen LM, Johnson SB, Kolb LE, Kordonouri O, Lange K, Lash RW, Lernmark Å, Libman I, Lundgren M, Maahs DM, Marcovecchio ML, Mathieu C, Miller KM, O'Donnell HK, Oron T, Patil SP, Pop-Busui R, Rewers MJ, Rich SS, Schatz DA, Schulman-Rosenbaum R, Simmons KM, Sims EK, Skyler JS, Smith LB, Speake C, Steck AK, Thomas NPB, Tonyushkina KN, Veijola R, Wentworth JM, Wherrett DK, Wood JR, Ziegler AG, DiMeglio LA. Consensus Guidance for Monitoring Individuals With Islet Autoantibody-Positive Pre-Stage 3 Type 1 Diabetes. Diabetes Care. 2024 Jun 24:dci240042. doi: 10.2337/dci24-0042.
Phillip M, Achenbach P, Addala A, Albanese-O'Neill A, Battelino T, Bell KJ, Besser REJ, Bonifacio E, Colhoun HM, Couper JJ, Craig ME, Danne T, de Beaufort C, Dovc K, Driscoll KA, Dutta S, Ebekozien O, Larsson HE, Feiten DJ, Frohnert BI, Gabbay RA, Gallagher MP, Greenbaum CJ, Griffin KJ, Hagopian W, Haller MJ, Hendrieckx C, Hendriks E, Holt RIG, Hughes L, Ismail HM, Jacobsen LM, Johnson SB, Kolb LE, Kordonouri O, Lange K, Lash RW, Lernmark Å, Libman I, Lundgren M, Maahs DM, Marcovecchio ML, Mathieu C, Miller KM, O'Donnell HK, Oron T, Patil SP, Pop-Busui R, Rewers MJ, Rich SS, Schatz DA, Schulman-Rosenbaum R, Simmons KM, Sims EK, Skyler JS, Smith LB, Speake C, Steck AK, Thomas NPB, Tonyushkina KN, Veijola R, Wentworth JM, Wherrett DK, Wood JR, Ziegler AG, DiMeglio LA. Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes. Diabetologia. 2024 Jun 24. doi: 10.1007/s00125-024-06205-5.
Grimus S, Sarangova V, Welzel PB, Ludwig B, Seissler J, Kemter E, Wolf E, Ali A. Immunoprotection Strategies in β-Cell Replacement Therapy: A Closer Look at Porcine Islet Xenotransplantation. Adv Sci (Weinh). 2024 Jun 17:e2401385. doi: 10.1002/advs.202401385.
Zeller I, Weiss A, Arnolds S, Schütte-Borkovec K, Arabi S, von dem Berge T, Casteels K, Hommel A, Kordonouri O, Larsson HE, Lundgren M, Rochtus A, Snape MD, Szypowka A, Vatish M, Winkler C, Bonifacio E, Ziegler AG; GPPAD Study Group. Infection episodes and islet autoantibodies in children at increased risk for type 1 diabetes before and during the COVID-19 pandemic. Infection. 2024 Jun 14. doi: 10.1007/s15010-024-02312-y.
Meyer NMT, Kabisch S, Dambeck U, Honsek C, Kemper M, Gerbracht C, Arafat AM, Birkenfeld AL, Schwarz PEH, Machann J, Osterhoff MA, Weickert MO, Pfeiffer AFH. IGF-1 and IGFBP-1 as Possible Predictors of Response to Lifestyle Intervention-Results from Randomized Controlled Trials. Int J Mol Sci. 2024 Jun 10;25(12):6400. doi: 10.3390/ijms25126400.
Bonifacio E, Winkler C, Achenbach P, Ziegler AG. Effect of population-wide screening for presymptomatic early-stage type 1 diabetes on paediatric clinical care. Lancet Diabetes Endocrinol. 2024 Jun;12(6):376-378. doi: 10.1016/S2213-8587(24)00101-3. Epub 2024 May 6.
Singh T, Weiss A, Vehik K, Krischer J, Rewers M, Toppari J, Lernmark Å, Hagopian W, Akolkar B, Bonifacio E, Ziegler AG, Winkler C; TEDDY Study Group. Caesarean section and risk of type 1 diabetes. Diabetologia. 2024 May 31. doi: 10.1007/s00125-024-06176-7.
Elsner L, Heimann L, Geisler A, Dieringer B, Knoch KP, Hinze L, Klingel K, Solimena M, Kurreck J, Fechner H. Fast Track Adaptation of Oncolytic Coxsackie B3 Virus to Resistant Colorectal Cancer Cells - a Method to Personalize Virotherapy. Biol Proced Online. 2024 Apr 25;26(1):11. doi: 10.1186/s12575-024-00237-2.
Zocher S, McCloskey A, Karasinsky A, Schulte R, Friedrich U, Lesche M, Rund N, Gage FH, Hetzer MW, Toda T. Lifelong persistence of nuclear RNAs in the mouse brain. Science. 2024 Apr 5;384(6691):53-59. doi: 10.1126/science.adf3481. Epub 2024 Apr 4.
Hummel S, Rosenberger S, von dem Berge T, Besser REJ, Casteels K, Hommel A, Kordonouri O, Elding Larsson H, Lundgren M, Marcus BA, Oltarzewski M, Rochtus A, Szypowska A, Todd JA, Weiss A, Winkler C, Bonifacio E, Ziegler AG; GPPAD and POInT Study Group. Early-childhood body mass index and its association with the COVID-19 pandemic, containment measures and islet autoimmunity in children with increased risk for type 1 diabetes. Diabetologia. 2024 Apr;67(4):670-678. doi: 10.1007/s00125-023-06079-z
Panagiotou S, Tan KW, Nguyen PM, Müller A, Oqua AI, Tomas A, Wendt A, Eliasson L, Tengholm A, Solimena M, Idevall-Hagren O. OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion. Cell Rep. 2024 Mar 26;43(4):113992. doi: 10.1016/j.celrep.2024.113992.
Neukam M, Sala P, Brunner AD, Ganß K, Palladini A, Grzybek M, Topcheva O, Vasiljević J, Broichhagen J, Johnsson K, Kurth T, Mann M, Coskun Ü, Solimena M. Purification of time-resolved insulin granules reveals proteomic and lipidomic changes during granule aging. Cell Rep. 2024 Mar 26;43(3):113836. doi: 10.1016/j.celrep.2024.113836
von Mässenhausen A, Schlecht MN, Beer K, Maremonti F, Tonnus W, Belavgeni A, Gavali S, Flade K, Riley JS, Zamora Gonzalez N, Brucker A, Becker JN, Tmava M, Meyer C, Peitzsch M, Hugo C, Gembardt F, Angeli JPF, Bornstein SR, Tait SWG, Linkermann A. Treatment with siRNAs is commonly associated with GPX4 up-regulation and target knockdown-independent sensitization to ferroptosis. Sci Adv. 2024 Mar 15;10(11):eadk7329. doi: 10.1126/sciadv.adk7329.
Schubert U, Lehmann S, Schmid J, Morawietz H, Bornstein SR, Ludwig B. The Adrenal Gland and Pancreatic Islets - A Beneficial Endocrine Alliance. Horm Metab Res. 2024 Mar 12. doi: 10.1055/a-2256-6344.
Vecchio F, Carré A, Korenkov D, Zhou Z, Apaolaza P, Tuomela S, Burgos-Morales O, Snowhite I, Perez-Hernandez J, Brandao B, Afonso G, Halliez C, Kaddis J, Kent SC, Nakayama M, Richardson SJ, Vinh J, Verdier Y, Laiho J, Scharfmann R, Solimena M, Marinicova Z, Bismuth E, Lucidarme N, Sanchez J, Bustamante C, Gomez P, Buus S; nPOD-Virus Working Group; You S, Pugliese A, Hyoty H, Rodriguez-Calvo T, Flodstrom-Tullberg M, Mallone R. Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8+ T cell responses. Sci Adv. 2024 Mar 8;10(10):eadl1122. doi: 10.1126/sciadv.adl1122.
Chavakis T, Alexaki VI, Ferrante AW Jr. Author Correction: Macrophage function in adipose tissue homeostasis and metabolic inflammation. Nat Immunol. 2024 Mar;25(3):576. doi: 10.1038/s41590-023-01726-4.
Müller A, Schmidt D, Albrecht JP, Rieckert L, Otto M, Galicia Garcia LE, Fabig G, Solimena M, Weigert M. Modular segmentation, spatial analysis and visualization of volume electron microscopy datasets. Nat Protoc. 2024 Feb 29. doi: 10.1038/s41596-024-00957-5.
Riquelme-Guzmán C, Sandoval-Guzmán T. The salamander limb: a perfect model to understand imperfect integration during skeletal regeneration. Biol Open. 2024 Feb 15;13(2):bio060152. doi: 10.1242/bio.060152.
Gado M, Tsaousidou E, Bornstein SR, Perakakis N. Sex-based differences in insulin resistance. J Endocrinol. 2024 Feb 12;261(1):e230245. doi: 10.1530/JOE-23-0245.
Jarc L, Bandral M, Zanfrini E, Lesche M, Kufrin V, Sendra R, Pezzolla D, Giannios I, Khattak S, Neumann K, Ludwig B, Gavalas A. Regulation of multiple signaling pathways promotes the consistent expansion of human pancreatic progenitors in defined conditions. Elife. 2024 Jan 5;12:RP89962. doi: 10.7554/eLife.89962.
Cohrs CM, Chen C, Atkinson MA, Drotar DM, Speier S. Bridging the Gap: Pancreas Tissue Slices From Organ and Tissue Donors for the Study of Diabetes Pathogenesis. Diabetes. 2024 Jan 1;73(1):11-22. doi: 10.2337/dbi20-0018.
2023
Yilmazer A, Zevla DM, Malmkvist R, Rodríguez CAB, Undurraga P, Kirgin E, Boernert M, Voehringer D, Kershaw O, Schlenner S, Kretschmer K. Selective ablation of thymic and peripheral Foxp3+ regulatory T cell development. Front Immunol. 2023 Dec 18;14:1298938. doi: 10.3389/fimmu.2023.1298938.
Egorov D, Kopaliani I, Ameln AK, Speier S, Deussen A. Mechanism of pro-MMP9 activation in co-culture of pro-inflammatory macrophages and cardiomyocytes. Exp Cell Res. 2023 Dec 1:113868. doi: 10.1016/j.yexcr.2023.113868.
Schepp F, Schubert U, Schmid J, Lehmann S, Latunde-Dada GO, Kose T, Steenblock C, Bornstein SR, Linkermann A, Ludwig B. Mechanistic Insights into Ferroptotic Cell Death in Pancreatic Islets. Horm Metab Res. 2023 Nov 13. doi: 10.1055/a-2190-2803.
Beydag-Tasöz BS, D'Costa JV, Hersemann L, Lee BH, Luppino F, Kim YH, Zechner C, Grapin-Botton A. Integrating single-cell imaging and RNA sequencing datasets links differentiation and morphogenetic dynamics of human pancreatic endocrine progenitors. Dev Cell. 2023 Nov 6;58(21):2292-2308.e6. doi: 10.1016/j.devcel.2023.07.019.
Makhmudova U, Schatz U, Perakakis N, Kassner U, Schumann F, Axthelm C, Stürzebecher P, Sinning DL, Doevelaar A, Rohn B, Westhoff T, Vogt A, Scholl M, Kästner U, Geiling JA, Stach K, Mensch J, Lorenz E, Paitazoglou C, Eitel I, Baessler A, Steinhagen-Thiessen E, Koenig W, Schulze PC, Landmesser U, Laufs U, Weingärtner O; German Inclisiran Network (GIN). High interindividual variability in LDL-cholesterol reductions after inclisiran administration in a real-world multicenter setting in Germany. Clin Res Cardiol. 2023 Nov;112(11):1639-1649. doi: 10.1007/s00392-023-02247-8.
Zhong J, Aires R, Tsissios G, Skoufa E, Brandt K, Sandoval-Guzmán T, Aztekin C. Multi-species atlas resolves an axolotl limb development and regeneration paradox. Nat Commun. 2023 Oct 10;14(1):6346. doi: 10.1038/s41467-023-41944-w.
Perakakis N, Bornstein SR, Birkenfeld AL, Linkermann A, Demir M, Anker SD, Filippatos G, Pitt B, Rossing P, Ruilope LM, Kolkhof P, Lawatscheck R, Scott C, Bakris GL; FIDELIO-DKD and FIGARO-DKD investigators. Efficacy of finerenone in patients with type 2 diabetes, chronic kidney disease and altered markers of liver steatosis and fibrosis: A FIDELITY subgroup analysis. Diabetes Obes Metab. 2023 Oct 10. doi: 10.1111/dom.15305.
Warncke K, Eckert A, Bonifacio E, Achenbach P, Kordonouri O, Meissner T, Ohlenschläger U, Bonfig W, Ziegler AG, Holl RW. Characterisation and clinical outcomes in children and adolescents with diabetes according to newly defined subgroups: a cohort study from the DPV registry. EClinicalMedicine. 2023 Sep 8;64:102208. doi: 10.1016/j.eclinm.2023.102208.
Lugar M, Eugster A, Achenbach P, von dem Berge T, Berner R, Besser REJ, Casteels K, Elding Larsson H, Gemulla G, Kordonouri O, Lindner A, Lundgren M, Müller D, Oltarzewski M, Rochtus A, Scholz M, Szypowska A, Todd JA, Ziegler AG, Bonifacio E; GPPAD Study Group. SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood. JAMA. 2023 Sep 26;330(12):1151-1160. doi: 10.1001/jama.2023.16348.
