Publications of the PLID since 2013
2023
Gado M, Heinrich A, Wiedersich D, Sameith K, Dahl A, Alexaki VI, Swarbrick MM, Baschant U, Grafe I, Perakakis N, Bornstein SR, Rauner M, Hofbauer LC, Henneicke H. Activation of beta-adrenergic receptor signaling prevents glucocorticoid-induced obesity and adipose tissue dysfunction in male mice. Am J Physiol Endocrinol Metab. 2023
Chavakis T, Alexaki VI, Ferrante AW Jr. Macrophage function in adipose tissue homeostasis and metabolic inflammation. Nat Immunol. 2023
Hoffmann C, Schwarz PE, Mantzoros CS, Birkenfeld AL, Wolfrum C, Solimena M, Bornstein SR, Perakakis N. Circulating levels of gastrointestinal hormones in prediabetes reversing to normoglycemia or progressing to diabetes in a year-A cross-sectional and prospective analysis. Diabetes Res Clin Pract. 2023
Steenblock C, Toepfner N, Beuschlein F, Perakakis N, Mohan Anjana R, Mohan V, Mahapatra NR, Bornstein SR. SARS-CoV-2 infection and its effects on the endocrine system. Best Pract Res Clin Endocrinol Metab. 2023
Amponsah-Offeh M, Diaba-Nuhoho P, Speier S, Morawietz H. Oxidative Stress, Antioxidants and Hypertension. Antioxidants (Basel). 2023
Subramanian P, Chavakis T. The complex function of macrophages and their subpopulations in metabolic injury associated fatty liver disease. J Physiol. 2023
Broadaway KA, Yin X, Williamson A, Parsons VA, Wilson EP, Moxley AH, Vadlamudi S, Varshney A, Jackson AU, Ahuja V, Bornstein SR, Corbin LJ, Delgado GE, Dwivedi OP, Silva LF, Frayling TM, Grallert H, Gustafsson S, Hakaste L, Hammar U, Herder C, Herrmann S, Højlund K, Hughes DA, Kleber ME, Lindgren CM, Liu CT, Luan J, Malmberg A, Moissl AP, Morris AP, Perakakis N, Peters A, Petrie JR, Roden M, Schwarz PEH, Sharma S, Silveira A, Strawbridge RJ, Tuomi T, Wood AR, Wu P, Zethelius B, Baldassarre D, Eriksson JG, Fall T, Florez JC, Fritsche A, Gigante B, Hamsten A, Kajantie E, Laakso M, Lahti J, Lawlor DA, Lind L, März W, Meigs JB, Sundström J, Timpson NJ, Wagner R, Walker M, Wareham NJ, Watkins H, Barroso I, O'Rahilly S, Grarup N, Parker SC, Boehnke M, Langenberg C, Wheeler E, Mohlke KL. Loci for insulin processing and secretion provide insight into type 2 diabetes risk. Am J Hum Genet. 2023
Beydag-Tasöz BS, Yennek S, Grapin-Botton A. Towards a better understanding of diabetes mellitus using organoid models. Nat Rev Endocrinol. 2023
Mahmood L, Gonzalez-Gil EM, Makrilakis K, Liatis S, Schwarz P, Herrmann S, Willems R, Cardon G, Latomme J, Rurik I, Radó S, Iotova V, Usheva N, Tankova T, Karaglani E, Manios Y, Moreno LA; Feel4Diabetes-Study Group. Cross-sectional and longitudinal associations between family meals frequency and children's overweight/obesity in families at high risk of type 2 diabetes: The Feel4Diabetes-study. Pediatr Obes. 2023
2022
Eugster A, Müller D, Gompf A, Reinhardt S, Lindner A, Ashton M, Zimmermann N, Beissert S, Bonifacio E, Günther C. Corrigendum: A novel type I interferon primed dendritic cell subpopulation in TREX1 mutant chilblain lupus patients. Front Immunol. 2022 Grapin-Botton A, Kim YH. Pancreas organoid models of development and regeneration. Development. 2022
Katsumoto K, Yennek S, Chen C, Silva LFD, Traikov S, Sever D, Azad A, Shan J, Vainio S, Ninov N, Speier S, Grapin-Botton A. Wnt4 is heterogeneously activated in maturing β-cells to control calcium signaling, metabolism and function. Nat Commun. 2022
Warncke K, Weiss A, Achenbach P, von dem Berge T, Berner R, Casteels K, Groele L, Hatzikotoulas K, Hommel A, Kordonouri O, Elding Larsson H, Lundgren M, Marcus BA, Snape MD, Szypowska A, Todd JA, Bonifacio E, Ziegler AG; GPPAD and POInT Study Groups. Elevations in blood glucose before and after the appearance of islet autoantibodies in children. J Clin Invest. 2022
Riquelme-Guzmán C, Tsai SL, Carreon Paz K, Nguyen C, Oriola D, Schuez M, Brugués J, Currie JD, Sandoval-Guzmán T. Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration. Elife. 2022
Weiss A, Zapardiel-Gonzalo J, Voss F, Jolink M, Stock J, Haupt F, Kick K, Welzhofer T, Heublein A, Winkler C, Achenbach P, Ziegler AG, Bonifacio E; Fr1da-study group. Correction to: Progression likelihood score identifies substages of presymptomatic type 1 diabetes in childhood public health screening. Diabetologia. 2022
Simonetti M, Yilmazer A, Kretschmer K. Genetic Tools for Analyzing Foxp3+ Treg Cells: Fluorochrome-Based Transcriptional Reporters and Genetic Fate-Mapping. Methods Mol Biol. 2022
Tritschler S, Thomas M, Böttcher A, Ludwig B, Schmid J, Schubert U, Kemter E, Wolf E, Lickert H, Theis FJ. A transcriptional cross species map of pancreatic islet cells. Mol Metab. 2022
Tonnus W, Maremonti F, Belavgeni A, Latk M, Kusunoki Y, Brucker A, von Mässenhausen A, Meyer C, Locke S, Gembardt F, Beer K, Hoppenz P, Becker JU, Hugo C, Anders HJ, Bornstein SR, Shao F, Linkermann A. Gasdermin D-deficient mice are hypersensitive to acute kidney injury. Cell Death Dis. 2022
Weiss A, Zapardiel-Gonzalo J, Voss F, Jolink M, Stock J, Haupt F, Kick K, Welzhofer T, Heublein A, Winkler C, Achenbach P, Ziegler AG, Bonifacio E; Fr1da-study group. Progression likelihood score identifies substages of presymptomatic type 1 diabetes in childhood public health screening. Diabetologia. 2022
Ellis JL, Evason KJ, Zhang C, Fourman MN, Liu J, Ninov N, Delous M, Vanhollebeke B, Fiddes I, Otis JP, Houvras Y, Farber SA, Xu X, Lin X, Stainier DYR, Yin C. A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish. Hepatol Commun. 2022
Gloyn AL, Ibberson M, Marchetti P, Powers AC, Rorsman P, Sander M, Solimena M. Every islet matters: improving the impact of human islet research. Nat Metab. 2022
Asplund O, Storm P, Chandra V, Hatem G, Ottosson-Laakso E, Mansour-Aly D, Krus U, Ibrahim H, Ahlqvist E, Tuomi T, Renström E, Korsgren O, Wierup N, Ibberson M, Solimena M, Marchetti P, Wollheim C, Artner I, Mulder H, Hansson O, Otonkoski T, Groop L, Prasad RB. Islet Gene View-a tool to facilitate islet research. Life Sci Alliance. 2022
Perakakis N, Barthel A, Bornstein SR. The Role of Endocrine and Metabolic System in COVID-19 Disease - The Transcampus Experience and Review of Evidence From International Collaborating Groups. Horm Metab Res. 2022
Bakhti M, Bastidas-Ponce A, Tritschler S, Czarnecki O, Tarquis-Medina M, Nedvedova E, Jaki J, Willmann SJ, Scheibner K, Cota P, Salinno C, Boldt K, Horn N, Ueffing M, Burtscher I, Theis FJ, Coskun Ü, Lickert H. Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis. Nat Commun. 2022
Eugster A, Müller D, Gompf A, Reinhardt S, Lindner A, Ashton M, Zimmermann N, Beissert S, Bonifacio E, Günther C. A Novel Type I Interferon Primed Dendritic Cell Subpopulation in TREX1 Mutant Chilblain Lupus Patients. Front Immunol. 2022
Subramanian P, Hampe J, Tacke F, Chavakis T. Fibrogenic Pathways in Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD). Int J Mol Sci. 2022
Duin S, Bhandarkar S, Lehmann S, Kemter E, Wolf E, Gelinsky M, Ludwig B, Lode A. Viability and Functionality of Neonatal Porcine Islet-like Cell Clusters Bioprinted in Alginate-Based Bioinks. Biomedicines. 2022
Patsenker E, Thangapandi VR, Knittelfelder O, Palladini A, Hefti M, Beil-Wagner J, Rogler G, Buch T, Shevchenko A, Hampe J, Stickel F. The PNPLA3 variant I148M reveals protective effects toward hepatocellular carcinoma in mice via restoration of omega-3 polyunsaturated fats. J Nutr Biochem. 2022
Stefan N, Sippel K, Heni M, Fritsche A, Wagner R, Jakob CEM, Preißl H, von Werder A, Khodamoradi Y, Borgmann S, Rüthrich MM, Hanses F, Haselberger M, Piepel C, Hower M, Vom Dahl J, Wille K, Römmele C, Vehreschild J, Stecher M, Solimena M, Roden M, Schürmann A, Gallwitz B, Hrabe de Angelis M, Ludwig DS, Schulze MB, Jensen BEO, Birkenfeld AL. Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry. Front Med (Lausanne). 2022
Rohner M, Schwarz PEH, Bornstein SR. Treating Insulin Resistance with Intermittent Personalized Nutrition to Sustain Metabolic Health and Functioning Immune System for Risk Reduction of Viral Diseases Especially COVID-19 and Long-COVID. Horm Metab Res. 2022
Ludwig S, Distler M, Schubert U, Schmid J, Thies H, Welsch T, Hempel S, Tonn T, Weitz J, Bornstein SR, Ludwig B. Quality of life and metabolic outcomes after total pancreatectomy and simultaneous islet autotransplantation. Commun Med (Lond). 2022
Kübler IC, Kretzschmar J, Brankatschk M, Sandoval-Guzmán T. Local problems need global solutions: The metabolic needs of regenerating organisms. Wound Repair Regen. 2022
Bornstein SR, Ludwig B, Steenblock C. Progress in islet transplantation is more important than ever. Nat Rev Endocrinol. 2022
Bretschneider MP, Klásek J, Karbanová M, Timpel P, Herrmann S, Schwarz PEH. Impact of a Digital Lifestyle Intervention on Diabetes Self-Management: A Pilot Study. Nutrients. 2022
Zielmann ML, Jolink M, Winkler C, Eugster A, Müller D, Scholz M, Ziegler AG, Bonifacio E. Autoantibodies against ATP4A are a feature of the abundant autoimmunity that develops in first-degree relatives of patients with type 1 diabetes. Pediatr Diabetes. 2022