Sandforth A, von Schwartzenberg RJ, Arreola EV, Hanson RL, Sancar G, Katzenstein S, Lange K, Preißl H, Dreher SI, Weigert C, Wagner R, Kantartzis K, Machann J, Schick F, Lehmann R, Peter A, Katsouli N, Ntziachristos V, Dannecker C, Fritsche L, Perakakis N, Heni M, Nawroth PP, Kopf S, Pfeiffer AFH, Kabisch S, Stumvoll M, Schwarz PEH, Hauner H, Lechner A, Seissler J, Yurchenko I, Icks A, Solimena M, Häring HU, Szendroedi J, Schürmann A, de Angelis MH, Blüher M, Roden M, Bornstein SR, Stefan N, Fritsche A, Birkenfeld AL. Mechanisms of weight loss-induced remission in people with prediabetes: a post-hoc analysis of the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS). Lancet Diabetes Endocrinol. 2023 Sep 25:S2213-8587(23)00235-8. doi: 10.1016/S2213-8587(23)00235-8.
Gopalakrishnan J, Feistel K, Friedrich BM, Grapin-Botton A, Jurisch-Yaksi N, Mass E, Mick DU, Müller RU, May-Simera H, Schermer B, Schmidts M, Walentek P, Wachten D. Emerging principles of primary cilia dynamics in controlling tissue organization and function. EMBO J. 2023 Sep 25:e113891. doi: 10.15252/embj.2023113891.
Sigala S, Bothou C, Penton D, Abate A, Peitzsch M, Cosentini D, Tiberio GAM, Bornstein SR, Berruti A, Hantel C. Correction: Sigala et al. A Comprehensive Investigation of Steroidogenic Signaling in Classical and New Experimental Cell Models of Adrenocortical Carcinoma. Cells 2022, 11, 1439. Cells. 2023 Sep 14;12(18):2274. doi: 10.3390/cells12182274.
Morawietz H, Brendel H, Diaba-Nuhoho P, Catar R, Perakakis N, Wolfrum C, Bornstein SR. Cross-Talk of NADPH Oxidases and Inflammation in Obesity. Antioxidants (Basel). 2023 Aug 9;12(8):1589. doi: 10.3390/antiox12081589.
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Hippich M, Holthaus L, Assfalg R, Zapardiel Gonzalo JM, Kapfelsperger H, Heigermoser M, Haupt F, Ewald DA, Welzhofer TC, Marcus BA, Heck S, Koelln A, Stock J, Voss F, Secchi M, Piemonti L, Rosa K, Protzer U, Boehmer M, Achenbach P, Lampasona V, Bonifacio E, Ziegler AG. Public health antibody screening indicates a six-fold higher SARS-CoV-2 exposure rate than reported cases in children. Med (N Y). 2020
Imam A, Winnebeck EC, Buchholz N, Froguel P, Bonnefond A, Solimena M, Ivanova A, Bouvier M, Plouffe B, Charpentier G, Karamitri A, Jockers R, Roenneberg T, Vetter C. Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study. Front Physiol. 2020
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Ziegler AG, Bonifacio E. Why is the presence of autoantibodies against GAD associated with a relatively slow progression to clinical diabetes? Diabetologia. 2020
Carrat GR, Haythorne E, Tomas A, Haataja L, Müller A, Arvan P, Piunti A, Cheng K, Huang M, Pullen TJ, Georgiadou E, Stylianides T, Amirruddin NS, Salem V, Distaso W, Cakebread A, Heesom KJ, Lewis PA, Hodson DJ, Briant LJ, Fung ACH, Sessions RB, Alpy F, Kong APS, Benke PI, Torta F, Teo AKK, Leclerc I, Solimena M, Wigley DB, Rutter GA. The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis. Mol Metab. 2020
Rubino F, Cohen RV, Mingrone G, le Roux CW, Mechanick JI, Arterburn DE, Vidal J, Alberti G, Amiel SA, Batterham RL, Bornstein S, Chamseddine G, Del Prato S, Dixon JB, Eckel RH, Hopkins D, McGowan BM, Pan A, Patel A, Pattou F, Schauer PR, Zimmet PZ, Cummings DE. Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery. Lancet Diabetes Endocrinol. 2020
Kabeza CB, Harst L, Schwarz PEH, Timpel P. A qualitative study of users' experiences after 3 months: the first Rwandan diabetes self-management Smartphone application "Kir'App". Ther Adv Endocrinol Metab. 2020
Bornstein SR, Rubino F, Khunti K, Mingrone G, Hopkins D, Birkenfeld AL, Boehm B, Amiel S, Holt RI, Skyler JS, DeVries JH, Renard E, Eckel RH, Zimmet P, Alberti KG, Vidal J, Geloneze B, Chan JC, Ji L, Ludwig B. Practical recommendations for the management of diabetes in patients with COVID-19. Lancet Diabetes Endocrinol. 2020
Panzer JK, Hiller H, Cohrs CM, Almaça J, Enos SJ, Beery M, Cechin S, Drotar DM, Weitz JR, Santini J, Huber MK, Muhammad Fahd Qadir M, Pastori RL, Domínguez-Bendala J, Phelps EA, Atkinson MA, Pugliese A, Caicedo A, Kusmartseva I, Speier S. Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis. JCI Insight. 2020
Timpel P, Lang C, Wens J, Contel JC, Schwarz PEH; MANAGE CARE Study Group. The Manage Care Model - Developing an Evidence-Based and Expert-Driven Chronic Care Management Model for Patients with Diabetes. Int J Integr Care. 2020
Cohrs CM, Panzer JK, Drotar DM, Enos SJ, Kipke N, Chen C, Bozsak R, Schöniger E, Ehehalt F, Distler M, Brennand A, Bornstein SR, Weitz J, Solimena M, Speier S. Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis. Cell Rep. 2020
Fischer T, Stumpf P, Reinhardt G, Schwarz PEH, Timpel P. Video-based smartphone app ('VIDEA bewegt') for physical activity support in German adults: a study protocol for a single-armed observational study. BMJ Open. 2020
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Timpel P, Oswald S, Schwarz PEH, Harst L. Mapping the Evidence on the Effectiveness of Telemedicine Interventions in Diabetes, Dyslipidemia, and Hypertension: An Umbrella Review of Systematic Reviews and Meta-Analyses. J Med Internet Res. 2020
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Kyrou I, Tsigos C, Mavrogianni C, Cardon G, Van Stappen V, Latomme J, Kivelä J, Wikström K, Tsochev K, Nanasi A, Semanova C, Mateo-Gallego R, Lamiquiz-Moneo I, Dafoulas G, Timpel P, Schwarz PEH, Iotova V, Tankova T, Makrilakis K, Manios Y; Feel4Diabetes-study Group. Sociodemographic and lifestyle-related risk factors for identifying vulnerable groups for type 2 diabetes: a narrative review with emphasis on data from Europe. BMC Endocr Disord. 2020
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Mirea AM, Stienstra R, Kanneganti TD, Tack CJ, Chavakis T, Toonen EJM, Joosten LAB. Mice Deficient in the IL-1β Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD. Inflammation. 2020
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Cohrs CM, Chen C, Speier S. Transplantation of Islets of Langerhans into the Anterior Chamber of the Eye for Longitudinal In Vivo Imaging. Methods Mol Biol. 2020
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Chen, C. ; Cohrs, C.M. ; Stertmann, J. ; Bozsak, R. ; Speier, S. Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis. Mol. Metab. (2017)
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Müller, A. ; Neukam, M. ; Ivanova, A. ; Sönmez, A. ; Münster, C. ; Kretschmar, S. ; Kalaidzidis, Y. ; Kurth, T. ; Verbavatz, J.-M. ; Solimena, M. A global approach for quantitative super resolution and electron microscopy on cryo and epoxy sections using self-labeling protein tags. Sci. Rep. 7:23 (2017)
Müller, A. ; Mziaut, H. ; Neukam, M. ; Knoch, K.-P. ; Solimena, M. A 4D view on insulin secretory granule turnover in the β-cell. Diabetes Obes. Metab. 19, 107-114 (2017)
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Rissanen, S. ; Grzybek, M. ; Orlowski, A. ; Róg, T. ; Cramariuc, O. ; Levental, I. ; Eggeling, C. ; Sezgin, E. ; Vattulainen, I. Phase partitioning of GM1 and its bodipy-labeled analog determine their different binding to Cholera Toxin. Front. Physiol. 8:252 (2017)
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2016
Alexaki, V.I. ; Chavakis, T. The role of innate immunity in the regulation of brown and beige adipogenesis. Rev. Endocr. Metab. Disord. 17, 41-49 (2016)
Anastasiou, V. ; Ninou, E. ; Alexopoulou, D. ; Stertmann, J. ; Müller, A. ; Dahl, A. ; Solimena, M. ; Speier, S. ; Serafimidis, I. ; Gavalas, A. Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice. Diabetologia 59, 139-150 (2016)
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Chen, C. ; Chmelova, H. ; Cohrs, C.M. ; Chouinard, J.A. ; Jahn, S. ; Stertmann, J. ; Uphues, I. ; Speier, S. Alterations in β-cell calcium dynamics and efficacy outweigh islet mass adaptation in compensation of insulin resistance and prediabetes onset. Diabetes 65, 2676-2685 (2016)
Chmelar, J. ; Chatzigeorgiou, A. ; Chung, K.-J. ; Prucnal, M. ; Voehringer, D. ; Roers, A. ; Chavakis, T. No role for mast cells in obesity-related metabolic dysregulation. Front. Immunol. 7:524 (2016)
Daniels, M.A. ; Kan, C. ; Willmes, D.M. ; Ismail, K. ; Pistrosch, F. ; Hopkins, D. ; Mingrone, G. ; Bornstein, S.R. ; Birkenfeld, A.L. Pharmacogenomics in type 2 diabetes: Oral antidiabetic drugs. Pharmacogenomics J. 16, 399-410 (2016)
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Gruetzmann, R. ; Ludwig, B. ; Weitz, J. ; Ludwig, S. Totale Pankreatektomie und Isletautotransplantation bei einem Kind mit chronisch rezidivierender Pankreatitis. Zentralbl. Chir. 141, 17-20 (2016)
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Kragl, M. ; Schubert, R. ; Karsjens, H. ; Otter, S. ; Bartosinska, B. ; Jeruschke, K. ; Weiss, J. ; Chen, C. ; Alsteens, D. ; Kuss, O. ; Speier, S. ; Eberhard, D. ; Müller, D.J. ; Lammert, E. The biomechanical properties of an epithelial tissue determine the location of its vasculature. Nat. Commun. 7:13560 (2016)
Liikanen, I. ; Tahtinen, S. ; Guse, K. ; Gutmann, T. ; Savola, P. ; Oksanen, M. ; Kanerva, A. ; Hemminki, A. Oncolytic adenovirus expressing monoclonal antibody trastuzumab for treatment of HER2-positive cancer. Mol. Cancer Ther. 15, 2259-2269 (2016)
Markmann, J.F. ; Bartlett, S.T. ; Johnson, P. ; Korsgren, O. ; Hering, B.J. ; Scharp, D. ; Kay, T.W. ; Bromberg, J. ; Odorico, J.S. ; Weir, G.C. ; Bridges, N.D. ; Kandaswamy, R. ; Stock, P. ; Friend, P. ; Gotoh, M. ; Cooper, D.K. ; Park, C.G. ; OʼConnell, P.J. ; Stäbler, C. ; Matsumoto, S. ; Ludwig, B. ; Choudhary, P. ; Khovatchev, B. ; Rickels, M.R. ; Sykes, M. ; Wood, K. ; Kraemer, K. ; Hwa, A. ; Stanley, E. ; Ricordi, C. ; Zimmerman, M. ; Greenstein, J. ; Montanya, E. ; Otonkoski, T. Executive summary of IPITA-TTS opinion leaders report on the future of β-cell replacement. Transplantation 100, E25-E31 (2016)
Morozov, V.A. ; Ludwig, S. ; Ludwig, B. ; Rotem, A. ; Barkai, U. ; Bornstein, S.R. ; Denner, J. Islet cell transplantation from Gottingen minipigs to cynomolgus monkeys: Analysis of virus safety. Xenotransplantation 23, 320-327 (2016)
Mziaut, H. ; Mulligan, B. ; Hoboth, P. ; Otto, O. ; Ivanova, A. ; Herbig, M. ; Schumann, D. ; Hildebrandt, T.B. ; Dehghany, J. ; Sönmez, A. ; Münster, C. ; Meyer-Hermann, M. ; Guck, J. ; Kalaidzidis, Y. ; Solimena, M. The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512. Mol. Metab. 5, 656-68 (2016)
Nati, M. ; Haddad, D. ; Birkenfeld, A.L. ; Koch, C.A. ; Chavakis, T. ; Chatzigeorgiou, A. The role of immune cells in metabolism-related liver inflammation and development of Non-Alcoholic Steatohepatitis (NASH). Rev. Endocr. Metab. Disord. 17, 29-39 (2016)
Raab, J. ; Haupt, F. ; Scholz, M. ; Matzke, C. ; Warncke, K. ; Lange, K. ; Assfalg, R. ; Weininger, K. ; Wittich, S. ; Löbner, S. ; Beyerlein, A. ; Nennstiel-Ratzel, U. ; Lang, M. ; Laub, O. ; Dunstheimer, D. ; Bonifacio, E. ; Achenbach, P. ; Winkler, C. ; Ziegler, A.-G. Capillary blood islet autoantibody screening for identifying pre-type 1 diabetes in the general population: Design and initial results of the Fr1da study. BMJ Open 6:e011144 (2016)
Richter, K. ; Barthel, A. ; Bornstein, S.R. ; El-Armouche, A. ; Wagner, M. PCSK9-Inhibitoren – Durchbruch bei der LDL-Cholesterin-Senkung? Dtsch. Med. Wochenschr. 141, 863-869 (2016)
Simons, K. ; Coskun, Ü. Membrane lipid galore. J. Mol. Biol. 428, 4737-4738 (2016)
Sosa, L. ; Torkko, J.M. ; Primo, M.E. ; Llovera, R.E. ; Toledo, P.L. ; Rios, A.S. ; Gonzalez Flecha, F.L. ; Trabucchi, A. ; Valdez, S.N. ; Poskus, E. ; Solimena, M. ; Ermácora, M.R. Biochemical, biophysical, and functional properties of ICA512/IA-2 RESP18 homology domain. Biochim. Biophys. Acta-Proteins Proteom. 1864, 511-522 (2016)
Struecker, B. ; Ludwig, S. ; Schmelzle, M. ; Ludwig, B. Cell transplantation for regeneration and function recovery before and after oncological resections. Onkologe 22, 478-487 (2016)
Ullrich, M. ; Bergmann, R. ; Peitzsch, M. ; Zenker, E.F. ; Cartellieri, M. ; Bachmann, M. ; Ehrhart-Bornstein, M. ; Block, N.L. ; Schally, A.V. ; Eisenhofer, G. ; Bornstein, S.R. ; Pietzsch, J. ; Ziegler, C.G. Multimodal somatostatin receptor theranostics using [64Cu]Cu-/[177Lu]Lu-DOTA-(Tyr3)octreotate and AN-238 in a mouse pheochromocytoma model. Theranostics 6, 650-665 (2016)
Ziegler, A.-G. ; Haupt, F. ; Scholz, M. ; Weininger, K. ; Wittich, S. ; Löbner, S. ; Matzke, C. ; Gezginci, C. ; Riethausen, S. ; Beyerlein, A. ; Zillmer, S. ; Amoroso, M. ; Coles, R. ; Powell, M. ; Furmaniak, J. ; Rees Smith, B. ; Winkler, C. ; Bonifacio, E. ; Achenbach, P. 3 screen ELISA for high-throughput detection of beta cell autoantibodies in capillary blood. Diabetes Technol. Ther. 18, 687-693 (2016)
2015
Balyura, M. ; Gelfgat, E. ; Ehrhart-Bornstein, M. ; Ludwig, B. ; Gendler, Z. ; Barkai, U. ; Zimerman, B. ; Rotem, A. ; Block, N.L. ; Schally, A.V. ; Bornstein, S.R. Transplantation of bovine adrenocortical cells encapsulated in alginate. Proc. Natl. Acad. Sci. U.S.A. 112, 2527-2532 (2015)
Benazra, M. ; Lecomte, M.J. ; Colace, C. ; Müller, A. ; Machado, C. ; Pechberty, S. ; Bricout-Neveu, E. ; Grenier-Godard, M. ; Solimena, M. ; Scharfmann, R. ; Czernichow, P. ; Ravassard, P. A human beta cell line with drug inducible excision of immortalizing transgenes. Mol. Metab. 4, 916-925 (2015)
Bergmann, A. ; Schwarz, P.E. Dem Diabetes davonlaufen, den Diabetes wegessen. Diabetes akt. 13, 3 (2015)
Bergmann, A. ; Schwarz, P.E. Herz im Visier. Diabetes akt. 13, 99 (2015)
Beutel, O. ; Roder, F. ; Birkholz, O. ; Rickert, C. ; Steinhoff, H. ; Grzybek, M. ; Coskun, Ü. ; Piehler, J. Two-dimensional trap for ultrasensitive quantification of transient protein interactions. ACS Nano 9, 9783-9791 (2015)
Bonifacio, E. ; Ziegler, A.-G. ; Klingensmith, G. ; Schober, E. ; Bingley, P.J. ; Rottenkolber, M. ; Theil, A. ; Eugster, A. ; Puff, R. ; Peplow, C. ; Buettner, F. ; Lange, K. ; Hasford, J. ; Achenbach, P. Effects of high-dose oral insulin on immune responses in children at high risk for type 1 diabetes: The Pre-POINT randomized clinical trial. JAMA 313, 1541-1549 (2015)
Bonifacio, E. Predicting type 1 diabetes using biomarkers. Diabetes Care 38, 989-996 (2015)
Bork, U. ; Rahbari, N.N. ; Schölch, S. ; Reissfelder, C. ; Kahlert, C. ; Büchler, M.W. ; Weitz, J. ; Koch, M. Circulating tumour cells and outcome in non-metastatic colorectal cancer: A prospective study. Br. J. Cancer 112, 1306-1313 (2015)
Brooke-Smith, M. ; Figueras, J. ; Ullah, S. ; Rees, M. ; Vauthey, J.N. ; Hugh, T.J. ; Garden, O.J. ; Fan, S.T. ; Crawford, M. ; Makuuchi, M. ; Yokoyama, Y. ; Büchler, M. ; Weitz, J. ; Padbury, R. Prospective evaluation of the International Study Group for Liver Surgery definition of bile leak after a liver resection and the role of routine operative drainage: an international multicentre study. HPB 17, 46-51 (2015)
Catar, R.A. ; Müller, G. ; Brandt, A. ; Langbein, H. ; Brunssen, C. ; Goettsch, C. ; Frenzel, A. ; Hofmann, A. ; Goettsch, W. ; Steinbronn, N. ; Strasser, R.H. ; Schubert, U. ; Ludwig, B. ; Bornstein, S.R. ; Morawietz, H. Increased gene expression of the cardiac endothelin system in obese mice. Horm. Metab. Res. 47, 509-515 (2015)
Chmelova, H. ; Cohrs, C.M. ; Chouinard, J.A. ; Petzold, C. ; Kuhn, M. ; Chen, C. ; Roeder, I. ; Kretschmer, K. ; Speier, S. Distinct roles of β-cell mass and function during type 1 diabetes onset and remission. Diabetes 64, 2148-2160 (2015)
Chmiel, R. ; Giannopoulou, E.Z. ; Winkler, C. ; Achenbach, P. ; Ziegler, A.-G. ; Bonifacio, E. Progression from single to multiple islet autoantibodies often occurs soon after seroconversion: Implications for early screening. Diabetologia 58, 411-413 (2015)
Choi, E.Y. ; Lim, J.H. ; Neuwirth, A. ; Economopoulou, M. ; Chatzigeorgiou, A. ; Chung, K.-J. ; Bittner, S. ; Lee, S.H. ; Langer, H. ; Samus, M. ; Kim, H. ; Cho, G.S. ; Ziemssen, T. ; Bdeir, K. ; Chavakis, E. ; Koh, J.Y. ; Boon, L. ; Hosur, K. ; Bornstein, S.R. ; Meuth, S.G. ; Hajishengallis, G. ; Chavakis, T. Developmental endothelial locus-1 is a homeostatic factor in the central nervous system limiting neuroinflammation and demyelination. Mol. Psychiatry 20, 880–888 (2015)
Czogalla, A. ; Kauert, D.J. ; Seidel, R. ; Schwille, P. ; Petrov, E.P. DNA origami nanoneedles on freestanding lipid membranes as a tool to observe isotropic-nematic transition in two dimensions. Nano Lett. 15, 649-655 (2015)
Dehghany, J. ; Hoboth, P. ; Ivanova, A. ; Mziaut, H. ; Müller, A. ; Kalaidzidis, Y. ; Solimena, M. ; Meyer-Hermann, M. A spatial model of insulin-granule dynamics in pancreatic β-cells. Traffic 16, 797-813 (2015)
Dopico, X.C. ; Evangelou, M. ; Ferreira, R.C. ; Guo, H. ; Pekalski, M.L. ; Smyth, D.J. ; Cooper, N. ; Burren, O.S. ; Fulford, A.J. ; Hennig, B.J. ; Prentice, A.M. ; Ziegler, A.-G. ; Bonifacio, E. ; Wallace, C. ; Todd, J.A. Widespread seasonal gene expression reveals annual differences in human immunity and physiology. Nat. Commun. 6:7000 (2015)
Ehehalt, F. ; Sturm, D. ; Rösler, M. ; Distler, M. ; Weitz, J. ; Kersting, S. ; Ludwig, B. ; Schwanebeck, U. ; Saeger, H.-D. ; Solimena, M. ; Grützmann, R. Blood glucose homeostasis in the course of partial pancreatectomy - evidence for surgically reversible diabetes induced by cholestasis. PLoS ONE 10:e0134140 (2015)
Eugster, A. ; Lindner, A. ; Catani, M. ; Heninger, A.K. ; Dahl, A. ; Klemroth, S. ; Kühn, D. ; Dietz, S. ; Bickle, M. ; Ziegler, A.-G. ; Bonifacio, E. High diversity in the TCR repertoire of GAD65 autoantigen-specific human CD4+ T cells. J. Immunol. 194, 2531-2538 (2015)
Evron, Y. ; Zimermann, B. ; Ludwig, B. ; Barkai, U. ; Colton, C.K. ; Weir, G.C. ; Arieli, B. ; Maimon, S. ; Shalev, N. ; Yavriyants, K. ; Goldman, T. ; Gendler, Z. ; Eizen, L. ; Vardi, P. ; Bloch, K. ; Barthel, A. ; Bornstein, S.R. ; Rotem, A. Oxygen supply by photosynthesis to an implantable islet cell device. Horm. Metab. Res. 47, 24-30 (2015)
Fuchs, Y.F. ; Jainta, G.W. ; Kühn, D. ; Wilhelm, C. ; Weigelt, M. ; Karasinsky, A. ; Upadhyaya, B. ; Ziegler, A.-G. ; Bonifacio, E. Vagaries of the ELISpot assay: Specific detection of antigen responsive cells requires purified CD8+ T cells and MHC class I expressing antigen presenting cell lines. Clin. Immunol. 157, 216-225 (2015)
Giannopoulou, E.Z. ; Winkler, C. ; Chmiel, R. ; Matzke, C. ; Scholz, M. ; Beyerlein, A. ; Achenbach, P. ; Bonifacio, E. ; Ziegler, A.-G. Islet autoantibody phenotypes and incidence in children at increased risk for type 1 diabetes. Diabetologia 58, 2317-2323 (2015)
Grützmann, R. ; Distler, M. ; Weitz, J. Appleby-Operation bei ausgedehntem Pankreaskorpus- und -schwanztumor – Video eines Falles. Zentralbl. Chir. 140, 151-15 (2015)
Hackert, T. ; Weitz, J. ; Büchler, M.W. Reinsertion of the gastric coronary vein to avoid venous gastric congestion in pancreatic surgery. HPB 17, 368-370 (2015)
Hamm, A. ; Prenen, H. ; van Delm, W. ; di Matteo, M. ; Wenes, M. ; Delamarre, E. ; Schmidt, T. ; Weitz, J. ; Sarmiento, R. ; Dezi, A. ; Gasparini, G. ; Rothé, F. ; Schmitz, R. ; D'Hoore, A. ; Iserentant, H. ; Hendlisz, A. ; Mazzone, M. Tumour-educated circulating monocytes are powerful candidate biomarkers for diagnosis and disease follow-up of colorectal cancer. Gut, DOI: 10.1136/gutjnl-2014-308988 (2015)
Häring, H.-U. ; Hrabě de Angelis, M. ; Joost, H.G. ; Roden, M. ; Schürmann, A. ; Solimena, M. 5 Jahre erfolgreiche translationale Forschung - Deutsches Zentrum für Diabetesforschung. Diabetes akt. 13, 58-62 (2015)
Haufe, S. ; Kaminski, J. ; Utz, W. ; Haas, V. ; Mähler, A. ; Daniels, M.A. ; Birkenfeld, A.L. ; Lichtinghagen, R. ; Luft, F.C. ; Schulz-Menger, J. ; Engeli, S. ; Jordan, J. Differential response of the natriuretic peptide system to weight loss and exercise in overweight or obese patients. J. Hypertens. 33, 1458-1464 (2015)
Hoboth, P. ; Müller, A. ; Ivanova, A. ; Mziaut, H. ; Dehghany, J. ; Sönmez, A. ; Lachnit, M. ; Meyer-Hermann, M. ; Kalaidzidis, Y. ; Solimena, M. Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies. Proc. Natl. Acad. Sci. U.S.A. 112, E667-E676 (2015)
Kahlert, C. ; Lerbs, T. ; Pecqueux, M. ; Herpel, E. ; Hoffmeister, M. ; Jansen, L. ; Brenner, H. ; Chang-Claude, J. ; Bläker, H. ; Kloor, M. ; Roth, W. ; Pilarsky, C. ; Rahbari, N.N. ; Schölch, S. ; Bork, U. ; Reissfelder, C. ; Weitz, J. ; Aust, D. ; Koch, M. Overexpression of SIX1 is an independent prognostic marker in stage I-III colorectal cancer. Int. J. Cancer 137, 2104–2113 (2015)
Kamvissi, V. ; Salerno, A. ; Bornstein, S.R. ; Mingrone, G. ; Rubino, F. Incretins or anti-incretins? A new model for the "entero-pancreatic axis". Horm. Metab. Res. 47, 84-87 (2015)
Kanczkowski, W. ; Sue, M. ; Zacharowski, K. ; Reincke, M. ; Bornstein, S.R. The role of adrenal gland microenvironment in the HPA axis function and dysfunction during sepsis. Mol. Cell. Endocrinol. 408, 241-248 (2015)
Kaszuba, K. ; Grzybek, M. ; Orłowski, A. ; Danne, R. ; Róg, T. ; Simons, K. ; Coskun, Ü. ; Vattulainen, I. N-Glycosylation as determinant of epidermal growth factor receptor conformation in membranes. Proc. Natl. Acad. Sci. U.S.A. 112, 4334–4339 (2015)