Rehn M, Wenzel A, Frank AK, Schuster MB, Pundhir S, Jørgensen N, Vitting-Seerup K, Ge Y, Jendholm J, Michaut M, Schoof EM, Jensen TL, Rapin N, Sapio RT, Andersen KL, Lund AH, Solimena M, Holzenberger M, Pestov DG, Porse BT. PTBP1 promotes hematopoietic stem cell maintenance and red blood cell development by ensuring sufficient availability of ribosomal constituents. Cell Rep. 2022
Nakamura A, Wong YF, Venturato A, Michaut M, Venkateswaran S, Santra M, Gonçalves C, Larsen M, Leuschner M, Kim YH, Brickman J, Bradley M, Grapin-Botton A. Long-term feeder-free culture of human pancreatic progenitors on fibronectin or matrix-free polymer potentiates β cell differentiation. Stem Cell Reports. 2022
Xiong X, Blakely A, Kim JH, Menting JG, Schäfer IB, Schubert HL, Agrawal R, Gutmann T, Delaine C, Zhang YW, Artik GO, Merriman A, Eckert D, Lawrence MC, Coskun Ü, Fisher SJ, Forbes BE, Safavi-Hemami H, Hill CP, Chou DH. Symmetric and asymmetric receptor conformation continuum induced by a new insulin. Nat Chem Biol. 2022
Belavgeni A, Maremonti F, Stadtmüller M, Bornstein SR, Linkermann A. Schwann cell necroptosis in diabetic neuropathy. Proc Natl Acad Sci U S A. 2022
Grapin-Botton A, Ludwig B. Stem cell-derived β cells go in monkeys. Cell Stem Cell. 2022
Subramanian P, Gargani S, Palladini A, Chatzimike M, Grzybek M, Peitzsch M, Papanastasiou AD, Pyrina I, Ntafis V, Gercken B, Lesche M, Petzold A, Sinha A, Nati M, Thangapandi VR, Kourtzelis I, Andreadou M, Witt A, Dahl A, Burkhardt R, Haase R, Domingues AMJ, Henry I, Zamboni N, Mirtschink P, Chung KJ, Hampe J, Coskun Ü, Kontoyiannis DL, Chavakis T. The RNA binding protein human antigen R is a gatekeeper of liver homeostasis. Hepatology. 2022
Mahmood L, González-Gil EM, Schwarz P, Herrmann S, Karaglani E, Cardon G, De Vylder F, Willems R, Makrilakis K, Liatis S, Iotova V, Tsochev K, Tankova T, Rurik I, Radó S, Moreno LA, Manios Y; Feel4Diabetes-Study Group. Frequency of family meals and food consumption in families at high risk of type 2 diabetes: the Feel4Diabetes-study. Eur J Pediatr. 2022
Pazur K, Giannios I, Lesche M, Rodriguez-Aznar E, Gavalas A. Hoxb1 Regulates Distinct Signaling Pathways in Neuromesodermal and Hindbrain Progenitors to Promote Cell Survival and Specification. Stem Cells. 2022
Xiong X, Blakely A, Kim JH, Menting JG, Schäfer IB, Schubert HL, Agrawal R, Gutmann T, Delaine C, Zhang YW, Artik GO, Merriman A, Eckert D, Lawrence MC, Coskun Ü, Fisher SJ, Forbes BE, Safavi-Hemami H, Hill CP, Chou DH. Symmetric and asymmetric receptor conformation continuum induced by a new insulin. Nat Chem Biol. 2022
Tonnus W, Locke S, Meyer C, Maremonti F, Eggert L, von Mässenhausen A, Bornstein SR, Green DR, Linkermann A. Rubicon-deficiency sensitizes mice to mixed lineage kinase domain-like (MLKL)-mediated kidney ischemia-reperfusion injury. Cell Death Dis. 2022
Kraus G, Weigelt M, Reinhardt S, Petzold A, Dahl A, Bonifacio E. Reproducibility of 10x Genomics single cell RNA sequencing method in the immune cell environment. J Immunol Methods. 2022
Reinhardt J, Sharma V, Stavridou A, Lindner A, Reinhardt S, Petzold A, Lesche M, Rost F, Bonifacio E, Eugster A. Distinguishing activated T regulatory cell and T conventional cells by single-cell technologies. Immunology. 2022
Fritsche L, Hummel J, Wagner R, Löffler D, Hartkopf J, Machann J, Hilberath J, Kantartzis K, Jakubowski P, Pauluschke-Fröhlich J, Brucker S, Hörber S, Häring HU, Roden M, Schürmann A, Solimena M, de Angelis MH, Peter A, Birkenfeld AL, Preissl H, Fritsche A, Heni M. The German Gestational Diabetes Study (PREG), a prospective multicentre cohort study: rationale, methodology and design. BMJ Open. 2022
von Mässenhausen A, Zamora Gonzalez N, Maremonti F, Belavgeni A, Tonnus W, Meyer C, Beer K, Hannani MT, Lau A, Peitzsch M, Hoppenz P, Locke S, Chavakis T, Kramann R, Muruve DA, Hugo C, Bornstein SR, Linkermann A. Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion. Sci Adv. 2022
Hempel S, Oehme F, Ehehalt F, Solimena M, Kolbinger FR, Bogner A, Welsch T, Weitz J, Distler M. The Impact of Pancreatic Head Resection on Blood Glucose Homeostasis in Patients with Chronic Pancreatitis. J Clin Med. 2022
Singh SP, Chawla P, Hnatiuk A, Kamel M, Silva LD, Spanjaard B, Eski SE, Janjuha S, Olivares-Chauvet P, Kayisoglu O, Rost F, Bläsche J, Kränkel A, Petzold A, Kurth T, Reinhardt S, Junker JP, Ninov N. A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish. Development. 2022
Steenblock C, Schwarz PEH, Perakakis N, Brajshori N, Beqiri P, Bornstein SR. The interface of COVID-19, diabetes, and depression. Discov Ment Health. 2022
2021
Ziegler AG, Danne T, Daniel C, Bonifacio E. 100 Years of Insulin: Lifesaver, immune target, and potential remedy for prevention. Med (N Y). 2021
Goveas N, Waskow C, Arndt K, Heuberger J, Zhang Q, Alexopoulou D, Dahl A, Birchmeier W, Anastassiadis K, Stewart AF, Kranz A. MLL1 is required for maintenance of intestinal stem cells. PLoS Genet. 2021
Reinhardt G, Timpel P, Schwarz PEH, Harst L. Long-Term Effects of a Video-Based Smartphone App ("VIDEA Bewegt") to Increase the Physical Activity of German Adults: A Single-Armed Observational Follow-Up Study. Nutrients. 2021
Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV Jr, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF. Publisher Correction: An open-access volume electron microscopy atlas of whole cells and tissues. Nature. 2021
von Herrath M, Bonifacio E. How benign autoimmunity becomes detrimental in type 1 diabetes. Proc Natl Acad Sci U S A. 2021
Wagner R, Eckstein SS, Yamazaki H, Gerst F, Machann J, Jaghutriz BA, Schürmann A, Solimena M, Singer S, Königsrainer A, Birkenfeld AL, Häring HU, Fritsche A, Ullrich S, Heni M. Metabolic implications of pancreatic fat accumulation. Nat Rev Endocrinol. 2021
Delgadillo-Silva LF, Akhtar MN, Taşöz E, Ninov N. Simultaneous Calcium Imaging and Glucose Stimulation in Living Zebrafish to Investigate In Vivo β-Cell Function. J Vis Exp. 2021
Steenblock C, Schwarz PEH, Ludwig B, Linkermann A, Zimmet P, Kulebyakin K, Tkachuk VA, Markov AG, Lehnert H, de Angelis MH, Rietzsch H, Rodionov RN, Khunti K, Hopkins D, Birkenfeld AL, Boehm B, Holt RIG, Skyler JS, DeVries JH, Renard E, Eckel RH, Alberti KGMM, Geloneze B, Chan JC, Mbanya JC, Onyegbutulem HC, Ramachandran A, Basit A, Hassanein M, Bewick G, Spinas GA, Beuschlein F, Landgraf R, Rubino F, Mingrone G, Bornstein SR. COVID-19 and metabolic disease: mechanisms and clinical management. Lancet Diabetes Endocrinol. 2021
Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV Jr, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF. An open-access volume electron microscopy atlas of whole cells and tissues. Nature. 2021
Holthaus L, Sharma V, Brandt D, Ziegler AG, Jastroch M, Bonifacio E. Functional and metabolic fitness of human CD4+ T lymphocytes during metabolic stress. Life Sci Alliance. 2021
Pinter A, Schwarz P, Gerdes S, Simon JC, Saalbach A, Rush J, Melzer N, Kramps T, Häberle B, Reinhardt M. Biologic Treatment in Combination with Lifestyle Intervention in Moderate to Severe Plaque Psoriasis and Concomitant Metabolic Syndrome: Rationale and Methodology of the METABOLyx Randomized Controlled Clinical Trial. Nutrients. 2021
Subramanian P, Gargani S, Palladini A, Chatzimike M, Grzybek M, Peitzsch M, Papanastasiou AD, Pyrina I, Ntafis V, Gercken B, Lesche M, Petzold A, Sinha A, Nati M, Thangapandi VR, Kourtzelis I, Andreadou M, Witt A, Dahl A, Burkhardt R, Haase R, Domingues AMJ, Henry I, Zamboni N, Mirtschink P, Chung KJ, Hampe J, Coskun Ü, Kontoyiannis DL, Chavakis T. The RNA binding protein HuR is a gatekeeper of liver homeostasis. Hepatology. 2021
Nati M, Chung KJ, Chavakis T. The Role of Innate Immune Cells in Nonalcoholic Fatty Liver Disease. J Innate Immun. 2021
Kemter E, Müller A, Neukam M, Ivanova A, Klymiuk N, Renner S, Yang K, Broichhagen J, Kurome M, Zakhartchenko V, Kessler B, Knoch KP, Bickle M, Ludwig B, Johnsson K, Lickert H, Kurth T, Wolf E, Solimena M. Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs. Proc Natl Acad Sci U S A. 2021
Watts D, Janßen M, Jaykar M, Palmucci F, Weigelt M, Petzold C, Hommel A, Sparwasser T, Bonifacio E, Kretschmer K. Transient Depletion of Foxp3+ Regulatory T Cells Selectively Promotes Aggressive β Cell Autoimmunity in Genetically Susceptible DEREG Mice. Front Immunol. 2021
Spears E, Serafimidis I, Powers AC, Gavalas A. Debates in Pancreatic Beta Cell Biology: Proliferation Versus Progenitor Differentiation and Transdifferentiation in Restoring β Cell Mass. Front Endocrinol (Lausanne). 2021
Vvedenskaya O, Rose TD, Knittelfelder O, Palladini A, Wodke JAH, Schumann K, Ackerman JM, Wang Y, Has C, Brosch M, Thangapandi VR, Buch S, Züllig T, Hartler J, Köfeler HC, Röcken C, Coskun Ü, Klipp E, von Schoenfels W, Gross J, Schafmayer C, Hampe J, Pauling JK, Shevchenko A. Non-alcoholic fatty liver disease Stratification by Liver Lipidomics. J Lipid Res. 2021