Kemppainen, K.M. ; Ardissone, A.N. ; Davis-Richardson, A.G. ; Fagen, J.R. ; Gano, K.A. ; León-Novelo, L.G. ; Vehik, K. ; Casella, G. ; Simell, O. ; Ziegler, A.-G. ; Rewers, M.J. ; Lernmark, A. ; Hagopian, W. ; She, J.X. ; Krischer, J.P. ; Akolkar, B. ; Schatz, D.A. ; Atkinson, M.A. ; Triplett, E.W. ; TEDDY Study Group (Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Hummel, S. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Roth, R. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.) Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes. Diabetes Care 38, 329-332 (2015)
Klupp, F. ; Diers, J. ; Kahlert, C. ; Neumann, L. ; Halama, N. ; Franz, C. ; Schmidt, T. ; Lasitschka, F. ; Warth, A. ; Weitz, J. ; Koch, M. ; Schneider, M. ; Ulrich, A. Expressional STAT3/STAT5 ratio is an independent prognostic marker in colon carcinoma. Ann. Surg. Oncol., DOI: 10.1245/s10434-015-4485-4 (2015)
Kourtzelis, I. ; Ferreira, A. ; Mitroulis, I. ; Ricklin, D. ; Bornstein, S.R. ; Waskow, C. ; Lambris, J.D. ; Chavakis, T. Complement inhibition in a xenogeneic model of interactions between human whole blood and porcine endothelium. Horm. Metab. Res. 47, 36-42 (2015)
Krüger, J. ; Brachs, S. ; Trappiel, M. ; Kintscher, U. ; Meyborg, H. ; Wellnhofer, E. ; Thöne-Reineke, C. ; Stawowy, P. ; Östman, A. ; Birkenfeld, A.L. ; Böhmer, F.D. ; Kappert, K. Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout mice. Mol. Metab. 4, 325-336 (2015)
Lamounier-Zepter, V. ; Look, C. ; Schunck, W.H. ; Schlottmann, I. ; Woischwill, C. ; Bornstein, S.R. ; Xu, A. ; Morano, I. Interaction of epoxyeicosatrienoic acids and adipocyte fatty acid-binding protein in the modulation of cardiomyocyte contractility. Int. J. Obes. 39, 755-761 (2015)
Lenoir, M. ; Grzybek, M. ; Majkowski, M. ; Rajesh, S. ; Kaur, J. ; Whittaker, S.B. ; Coskun, Ü. ; Overduin, M. Structural basis of dynamic membrane recognition by trans-Golgi network specific FAPP proteins. J. Mol. Biol. 427, 966-981 (2015)
Löffler, T. ; Rossion, I. ; Gooßen, K. ; Saure, D. ; Weitz, J. ; Ulrich, A. ; Büchler, M.W. ; Diener, M.K. Hand suture versus stapler for closure of loop ileostomy--a systematic review and meta-analysis of randomized controlled trials. Langenbecks Arch. Chir. 400, 193-205 (2015)
Ludwig, B. ; Reichel, A. ; Kruppa, A. ; Ludwig, S. ; Steffen, A. ; Weitz, J. ; Bornstein, S.R. Islet transplantation at the Dresden diabetes center: five years' experience. Horm. Metab. Res. 47, 4-8 (2015)
Ludwig, B. ; Ludwig, S. Transplantable bioartificial pancreas devices: Current status and future prospects. Langenbecks Arch. Surg. 400, 531-540 (2015)
Ludwig, B. Bioartifizielles Pankreas durch Inselzellverkapselung. Diabetologe 11, 558-567 (2015)
Luisoni, S. ; Suomalainen, M. ; Boucke, K. ; Tanner, L.B. ; Wenk, M.R. ; Guan, X.L. ; Grzybek, M. ; Coskun, Ü. ; Greber, U.F. Co-option of membrane wounding enables virus penetration into cells. Cell Host Microbe 18, 75-85 (2015)
Mitroulis, I. ; Alexaki, V.I. ; Kourtzelis, I. ; Ziogas, A. ; Hajishengallis, G. ; Chavakis, T. Leukocyte integrins: Role in leukocyte recruitment and as therapeutic targets in inflammatory disease. Pharmacol. Ther. 147, 123-135 (2015)
Müller, G. ; Olschewski, J. ; Stange, T. ; Hjellset, V.T. ; Bornstein, S.R. ; Schwarz, P.E. Non-invasive screening of diabetes risk by assessing abnormalities of sudomotor function. Exp. Clin. Endocrinol. Diabet. 123, 34-38 (2015)
Noguera, M.E. ; Primo, M.E. ; Jakoncic, J. ; Poskus, E. ; Solimena, M. ; Ermácora, M.R. X-ray structure of the mature ectodomain of phogrin. J. Struct. Funct. Genomics 16, 1-9 (2015)
Pers, T.H. ; Karjalainen, J.M. ; Chan, Y. ; Westra, H.J. ; Wood, A.R. ; Yang, J. ; Lui, J.C. ; Vedantam, S. ; Gustafsson, S. ; Esko, T. ; Frayling, T. ; Speliotes, E.K. ; Boehnke, M. ; Raychaudhuri, S. ; Fehrmann, R.S.N. ; Hirschhorn, J.N. ; Franke, L. Biological interpretation of genome-wide association studies using predicted gene functions. Nat. Commun. 6:5890 (2015)
Petzold, A. ; Solimena, M. ; Knoch, K.-P. Mechanisms of beta cell dysfunction associated with viral infection. Curr. Diab. Rep. 15:654 (2015)
Pistrosch, F. ; Ganz, X. ; Bornstein, S.R. ; Birkenfeld, A.L. ; Henkel, E. ; Hanefeld, M. Risk of and risk factors for hypoglycemia and associated arrhythmias in patients with type 2 diabetes and cardiovascular disease: A cohort study under real-world conditions. Acta Diabetol., DOI: 10.1007/s00592-015-0727-y (2015)
Podkalicka, J. ; Biernatowska, A. ; Majkowski, M. ; Grzybek, M. ; Sikorski, A.F. MPP1 as a factor regulating phase separation in giant plasma membrane-derived vesicles. Biophys. J. 108, 2201-2211 (2015)
Rahmig, S. ; Bornstein, S.R. ; Chavakis, T. ; Jaeckel, E. ; Waskow, C. Humanized mouse models for type 1 diabetes including pancreatic islet transplantation. Horm. Metab. Res. 47, 43-47 (2015)
Reichart, B. ; Niemann, H. ; Chavakis, T. ; Denner, J. ; Jaeckel, E. ; Ludwig, B. ; Marckmann, G. ; Schnieke, A. ; Schwinzer, R. ; Seissler, J. ; Tönjes, R.R. ; Klymiuk, N. ; Wolf, E. ; Bornstein, S.R. Xenotransplantation of porcine islet cells as a potential option for the treatment of type 1 diabetes in the future. Horm. Metab. Res. 47, 31-35 (2015)
Reissfelder, C. ; Stamova, S. ; Gossmann, C. ; Braun, M. ; Bonertz, A. ; Walliczek, U. ; Grimm, M. ; Rahbari, N.N. ; Koch, M. ; Saadati, M. ; Benner, A. ; Büchler, M.W. ; Jäger, D. ; Halama, N. ; Khazaie, K. ; Weitz, J. ; Beckhove, P. Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis. J. Clin. Invest. 125, 739-751 (2015)
Reissfelder, C. ; Stamova, S. ; Gossmann, C. ; Braun, M. ; Bonertz, A. ; Walliczek, U. ; Grimm, M. ; Rahbari, N.N. ; Koch, M. ; Saadati, M. ; Benner, A. ; Büchler, M.W. ; Jäger, D. ; Halama, N. ; Khazaie, K. ; Weitz, J. ; Beckhove, P. Corrigendum. Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis. J. Clin. Invest. 125:1364 (2015)
Saha, S. ; Bornstein, S.R. ; Graessler, J. ; Kopprasch, S. Crosstalk between glycoxidative modification of low-density lipoprotein, angiotensin II-sensitization, and adrenocortical aldosterone release. Horm. Metab. Res., DOI: 10.1055/s-0034-1395568 (2015)
Schenk, M. ; Aykut, B. ; Teske, C. ; Giese, N.A. ; Weitz, J. ; Welsch, T. Salinomycin inhibits growth of pancreatic cancer and cancer cell migration by disruption of actin stress fiber integrity. Cancer Lett. 358, 161-169 (2015)
Schirrmacher, V. ; Schlude, C. ; Weitz, J. ; Beckhove, P. Strong T‑cell costimulation can reactivate tumor antigen‑specific T cells in late‑stage metastasized colorectal carcinoma patients: Results from a phase Ⅰ clinical study. Int. J. Oncol. 46, 71-77 (2015)
Schölch, S. ; Räuber, C. ; Tietz, A. ; Rahbari, N.N. ; Bork, U. ; Schmidt, T. ; Kahlert, C. ; Haberkorn, U. ; Tomai, M.A. ; Lipson, K.E. ; Carretero, R. ; Weitz, J. ; Koch, M. ; Huber, P.E. Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors. Oncotarget 6, 4663-4676 (2015)
Schubert, N. ; Dudeck, J. ; Liu, P. ; Karutz, A. ; Speier, S. ; Maurer, M. ; Tuckermann, J.P. ; Dudeck, A. Mast cell promotion of T cell-driven antigen-induced arthritis despite being dispensable for antibody-induced arthritis in which T cells are bypassed. Arthritis Rheum. 67, 903-913 (2015)
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The influence of age and sex on genetic associations with adult body size and shape: A large-scale genome-wide interaction study. PLoS Genet. 11:e1005378 (2015)
Xie, T.Y. ; Ngo, S.T. ; Veldhuis, J.D. ; Jeffery, P.L. ; Chopin, L.K. ; Tschöp, M. ; Waters, M.J. ; Tolle, V. ; Epelbaum, J. ; Chen, C.C. ; Steyn, F.J. Effect of deletion of ghrelin-o-acyltransferase on the pulsatile release of growth hormone in mice. J. Neuroendocrinol. 27, 872-886 (2015)
Yang, C. ; Rahbari, N.N. ; Mees, S.T. ; Schaab, F. ; Koch, M. ; Weitz, J. ; Reissfelder, C. Staged resection of bilobar colorectal liver metastases: Surgical strategies. Langenbecks Arch. Surg. 400, 633-640 (2015)
Zhao, M. ; Choudhary, P. ; Srinivasan, P. ; Tang, H. ; Heaton, N. ; Fung, M. ; Barthel, A. ; Bornstein, S.R. ; Amiel, S.A. ; Huang, G.C. Modification of human islet preparation: An effective approach to improve graft outcome after islet transplantation? Horm. Metab. Res. 47, 72-77 (2015)
2014
Abe, T. ; Shin, J.T. ; Hosur, K. ; Udey, M.C. ; Chavakis, T. ; Hajishengallis, G. Regulation of osteoclast homeostasis and inflammatory bone loss by MFG-E8. J. Immunol. 193, 1383-1391 (2014)
Ansurudeen, I. ; Kopf, P.G. ; Gauthier, K.M. ; Bornstein, S.R. ; Cowley, A.W. ; Campbell, W.B. Aldosterone secretagogues increase adrenal blood flow in male rats. Endocrinology 155, 127-132 (2014)
Baessler, A. ; Lamounier-Zepter, V. ; Fenk, S. ; Strack, C. ; Lahmann, C. ; Loew, T. ; Schmitz, G. ; Blüher, M. ; Bornstein, S.R. ; Fischer, M. Adipocyte fatty acid-binding protein levels are associated with left ventricular diastolic dysfunction in morbidly obese subjects. Nutr. Diabetes 4:e106 (2014)
Ban, R.H. ; Kamvissi, V. ; Schulte, K.M. ; Bornstein, S.R. ; Rubino, F. ; Graessler, J. Lipidomic profiling at the interface of metabolic surgery and cardiovascular disease. Curr. Atheroscler. Rep. 16:455 (2014)
Bellemann, N. ; Sommer, C.M. ; Mokry, T. ; Kortes, N. ; Gnutzmann, D. ; Gockner, T. ; Schmitz, A. ; Weitz, J. ; Kauczor, H.U. ; Radeleff, B. ; Stampfl, U. Hepatic artery stent-grafts for the emergency treatment of acute bleeding. Eur. J. Radiol. 83, 1799-1803 (2014)
Beyerlein, A. ; Chmiel, R. ; Hummel, S. ; Winkler, C. ; Bonifacio, E. ; Ziegler, A.-G. Timing of gluten introduction and islet autoimmunity in young children: Updated results from the BABYDIET study. Diabetes Care 37, e194-e195 (2014)
Birkenfeld, A.L. ; Shulman, G.I. Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology 59, 713-723 (2014)
Bogusławska, D.M. ; Machnicka, B. ; Hryniewicz-Jankowska, A. ; Czogalla, A. Spectrin and phospholipids - the current picture of their fascinating interplay. Cell. Mol. Biol. Lett. 19, 158-179 (2014)
Bonifacio, E. ; Krumsiek, J. ; Winkler, C. ; Theis, F.J. ; Ziegler, A.-G. A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion. Acta Diabetol. 51, 403-411 (2014)
Borg, D.J. ; Weigelt, M. ; Wilhelm, C. ; Gerlach, M. ; Bickle, M. ; Speier, S. ; Bonifacio, E. ; Hommel, A. Mesenchymal stromal cells improve transplanted islet survival and islet function in a syngeneic mouse model. Diabetologia 57, 522-531 (2014)
Bork, U. ; Grützmann, R. ; Rahbari, N.N. ; Schölch, S. ; Distler, M. ; Reissfelder, C. ; Koch, M. ; Weitz, J. Prognostic relevance of minimal residual disease in colorectal cancer. World J. Gastroenterol. 20, 10296-10304 (2014)
Bornstein, S.R. ; Amiel, S.A. ; Rubino, F. ; Mingrone, G. ; Kamvissi, V. ; Solimena, M. ; Bonifacio, E. ; Jones, P. ; Schwarz, P. ; Birkenfeld, A.L. ; Behrens, A. ; Barthel, A. ; Lechler, R. ; Peakman, M. Creating a "Transcampus" in diabetes research between King's College London and the Technische Universität Dresden: Update on islet biology and transplantation. Horm. Metab. Res. 47, DOI: 10.1055/s-0034-1396842 (2014)