Tonnus W, Meyer C, Steinebach C, Belavgeni A, von Mässenhausen A, Gonzalez NZ, Maremonti F, Gembardt F, Himmerkus N, Latk M, Locke S, Marschner J, Li W, Short S, Doll S, Ingold I, Proneth B, Daniel C, Kabgani N, Kramann R, Motika S, Hergenrother PJ, Bornstein SR, Hugo C, Becker JU, Amann K, Anders HJ, Kreisel D, Pratt D, Gütschow M, Conrad M, Linkermann A. Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury. Nat Commun. 2021
Schumann T, König J, von Loeffelholz C, Vatner DF, Zhang D, Perry RJ, Bernier M, Chami J, Henke C, Kurzbach A, El-Agroudy NN, Willmes DM, Pesta D, de Cabo R, O Sullivan JF, Simon E, Shulman GI, Hamilton BS, Birkenfeld AL. Publisher Correction: Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Commun Biol. 2021
Willems R, Tsoutsoulopoulou K, Brondeel R, Cardon G, Makrilakis K, Liatis S, Lindström J, Kivelä J, González-Gil EM, Giménez-Legarre N, Usheva N, Iotova V, Tankova T, Antal E, Rurik I, Timpel P, Schwarz PEH, Manios Y, Annemans L. Cost-effectiveness analysis of a school- and community-based intervention to promote a healthy lifestyle and prevent type 2 diabetes in vulnerable families across Europe: the Feel4Diabetes-study. Prev Med. 2021
Schumann T, König J, von Loeffelholz C, Vatner DF, Zhang D, Perry RJ, Bernier M, Chami J, Henke C, Kurzbach A, El-Agroudy NN, Willmes DM, Pesta D, de Cabo R, O Sullivan JF, Simon E, Shulman GI, Hamilton BS, Birkenfeld AL. Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Commun Biol. 2021
Janke U, Mitlehner A, Weide A, Gutmann T, Delcea M. Reconstitution of Functional Integrin αIIbβ3 and Its Activation in Plasma Membrane-Mimetic Lipid Environments. Membranes (Basel). 2021
Wigger L, Barovic M, Brunner AD, Marzetta F, Schöniger E, Mehl F, Kipke N, Friedland D, Burdet F, Kessler C, Lesche M, Thorens B, Bonifacio E, Legido-Quigley C, Barbier Saint Hilaire P, Delerive P, Dahl A, Klose C, Gerl MJ, Simons K, Aust D, Weitz J, Distler M, Schulte AM, Mann M, Ibberson M, Solimena M. Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes. Nat Metab. 2021
Bornstein SR, Voit-Bak K, Donate T, Rodionov RN, Gainetdinov RR, Tselmin S, Kanczkowski W, Müller GM, Achleitner M, Wang J, Licinio J, Bauer M, Young AH, Thuret S, Bechmann N, Straube R. Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis? Mol Psychiatry. 2021
Sormendi S, Deygas M, Sinha A, Bernard M, Krüger A, Kourtzelis I, Le Lay G, Sáez PJ, Gerlach M, Franke K, Meneses A, Kräter M, Palladini A, Guck J, Coskun Ü, Chavakis T, Vargas P, Wielockx B. HIF2α is a direct regulator of neutrophil motility. Blood. 2021
Steenblock C, Richter S, Berger I, Barovic M, Schmid J, Schubert U, Jarzebska N, von Mässenhausen A, Linkermann A, Schürmann A, Pablik J, Dienemann T, Evert K, Rodionov RN, Semenova NY, Zinserling VA, Gainetdinov RR, Baretton G, Lindemann D, Solimena M, Ludwig B, Bornstein SR. Viral infiltration of pancreatic islets in patients with COVID-19. Nat Commun. 2021
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Serafimidis, I. ; Rodriguez-Aznar, E. ; Lesche, M. ; Yoshioka, K. ; Takuwa, Y. ; Dahl, A. ; Pan, D. ; Gavalas, A. Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling. PLoS Biol. 15:e2000949 (2017)
Singh, S.P. ; Janjuha, S. ; Hartmann, T. ; Kayisoglu, O. ; Konantz, J. ; Birke, S. ; Murawala, P. ; Alfar, E.A. ; Murata, K. ; Eugster, A. ; Tsuji, N. ; Morrissey, E.R. ; Brand, M. ; Ninov, N. Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth. Nat. Commun. 8:664 (2017)
Solimena, M. ; Schulte, A.M. ; Marselli, L. ; Ehehalt, F. ; Richter, D. ; Kleeberg, M. ; Mziaut, H. ; Knoch, K.-P. ; Parnis, J. ; Bugliani, M. ; Siddiq, A. ; Jörns, A. ; Burdet, F. ; Liechti, R. ; Suleiman, M. ; Margerie, D. ; Syed, F. ; Distler, M. ; Grützmann, R. ; Petretto, E. ; Moreno-Moral, A. ; Wegbrod, C. ; Sönmez, A. ; Pfriem, K. ; Friedrich, A. ; Meinel, J. ; Wollheim, C.B. ; Baretton, G.B. ; Scharfmann, R. ; Nogoceke, E. ; Bonifacio, E. ; Sturm, D. ; Meyer-Puttlitz, B. ; Boggi, U. ; Saeger, H.-D. ; Filipponi, F. ; Lesche, M. ; Meda, P. ; Dahl, A. ; Wigger, L. ; Xenarios, I. ; Falchi, M. ; Thorens, B. ; Weitz, J. ; Bokvist, K. ; Lenzen, S. ; Rutter, G.A. ; Froguel, P. ; von Bülow, M. ; Ibberson, M. ; Marchetti, P. Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes. Diabetologia, 1-17 (2017)
Stefanko, A. ; Thiede, C. ; Ehninger, G. ; Simons, K. ; Grzybek, M. Lipidomic approach for stratification of acute myeloid leukemia patients. PLoS ONE 12:e0168781 (2017)
Steffen, A. ; Kiss, T. ; Schmid, J. ; Schubert, U. ; Heinke, S. ; Lehmann, S. ; Bornstein, S.R. ; Ludwig, B. ; Ludwig, S. Production of high-quality islets from goettingen minipigs: Choice of organ preservation solution, donor pool, and optimal cold ischemia time. Xenotransplantation 24:e12284 (2017)
Steringer, J.P. ; Lange, S. ; Čujová, S. ; Šachl, R. ; Poojari, C. ; Lolicato, F. ; Beutel, O. ; Müller, H.M. ; Unger, S. ; Coskun, Ü. ; Honigmann, A. ; Vattulainen, I. ; Hof, M. ; Freund, C. ; Nickel, W. Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components. eLife 6:e28985 (2017)
von Bibra, H. ; Saha, S. ; Hapfelmeier, A. ; Mueller, G. ; Schwarz, P.E. Impact of the triglyceride/high-density lipoprotein cholesterol ratio and the hypertriglyceremic-waist phenotype to predict the metabolic syndrome and insulin resistance. Horm. Metab. Res. 49, 542-549 (2017)
von Loeffelholz, C. ; Lieske, S. ; Neuschäfer-Rube, F. ; Willmes, D.M. ; Raschzok, N. ; Sauer, I.M. ; König, J. ; Fromm, M. ; Horn, P. ; Chatzigeorgiou, A. ; Pathe-Neuschäfer-Rube, A. ; Jordan, J. ; Pfeiffer, A.F.H. ; Mingrone, G. ; Bornstein, S.R. ; Ströhle, P. ; Harms, C. ; Wunderlich, F.T. ; Helfand, S.L. ; Bernier, M. ; de Cabo, R. ; Shulman, G.I. ; Chavakis, T. ; Püschel, G.P. ; Birkenfeld, A.L. The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism. Hepatology 66, 616-630 (2017)
Weitz, J.R. ; Makhmutova, M. ; Almaça, J. ; Stertmann, J. ; Aamodt, K. ; Brissova, M. ; Speier, S. ; Rodriguez-Diaz, R. ; Caicedo, A. Mouse pancreatic islet macrophages use locally released ATP to monitor beta cell activity. Diabetologia 61, 1-11 (2017)
Willmes, D.M. ; Kurzbach, A. ; Henke, C. ; Zahn, G. ; Heifetz, A. ; Jordan, J. ; Helfand, S.L. ; Birkenfeld, A.L. The longevity gene INDY (I'm Not Dead Yet) in metabolic control: Potential as pharmacological target. Pharmacol. Ther., DOI: 10.1016/j.pharmthera.2017.10.003 (2017)
2016
Alexaki, V.I. ; Chavakis, T. The role of innate immunity in the regulation of brown and beige adipogenesis. Rev. Endocr. Metab. Disord. 17, 41-49 (2016)
Anastasiou, V. ; Ninou, E. ; Alexopoulou, D. ; Stertmann, J. ; Müller, A. ; Dahl, A. ; Solimena, M. ; Speier, S. ; Serafimidis, I. ; Gavalas, A. Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice. Diabetologia 59, 139-150 (2016)
Bader, E. ; Migliorini, A. ; Gegg, M. ; Moruzzi, N. ; Gerdes, J.M. ; Roscioni, S. ; Bakhti, M. ; Brandl, E. ; Irmler, M. ; Beckers, J. ; Aichler, M. ; Feuchtinger, A. ; Leitzinger, C. ; Zischka, H. ; Wang-Sattler, R. ; Jastroch, M. ; Tschöp, M. ; Machicao, F. ; Staiger, H. ; Häring, H.-U. ; Chmelova, H. ; Chouinard, J.A. ; Oskolkov, N. ; Korsgren, O. ; Speier, S. ; Lickert, H. Identification of proliferative and mature β-cells in the islets of Langerhans. Nature 535, 430-434 (2016)
Catani, M. ; Walther, D. ; Christie, M.R. ; McLaughlin, K.A. ; Bonifacio, E. ; Eugster, A. Isolation of human monoclonal autoantibodies derived from pancreatic lymph node and peripheral blood B cells of islet autoantibody-positive patients. Diabetologia 59, 294-298 (2016)
Chen, C. ; Chmelova, H. ; Cohrs, C.M. ; Chouinard, J.A. ; Jahn, S. ; Stertmann, J. ; Uphues, I. ; Speier, S. Alterations in β-cell calcium dynamics and efficacy outweigh islet mass adaptation in compensation of insulin resistance and prediabetes onset. Diabetes 65, 2676-2685 (2016)
Chmelar, J. ; Chatzigeorgiou, A. ; Chung, K.-J. ; Prucnal, M. ; Voehringer, D. ; Roers, A. ; Chavakis, T. No role for mast cells in obesity-related metabolic dysregulation. Front. Immunol. 7:524 (2016)
Daniels, M.A. ; Kan, C. ; Willmes, D.M. ; Ismail, K. ; Pistrosch, F. ; Hopkins, D. ; Mingrone, G. ; Bornstein, S.R. ; Birkenfeld, A.L. Pharmacogenomics in type 2 diabetes: Oral antidiabetic drugs. Pharmacogenomics J. 16, 399-410 (2016)