Chatzigeorgiou, A. ; Chung, K.-J. ; Garcia-Martin, R. ; Alexaki, V.I. ; Klotzsche-von Ameln, A. ; Phieler, J. ; Sprott, D. ; Kanczkowski, W. ; Tzanavari, T. ; Bdeir, M. ; Bergmann, S. ; Cartellieri, M. ; Bachmann, M. ; Nikolakopoulou, P. ; Androutsellis-Theotokis, A. ; Siegert, G. ; Bornstein, S.R. ; Muders, M.H. ; Boon, L. ; Karalis, K.P. ; Lutgens, E. ; Chavakis, T. Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation. Hepatology 60, 1196-1210 (2014)
Chatzigeorgiou, A. ; Seijkens, T. ; Zarzycka, B. ; Engel, D. ; Poggi, M. ; van den Berg, S. ; Soehnlein, O. ; Winkels, H. ; Beckers, L. ; Lievens, D. ; Driessen, A. ; Kusters, P. ; Biessen, E. ; Garcia-Martin, R. ; Klotzsche-von Ameln, A. ; Gijbels, M.J. ; Noelle, R. ; Boon, L. ; Hackeng, T.M. ; Schulte, K.M. ; Schulte, K. ; Xu, A. ; Vriend, G. ; Nabuurs, S.B. ; Chung, K.-J. ; Willems van Dijk, K. ; Rensen, P.C. ; Gerdes, N. ; de Winther, M.P. ; Block, N.L. ; Schally, A.V. ; Weber, C. ; Bornstein, S.R. ; Nicolaes, G.A.F. ; Chavakis, T. ; Lutgens, E. Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc. Natl. Acad. Sci. U.S.A. 111, 2686-2691 (2014)
Choi, T.Y. ; Ninov, N. ; Stainier, D.Y. ; Shin, D. Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish. Gastroenterology 146, 776-788 (2014)
Chung, K.-J. ; Mitroulis, I. ; Wiessner, J.R. ; Zheng, Y.Y. ; Siegert, G. ; Sperandio, M. ; Chavakis, T. A novel pathway of rapid TLR-triggered activation of integrin-dependent leukocyte adhesion that requires Rap1 GTPase. Mol. Biol. Cell 25, 2948-2955 (2014)
Czogalla, A. ; Grzybek, M. ; Jones, W. ; Coskun, Ü. Validity and applicability of membrane model systems for studying interactions of peripheral membrane proteins with lipids. Biochim. Biophys. Acta-Mol. Cell Biol. Lipids 1841, 1049-1059 (2014)
Därr, R. ; Pamporaki, C. ; Peitzsch, M. ; Miehle, K. ; Prejbisz, A. ; Peczkowska, M. ; Weismann, D. ; Beuschlein, F. ; Sinnott, R. ; Bornstein, S.R. ; Neumann, H.P. ; Januszewicz, A. ; Lenders, J.W. ; Eisenhofer, G. Biochemical diagnosis of phaeochromocytoma using plasma-free normetanephrine, metanephrine and methoxytyramine: Importance of supine sampling under fasting conditions. Clin. Endocrinol. 80, 478-486 (2014)
Distler, M. ; Kersting, S. ; Rückert, F. ; Kross, P. ; Saeger, H.-D. ; Weitz, J. ; Grützmann, R. Chronic pancreatitis of the pancreatic remnant is an independent risk factor for pancreatic fistula after distal pancreatectomy. BMC Surg. 14:54 (2014)
Distler, M. ; Aust, D. ; Weitz, J. ; Pilarsky, C. ; Grützmann, R. Precursor lesions for sporadic pancreatic cancer: PanIN, IPMN, and MCN. Biomed Res. Int. 2014:474905 (2014)
Economopoulou, M. ; Masjkur, J. ; Raiskup, F. ; Ebermann, D. ; Saha, S. ; Karl, M.O. ; Funk, R. ; Jaszai, J. ; Chavakis, T. ; Ehrhart-Bornstein, M. ; Pillunat, L.E. ; Kunz-Schughart, L.A. ; Kurth, I. ; Dubrovska, A. ; Androutsellis-Theotokis, A. Expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium. Int. J. Radiat. Biol. 90, 700-709 (2014)
Elding Larsson, H. ; Vehik, K. ; Gesualdo, P. ; Akolkar, B. ; Hagopian, W. ; Krischer, J.P. ; Lernmark, A. ; Rewers, M. ; Simell, O. ; She, J.-X. ; Ziegler, A.-G. ; Haller, M.J. ; TEDDY Study Group (Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Hummel, S. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Roth, R. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.) Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease. Pediatr. Diabetes 15, 118-126 (2014)
Endesfelder, D. ; zu Castell, W. ; Ardissone, A. ; Davis-Richardson, A.G. ; Achenbach, P. ; Hagen, M. ; Pflueger, M. ; Gano, K.A. ; Fagen, J.R. ; Drew, J.C. ; Brown, C.T. ; Kolaczkowski, B. ; Atkinson, M.J. ; Schatz, D. ; Bonifacio, E. ; Triplett, E.W. ; Ziegler, A.-G. Compromised gut microbiota networks in children with anti-islet cell autoimmunity. Diabetes 63, 2006-2014 (2014)
Ferreira, R.C. ; Guo, H. ; Coulson, R.M. ; Smyth, D.J. ; Pekalski, M.L. ; Burren, O.S. ; Cutler, A.J. ; Doecke, J.D. ; Flint, S. ; McKinney, E.F. ; Lyons, P.A. ; Smith, K.G. ; Achenbach, P. ; Beyerlein, A. ; Dunger, D.B. ; Wicker, L.S. ; Todd, J.A. ; Bonifacio, E. ; Wallace, C. ; Ziegler, A.-G. A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk of type 1 diabetes. Diabetes 63, 2538-2550 (2014)
Folprecht, G. ; Gruenberger, T. ; Bechstein, W. ; Raab, H.R. ; Weitz, J. ; Lordick, F. ; Hartmann, J.T. ; Stoehlmacher-Williams, J. ; Lang, H. ; Trarbach, T. ; Liersch, T. ; Ockert, D. ; Jaeger, D. ; Steger, U. ; Suedhoff, T. ; Rentsch, A. ; Köhne, C.H. Survival of patients with initially unresectable colorectal liver metastases treated with FOLFOX/cetuximab or FOLFIRI/cetuximab in a multidisciplinary concept (CELIM study). Ann. Oncol. 25, 1018-1025 (2014)
Folprecht, G. ; Weitz, J. ; Hoffmann, R.T. CT-morphologische Evaluation neoadjuvanter Chemotherapie. Chirurg 85, 31-36 (2014)
Franquelim, H.G. ; Linko, V. ; Czogalla, A. ; Dietz, H. ; Schwille, P. Synthetic membrane curvature-inducing DNA origami scaffolds. Biophys. J. 106:617a (2014)
Fuchs, Y.F. ; Adler, K. ; Lindner, A. ; Karasinsky, A. ; Wilhelm, C. ; Weigelt, M. ; Balke, H. ; Förtsch, K. ; Mortler-Hildebrandt, L.F. ; Harlan, D.M. ; Pechhold, K. ; Ziegler, A.-G. ; Bonifacio, E. Igrp and insulin vaccination induce CD8+ T cell mediated autoimmune diabetes in the RIP-CD80GP mouse. Clin. Exp. Immunol. 176, 199-206 (2014)
Gattu, A.K. ; Birkenfeld, A.L. ; Iwakiri, Y. ; Jay, S. ; Saltzman, M. ; Doll, J. ; Protiva, P. ; Samuel, V.T. ; Crawford, S.E. ; Chung, C. Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. Endocrinology 155, 1373-1385 (2014)
Gerl, M.J. ; Sachsenheimer, T. ; Grzybek, M. ; Coskun, Ü. ; Wieland, F.T. ; Brügger, B. Analysis of transmembrane domains and lipid modified peptides with matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. Anal. Chem. 86, 3722-3726 (2014)
Graessler, J. ; Bornstein, T.D. ; Goel, D. ; Bhalla, V.P. ; Lohmann, T. ; Wolf, T. ; Koch, M. ; Qin, Y. ; Licinio, J. ; Wong, M.L. ; Chavakis, T. ; Xu, A. ; Shevchenko, A. ; Schuhmann, K. ; Schwarz, P.E. ; Schulte, K.M. ; Patel, A. ; Bornstein, S.R. Lipidomic profiling before and after Roux-en-Y gastric bypass in obese patients with diabetes. Pharmacogenomics J. 14, 201-207 (2014)
Grützmann, R. ; Kersting, S. ; Distler, M. ; Weitz, J. Arterielle Rekonstruktion beim duktalen Pankreaskarzinom – Darstellung chirurgischer Techniken. Zentralbl. Chir. 139, 261-264 (2014)
Hackert, T. ; Weitz, J. ; Büchler, M.W. Splenic artery use for arterial reconstruction in pancreatic surgery. Langenbecks Arch. Surg. 399, 667-671 (2014)
Hajishengallis, G. ; Chavakis, T. ; Hajishengallis, E. ; Lambris, J.D. Neutrophil homeostasis and inflammation: Novel paradigms from studying periodontitis. J. Leukoc. Biol., DOI: 10.1189/jlb.3VMR1014-468R (2014)
Hanefeld, M. ; Bornstein, S.R. ; Barthel, A. Moderne medikamentöse Therapie des Typ-2-Diabetes. Dtsch. Med. Wochenschr. 139, 2494-2497 (2014)
Hummel, S. ; Vehik, K. ; Uusitalo, U. ; McLeod, W. ; Aronsson, C.A. ; Frank, N. ; Gesualdo, P. ; Yang, J. ; Norris, J.M. ; Virtanen, S.M. ; TEDDY Study Group (Ziegler, A.-G. ; Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Roth, R. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.) Infant feeding patterns in families with a diabetes history - observations from The Environmental Determinants of Diabetes in the Young (TEDDY) birth cohort study. Public Health Nutr. 17, 2853-2862 (2014)
Kahlert, C. ; Fiala, M. ; Musso, G. ; Halama, N. ; Keim, S. ; Mazzone, M. ; Lasitschka, F. ; Pecqueux, M. ; Klupp, F. ; Schmidt, T. ; Rahbari, N.N. ; Schölch, S. ; Pilarsky, C. ; Ulrich, A. ; Schneider, M. ; Weitz, J. ; Koch, M. Prognostic impact of a compartment-specific angiogenic marker profile in patients with pancreatic cancer. Oncotarget 5, 12978-12989 (2014)
Kahlert, C. ; Melo, S.A. ; Protopopov, A. ; Tang, J. ; Seth, S. ; Koch, M. ; Zhang, J. ; Weitz, J. ; Chin, L. ; Futreal, A. ; Kalluri, R. Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer. J. Biol. Chem. 289, 3869-3875 (2014)
Kibbey, R.G. ; Choi, C.S. ; Lee, H.Y. ; Cabrera, O. ; Pongratz, R.L. ; Zhao, X. ; Birkenfeld, A.L. ; Li, C. ; Berggren, P.O. ; Stanley, C. ; Shulman, G.I. Mitochondrial GTP insensitivity contributes to hypoglycemia in hyperinsulinemia hyperammonemia by inhibiting glucagon release. Diabetes 63, 4218-4229 (2014)
Kirchberg, J. ; Weitz, J. Minimalinvasive Chirurgie primärer und sekundärer Lebertumoren. Chirurg 85, 689-695 (2014)
Knoch, K.P. ; Nath-Sain, S. ; Petzold, A. ; Schneider, H. ; Beck, M. ; Wegbrod, C. ; Sönmez, A. ; Münster, C. ; Friedrich, A. ; Roivainen, M. ; Solimena, M. PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells. Mol. Metab. 3, 518-530 (2014)
Krause, S. ; Landherr, U. ; Agardh, C.-D. ; Hausmann, S. ; Link, K. ; Hansen, J.M. ; Lynch, K.F. ; Powell, M. ; Furmaniak, J. ; Rees-Smith, B. ; Bonifacio, E. ; Ziegler, A.-G. ; Lernmark, A. ; Achenbach, P. GAD autoantibody affinity in adult patients with latent autoimmune diabetes, the study participants of a GAD65 vaccination trial. Diabetes Care 37, 1675-1680 (2014)
Krause, S. ; Beyerlein, A. ; Winkler, C. ; Gavrisan, A. ; Kayser, C. ; Puff, R. ; Bonifacio, E. ; Ziegler, A.-G. ; Achenbach, P. Soluble interleukin-2 receptor alpha in preclinical type 1 diabetes. Acta Diabetol. 51, 517-518 (2014)
Krautz, C. ; Kuithan, F. ; Dobroschke, J. ; Nagel, I. ; Hartmann, S. ; Aust, D.E. ; Baretton, G. ; Weitz, J. ; Reissfelder, C. Peritoneal dissemination of a gastric API2-MALT1-positive MALT lymphoma. J. Clin. Pathol. 67, 746-748 (2014)
Lee, H.S. ; Burkhardt, B.R. ; McLeod, W. ; Smith, S. ; Eberhard, C. ; Lynch, K. ; Hadley, D. ; Rewers, M. ; Simell, O. ; She, J.X. ; Hagopian, B. ; Lernmark, A. ; Akolkar, B. ; Ziegler, A.-G. ; Krischer, J.P. ; TEDDY Study Group (Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Hummel, S. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Roth, R. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.) Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Diabetes Metab. Res. Rev. 30, 424-434 (2014)
Lee, H.Y. ; Gattu, A.K. ; Camporez, J.P. ; Kanda, S. ; Guigni, B. ; Kahn, M. ; Zhang, D. ; Galbo, T. ; Birkenfeld, A.L. ; Jornayvaz, F.R. ; Jurczak, M.J. ; Choi, C.S. ; Yan, Z. ; Williams, R.S. ; Shulman, G.I. ; Samuel, V.T. Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice. Diabetologia 57, 1232-1241 (2014)
Liang, Q. ; Zhong, L. ; Zhang, J. ; Wang, Y. ; Bornstein, S.R. ; Triggle, C.R. ; Ding, H. ; Lam, K.S. ; Xu, A. FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting. Diabetes 63, 4064-4075 (2014)