Ehret, G.B. ; Ferreira, T. ; Chasman, D.I. ; Jackson, A.U. ; Schmidt, E.M. ; Johnson, T. ; Thorleifsson, G. ; Luan, J. ; Donnelly, L.A. ; Kanoni, S. ; Petersen, A.-K. ; Pihur, V. ; Strawbridge, R.J. ; Shungin, D. ; Hughes, M.F. ; Meirelles, O. ; Kaakinen, M. ; Bouatia-Naji, N. ; Kristiansson, K. ; Shah, S. ; Kleber, M.E. ; Guo, X. ; Lyytikäinen, L.P. ; Fava, C. ; Eriksson, N. ; Nolte, I.M. ; Magnusson, P.K. ; Salfati, E.L. ; Rallidis, L.S. ; Theusch, E. ; Smith, A.J. ; Folkersen, L. ; Witkowska, K. ; Pers, T.H. ; Joehanes, R. ; Kim, S.K. ; Lataniotis, L. ; Jansen, R. ; Johnson, A.D. ; Warren, H. ; Kim, Y.J. ; Zhao, W. ; Wu, Y. ; Tayo, B.O. ; Bochud, M. ; Absher, D. ; Adair, L.S. ; Amin, N. ; Arking, D.E. ; Axelsson, T. ; Baldassarre, D. ; Balkau, B. ; Bandinelli, S. ; Barnes, M.R. ; Barroso, I. ; Bevan, S. ; Bis, J.C. ; Bjornsdottir, G. ; Boehnke, M. ; Boerwinkle, E. ; Bonnycastle, L.L. ; Boomsma, D.I. ; Bornstein, S. ; Brown, M.J. ; Burnier, M. ; Cabrera, C.P. ; Chambers, J.C. ; Chang, I.S. ; Cheng, C.Y. ; Chines, P.S. ; Chung, R.H. ; Collins, F.S. ; Connell, J.M. ; Döring, A. ; Dallongeville, J. ; Danesh, J. ; de Faire, U. ; Delgado, G. ; Dominiczak, A.F. ; Doney, A.S. ; Drenos, F. ; Edkins, S. ; Eicher, J.D. ; Elosua, R. ; Enroth, S. ; Erdmann, J. ; Eriksson, P. ; Esko, T. ; Evangelou, E. ; Evans, A. ; Fall, T. ; Farrall, M. ; Felix, J.F. ; Ferrieres, J. ; Ferrucci, L. ; Fornage, M. ; Forrester, T. ; Franceschini, N. ; Franco, O.H. ; Franco-Cereceda, A. ; Fraser, R.M. ; Ganesh, S.K. ; Gao, H. ; Gertow, K. ; Gianfagna, F. ; Gigante, B. ; Giulianini, F. ; Goel, A. ; Goodall, A.H. ; Goodarzi, M.O. ; Gorski, M. ; Gräßler, J. ; Groves, C.J. ; Gudnason, V. ; Gyllensten, U. ; Hallmans, G. ; Hartikainen, A.L. ; Hassinen, M. ; Havulinna, A.S. ; Hayward, C. ; Hercberg, S. ; Herzig, K.H. ; Hicks, A.A. ; Hingorani, A.D. ; Hirschhorn, J.N. ; Hofman, A. ; Holmen, J. ; Holmen, O.L. ; Hottenga, J.J. ; Howard, P. ; Hsiung, C.A. ; Hunt, S.C. ; Ikram, M.A. ; Illig, T. ; Iribarren, C. ; Jensen, R.A. ; Kähönen, M. ; Kang, H.M. ; Kathiresan, S. ; Keating, B.J. ; Khaw, K.T. ; Kim, Y.K. ; Kim, E. ; Kivimaki, M. ; Klopp, N. ; Kolovou, G. ; Komulainen, P. ; Kooner, J.S. ; Kosova, G. ; Krauss, R.M. ; Kuh, D. ; Kutalik, Z. ; Kuusisto, J. ; Kvaløy, K. ; Lakka, T.A. ; Lee, N.R. ; Lee, I.T. ; Lee, W.J. ; Levy, D. ; Li, X. ; Liang, K.W. ; Lin, H. ; Lin, L. ; Lindstrom, J. ; Lobbens, S. ; Männisto, S. ; Müller, G. ; Müller-Nurasyid, M. ; Mach, F. ; Markus, H.S. ; Marouli, E. ; McCarthy, M.I. ; McKenzie, C.A. ; Meneton, P. ; Menni, C. ; Metspalu, A. ; Mijatovic, V. ; Moilanen, L. ; Montasser, M.E. ; Morris, A.D. ; Morrison, A.C. ; Mulas, A. ; Nagaraja, R. ; Narisu, N. ; Nikus, K. ; O'Donnell, C.J. ; O'Reilly, P.F. ; Ong, K.K. ; Paccaud, F. ; Palmer, C.D. ; Parsa, A. ; Pedersen, N.L. ; Penninx, B.W. ; Perola, M. ; Peters, A. ; Poulter, N. ; Pramstaller, P.P. ; Psaty, B.M. ; Quertermous, T. ; Rao, D.C. ; Rasheed, A. ; Rayner, N.W. ; Renström, F. ; Rettig, R. ; Rice, K.M. ; Roberts, R. ; Rose, L.M. ; Rossouw, J. ; Samani, N.J. ; Sanna, S. ; Saramies, J. ; Schunkert, H. ; Sebert, S. ; Sheu, W.H. ; Shin, Y.A. ; Sim, X. ; Smit, J.H. ; Smith, A.V. ; Sosa, M.X. ; Spector, T.D. ; Stancáková, A. ; Stanton, A.V. ; Stirrups, K.E. ; Stringham, H.M. ; Sundström, J. ; Swift, A.J. ; Syvanen, A.C. ; Tai, E.S. ; Tanaka, T. ; Tarasov, K.V. ; Teumer, A. ; Thorsteinsdottir, U. ; Tobin, M.D. ; Tremoli, E. ; Uitterlinden, A.G. ; Uusitupa, M. ; Vaez, A. ; Vaidya, D. ; van Duijn, C.M. ; van Iperen, E.P. ; Vasan, R.S. ; Verwoert, G.C. ; Virtamo, J. ; Vitart, V. ; Voight, B.F. ; Vollenweider, P. ; Wagner, A. ; Wain, L.V. ; Wareham, N.J. ; Watkins, H. ; Weder, A.B. ; Westra, H.J. ; Wilks, R.J. ; Wilsgaard, T. ; Wilson, J.F. ; Wong, T.Y. ; Yang, T.P. ; Yao, J. ; Yengo, L. ; Zhang, W. ; Zhao, J.H. ; Zhu, X. ; Bovet, P. ; Cooper, R.S. ; Mohlke, K.L. ; Saleheen, D. ; Lee, J.Y. ; Elliott, P. ; Gierman, H.J. ; Willer, C.J. ; Franke, L. ; Hovingh, G.K. ; Taylor, K.D. ; Dedoussis, G. ; Sever, P. ; Wong, A. ; Lind, L. ; Assimes, T.L. ; Njølstad, I. ; Schwarz, P.E.H. ; Langenberg, C. ; Snieder, H. ; Caulfield, M.J. ; Melander, O. ; Laakso, M. ; Saltevo, J. ; Rauramaa, R. ; Tuomilehto, J. ; Ingelsson, E. ; Lehtimäki, T. ; Hveem, K. ; Palmas, W. ; Marz, W. ; Kumari, M. ; Salomaa, V. ; Chen, Y.I. ; Rotter, J.I. ; Froguel, P. ; Jarvelin, M.R. ; Lakatta, E.G. ; Kuulasmaa, K. ; Franks, P.W. ; Hamsten, A. ; CHARGE-EchoGen Consortium (Wichmann, H.-E. ; Meitinger, T.) ; Palmer, C.N. ; Stefansson, K. ; Ridker, P.M. ; Loos, R.J. ; Chakravarti, A. ; Deloukas, P. ; Morris, A.P. ; Newton-Cheh, C. ; Munroe, P.B. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat. Genet. 48, 1171-1184 (2016)
Garcia-Martin, R. ; Alexaki, V.I. ; Qin, N. ; Rubin de Celis, M.F. ; Economopoulou, M. ; Ziogas, A. ; Gercken, B. ; Kotlabova, K. ; Phieler, J. ; Ehrhart-Bornstein, M. ; Bornstein, S.R. ; Eisenhofer, G. ; Breier, G. ; Blueher, M. ; Hampe, J. ; El-Armouche, A. ; Chatzigeorgiou, A. ; Chung, K.-J. ; Chavakis, T. Adipocyte-specific hypoxia-inducible factor 2α deficiency exacerbates obesity-induced brown adipose tissue dysfunction and metabolic dysregulation. Mol. Cell. Biol. 36, 376-393 (2016)
Gruetzmann, R. ; Ludwig, B. ; Weitz, J. ; Ludwig, S. Totale Pankreatektomie und Isletautotransplantation bei einem Kind mit chronisch rezidivierender Pankreatitis. Zentralbl. Chir. 141, 17-20 (2016)
Hanefeld, M. ; Pistrosch, F. ; Bornstein, S.R. ; Birkenfeld, A.L. The metabolic vascular syndrome - guide to an individualized treatment. Rev. Endocr. Metab. Disord. 17, 5-17 (2016)
Heinke, S. ; Ludwig, B. ; Schubert, U. ; Schmid, J. ; Kiss, T. ; Steffen, A. ; Bornstein, S.R. ; Ludwig, S. Diabetes induction by total pancreatectomy in minipigs with simultaneous splenectomy: A feasible approach for advanced diabetes research. Xenotransplantation 23, 405-413 (2016)
Klose, C. ; Coskun, Ü. Shotgun Lipidomics in der biomedizinischen und klinischen Forschung: Hochdurchsatzscreening. BIOspektrum 22, 617-619 (2016)
Kourtzelis, I. ; Kotlabova, K. ; Lim, J.H. ; Mitroulis, I. ; Ferreira, A. ; Chen, L. ; Gercken, B. ; Steffen, A. ; Kemter, E. ; Klotzsche-von Ameln, A. ; Waskow, C. ; Hosur, K. ; Chatzigeorgiou, A. ; Ludwig, B. ; Wolf, E. ; Hajishengallis, G. ; Chavakis, T. Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation. Thromb. Haemost. 115, 781-788 (2016)
Kragl, M. ; Schubert, R. ; Karsjens, H. ; Otter, S. ; Bartosinska, B. ; Jeruschke, K. ; Weiss, J. ; Chen, C. ; Alsteens, D. ; Kuss, O. ; Speier, S. ; Eberhard, D. ; Müller, D.J. ; Lammert, E. The biomechanical properties of an epithelial tissue determine the location of its vasculature. Nat. Commun. 7:13560 (2016)
Liikanen, I. ; Tahtinen, S. ; Guse, K. ; Gutmann, T. ; Savola, P. ; Oksanen, M. ; Kanerva, A. ; Hemminki, A. Oncolytic adenovirus expressing monoclonal antibody trastuzumab for treatment of HER2-positive cancer. Mol. Cancer Ther. 15, 2259-2269 (2016)
Markmann, J.F. ; Bartlett, S.T. ; Johnson, P. ; Korsgren, O. ; Hering, B.J. ; Scharp, D. ; Kay, T.W. ; Bromberg, J. ; Odorico, J.S. ; Weir, G.C. ; Bridges, N.D. ; Kandaswamy, R. ; Stock, P. ; Friend, P. ; Gotoh, M. ; Cooper, D.K. ; Park, C.G. ; OʼConnell, P.J. ; Stäbler, C. ; Matsumoto, S. ; Ludwig, B. ; Choudhary, P. ; Khovatchev, B. ; Rickels, M.R. ; Sykes, M. ; Wood, K. ; Kraemer, K. ; Hwa, A. ; Stanley, E. ; Ricordi, C. ; Zimmerman, M. ; Greenstein, J. ; Montanya, E. ; Otonkoski, T. Executive summary of IPITA-TTS opinion leaders report on the future of β-cell replacement. Transplantation 100, E25-E31 (2016)
Morozov, V.A. ; Ludwig, S. ; Ludwig, B. ; Rotem, A. ; Barkai, U. ; Bornstein, S.R. ; Denner, J. Islet cell transplantation from Gottingen minipigs to cynomolgus monkeys: Analysis of virus safety. Xenotransplantation 23, 320-327 (2016)
Mziaut, H. ; Mulligan, B. ; Hoboth, P. ; Otto, O. ; Ivanova, A. ; Herbig, M. ; Schumann, D. ; Hildebrandt, T.B. ; Dehghany, J. ; Sönmez, A. ; Münster, C. ; Meyer-Hermann, M. ; Guck, J. ; Kalaidzidis, Y. ; Solimena, M. The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512. Mol. Metab. 5, 656-68 (2016)
Nati, M. ; Haddad, D. ; Birkenfeld, A.L. ; Koch, C.A. ; Chavakis, T. ; Chatzigeorgiou, A. The role of immune cells in metabolism-related liver inflammation and development of Non-Alcoholic Steatohepatitis (NASH). Rev. Endocr. Metab. Disord. 17, 29-39 (2016)
Raab, J. ; Haupt, F. ; Scholz, M. ; Matzke, C. ; Warncke, K. ; Lange, K. ; Assfalg, R. ; Weininger, K. ; Wittich, S. ; Löbner, S. ; Beyerlein, A. ; Nennstiel-Ratzel, U. ; Lang, M. ; Laub, O. ; Dunstheimer, D. ; Bonifacio, E. ; Achenbach, P. ; Winkler, C. ; Ziegler, A.-G. Capillary blood islet autoantibody screening for identifying pre-type 1 diabetes in the general population: Design and initial results of the Fr1da study. BMJ Open 6:e011144 (2016)
Richter, K. ; Barthel, A. ; Bornstein, S.R. ; El-Armouche, A. ; Wagner, M. PCSK9-Inhibitoren – Durchbruch bei der LDL-Cholesterin-Senkung? Dtsch. Med. Wochenschr. 141, 863-869 (2016)
Simons, K. ; Coskun, Ü. Membrane lipid galore. J. Mol. Biol. 428, 4737-4738 (2016)
Sosa, L. ; Torkko, J.M. ; Primo, M.E. ; Llovera, R.E. ; Toledo, P.L. ; Rios, A.S. ; Gonzalez Flecha, F.L. ; Trabucchi, A. ; Valdez, S.N. ; Poskus, E. ; Solimena, M. ; Ermácora, M.R. Biochemical, biophysical, and functional properties of ICA512/IA-2 RESP18 homology domain. Biochim. Biophys. Acta-Proteins Proteom. 1864, 511-522 (2016)
Struecker, B. ; Ludwig, S. ; Schmelzle, M. ; Ludwig, B. Cell transplantation for regeneration and function recovery before and after oncological resections. Onkologe 22, 478-487 (2016)
Ullrich, M. ; Bergmann, R. ; Peitzsch, M. ; Zenker, E.F. ; Cartellieri, M. ; Bachmann, M. ; Ehrhart-Bornstein, M. ; Block, N.L. ; Schally, A.V. ; Eisenhofer, G. ; Bornstein, S.R. ; Pietzsch, J. ; Ziegler, C.G. Multimodal somatostatin receptor theranostics using [64Cu]Cu-/[177Lu]Lu-DOTA-(Tyr3)octreotate and AN-238 in a mouse pheochromocytoma model. Theranostics 6, 650-665 (2016)
Ziegler, A.-G. ; Haupt, F. ; Scholz, M. ; Weininger, K. ; Wittich, S. ; Löbner, S. ; Matzke, C. ; Gezginci, C. ; Riethausen, S. ; Beyerlein, A. ; Zillmer, S. ; Amoroso, M. ; Coles, R. ; Powell, M. ; Furmaniak, J. ; Rees Smith, B. ; Winkler, C. ; Bonifacio, E. ; Achenbach, P. 3 screen ELISA for high-throughput detection of beta cell autoantibodies in capillary blood. Diabetes Technol. Ther. 18, 687-693 (2016)
2015
Balyura, M. ; Gelfgat, E. ; Ehrhart-Bornstein, M. ; Ludwig, B. ; Gendler, Z. ; Barkai, U. ; Zimerman, B. ; Rotem, A. ; Block, N.L. ; Schally, A.V. ; Bornstein, S.R. Transplantation of bovine adrenocortical cells encapsulated in alginate. Proc. Natl. Acad. Sci. U.S.A. 112, 2527-2532 (2015)
Benazra, M. ; Lecomte, M.J. ; Colace, C. ; Müller, A. ; Machado, C. ; Pechberty, S. ; Bricout-Neveu, E. ; Grenier-Godard, M. ; Solimena, M. ; Scharfmann, R. ; Czernichow, P. ; Ravassard, P. A human beta cell line with drug inducible excision of immortalizing transgenes. Mol. Metab. 4, 916-925 (2015)
Bergmann, A. ; Schwarz, P.E. Dem Diabetes davonlaufen, den Diabetes wegessen. Diabetes akt. 13, 3 (2015)
Bergmann, A. ; Schwarz, P.E. Herz im Visier. Diabetes akt. 13, 99 (2015)
Beutel, O. ; Roder, F. ; Birkholz, O. ; Rickert, C. ; Steinhoff, H. ; Grzybek, M. ; Coskun, Ü. ; Piehler, J. Two-dimensional trap for ultrasensitive quantification of transient protein interactions. ACS Nano 9, 9783-9791 (2015)
Bonifacio, E. ; Ziegler, A.-G. ; Klingensmith, G. ; Schober, E. ; Bingley, P.J. ; Rottenkolber, M. ; Theil, A. ; Eugster, A. ; Puff, R. ; Peplow, C. ; Buettner, F. ; Lange, K. ; Hasford, J. ; Achenbach, P. Effects of high-dose oral insulin on immune responses in children at high risk for type 1 diabetes: The Pre-POINT randomized clinical trial. JAMA 313, 1541-1549 (2015)
Bonifacio, E. Predicting type 1 diabetes using biomarkers. Diabetes Care 38, 989-996 (2015)
Bork, U. ; Rahbari, N.N. ; Schölch, S. ; Reissfelder, C. ; Kahlert, C. ; Büchler, M.W. ; Weitz, J. ; Koch, M. Circulating tumour cells and outcome in non-metastatic colorectal cancer: A prospective study. Br. J. Cancer 112, 1306-1313 (2015)
Brooke-Smith, M. ; Figueras, J. ; Ullah, S. ; Rees, M. ; Vauthey, J.N. ; Hugh, T.J. ; Garden, O.J. ; Fan, S.T. ; Crawford, M. ; Makuuchi, M. ; Yokoyama, Y. ; Büchler, M. ; Weitz, J. ; Padbury, R. Prospective evaluation of the International Study Group for Liver Surgery definition of bile leak after a liver resection and the role of routine operative drainage: an international multicentre study. HPB 17, 46-51 (2015)
Catar, R.A. ; Müller, G. ; Brandt, A. ; Langbein, H. ; Brunssen, C. ; Goettsch, C. ; Frenzel, A. ; Hofmann, A. ; Goettsch, W. ; Steinbronn, N. ; Strasser, R.H. ; Schubert, U. ; Ludwig, B. ; Bornstein, S.R. ; Morawietz, H. Increased gene expression of the cardiac endothelin system in obese mice. Horm. Metab. Res. 47, 509-515 (2015)
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Straatman, J. ; van der Wielen, N. ; Cuesta, M.A. ; Gisbertz, S.S. ; Hartemink, K.J. ; Alonso Poza, A. ; Weitz, J. ; Vallejo, F.M. ; Ahktar, K. ; Diez Del Val, I. ; Roig Garcia, J. ; van der Peet, D.L. Surgical techniques, open versus minimally invasive gastrectomy after chemotherapy (STOMACH trial): Study protocol for a randomized controlled trial. Trials 16:123 (2015)
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Swierczynska, M.M. ; Mateska, I. ; Peitzsch, M. ; Bornstein, S.R. ; Chavakis, T. ; Eisenhofer, G. ; Lamounier-Zepter, V. ; Eaton, S. Changes in morphology and function of adrenal cortex in mice fed a high-fat diet. Int. J. Obes. 39, 321-330 (2015)
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Vukicevic, V. ; Qin, N. ; Balyura, M. ; Eisenhofer, G. ; Wong, M.L. ; Licinio, J. ; Bornstein, S.R. ; Ehrhart-Bornstein, M. Valproic acid enhances neuronal differentiation of sympathoadrenal progenitor cells. Mol. Psychiatry 20, 941–950 (2015)
Warth, S.C. ; Höfig, K.P. ; Hiekel, A. ; Schallenberg, S. ; Jovanovic, K. ; Klein, L. ; Kretschmer, K. ; Ansel, K.M. ; Heissmeyer, V. Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiation. EMBO J. 34, 1195-1213 (2015)
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The influence of age and sex on genetic associations with adult body size and shape: A large-scale genome-wide interaction study. PLoS Genet. 11:e1005378 (2015)
Xie, T.Y. ; Ngo, S.T. ; Veldhuis, J.D. ; Jeffery, P.L. ; Chopin, L.K. ; Tschöp, M. ; Waters, M.J. ; Tolle, V. ; Epelbaum, J. ; Chen, C.C. ; Steyn, F.J. Effect of deletion of ghrelin-o-acyltransferase on the pulsatile release of growth hormone in mice. J. Neuroendocrinol. 27, 872-886 (2015)
Yang, C. ; Rahbari, N.N. ; Mees, S.T. ; Schaab, F. ; Koch, M. ; Weitz, J. ; Reissfelder, C. Staged resection of bilobar colorectal liver metastases: Surgical strategies. Langenbecks Arch. Surg. 400, 633-640 (2015)
Zhao, M. ; Choudhary, P. ; Srinivasan, P. ; Tang, H. ; Heaton, N. ; Fung, M. ; Barthel, A. ; Bornstein, S.R. ; Amiel, S.A. ; Huang, G.C. Modification of human islet preparation: An effective approach to improve graft outcome after islet transplantation? Horm. Metab. Res. 47, 72-77 (2015)
2014
Abe, T. ; Shin, J.T. ; Hosur, K. ; Udey, M.C. ; Chavakis, T. ; Hajishengallis, G. Regulation of osteoclast homeostasis and inflammatory bone loss by MFG-E8. J. Immunol. 193, 1383-1391 (2014)
Ansurudeen, I. ; Kopf, P.G. ; Gauthier, K.M. ; Bornstein, S.R. ; Cowley, A.W. ; Campbell, W.B. Aldosterone secretagogues increase adrenal blood flow in male rats. Endocrinology 155, 127-132 (2014)
Baessler, A. ; Lamounier-Zepter, V. ; Fenk, S. ; Strack, C. ; Lahmann, C. ; Loew, T. ; Schmitz, G. ; Blüher, M. ; Bornstein, S.R. ; Fischer, M. Adipocyte fatty acid-binding protein levels are associated with left ventricular diastolic dysfunction in morbidly obese subjects. Nutr. Diabetes 4:e106 (2014)
Ban, R.H. ; Kamvissi, V. ; Schulte, K.M. ; Bornstein, S.R. ; Rubino, F. ; Graessler, J. Lipidomic profiling at the interface of metabolic surgery and cardiovascular disease. Curr. Atheroscler. Rep. 16:455 (2014)
Bellemann, N. ; Sommer, C.M. ; Mokry, T. ; Kortes, N. ; Gnutzmann, D. ; Gockner, T. ; Schmitz, A. ; Weitz, J. ; Kauczor, H.U. ; Radeleff, B. ; Stampfl, U. Hepatic artery stent-grafts for the emergency treatment of acute bleeding. Eur. J. Radiol. 83, 1799-1803 (2014)
Beyerlein, A. ; Chmiel, R. ; Hummel, S. ; Winkler, C. ; Bonifacio, E. ; Ziegler, A.-G. Timing of gluten introduction and islet autoimmunity in young children: Updated results from the BABYDIET study. Diabetes Care 37, e194-e195 (2014)
Birkenfeld, A.L. ; Shulman, G.I. Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology 59, 713-723 (2014)
Bogusławska, D.M. ; Machnicka, B. ; Hryniewicz-Jankowska, A. ; Czogalla, A. Spectrin and phospholipids - the current picture of their fascinating interplay. Cell. Mol. Biol. Lett. 19, 158-179 (2014)
Bonifacio, E. ; Krumsiek, J. ; Winkler, C. ; Theis, F.J. ; Ziegler, A.-G. A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion. Acta Diabetol. 51, 403-411 (2014)
Borg, D.J. ; Weigelt, M. ; Wilhelm, C. ; Gerlach, M. ; Bickle, M. ; Speier, S. ; Bonifacio, E. ; Hommel, A. Mesenchymal stromal cells improve transplanted islet survival and islet function in a syngeneic mouse model. Diabetologia 57, 522-531 (2014)
Bork, U. ; Grützmann, R. ; Rahbari, N.N. ; Schölch, S. ; Distler, M. ; Reissfelder, C. ; Koch, M. ; Weitz, J. Prognostic relevance of minimal residual disease in colorectal cancer. World J. Gastroenterol. 20, 10296-10304 (2014)
Bornstein, S.R. ; Amiel, S.A. ; Rubino, F. ; Mingrone, G. ; Kamvissi, V. ; Solimena, M. ; Bonifacio, E. ; Jones, P. ; Schwarz, P. ; Birkenfeld, A.L. ; Behrens, A. ; Barthel, A. ; Lechler, R. ; Peakman, M. Creating a "Transcampus" in diabetes research between King's College London and the Technische Universität Dresden: Update on islet biology and transplantation. Horm. Metab. Res. 47, DOI: 10.1055/s-0034-1396842 (2014)
Chatzigeorgiou, A. ; Chung, K.-J. ; Garcia-Martin, R. ; Alexaki, V.I. ; Klotzsche-von Ameln, A. ; Phieler, J. ; Sprott, D. ; Kanczkowski, W. ; Tzanavari, T. ; Bdeir, M. ; Bergmann, S. ; Cartellieri, M. ; Bachmann, M. ; Nikolakopoulou, P. ; Androutsellis-Theotokis, A. ; Siegert, G. ; Bornstein, S.R. ; Muders, M.H. ; Boon, L. ; Karalis, K.P. ; Lutgens, E. ; Chavakis, T. Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation. Hepatology 60, 1196-1210 (2014)
Chatzigeorgiou, A. ; Seijkens, T. ; Zarzycka, B. ; Engel, D. ; Poggi, M. ; van den Berg, S. ; Soehnlein, O. ; Winkels, H. ; Beckers, L. ; Lievens, D. ; Driessen, A. ; Kusters, P. ; Biessen, E. ; Garcia-Martin, R. ; Klotzsche-von Ameln, A. ; Gijbels, M.J. ; Noelle, R. ; Boon, L. ; Hackeng, T.M. ; Schulte, K.M. ; Schulte, K. ; Xu, A. ; Vriend, G. ; Nabuurs, S.B. ; Chung, K.-J. ; Willems van Dijk, K. ; Rensen, P.C. ; Gerdes, N. ; de Winther, M.P. ; Block, N.L. ; Schally, A.V. ; Weber, C. ; Bornstein, S.R. ; Nicolaes, G.A.F. ; Chavakis, T. ; Lutgens, E. Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc. Natl. Acad. Sci. U.S.A. 111, 2686-2691 (2014)