Liu, E. ; Lee, H.S. ; Aronsson, C.A. ; Hagopian, W.A. ; Koletzko, S. ; Rewers, M.J. ; Eisenbarth, G.S. ; Bingley, P.J. ; Bonifacio, E. ; Simell, V. ; Agardh, D. ; TEDDY Study Group (Ziegler, A.-G. ; Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Hummel, S. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Roth, R. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.) Risk of pediatric celiac disease according to HLA haplotype and country. N. Engl. J. Med. 371, 42-49 (2014)
Ludwig, B. ; Barthel, A. ; Reichel, A. ; Block, N.L. ; Ludwig, S. ; Schally, A.V. ; Bornstein, S.R. Modulation of the pancreatic islet-stress axis as a novel potential therapeutic target in diabetes mellitus. Vitam. Horm. 95, 195-222 (2014)
Machnicka, B. ; Czogalla, A. ; Hryniewicz-Jankowska, A. ; Bogusławska, D.M. ; Grochowalska, R. ; Heger, E. ; Sikorski, A.F. Spectrins: A structural platform for stabilization and activation of membrane channels, receptors and transporters. Biochim. Biophys. Acta-Biomembr. 1838, 620-634 (2014)
Masjkur, J. ; Arps-Forker, C. ; Poser, S.W. ; Nikolakopoulou, P. ; Toutouna, L. ; Chenna, R. ; Chavakis, T. ; Chatzigeorgiou, A. ; Chen, L.S. ; Dubrovska, A. ; Choudhary, P. ; Uphues, I. ; Mark, M. ; Bornstein, S.R. ; Androutsellis-Theotokis, A. Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release. J. Biol. Chem. 289, 35503-35516 (2014)
Masjkur, J. ; Levenfus, I. ; Lange, S. ; Arps-Forker, C. ; Poser, S.W. ; Qin, N. ; Vukicevic, V. ; Chavakis, T. ; Eisenhofer, G. ; Bornstein, S.R. ; Ehrhart-Bornstein, M. ; Androutsellis-Theotokis, A. A defined, controlled culture system for primary bovine chromaffin progenitors reveals novel biomarkers and modulators. Stem Cells Trans. Med. 3, 801-808 (2014)
Mayer, C.T. ; Lahl, K. ; Milanez-Almeida, P. ; Watts, D. ; Dittmer, U. ; Fyhrquist, N. ; Huehn, J. ; Kopf, M. ; Kretschmer, K. ; Rouse, B. ; Sparwasser, T. Advantages of Foxp3+ regulatory T cell depletion using DEREG mice. Immun. Inflamm. Dis. 2, 162-165 (2014)
Mitroulis, I. ; Kang, Y.Y. ; Gahmberg, C.G. ; Siegert, G. ; Hajishengallis, G. ; Chavakis, T. ; Choi, E.Y. Developmental endothelial locus-1 attenuates complement-dependent phagocytosis through inhibition of Mac-1-integrin. Thromb. Haemost. 111, 1004-1006 (2014)
Moutsopoulos, N.M. ; Konkel, J. ; Sarmadi, M. ; Eskan, M.A. ; Wild, T. ; Dutzan, N. ; Abusleme, L. ; Zenobia, C. ; Hosur, K.B. ; Abe, T. ; Uzel, G. ; Chen, W. ; Chavakis, T. ; Holland, S.M. ; Hajishengallis, G. Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss. Sci. Transl. Med. 6:229ra40 (2014)
Neuschäfer-Rube, F. ; Lieske, S. ; Kuna, M. ; Henkel, J. ; Perry, R.J. ; Erion, D.M. ; Pesta, D. ; Willmes, D.M. ; Brachs, S. ; von Loeffelholz, C. ; Tolkachov, A. ; Schupp, M. ; Pathe-Neuschäfer-Rube, A. ; Pfeiffer, A.F. ; Shulman, G.I. ; Püschel, G.P. ; Birkenfeld, A.L. The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes. Diabetes 63, 1048-1057 (2014)
Niebling, J. ; Rünker, A. ; Schallenberg, S. ; Kretschmer, K. ; Kempermann, G. Myelin-specific T helper 17 cells promote adult hippocampal neurogenesis through indirect mechanisms. F1000Res. 3:169 (2014)
Pamporaki, C. ; Bursztyn, M. ; Reimann, M. ; Ziemssen, T. ; Bornstein, S.R. ; Sweep, F.C. ; Timmers, H. ; Lenders, J.W. ; Eisenhofer, G. Seasonal variation in plasma free normetanephrine concentrations: Implications for biochemical diagnosis of pheochromocytoma. Eur. J. Endocrinol. 170, 349-357 (2014)
Parfentyeva, E. ; Saha, S. ; Hjellset, V.T. ; Kopprasch, S. ; Schwarz, P.E. Assessment of small C-fiber status for screening of oxidative stress in patients at risk of diabetes. Horm. Metab. Res. 46, 360-364 (2014)
Petrov, E.P. ; Czogalla, A. ; Kauert, D.J. ; Seidel, R. ; Schwille, P. Diffusion and freezing transition of rod-like DNA origami on freestanding lipid membranes. Biophys. J. 106:701a (2014)
Petzold, C. ; Steinbronn, N. ; Gereke, M. ; Strasser, R.H. ; Sparwasser, T. ; Bruder, D. ; Geffers, R. ; Schallenberg, S. ; Kretschmer, K. Fluorochrome-based definition of naturally occurring Foxp3+ regulatory T cells of intra- and extrathymic origin. Eur. J. Immunol. 44, 3632-3645 (2014)
Qin, N. ; de Cubas, A.A. ; Garcia-Martin, R. ; Richter, S. ; Peitzsch, M. ; Menschikowski, M. ; Lenders, J.W. ; Timmers, H.J. ; Mannelli, M. ; Opocher, G. ; Economopoulou, M. ; Siegert, G. ; Chavakis, T. ; Pacak, K. ; Robledo, M. ; Eisenhofer, G. Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X. Int. J. Cancer 135, 2054-2064 (2014)
Rahbari, N.N. ; Reissfelder, C. ; Schulze-Bergkamen, H. ; Jäger, D. ; Büchler, M.W. ; Weitz, J. ; Koch, M. Adjuvant therapy after resection of colorectal liver metastases: the predictive value of the MSKCC clinical risk score in the era of modern chemotherapy. BMC Cancer 14:174 (2014)
Rahbari, N.N. ; Elbers, H. ; Koch, M. ; Vogler, P. ; Striebel, F. ; Bruckner, T. ; Mehrabi, A. ; Schemmer, P. ; Büchler, M.W. ; Weitz, J. Randomized clinical trial of stapler versus clamp-crushing transection in elective liver resection. Br. J. Surg. 101, 200-207 (2014)
Reissfelder, C. ; Brand, K. ; Sobiegalla, J. ; Rahbari, N.N. ; Bork, U. ; Schirmacher, P. ; Büchler, M.W. ; Weitz, J. ; Koch, M. Chemotherapy-associated liver injury and its influence on outcome after resection of colorectal liver metastases. Surgery 155, 245-254 (2014)
Reißfelder, C. ; Kirchberg, J. ; Weitz, J. Nervenschonende offene tiefe anteriore Rektumresektion beim Rektumkarzinom. Zentralbl. Chir. 139, 381-383 (2014)
Roth, R. ; Lynch, K. ; Lernmark, B. ; Baxter, J. ; Simell, T. ; Smith, L. ; Swartling, U. ; Ziegler, A.-G. ; Johnson, S.B. ; TEDDY Study Group (Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Hummel, S. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.) Maternal anxiety about a child's diabetes risk in the TEDDY study: The potential role of life stress, postpartum depression, and risk perception. Pediatr. Diabetes 16, 287-298 (2014)
Schlottmann, I. ; Ehrhart-Bornstein, M. ; Wabitsch, M. ; Bornstein, S.R. ; Lamounier-Zepter, V. Calcium-dependent release of adipocyte fatty acid binding protein from human adipocytes. Int. J. Obes. 38, 1221-1227 (2014)
Schlueter, N. ; de Sterke, A. ; Willmes, D.M. ; Spranger, J. ; Jordan, J. ; Birkenfeld, A.L. Metabolic actions of natriuretic peptides and therapeutic potential in the metabolic syndrome. Pharmacol. Ther. 144, 12-27 (2014)
Schulte, K.M. ; Talat, N. ; Galata, G. ; Aylwin, S. ; Izatt, L. ; Eisenhofer, G. ; Barthel, A. ; Bornstein, S.R. Genetics and the clinical approach to paragangliomas. Horm. Metab. Res. 46, 964-973 (2014)
Schulte, K.M. ; Talat, N. ; Galata, G. ; Gilbert, J. ; Miell, J. ; Hofbauer, L.C. ; Barthel, A. ; Diaz-Cano, S. ; Bornstein, S.R. Oncologic resection achieving r0 margins improves disease-free survival in parathyroid cancer. Ann. Surg. Oncol. 21, 1891-1897 (2014)
Seijkens, T. ; Kusters, P. ; Chatzigeorgiou, A. ; Chavakis, T. ; Lutgens, E. Immune cell crosstalk in obesity: A key role for costimulation? Diabetes 63, 3982-3991 (2014)
Steinert, G. ; Schölch, S. ; Niemietz, T. ; Iwata, N. ; García, S.A. ; Behrens, B. ; Voigt, A. ; Kloor, M. ; Benner, A. ; Bork, U. ; Rahbari, N.N. ; Büchler, M.W. ; Stoecklein, N.H. ; Weitz, J. ; Koch, M. Immune escape and survival mechanisms in circulating tumor cells of colorectal cancer. Cancer Res. 74, 1694-1704 (2014)
Stumpp, C. ; Beyerlein, A. ; Ziegler, A.-G. ; Bonifacio, E. Neonatal and infant beta cell hormone concentrations in relation to type 1 diabetes risk. Pediatr. Diabetes 15, 528-533 (2014)
Tsourdi, E. ; Heidrich, F.M. ; Winzer, M. ; Röllig, C. ; Kirsch, C.M. ; Meinel, J. ; Baretton, G.B. ; Bornstein, S.R. ; Hofbauer, L.C. An exotic cause of exudative enteropathy. Am. J. Case Rep. 15, 226-229 (2014)
Tsuji, N. ; Ninov, N. ; Delawary, M. ; Osman, S. ; Roh, A.S. ; Gut, P. ; Stainier, D.Y. Whole organism high content screening identifies stimulators of pancreatic beta-cell proliferation. PLoS ONE 9:e104112 (2014)
Ullrich, M. ; Bergmann, R. ; Peitzsch, M. ; Cartellieri, M. ; Qin, N. ; Ehrhart-Bornstein, M. ; Block, N.L. ; Schally, A.V. ; Pietzsch, J. ; Eisenhofer, G. ; Bornstein, S.R. ; Ziegler, C.G. In vivo fluorescence imaging and urinary monoamines as surrogate biomarkers of disease progression in a mouse model of pheochromocytoma. Endocrinology 155, 4149-4156 (2014)
Vahl, J.C. ; Drees, C. ; Heger, K. ; Heink, S. ; Fischer, J.C. ; Nedjic, J. ; Ohkura, N. ; Morikawa, H. ; Poeck, H. ; Schallenberg, S. ; Rieß, D. ; Hein, M.Y. ; Buch, T. ; Polic, B. ; Schönle, A. ; Zeiser, R. ; Schmitt-Gräff, A. ; Kretschmer, K. ; Klein, L. ; Korn, T. ; Sakaguchi, S. ; Schmidt-Supprian, M. Continuous T cell receptor signals maintain a functional regulatory T cell pool. Immunity 41, 722-736 (2014)
van Noort, V. ; Schölch, S. ; Iskar, M. ; Zeller, G. ; Ostertag, K. ; Schweitzer, C. ; Werner, K. ; Weitz, J. ; Koch, M. ; Bork, P. Novel drug candidates for the treatment of metastatic colorectal cancer through global inverse gene-expression profiling. Cancer Res. 74, 5690-5699 (2014)
Volk, A. ; Rahbari, N.N. ; Koch, M. ; Weitz, J. Leistenhernienversorgung nach Lichtenstein. Zentralbl. Chir. 139, 581-582 (2014)
Walter, U. ; Kohlert, T. ; Rahbari, N.N. ; Weitz, J. ; Welsch, T. Impact of preoperative diabetes on long-term survival after curative resection of pancreatic adenocarcinoma: A systematic review and meta-analysis. Ann. Surg. Oncol. 21, 1082-1089 (2014)
Wang, Y. ; Xiao, Y. ; Zhong, L. ; Ye, D. ; Zhang, J. ; Tu, Y. ; Bornstein, S.R. ; Zhou, Z. ; Lam, K.S. ; Xu, A. Increased neutrophil elastase and proteinase 3 and augmented NETosis are closely associated with β-cell autoimmunity in patients with type 1 diabetes. Diabetes 63, 4239-4248 (2014)
Wieduwild, R. ; Lin, W. ; Boden, A. ; Kretschmer, K. ; Zhang, Y. A repertoire of peptide tags for controlled drug release from injectable noncovalent hydrogel. Biomacromolecules 15, 2058-2066 (2014)
Winkler, C. ; Krumsiek, J. ; Buettner, F. ; Angermüller, C. ; Giannopoulou, E.Z. ; Theis, F.J. ; Ziegler, A.-G. ; Bonifacio, E. Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes. Diabetologia 57, 2521-2529 (2014)
Xiao, S. ; Yosef, N. ; Yang, J. ; Wang, Y. ; Zhou, L. ; Zhu, C. ; Wu, C. ; Baloglu, E. ; Schmidt, D. ; Ramesh, R. ; Lobera, M. ; Sundrud, M.S. ; Tsai, P.Y. ; Xiang, Z. ; Wang, J. ; Xu, Y. ; Lin, X. ; Kretschmer, K. ; Rahl, P.B. ; Young, R.A. ; Zhong, Z. ; Hafler, D.A. ; Regev, A. ; Ghosh, S. ; Marson, A. ; Kuchroo, V.K. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity 40, 477-489 (2014)