Choi, T.Y. ; Ninov, N. ; Stainier, D.Y. ; Shin, D. Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish. Gastroenterology 146, 776-788 (2014)
Chung, K.-J. ; Mitroulis, I. ; Wiessner, J.R. ; Zheng, Y.Y. ; Siegert, G. ; Sperandio, M. ; Chavakis, T. A novel pathway of rapid TLR-triggered activation of integrin-dependent leukocyte adhesion that requires Rap1 GTPase. Mol. Biol. Cell 25, 2948-2955 (2014)
Czogalla, A. ; Grzybek, M. ; Jones, W. ; Coskun, Ü. Validity and applicability of membrane model systems for studying interactions of peripheral membrane proteins with lipids. Biochim. Biophys. Acta-Mol. Cell Biol. Lipids 1841, 1049-1059 (2014)
Därr, R. ; Pamporaki, C. ; Peitzsch, M. ; Miehle, K. ; Prejbisz, A. ; Peczkowska, M. ; Weismann, D. ; Beuschlein, F. ; Sinnott, R. ; Bornstein, S.R. ; Neumann, H.P. ; Januszewicz, A. ; Lenders, J.W. ; Eisenhofer, G. Biochemical diagnosis of phaeochromocytoma using plasma-free normetanephrine, metanephrine and methoxytyramine: Importance of supine sampling under fasting conditions. Clin. Endocrinol. 80, 478-486 (2014)
Distler, M. ; Kersting, S. ; Rückert, F. ; Kross, P. ; Saeger, H.-D. ; Weitz, J. ; Grützmann, R. Chronic pancreatitis of the pancreatic remnant is an independent risk factor for pancreatic fistula after distal pancreatectomy. BMC Surg. 14:54 (2014)
Distler, M. ; Aust, D. ; Weitz, J. ; Pilarsky, C. ; Grützmann, R. Precursor lesions for sporadic pancreatic cancer: PanIN, IPMN, and MCN. Biomed Res. Int. 2014:474905 (2014)
Economopoulou, M. ; Masjkur, J. ; Raiskup, F. ; Ebermann, D. ; Saha, S. ; Karl, M.O. ; Funk, R. ; Jaszai, J. ; Chavakis, T. ; Ehrhart-Bornstein, M. ; Pillunat, L.E. ; Kunz-Schughart, L.A. ; Kurth, I. ; Dubrovska, A. ; Androutsellis-Theotokis, A. Expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium. Int. J. Radiat. Biol. 90, 700-709 (2014)
Elding Larsson, H. ; Vehik, K. ; Gesualdo, P. ; Akolkar, B. ; Hagopian, W. ; Krischer, J.P. ; Lernmark, A. ; Rewers, M. ; Simell, O. ; She, J.-X. ; Ziegler, A.-G. ; Haller, M.J. ; TEDDY Study Group (Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Hummel, S. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Roth, R. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.) Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease. Pediatr. Diabetes 15, 118-126 (2014)
Endesfelder, D. ; zu Castell, W. ; Ardissone, A. ; Davis-Richardson, A.G. ; Achenbach, P. ; Hagen, M. ; Pflueger, M. ; Gano, K.A. ; Fagen, J.R. ; Drew, J.C. ; Brown, C.T. ; Kolaczkowski, B. ; Atkinson, M.J. ; Schatz, D. ; Bonifacio, E. ; Triplett, E.W. ; Ziegler, A.-G. Compromised gut microbiota networks in children with anti-islet cell autoimmunity. Diabetes 63, 2006-2014 (2014)
Ferreira, R.C. ; Guo, H. ; Coulson, R.M. ; Smyth, D.J. ; Pekalski, M.L. ; Burren, O.S. ; Cutler, A.J. ; Doecke, J.D. ; Flint, S. ; McKinney, E.F. ; Lyons, P.A. ; Smith, K.G. ; Achenbach, P. ; Beyerlein, A. ; Dunger, D.B. ; Wicker, L.S. ; Todd, J.A. ; Bonifacio, E. ; Wallace, C. ; Ziegler, A.-G. A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk of type 1 diabetes. Diabetes 63, 2538-2550 (2014)
Folprecht, G. ; Gruenberger, T. ; Bechstein, W. ; Raab, H.R. ; Weitz, J. ; Lordick, F. ; Hartmann, J.T. ; Stoehlmacher-Williams, J. ; Lang, H. ; Trarbach, T. ; Liersch, T. ; Ockert, D. ; Jaeger, D. ; Steger, U. ; Suedhoff, T. ; Rentsch, A. ; Köhne, C.H. Survival of patients with initially unresectable colorectal liver metastases treated with FOLFOX/cetuximab or FOLFIRI/cetuximab in a multidisciplinary concept (CELIM study). Ann. Oncol. 25, 1018-1025 (2014)
Folprecht, G. ; Weitz, J. ; Hoffmann, R.T. CT-morphologische Evaluation neoadjuvanter Chemotherapie. Chirurg 85, 31-36 (2014)
Franquelim, H.G. ; Linko, V. ; Czogalla, A. ; Dietz, H. ; Schwille, P. Synthetic membrane curvature-inducing DNA origami scaffolds. Biophys. J. 106:617a (2014)
Fuchs, Y.F. ; Adler, K. ; Lindner, A. ; Karasinsky, A. ; Wilhelm, C. ; Weigelt, M. ; Balke, H. ; Förtsch, K. ; Mortler-Hildebrandt, L.F. ; Harlan, D.M. ; Pechhold, K. ; Ziegler, A.-G. ; Bonifacio, E. Igrp and insulin vaccination induce CD8+ T cell mediated autoimmune diabetes in the RIP-CD80GP mouse. Clin. Exp. Immunol. 176, 199-206 (2014)
Gattu, A.K. ; Birkenfeld, A.L. ; Iwakiri, Y. ; Jay, S. ; Saltzman, M. ; Doll, J. ; Protiva, P. ; Samuel, V.T. ; Crawford, S.E. ; Chung, C. Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. Endocrinology 155, 1373-1385 (2014)
Gerl, M.J. ; Sachsenheimer, T. ; Grzybek, M. ; Coskun, Ü. ; Wieland, F.T. ; Brügger, B. Analysis of transmembrane domains and lipid modified peptides with matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. Anal. Chem. 86, 3722-3726 (2014)
Graessler, J. ; Bornstein, T.D. ; Goel, D. ; Bhalla, V.P. ; Lohmann, T. ; Wolf, T. ; Koch, M. ; Qin, Y. ; Licinio, J. ; Wong, M.L. ; Chavakis, T. ; Xu, A. ; Shevchenko, A. ; Schuhmann, K. ; Schwarz, P.E. ; Schulte, K.M. ; Patel, A. ; Bornstein, S.R. Lipidomic profiling before and after Roux-en-Y gastric bypass in obese patients with diabetes. Pharmacogenomics J. 14, 201-207 (2014)
Grützmann, R. ; Kersting, S. ; Distler, M. ; Weitz, J. Arterielle Rekonstruktion beim duktalen Pankreaskarzinom – Darstellung chirurgischer Techniken. Zentralbl. Chir. 139, 261-264 (2014)
Hackert, T. ; Weitz, J. ; Büchler, M.W. Splenic artery use for arterial reconstruction in pancreatic surgery. Langenbecks Arch. Surg. 399, 667-671 (2014)
Hajishengallis, G. ; Chavakis, T. ; Hajishengallis, E. ; Lambris, J.D. Neutrophil homeostasis and inflammation: Novel paradigms from studying periodontitis. J. Leukoc. Biol., DOI: 10.1189/jlb.3VMR1014-468R (2014)
Hanefeld, M. ; Bornstein, S.R. ; Barthel, A. Moderne medikamentöse Therapie des Typ-2-Diabetes. Dtsch. Med. Wochenschr. 139, 2494-2497 (2014)
Hummel, S. ; Vehik, K. ; Uusitalo, U. ; McLeod, W. ; Aronsson, C.A. ; Frank, N. ; Gesualdo, P. ; Yang, J. ; Norris, J.M. ; Virtanen, S.M. ; TEDDY Study Group (Ziegler, A.-G. ; Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Roth, R. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.) Infant feeding patterns in families with a diabetes history - observations from The Environmental Determinants of Diabetes in the Young (TEDDY) birth cohort study. Public Health Nutr. 17, 2853-2862 (2014)
Kahlert, C. ; Fiala, M. ; Musso, G. ; Halama, N. ; Keim, S. ; Mazzone, M. ; Lasitschka, F. ; Pecqueux, M. ; Klupp, F. ; Schmidt, T. ; Rahbari, N.N. ; Schölch, S. ; Pilarsky, C. ; Ulrich, A. ; Schneider, M. ; Weitz, J. ; Koch, M. Prognostic impact of a compartment-specific angiogenic marker profile in patients with pancreatic cancer. Oncotarget 5, 12978-12989 (2014)
Kahlert, C. ; Melo, S.A. ; Protopopov, A. ; Tang, J. ; Seth, S. ; Koch, M. ; Zhang, J. ; Weitz, J. ; Chin, L. ; Futreal, A. ; Kalluri, R. Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer. J. Biol. Chem. 289, 3869-3875 (2014)
Kibbey, R.G. ; Choi, C.S. ; Lee, H.Y. ; Cabrera, O. ; Pongratz, R.L. ; Zhao, X. ; Birkenfeld, A.L. ; Li, C. ; Berggren, P.O. ; Stanley, C. ; Shulman, G.I. Mitochondrial GTP insensitivity contributes to hypoglycemia in hyperinsulinemia hyperammonemia by inhibiting glucagon release. Diabetes 63, 4218-4229 (2014)
Kirchberg, J. ; Weitz, J. Minimalinvasive Chirurgie primärer und sekundärer Lebertumoren. Chirurg 85, 689-695 (2014)
Knoch, K.P. ; Nath-Sain, S. ; Petzold, A. ; Schneider, H. ; Beck, M. ; Wegbrod, C. ; Sönmez, A. ; Münster, C. ; Friedrich, A. ; Roivainen, M. ; Solimena, M. PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells. Mol. Metab. 3, 518-530 (2014)
Krause, S. ; Landherr, U. ; Agardh, C.-D. ; Hausmann, S. ; Link, K. ; Hansen, J.M. ; Lynch, K.F. ; Powell, M. ; Furmaniak, J. ; Rees-Smith, B. ; Bonifacio, E. ; Ziegler, A.-G. ; Lernmark, A. ; Achenbach, P. GAD autoantibody affinity in adult patients with latent autoimmune diabetes, the study participants of a GAD65 vaccination trial. Diabetes Care 37, 1675-1680 (2014)
Krause, S. ; Beyerlein, A. ; Winkler, C. ; Gavrisan, A. ; Kayser, C. ; Puff, R. ; Bonifacio, E. ; Ziegler, A.-G. ; Achenbach, P. Soluble interleukin-2 receptor alpha in preclinical type 1 diabetes. Acta Diabetol. 51, 517-518 (2014)
Krautz, C. ; Kuithan, F. ; Dobroschke, J. ; Nagel, I. ; Hartmann, S. ; Aust, D.E. ; Baretton, G. ; Weitz, J. ; Reissfelder, C. Peritoneal dissemination of a gastric API2-MALT1-positive MALT lymphoma. J. Clin. Pathol. 67, 746-748 (2014)
Lee, H.S. ; Burkhardt, B.R. ; McLeod, W. ; Smith, S. ; Eberhard, C. ; Lynch, K. ; Hadley, D. ; Rewers, M. ; Simell, O. ; She, J.X. ; Hagopian, B. ; Lernmark, A. ; Akolkar, B. ; Ziegler, A.-G. ; Krischer, J.P. ; TEDDY Study Group (Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Hummel, S. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Roth, R. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.) Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Diabetes Metab. Res. Rev. 30, 424-434 (2014)
Lee, H.Y. ; Gattu, A.K. ; Camporez, J.P. ; Kanda, S. ; Guigni, B. ; Kahn, M. ; Zhang, D. ; Galbo, T. ; Birkenfeld, A.L. ; Jornayvaz, F.R. ; Jurczak, M.J. ; Choi, C.S. ; Yan, Z. ; Williams, R.S. ; Shulman, G.I. ; Samuel, V.T. Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice. Diabetologia 57, 1232-1241 (2014)
Liang, Q. ; Zhong, L. ; Zhang, J. ; Wang, Y. ; Bornstein, S.R. ; Triggle, C.R. ; Ding, H. ; Lam, K.S. ; Xu, A. FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting. Diabetes 63, 4064-4075 (2014)
Liu, E. ; Lee, H.S. ; Aronsson, C.A. ; Hagopian, W.A. ; Koletzko, S. ; Rewers, M.J. ; Eisenbarth, G.S. ; Bingley, P.J. ; Bonifacio, E. ; Simell, V. ; Agardh, D. ; TEDDY Study Group (Ziegler, A.-G. ; Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Hummel, S. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Roth, R. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.) Risk of pediatric celiac disease according to HLA haplotype and country. N. Engl. J. Med. 371, 42-49 (2014)
Ludwig, B. ; Barthel, A. ; Reichel, A. ; Block, N.L. ; Ludwig, S. ; Schally, A.V. ; Bornstein, S.R. Modulation of the pancreatic islet-stress axis as a novel potential therapeutic target in diabetes mellitus. Vitam. Horm. 95, 195-222 (2014)
Machnicka, B. ; Czogalla, A. ; Hryniewicz-Jankowska, A. ; Bogusławska, D.M. ; Grochowalska, R. ; Heger, E. ; Sikorski, A.F. Spectrins: A structural platform for stabilization and activation of membrane channels, receptors and transporters. Biochim. Biophys. Acta-Biomembr. 1838, 620-634 (2014)
Masjkur, J. ; Arps-Forker, C. ; Poser, S.W. ; Nikolakopoulou, P. ; Toutouna, L. ; Chenna, R. ; Chavakis, T. ; Chatzigeorgiou, A. ; Chen, L.S. ; Dubrovska, A. ; Choudhary, P. ; Uphues, I. ; Mark, M. ; Bornstein, S.R. ; Androutsellis-Theotokis, A. Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release. J. Biol. Chem. 289, 35503-35516 (2014)
Masjkur, J. ; Levenfus, I. ; Lange, S. ; Arps-Forker, C. ; Poser, S.W. ; Qin, N. ; Vukicevic, V. ; Chavakis, T. ; Eisenhofer, G. ; Bornstein, S.R. ; Ehrhart-Bornstein, M. ; Androutsellis-Theotokis, A. A defined, controlled culture system for primary bovine chromaffin progenitors reveals novel biomarkers and modulators. Stem Cells Trans. Med. 3, 801-808 (2014)
Mayer, C.T. ; Lahl, K. ; Milanez-Almeida, P. ; Watts, D. ; Dittmer, U. ; Fyhrquist, N. ; Huehn, J. ; Kopf, M. ; Kretschmer, K. ; Rouse, B. ; Sparwasser, T. Advantages of Foxp3+ regulatory T cell depletion using DEREG mice. Immun. Inflamm. Dis. 2, 162-165 (2014)
Mitroulis, I. ; Kang, Y.Y. ; Gahmberg, C.G. ; Siegert, G. ; Hajishengallis, G. ; Chavakis, T. ; Choi, E.Y. Developmental endothelial locus-1 attenuates complement-dependent phagocytosis through inhibition of Mac-1-integrin. Thromb. Haemost. 111, 1004-1006 (2014)
Moutsopoulos, N.M. ; Konkel, J. ; Sarmadi, M. ; Eskan, M.A. ; Wild, T. ; Dutzan, N. ; Abusleme, L. ; Zenobia, C. ; Hosur, K.B. ; Abe, T. ; Uzel, G. ; Chen, W. ; Chavakis, T. ; Holland, S.M. ; Hajishengallis, G. Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss. Sci. Transl. Med. 6:229ra40 (2014)
Neuschäfer-Rube, F. ; Lieske, S. ; Kuna, M. ; Henkel, J. ; Perry, R.J. ; Erion, D.M. ; Pesta, D. ; Willmes, D.M. ; Brachs, S. ; von Loeffelholz, C. ; Tolkachov, A. ; Schupp, M. ; Pathe-Neuschäfer-Rube, A. ; Pfeiffer, A.F. ; Shulman, G.I. ; Püschel, G.P. ; Birkenfeld, A.L. The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes. Diabetes 63, 1048-1057 (2014)
Niebling, J. ; Rünker, A. ; Schallenberg, S. ; Kretschmer, K. ; Kempermann, G. Myelin-specific T helper 17 cells promote adult hippocampal neurogenesis through indirect mechanisms. F1000Res. 3:169 (2014)
Pamporaki, C. ; Bursztyn, M. ; Reimann, M. ; Ziemssen, T. ; Bornstein, S.R. ; Sweep, F.C. ; Timmers, H. ; Lenders, J.W. ; Eisenhofer, G. Seasonal variation in plasma free normetanephrine concentrations: Implications for biochemical diagnosis of pheochromocytoma. Eur. J. Endocrinol. 170, 349-357 (2014)
Parfentyeva, E. ; Saha, S. ; Hjellset, V.T. ; Kopprasch, S. ; Schwarz, P.E. Assessment of small C-fiber status for screening of oxidative stress in patients at risk of diabetes. Horm. Metab. Res. 46, 360-364 (2014)
Petrov, E.P. ; Czogalla, A. ; Kauert, D.J. ; Seidel, R. ; Schwille, P. Diffusion and freezing transition of rod-like DNA origami on freestanding lipid membranes. Biophys. J. 106:701a (2014)
Petzold, C. ; Steinbronn, N. ; Gereke, M. ; Strasser, R.H. ; Sparwasser, T. ; Bruder, D. ; Geffers, R. ; Schallenberg, S. ; Kretschmer, K. Fluorochrome-based definition of naturally occurring Foxp3+ regulatory T cells of intra- and extrathymic origin. Eur. J. Immunol. 44, 3632-3645 (2014)
Qin, N. ; de Cubas, A.A. ; Garcia-Martin, R. ; Richter, S. ; Peitzsch, M. ; Menschikowski, M. ; Lenders, J.W. ; Timmers, H.J. ; Mannelli, M. ; Opocher, G. ; Economopoulou, M. ; Siegert, G. ; Chavakis, T. ; Pacak, K. ; Robledo, M. ; Eisenhofer, G. Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X. Int. J. Cancer 135, 2054-2064 (2014)
Rahbari, N.N. ; Reissfelder, C. ; Schulze-Bergkamen, H. ; Jäger, D. ; Büchler, M.W. ; Weitz, J. ; Koch, M. Adjuvant therapy after resection of colorectal liver metastases: the predictive value of the MSKCC clinical risk score in the era of modern chemotherapy. BMC Cancer 14:174 (2014)
Rahbari, N.N. ; Elbers, H. ; Koch, M. ; Vogler, P. ; Striebel, F. ; Bruckner, T. ; Mehrabi, A. ; Schemmer, P. ; Büchler, M.W. ; Weitz, J. Randomized clinical trial of stapler versus clamp-crushing transection in elective liver resection. Br. J. Surg. 101, 200-207 (2014)
Reissfelder, C. ; Brand, K. ; Sobiegalla, J. ; Rahbari, N.N. ; Bork, U. ; Schirmacher, P. ; Büchler, M.W. ; Weitz, J. ; Koch, M. Chemotherapy-associated liver injury and its influence on outcome after resection of colorectal liver metastases. Surgery 155, 245-254 (2014)
Reißfelder, C. ; Kirchberg, J. ; Weitz, J. Nervenschonende offene tiefe anteriore Rektumresektion beim Rektumkarzinom. Zentralbl. Chir. 139, 381-383 (2014)
Roth, R. ; Lynch, K. ; Lernmark, B. ; Baxter, J. ; Simell, T. ; Smith, L. ; Swartling, U. ; Ziegler, A.-G. ; Johnson, S.B. ; TEDDY Study Group (Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Hummel, S. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.) Maternal anxiety about a child's diabetes risk in the TEDDY study: The potential role of life stress, postpartum depression, and risk perception. Pediatr. Diabetes 16, 287-298 (2014)
Schlottmann, I. ; Ehrhart-Bornstein, M. ; Wabitsch, M. ; Bornstein, S.R. ; Lamounier-Zepter, V. Calcium-dependent release of adipocyte fatty acid binding protein from human adipocytes. Int. J. Obes. 38, 1221-1227 (2014)
Schlueter, N. ; de Sterke, A. ; Willmes, D.M. ; Spranger, J. ; Jordan, J. ; Birkenfeld, A.L. Metabolic actions of natriuretic peptides and therapeutic potential in the metabolic syndrome. Pharmacol. Ther. 144, 12-27 (2014)
Schulte, K.M. ; Talat, N. ; Galata, G. ; Aylwin, S. ; Izatt, L. ; Eisenhofer, G. ; Barthel, A. ; Bornstein, S.R. Genetics and the clinical approach to paragangliomas. Horm. Metab. Res. 46, 964-973 (2014)
Schulte, K.M. ; Talat, N. ; Galata, G. ; Gilbert, J. ; Miell, J. ; Hofbauer, L.C. ; Barthel, A. ; Diaz-Cano, S. ; Bornstein, S.R. Oncologic resection achieving r0 margins improves disease-free survival in parathyroid cancer. Ann. Surg. Oncol. 21, 1891-1897 (2014)
Seijkens, T. ; Kusters, P. ; Chatzigeorgiou, A. ; Chavakis, T. ; Lutgens, E. Immune cell crosstalk in obesity: A key role for costimulation? Diabetes 63, 3982-3991 (2014)
Steinert, G. ; Schölch, S. ; Niemietz, T. ; Iwata, N. ; García, S.A. ; Behrens, B. ; Voigt, A. ; Kloor, M. ; Benner, A. ; Bork, U. ; Rahbari, N.N. ; Büchler, M.W. ; Stoecklein, N.H. ; Weitz, J. ; Koch, M. Immune escape and survival mechanisms in circulating tumor cells of colorectal cancer. Cancer Res. 74, 1694-1704 (2014)
Stumpp, C. ; Beyerlein, A. ; Ziegler, A.-G. ; Bonifacio, E. Neonatal and infant beta cell hormone concentrations in relation to type 1 diabetes risk. Pediatr. Diabetes 15, 528-533 (2014)
Tsourdi, E. ; Heidrich, F.M. ; Winzer, M. ; Röllig, C. ; Kirsch, C.M. ; Meinel, J. ; Baretton, G.B. ; Bornstein, S.R. ; Hofbauer, L.C. An exotic cause of exudative enteropathy. Am. J. Case Rep. 15, 226-229 (2014)
Tsuji, N. ; Ninov, N. ; Delawary, M. ; Osman, S. ; Roh, A.S. ; Gut, P. ; Stainier, D.Y. Whole organism high content screening identifies stimulators of pancreatic beta-cell proliferation. PLoS ONE 9:e104112 (2014)
Ullrich, M. ; Bergmann, R. ; Peitzsch, M. ; Cartellieri, M. ; Qin, N. ; Ehrhart-Bornstein, M. ; Block, N.L. ; Schally, A.V. ; Pietzsch, J. ; Eisenhofer, G. ; Bornstein, S.R. ; Ziegler, C.G. In vivo fluorescence imaging and urinary monoamines as surrogate biomarkers of disease progression in a mouse model of pheochromocytoma. Endocrinology 155, 4149-4156 (2014)
Vahl, J.C. ; Drees, C. ; Heger, K. ; Heink, S. ; Fischer, J.C. ; Nedjic, J. ; Ohkura, N. ; Morikawa, H. ; Poeck, H. ; Schallenberg, S. ; Rieß, D. ; Hein, M.Y. ; Buch, T. ; Polic, B. ; Schönle, A. ; Zeiser, R. ; Schmitt-Gräff, A. ; Kretschmer, K. ; Klein, L. ; Korn, T. ; Sakaguchi, S. ; Schmidt-Supprian, M. Continuous T cell receptor signals maintain a functional regulatory T cell pool. Immunity 41, 722-736 (2014)