Yang, J. ; Lernmark, A. ; Uusitalo, U.M. ; Lynch, K.F. ; Veijola, R. ; Winkler, C. ; Larsson, H.E. ; Rewers, M. ; She, J.X. ; Ziegler, A.-G. ; Simell, O.G. ; Hagopian, W.A. ; Akolkar, B. ; Krischer, J.P. ; Vehik, K. ; TEDDY Study Group (Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Hummel, S. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Roth, R. ; Stock, J. ; Strauss, E. ; Warncke, K.) Prevalence of obesity was related to HLA-DQ in 2-4 year old children at genetic risk for type 1 diabetes. Int. J. Obes. 38, 1491-1496 (2014)
2013
Barkai, U. ; Weir, G.C. ; Colton, C.K. ; Ludwig, B. ; Bornstein, S.R. ; Brendel, M.D. ; Neufeld, T.P. ; Bremer, C. ; Leon, A. ; Evron, Y. ; Yavriyants, K. ; Azarov, D. ; Zimermann, B. ; Maimon, S. ; Shabtay, N. ; Balyura, M. ; Rozenshtein, T. ; Vardi, P. ; Bloch, K. ; de Vos, P. ; Rotem, A. Enhanced oxygen supply improves islet viability in a new bioartificial pancreas. Cell Transplant. 22, 1463-1476 (2013)
Bauer, K. ; Nelius, N. ; Reuschenbach, M. ; Koch, M. ; Weitz, J. ; Steinert, G. ; Kopitz, J. ; Beckhove, P. ; Tariverdian, M. ; von Knebel Doeberitz, M. ; Kloor, M. T cell responses against microsatellite instability-induced frameshift peptides and influence of regulatory T cells in colorectal cancer. Cancer Immunol. Immunother. 62, 27-37 (2013)
Bonifacio, E. Targeting innate immunity in type 1 diabetes: Strike one. Lancet 381, 1880-1881 (2013)
Calvet, J.H. ; Dupin, J. ; Winiecki, H. ; Schwarz, P.E. Assessment of small fiber neuropathy through a quick, simple and non-invasive method in a German diabetes outpatient clinic. Exp. Clin. Endocrinol. Diabet. 121, 80-83 (2013)
Chatzigeorgiou, A. ; Phieler, J. ; Gebler, J. ; Bornstein, S.R. ; Chavakis, T. CD40L stimulates the crosstalk between adipocytes and inflammatory cells. Horm. Metab. Res. 45, 741-747 (2013)
Chavakis, T. ; Ehrhart-Bornstein, M. The adrenal gland in the center. Horm. Metab. Res. 45, 79-80 (2013)
Chmelar, J. ; Chung, K.-J. ; Chavakis, T. The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance. Thromb. Haemost. 109, 399-406 (2013)
Czogalla, A. ; Petrov, E.P. ; Kauert, D.J. ; Uzunova, V. ; Zhang, Y. ; Seidel, R. ; Schwille, P. Switchable domain partitioning and diffusion of DNA origami rods on membranes. Faraday Discuss. 161, 31-43 (2013)
Dekkers, T. ; Deinum, J. ; Schultzekool, L.J. ; Blondin, D. ; Vonend, O. ; Hermus, A.R. ; Peitzsch, M. ; Rump, L.C. ; Antoch, G. ; Sweep, F.C. ; Bornstein, S.R. ; Lenders, J.W. ; Willenberg, H.S. ; Eisenhofer, G. Plasma metanephrine for assessing the selectivity of adrenal venous sampling. Hypertension 62, 1152-1157 (2013)
Döcke, S. ; Lock, J.F. ; Birkenfeld, A.L. ; Hoppe, S. ; Lieske, S. ; Rieger, A. ; Raschzok, N. ; Sauer, I.M. ; Florian, S. ; Osterhoff, M.A. ; Heller, R. ; Herrmann, K. ; Lindenmüller, S. ; Horn, P. ; Bauer, M. ; Weickert, M.O. ; Neuhaus, P. ; Stockmann, M. ; Möhlig, M. ; Pfeiffer, A.F. ; von Loeffelholz, C. Elevated hepatic chemerin mRNA expression in human non-alcoholic fatty liver disease. Eur. J. Endocrinol. 169, 547-557 (2013)
Eugster, A. ; Lindner, A. ; Heninger, A.K. ; Wilhelm, C. ; Dietz, S. ; Ziegler, A.-G. ; Bonifacio, E. Measuring T cell receptor and T cell gene expression diversity in antigen-responsive human CD4+ T cells. J. Immunol. Methods 400-401, 13-22 (2013)
Ferraz, C. ; Lorenz, S. ; Wojtas, B. ; Bornstein, S.R. ; Paschke, R. ; Eszlinger, M. Inverse correlation of miRNA and cell cycle-associated genes suggests influence of miRNA on benign thyroid nodule tumorigenesis. J. Clin. Endocrinol. Metab. 98, 8-16 (2013)
Franke, K. ; Kalucka, J. ; Mamlouk, S. ; Singh, R.P. ; Muschter, A. ; Weidemann, A. ; Iyengar, V. ; Jahn, S. ; Wieczorek, K. ; Geiger, K. ; Muders, M.H. ; Sykes, A.M. ; Poitz, D.M. ; Ripich, T. ; Otto, T. ; Bergmann, S. ; Breier, G. ; Baretton, G. ; Fong, G.H. ; Greaves, D.R. ; Bornstein, S. ; Chavakis, T. ; Fandrey, J. ; Gassmann, M. ; Wielockx, B. HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis. Blood 121, 1436-1445 (2013)
Gavalas, A. ; Lan, T.H. ; Liu, Q. ; Corrêa, I.R. ; Javitch, J.A. ; Lambert, N.A. Segregation of family A G protein-coupled receptor protomers in the plasma membrane. Mol. Pharmacol. 84, 346-352 (2013)
Graessler, J. ; Qin, Y. ; Zhong, H. ; Zhang, J. ; Licinio, J. ; Wong, M.L. ; Xu, A. ; Chavakis, T. ; Bornstein, A.B. ; Ehrhart-Bornstein, M. ; Lamounier-Zepter, V. ; Lohmann, T. ; Wolf, T. ; Bornstein, S.R. Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: Correlation with inflammatory and metabolic parameters. Pharmacogenomics J. 13, 514-522 (2013)
Gräßler, J. ; Blüher, M. ; Chavakis, T. Adipositas und Inflammation. Dtsch. Med. Wochenschr. 138, 172-175 (2013)
Gräßler, J. ; Kopprasch, S. ; Passauer, J. ; Fischer, S. ; Schuhmann, K. ; Bergmann, S. ; Siegert, G. ; Shevchenko, A. ; Bornstein, S.R. ; Julius, U. Differential effects of lipoprotein apheresis by lipidfiltration or dextran sulfate adsorption on lipidomic profile. Atherosclerosis 14, 151-155 (2013)
Hajishengallis, G. ; Chavakis, T. Endogenous modulators of inflammatory cell recruitment. Trends Immunol. 34, 1-6 (2013)
Haufe, S. ; Haas, V. ; Utz, W. ; Birkenfeld, A.L. ; Jeran, S. ; Böhnke, J. ; Mähler, A. ; Luft, F.C. ; Schulz-Menger, J. ; Boschmann, M. ; Jordan, J. ; Engeli, S. Long-lasting improvements in liver fat and metabolism despite body weight regain after dietary weight loss. Diabetes Care 36, 3786-3792 (2013)
Heninger, A.K. ; Monti, P. ; Wilhelm, C. ; Schwaiger, P. ; Kuehn, D. ; Ziegler, A.-G. ; Bonifacio, E. Activation of islet autoreactive naive T cells in infants is influenced by homeostatic mechanisms and antigen presenting capacity. Diabetes 62, 2059-2066 (2013)
Hohenstein, B. ; Bornstein, S.R. ; Aringer, M. Immunoadsorption for connective tissue disease. Atherosclerosis 14, 185-189 (2013)
Ilegems, E. ; Dicker, A. ; Speier, S. ; Sharma, A. ; Bahow, A. ; Edlund, P.K. ; Leibiger, I.B. ; Berggren, P.O. Reporter islets in the eye reveal the plasticity of the endocrine pancreas. Proc. Natl. Acad. Sci. U.S.A. 110, 20581-20586 (2013)
Ioannou, M. ; Serafimidis, I. ; Arnes, L. ; Sussel, L. ; Singh, S. ; Vasiliou, V. ; Gavalas, A. ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools. Dev. Biol. 374, 153-163 (2013)
Ivanova, A. ; Kalaidzidis, Y. ; Dirkx, R. ; Sarov, M. ; Gerlach, M. ; Schroth-Diez, B. ; Müller, A. ; Liu, Y. ; Andree, C. ; Mulligan, B. ; Münster, C. ; Kurth, T. ; Bickle, M. ; Speier, S. ; Anastassiadis, K. ; Solimena, M. Age-dependent labeling and imaging of insulin secretory granules. Diabetes 62, 3687-3696 (2013)
Julius, U. ; Taseva, K. ; Fischer, S. ; Passauer, J. ; Bornstein, S.R. Current situation of lipoprotein apheresis in Saxony. Atherosclerosis 14, 51-55 (2013)
Kanczkowski, W. ; Alexaki, V.I. ; Tran, N. ; Großklaus, S. ; Zacharowski, K. ; Martinez, A. ; Popovics, P. ; Block, N.L. ; Chavakis, T. ; Schally, A.V. ; Bornstein, S.R. Hypothalamo-pituitary and immune-dependent adrenal regulation during systemic inflammation. Proc. Natl. Acad. Sci. U.S.A. 110, 14801-14806 (2013)
Kanczkowski, W. ; Chatzigeorgiou, A. ; Grossklaus, S. ; Sprott, D. ; Bornstein, S.R. ; Chavakis, T. Role of the endothelial-derived endogenous anti-inflammatory factor Del-1 in inflammation-mediated adrenal gland dysfunction. Endocrinology 154, 1181-1189 (2013)
Kanczkowski, W. ; Chatzigeorgiou, A. ; Samus, M. ; Tran, N. ; Zacharowski, K. ; Chavakis, T. ; Bornstein, S.R. Characterization of the LPS-induced inflammation of the adrenal gland in mice. Mol. Cell. Endocrinol. 371, 228-235 (2013)
Klotzsche-von Ameln, A. ; Prade, I. ; Grosser, M. ; Kettelhake, A. ; Rezaei, M. ; Chavakis, T. ; Flamme, I. ; Wielockx, B. ; Breier, G. PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-α. Mol. Cancer Res. 11, 1337-1348 (2013)
Kopprasch, S. ; Bornstein, S.R. ; Schwarz, P.E. ; Bergmann, S. ; Julius, U. ; Graessler, J. Single whole blood dextran sulfate adsorption favorably affects systemic oxidative balance in lipoprotein apheresis patients. Atherosclerosis 14, 157-160 (2013)
Korten, S. ; Brunssen, C. ; Poitz, D.M. ; Großklaus, S. ; Brux, M. ; Schnittler, H.J. ; Strasser, R.H. ; Bornstein, S.R. ; Morawietz, H. ; Goettsch, W. Impact of Hey2 and COUP-TFII on genes involved in arteriovenous differentiation in primary human arterial and venous endothelial cells. Basic Res. Cardiol. 108:362 (2013)
Krautz, C. ; Wolk, S. ; Steffen, A. ; Knoch, K.P. ; Ceglarek, U. ; Thiery, J. ; Bornstein, S. ; Saeger, H.-D. ; Solimena, M. ; Kersting, S. Effects of immunosuppression on alpha and beta cell renewal in transplanted mouse islets. Diabetologia 56, 1596-1604 (2013)
Kumashiro, N. ; Beddow, S.A. ; Vatner, D.F. ; Majumdar, S.K. ; Cantley, J.L. ; Guebre-Egziabher, F. ; Fat, I. ; Guigni, B. ; Jurczak, M.J. ; Birkenfeld, A.L. ; Kahn, M. ; Perler, B.K. ; Puchowicz, M.A. ; Manchem, V.P. ; Bhanot, S. ; Still, C.D. ; Gerhard, G.S. ; Petersen, K.F. ; Cline, G.W. ; Shulman, G.I. ; Samuel, V.T. Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance. Diabetes 62, 2183-2194 (2013)
Lamounier-Zepter, V. ; Look, C. ; Ehrhart-Bornstein, M. ; Bornstein, S.R. ; Fischer, S. ; Julius, U. Lipoprotein apheresis reduces adipocyte fatty acid-binding protein serum levels. Atherosclerosis 14, 129-134 (2013)
Langer, H.F. ; Chavakis, T. Platelets and neurovascular inflammation. Thromb. Haemost. 110, 888-893 (2013)
Lee, H.S. ; Briese, T. ; Winkler, C. ; Rewers, M. ; Bonifacio, E. ; Hyoty, H. ; Pflueger, M. ; Simell, O. ; She, J.X. ; Hagopian, W. ; Lernmark, A. ; Akolkar, B. ; Krischer, J.P. ; Ziegler, A.-G. ; TEDDY Study Group Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes. Diabetologia 56, 1705-1711 (2013)
Leinster, D.A. ; Colom, B. ; Whiteford, J.R. ; Ennis, D.P. ; Lockley, M. ; McNeish, I.A. ; Aurrand-Lions, M. ; Chavakis, T. ; Imhof, B.A. ; Balkwill, F.R. ; Nourshargh, S. Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer. FASEB J. 27, 4244-4253 (2013)
Lin, Z. ; Tian, H. ; Lam, K.S. ; Lin, S. ; Hoo, R.C. ; Konishi, M. ; Itoh, N. ; Wang, Y. ; Bornstein, S.R. ; Xu, A. ; Li, X. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab. 17, 779-789 (2013)
Löffler, M.G. ; Birkenfeld, A.L. ; Philbrick, K.M. ; Belman, J.P. ; Habtemichael, E.N. ; Booth, C.J. ; Castorena, C.M. ; Choi, C.S. ; Jornayvaz, F.R. ; Gassaway, B.M. ; Lee, H.Y. ; Cartee, G.D. ; Philbrick, W. ; Shulman, G.I. ; Samuel, V.T. ; Bogan, J.S. Enhanced fasting glucose turnover in mice with disrupted action of TUG protein in skeletal muscle. J. Biol. Chem. 288, 20135-20150 (2013)
Ludwig, B. ; Reichel, A. ; Steffen, A. ; Zimerman, B. ; Schally, A.V. ; Block, N.L. ; Colton, C.K. ; Ludwig, S. ; Kersting, S. ; Bonifacio, E. ; Solimena, M. ; Gendler, Z. ; Rotem, A. ; Barkai, U. ; Bornstein, S.R. Transplantation of human islets without immunosuppression. Proc. Natl. Acad. Sci. U.S.A. 110, 19054-19058 (2013)
Magro, M.G. ; Solimena, M. Regulation of β-cell function by RNA-binding proteins. Mol. Metab. 2, 348-355 (2013)
Maliga, Z. ; Junqueira, M. ; Toyoda, Y. ; Ettinger, A. ; Mora-Bermudez, F. ; Klemm, R.W. ; Vasilj, A. ; Guhr, E. ; Ibarlucea-Benitez, I. ; Poser, I. ; Bonifacio, E. ; Huttner, W.B. ; Shevchenko, A. ; Hyman, A.A. A genomic toolkit to investigate kinesin and myosin motor function in cells. Nat. Cell Biol. 15, 325-334 (2013)
Marciniak, A. ; Selck, C. ; Friedrich, B. ; Speier, S. Mouse pancreas tissue slice culture facilitates long-term studies of exocrine and endocrine cell physiology in situ. PLoS ONE 8:e78706 (2013)
Monti, P. ; Brigatti, C. ; Krasmann, M. ; Ziegler, A.-G. ; Bonifacio, E. Concentration and activity of the soluble form of the interleukin-7 receptor α in type I diabetes identifies an interplay between hyperglycemia and immune function. Diabetes 62, 2500-2508 (2013)
Morawietz, H. ; Goettsch, W. ; Brux, M. ; Reimann, M. ; Bornstein, S.R. ; Julius, U. ; Ziemssen, T. Lipoprotein apheresis of hypercholesterolemic patients mediates vasoprotective gene expression in human endothelial cells. Atherosclerosis 14, 107-113 (2013)
Müller, G. ; Parfentyeva, E. ; Olschewsky, J. ; Bornstein, S.R. ; Schwarz, P.E. Assessment of small fiber neuropathy to predict future risk of type 2 diabetes. Prim. Care Diabetes 7, 269-273 (2013)
Müller, G. ; Weser, G. ; Schwarz, P.E. The European perspective of diabetes prevention: The need for individualization of diabetes prevention. J. Endocrinol. Invest. 36, 352-357 (2013)
Neufeld, T.P. ; Ludwig, B. ; Barkai, U. ; Weir, G.C. ; Colton, C.K. ; Evron, Y. ; Balyura, M. ; Yavriyants, K. ; Zimermann, B. ; Azarov, D. ; Maimon, S. ; Shabtay, N. ; Rozenshtein, T. ; Lorber, D. ; Steffen, A. ; Willenz, U. ; Bloch, K. ; Vardi, P. ; Taube, R. ; de Vos, P. ; Lewis, E.C. ; Bornstein, S.R. ; Rotem, A. The efficacy of an immunoisolating membrane system for islet xenotransplantation in minipigs. PLoS ONE 8:e70150 (2013)
Ninov, N. ; Hesselson, D. ; Gut, P. ; Zhou, A. ; Fidelin, K. ; Stainier, D.Y. Metabolic regulation of cellular plasticity in the pancreas. Curr. Biol. 23, 1242-1250 (2013)
Palm, W. ; Swierczynska, M.M. ; Kumari, V. ; Ehrhart-Bornstein, M. ; Bornstein, S.R. ; Eaton, S. Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals. PLoS Biol. 11:e1001505 (2013)
Pamporaki, C. ; Därr, R. ; Bursztyn, M. ; Glöckner, S. ; Bornstein, S.R. ; Lenders, J.W. ; Pacak, K. ; Krinner, A. ; Eisenhofer, G. Plasma-free vs deconjugated metanephrines for diagnosis of phaeochromocytoma. Clin. Endocrinol. 79, 476-483 (2013)
Petrowski, K. ; Wintermann, G.B. ; Schaarschmidt, M. ; Bornstein, S.R. ; Kirschbaum, C. Blunted salivary and plasma cortisol response in patients with panic disorder under psychosocial stress. Int. J. Psychophysiol. 88, 35-39 (2013)
Petzold, C. ; Riewaldt, J. ; Watts, D. ; Sparwasser, T. ; Schallenberg, S. ; Kretschmer, K. Foxp3+ regulatory T cells in mouse models of type 1 diabetes. J. Diabetes Res. 2013:940710 (2013)
Phieler, J. ; Chung, K.-J. ; Chatzigeorgiou, A. ; Klotzsche-von Ameln, A. ; Garcia-Martin, R. ; Sprott, D. ; Moisidou, M. ; Tzanavari, T. ; Ludwig, B. ; Baraban, E. ; Ehrhart-Bornstein, M. ; Bornstein, S.R. ; Mziaut, H. ; Solimena, M. ; Karalis, K.P. ; Economopoulou, M. ; Lambris, J.D. ; Chavakis, T. The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance. J. Immunol. 191, 4367-4374 (2013)
Phieler, J. ; Garcia-Martin, R. ; Lambris, J.D. ; Chavakis, T. The role of the complement system in metabolic organs and metabolic diseases. Semin. Immunol. 25, 47-53 (2013)
Piemonti, L. ; Everly, M.J. ; Maffi, P. ; Scavini, M. ; Poli, F. ; Nano, R. ; Cardillo, M. ; Melzi, R. ; Mercalli, A. ; Sordi, V. ; Lampasona, V. ; Espadas de Arias, A. ; Scalamogna, M. ; Bosi, E. ; Bonifacio, E. ; Secchi, A. ; Terasaki, P.I. Alloantibody and autoantibody monitoring predicts islet transplantation outcome in human type 1 diabetes. Diabetes 62, 1656-1664 (2013)
Reichel, A. ; Rietzsch, H. ; Ludwig, B. ; Röthig, K. ; Moritz, A. ; Bornstein, S.R. Self-adjustment of insulin dose using graphically depicted self-monitoring of blood glucose measurements in patients with type 1 diabetes mellitus. J. Diabetes Sci. Technol. 7, 156-162 (2013)
Reimann, M. ; Julius, U. ; Bornstein, S.R. ; Fischer, S. ; Reichmann, H. ; Rüdiger, H. ; Ziemssen, T. Regular lipoprotein apheresis maintains residual cardiovascular and microvascular function in patients with advanced atherosclerotic disease. Atherosclerosis 14, 135-141 (2013)
Ringers, J. ; van der Torren, C.R. ; van de Linde, P. ; van der Boog, P.J. ; Mallat, M.J. ; Bonifacio, E. ; Roep, B.O. ; de Fijter, J.W. Pretransplantation GAD-autoantibody status to guide prophylactic antibody induction therapy in simultaneous pancreas and kidney transplantation. Transplantation 96, 745-752 (2013)
Ritter, P.S. ; Kretschmer, K. ; Pfennig, A. ; Soltmann, B. Disturbed sleep in bipolar disorder is related to an elevation of IL-6 in peripheral monocytes. Med. Hypotheses 81, 1031-1033 (2013)
Saha, S. ; Graessler, J. ; Bornstein, S.R. ; Schwarz, P.E. ; Kopprasch, S. Stimulation of phagocyte adhesion to endothelial cells by modified VLDL and HDL requires scavenger receptor BI. Mol. Cell. Biochem. 383, 21-28 (2013)
Saha, S. ; Schwarz, P.E. ; Bergmann, S. ; Bornstein, S.R. ; Graessler, J. ; Kopprasch, S. Circulating very-low-density lipoprotein from subjects with impaired glucose tolerance accelerates adrenocortical cortisol and aldosterone synthesis. Horm. Metab. Res. 45, 169-172 (2013)
Schatz, U. ; Arneth, B. ; Siegert, G. ; Siegels, D. ; Fischer, S. ; Julius, U. ; Bornstein, S.R. Iron deficiency and its management in patients undergoing lipoprotein apheresis. Comparison of two parenteral iron formulations. Atherosclerosis 14, 115-122 (2013)
Schöfl, C. ; Franz, H. ; Grussendorf, M. ; Honegger, J. ; Jaursch-Hancke, C. ; Mayr, B. ; Schopohl, J. Long-term outcome in patients with acromegaly: Analysis of 1344 patients from the German Acromegaly Register. Eur. J. Endocrinol. 168, 39-47 (2013)
Schubert, U. ; Schmid, J. ; Lehmann, S. ; Zhang, X.Y. ; Morawietz, H. ; Block, N.L. ; Kanczkowski, W. ; Schally, A.V. ; Bornstein, S.R. ; Ludwig, B. Transplantation of pancreatic islets to adrenal gland is promoted by agonists of growth-hormone-releasing hormone. Proc. Natl. Acad. Sci. U.S.A. 110, 2288-2293 (2013)
Schwarz, P.E. ; Gallein, G. ; Ebermann, D. ; Müller, A. ; Lindner, A. ; Rothe, U. ; Nebel, I.T. ; Müller, G. Global Diabetes Survey - an annual report on quality of diabetes care. Diabetes Res. Clin. Pract. 100, 11-18 (2013)
Shin, J.T. ; Hosur, K.B. ; Pyaram, K. ; Jotwani, R. ; Liang, S. ; Chavakis, T. ; Hajishengallis, G. Expression and function of the homeostatic molecule Del-1 in endothelial cells and the periodontal tissue. Clin. Dev. Immunol. 2013:617809 (2013)
Singh, R.P. ; Franke, K. ; Kalucka, J. ; Mamlouk, S. ; Muschter, A. ; Gembarska, A. ; Grinenko, T. ; Willam, C. ; Naumann, R. ; Anastassiadis, K. ; Stewart, A.F. ; Bornstein, S.R. ; Chavakis, T. ; Breier, G. ; Waskow, C. ; Wielockx, B. HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress. Blood 121, 5158-5166 (2013)
Stalder, T. ; Kirschbaum, C. ; Alexander, N. ; Bornstein, S.R. ; Gao, W. ; Miller, R. ; Stark, S. ; Bosch, J.A. ; Fischer, J.E. Cortisol in hair and the metabolic syndrome. J. Clin. Endocrinol. Metab. 98, 2573-2580 (2013)
Sturm, D. ; Marselli, L. ; Ehehalt, F. ; Richter, D. ; Distler, M. ; Kersting, S. ; Grützmann, R. ; Bokvist, K. ; Froguel, P. ; Liechti, R. ; Jörns, A. ; Meda, P. ; Baretton, G.B. ; Saeger, H.-D. ; Schulte, A.M. ; Marchetti, P. ; Solimena, M. Improved protocol for laser microdissection of human pancreatic islets from surgical specimens. J. Vis. Exp. 71:e50231 (2013)
Swierczynska, M.M. ; Lamounier-Zepter, V. ; Bornstein, S.R. ; Eaton, S. Lipoproteins and Hedgehog signalling - possible implications for the adrenal gland function. Eur. J. Clin. Invest. 43, 1178-1183 (2013)
Taseva, K. ; Fischer, S. ; Passauer, J. ; Weiss, N. ; Bornstein, S.R. ; Julius, U. Factors inducing cardiovascular events in patients treated by lipoprotein apheresis. Atherosclerosis 14, 45-50 (2013)
Tausche, A.K. ; Gehrisch, S. ; Panzner, I. ; Winzer, M. ; Range, U. ; Bornstein, S.R. ; Siegert, G. ; Wunderlich, C. ; Aringer, M. A 3-day delay in synovial fluid crystal identification did not hinder the reliable detection of monosodium urate and calcium pyrophosphate crystals. J. Clin. Rheumatol. 19, 241-245 (2013)
Toker, A. ; Engelbert, D. ; Garg, G. ; Polansky, J.K. ; Floess, S. ; Miyao, T. ; Baron, U. ; Düber, S. ; Geffers, R. ; Giehr, P. ; Schallenberg, S. ; Kretschmer, K. ; Olek, S. ; Walter, J. ; Weiss, S. ; Hori, S. ; Hamann, A. ; Huehn, J. Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus. J. Immunol. 190, 3180-3188 (2013)
Toporkiewicz, M. ; Grzybek, M. ; Meissner, J. ; Michalczyk, I. ; Dubielecka, P.M. ; Korycka, J. ; Seweryn, E. ; Sikorski, A.F. Release of an ~55kDa fragment containing the actin-binding domain of β-spectrin by caspase-8 during FND-induced apoptosis depends on the presence of protein 4.1. Arch. Biochem. Biophys. 535, 205-213 (2013)
Tsourdi, E. ; Barthel, A. ; Rietzsch, H. ; Reichel, A. ; Bornstein, S.R. Current aspects in the pathophysiology and treatment of chronic wounds in diabetes mellitus. Biomed Res. Int. 2013:385641 (2013)
Ullmann, E. ; Barthel, A. ; Licinio, J. ; Petrowski, K. ; Bornstein, S.R. ; Strauß, B. Increased rate of depression and psychosomatic symptoms in Jewish migrants from the post-Soviet-Union to Germany in the 3rd generation after the Shoa. Transl. Psychiatry 3:e241 (2013)
von Dryander, M. ; Fischer, S. ; Passauer, J. ; Müller, G. ; Bornstein, S.R. ; Julius, U. Differences in the atherogenic risk of patients treated by lipoprotein apheresis according to their lipid pattern. Atherosclerosis 14, 39-44 (2013)
Willmes, D.M. ; Birkenfeld, A.L. The role of INDY in metabolic regulation. Comp. Struc. Biotech. J. 6:e201303020 (2013)
Ziegler, A.-G. ; Rewers, M. ; Simell, O. ; Simell, T. ; Lempainen, J. ; Steck, A. ; Winkler, C. ; Ilonen, J. ; Veijola, R. ; Knip, M. ; Bonifacio, E. ; Eisenbarth, G.S. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 309, 2473-2479 (2013)
Ziegler, C.G. ; Ullrich, M. ; Schally, A.V. ; Bergmann, R. ; Pietzsch, J. ; Gebauer, L. ; Gondek, K. ; Qin, N. ; Pacak, K. ; Ehrhart-Bornstein, M. ; Eisenhofer, G. ; Bornstein, S.R. Anti-tumor effects of peptide analogs targeting neuropeptide hormone receptors on mouse pheochromocytoma cells. Mol. Cell. Endocrinol. 371, 189-194 (2013)