van Noort, V. ; Schölch, S. ; Iskar, M. ; Zeller, G. ; Ostertag, K. ; Schweitzer, C. ; Werner, K. ; Weitz, J. ; Koch, M. ; Bork, P. Novel drug candidates for the treatment of metastatic colorectal cancer through global inverse gene-expression profiling. Cancer Res. 74, 5690-5699 (2014)
Volk, A. ; Rahbari, N.N. ; Koch, M. ; Weitz, J. Leistenhernienversorgung nach Lichtenstein. Zentralbl. Chir. 139, 581-582 (2014)
Walter, U. ; Kohlert, T. ; Rahbari, N.N. ; Weitz, J. ; Welsch, T. Impact of preoperative diabetes on long-term survival after curative resection of pancreatic adenocarcinoma: A systematic review and meta-analysis. Ann. Surg. Oncol. 21, 1082-1089 (2014)
Wang, Y. ; Xiao, Y. ; Zhong, L. ; Ye, D. ; Zhang, J. ; Tu, Y. ; Bornstein, S.R. ; Zhou, Z. ; Lam, K.S. ; Xu, A. Increased neutrophil elastase and proteinase 3 and augmented NETosis are closely associated with β-cell autoimmunity in patients with type 1 diabetes. Diabetes 63, 4239-4248 (2014)
Wieduwild, R. ; Lin, W. ; Boden, A. ; Kretschmer, K. ; Zhang, Y. A repertoire of peptide tags for controlled drug release from injectable noncovalent hydrogel. Biomacromolecules 15, 2058-2066 (2014)
Winkler, C. ; Krumsiek, J. ; Buettner, F. ; Angermüller, C. ; Giannopoulou, E.Z. ; Theis, F.J. ; Ziegler, A.-G. ; Bonifacio, E. Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes. Diabetologia 57, 2521-2529 (2014)
Xiao, S. ; Yosef, N. ; Yang, J. ; Wang, Y. ; Zhou, L. ; Zhu, C. ; Wu, C. ; Baloglu, E. ; Schmidt, D. ; Ramesh, R. ; Lobera, M. ; Sundrud, M.S. ; Tsai, P.Y. ; Xiang, Z. ; Wang, J. ; Xu, Y. ; Lin, X. ; Kretschmer, K. ; Rahl, P.B. ; Young, R.A. ; Zhong, Z. ; Hafler, D.A. ; Regev, A. ; Ghosh, S. ; Marson, A. ; Kuchroo, V.K. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity 40, 477-489 (2014)
Yang, J. ; Lernmark, A. ; Uusitalo, U.M. ; Lynch, K.F. ; Veijola, R. ; Winkler, C. ; Larsson, H.E. ; Rewers, M. ; She, J.X. ; Ziegler, A.-G. ; Simell, O.G. ; Hagopian, W.A. ; Akolkar, B. ; Krischer, J.P. ; Vehik, K. ; TEDDY Study Group (Beyerlein, A. ; Bonifacio, E. ; Hummel, M. ; Hummel, S. ; Foterek, K. ; Kersting, M. ; Knopff, A. ; Koletzko, S. ; Peplow, C. ; Roth, R. ; Stock, J. ; Strauss, E. ; Warncke, K.) Prevalence of obesity was related to HLA-DQ in 2-4 year old children at genetic risk for type 1 diabetes. Int. J. Obes. 38, 1491-1496 (2014)
2013
Barkai, U. ; Weir, G.C. ; Colton, C.K. ; Ludwig, B. ; Bornstein, S.R. ; Brendel, M.D. ; Neufeld, T.P. ; Bremer, C. ; Leon, A. ; Evron, Y. ; Yavriyants, K. ; Azarov, D. ; Zimermann, B. ; Maimon, S. ; Shabtay, N. ; Balyura, M. ; Rozenshtein, T. ; Vardi, P. ; Bloch, K. ; de Vos, P. ; Rotem, A. Enhanced oxygen supply improves islet viability in a new bioartificial pancreas. Cell Transplant. 22, 1463-1476 (2013)
Bauer, K. ; Nelius, N. ; Reuschenbach, M. ; Koch, M. ; Weitz, J. ; Steinert, G. ; Kopitz, J. ; Beckhove, P. ; Tariverdian, M. ; von Knebel Doeberitz, M. ; Kloor, M. T cell responses against microsatellite instability-induced frameshift peptides and influence of regulatory T cells in colorectal cancer. Cancer Immunol. Immunother. 62, 27-37 (2013)
Bonifacio, E. Targeting innate immunity in type 1 diabetes: Strike one. Lancet 381, 1880-1881 (2013)
Calvet, J.H. ; Dupin, J. ; Winiecki, H. ; Schwarz, P.E. Assessment of small fiber neuropathy through a quick, simple and non-invasive method in a German diabetes outpatient clinic. Exp. Clin. Endocrinol. Diabet. 121, 80-83 (2013)
Chatzigeorgiou, A. ; Phieler, J. ; Gebler, J. ; Bornstein, S.R. ; Chavakis, T. CD40L stimulates the crosstalk between adipocytes and inflammatory cells. Horm. Metab. Res. 45, 741-747 (2013)
Chavakis, T. ; Ehrhart-Bornstein, M. The adrenal gland in the center. Horm. Metab. Res. 45, 79-80 (2013)
Chmelar, J. ; Chung, K.-J. ; Chavakis, T. The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance. Thromb. Haemost. 109, 399-406 (2013)
Czogalla, A. ; Petrov, E.P. ; Kauert, D.J. ; Uzunova, V. ; Zhang, Y. ; Seidel, R. ; Schwille, P. Switchable domain partitioning and diffusion of DNA origami rods on membranes. Faraday Discuss. 161, 31-43 (2013)
Dekkers, T. ; Deinum, J. ; Schultzekool, L.J. ; Blondin, D. ; Vonend, O. ; Hermus, A.R. ; Peitzsch, M. ; Rump, L.C. ; Antoch, G. ; Sweep, F.C. ; Bornstein, S.R. ; Lenders, J.W. ; Willenberg, H.S. ; Eisenhofer, G. Plasma metanephrine for assessing the selectivity of adrenal venous sampling. Hypertension 62, 1152-1157 (2013)
Döcke, S. ; Lock, J.F. ; Birkenfeld, A.L. ; Hoppe, S. ; Lieske, S. ; Rieger, A. ; Raschzok, N. ; Sauer, I.M. ; Florian, S. ; Osterhoff, M.A. ; Heller, R. ; Herrmann, K. ; Lindenmüller, S. ; Horn, P. ; Bauer, M. ; Weickert, M.O. ; Neuhaus, P. ; Stockmann, M. ; Möhlig, M. ; Pfeiffer, A.F. ; von Loeffelholz, C. Elevated hepatic chemerin mRNA expression in human non-alcoholic fatty liver disease. Eur. J. Endocrinol. 169, 547-557 (2013)
Eugster, A. ; Lindner, A. ; Heninger, A.K. ; Wilhelm, C. ; Dietz, S. ; Ziegler, A.-G. ; Bonifacio, E. Measuring T cell receptor and T cell gene expression diversity in antigen-responsive human CD4+ T cells. J. Immunol. Methods 400-401, 13-22 (2013)
Ferraz, C. ; Lorenz, S. ; Wojtas, B. ; Bornstein, S.R. ; Paschke, R. ; Eszlinger, M. Inverse correlation of miRNA and cell cycle-associated genes suggests influence of miRNA on benign thyroid nodule tumorigenesis. J. Clin. Endocrinol. Metab. 98, 8-16 (2013)
Franke, K. ; Kalucka, J. ; Mamlouk, S. ; Singh, R.P. ; Muschter, A. ; Weidemann, A. ; Iyengar, V. ; Jahn, S. ; Wieczorek, K. ; Geiger, K. ; Muders, M.H. ; Sykes, A.M. ; Poitz, D.M. ; Ripich, T. ; Otto, T. ; Bergmann, S. ; Breier, G. ; Baretton, G. ; Fong, G.H. ; Greaves, D.R. ; Bornstein, S. ; Chavakis, T. ; Fandrey, J. ; Gassmann, M. ; Wielockx, B. HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis. Blood 121, 1436-1445 (2013)
Gavalas, A. ; Lan, T.H. ; Liu, Q. ; Corrêa, I.R. ; Javitch, J.A. ; Lambert, N.A. Segregation of family A G protein-coupled receptor protomers in the plasma membrane. Mol. Pharmacol. 84, 346-352 (2013)
Graessler, J. ; Qin, Y. ; Zhong, H. ; Zhang, J. ; Licinio, J. ; Wong, M.L. ; Xu, A. ; Chavakis, T. ; Bornstein, A.B. ; Ehrhart-Bornstein, M. ; Lamounier-Zepter, V. ; Lohmann, T. ; Wolf, T. ; Bornstein, S.R. Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: Correlation with inflammatory and metabolic parameters. Pharmacogenomics J. 13, 514-522 (2013)
Gräßler, J. ; Blüher, M. ; Chavakis, T. Adipositas und Inflammation. Dtsch. Med. Wochenschr. 138, 172-175 (2013)
Gräßler, J. ; Kopprasch, S. ; Passauer, J. ; Fischer, S. ; Schuhmann, K. ; Bergmann, S. ; Siegert, G. ; Shevchenko, A. ; Bornstein, S.R. ; Julius, U. Differential effects of lipoprotein apheresis by lipidfiltration or dextran sulfate adsorption on lipidomic profile. Atherosclerosis 14, 151-155 (2013)
Hajishengallis, G. ; Chavakis, T. Endogenous modulators of inflammatory cell recruitment. Trends Immunol. 34, 1-6 (2013)
Haufe, S. ; Haas, V. ; Utz, W. ; Birkenfeld, A.L. ; Jeran, S. ; Böhnke, J. ; Mähler, A. ; Luft, F.C. ; Schulz-Menger, J. ; Boschmann, M. ; Jordan, J. ; Engeli, S. Long-lasting improvements in liver fat and metabolism despite body weight regain after dietary weight loss. Diabetes Care 36, 3786-3792 (2013)
Heninger, A.K. ; Monti, P. ; Wilhelm, C. ; Schwaiger, P. ; Kuehn, D. ; Ziegler, A.-G. ; Bonifacio, E. Activation of islet autoreactive naive T cells in infants is influenced by homeostatic mechanisms and antigen presenting capacity. Diabetes 62, 2059-2066 (2013)
Hohenstein, B. ; Bornstein, S.R. ; Aringer, M. Immunoadsorption for connective tissue disease. Atherosclerosis 14, 185-189 (2013)
Ilegems, E. ; Dicker, A. ; Speier, S. ; Sharma, A. ; Bahow, A. ; Edlund, P.K. ; Leibiger, I.B. ; Berggren, P.O. Reporter islets in the eye reveal the plasticity of the endocrine pancreas. Proc. Natl. Acad. Sci. U.S.A. 110, 20581-20586 (2013)
Ioannou, M. ; Serafimidis, I. ; Arnes, L. ; Sussel, L. ; Singh, S. ; Vasiliou, V. ; Gavalas, A. ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools. Dev. Biol. 374, 153-163 (2013)
Ivanova, A. ; Kalaidzidis, Y. ; Dirkx, R. ; Sarov, M. ; Gerlach, M. ; Schroth-Diez, B. ; Müller, A. ; Liu, Y. ; Andree, C. ; Mulligan, B. ; Münster, C. ; Kurth, T. ; Bickle, M. ; Speier, S. ; Anastassiadis, K. ; Solimena, M. Age-dependent labeling and imaging of insulin secretory granules. Diabetes 62, 3687-3696 (2013)
Julius, U. ; Taseva, K. ; Fischer, S. ; Passauer, J. ; Bornstein, S.R. Current situation of lipoprotein apheresis in Saxony. Atherosclerosis 14, 51-55 (2013)
Kanczkowski, W. ; Alexaki, V.I. ; Tran, N. ; Großklaus, S. ; Zacharowski, K. ; Martinez, A. ; Popovics, P. ; Block, N.L. ; Chavakis, T. ; Schally, A.V. ; Bornstein, S.R. Hypothalamo-pituitary and immune-dependent adrenal regulation during systemic inflammation. Proc. Natl. Acad. Sci. U.S.A. 110, 14801-14806 (2013)
Kanczkowski, W. ; Chatzigeorgiou, A. ; Grossklaus, S. ; Sprott, D. ; Bornstein, S.R. ; Chavakis, T. Role of the endothelial-derived endogenous anti-inflammatory factor Del-1 in inflammation-mediated adrenal gland dysfunction. Endocrinology 154, 1181-1189 (2013)
Kanczkowski, W. ; Chatzigeorgiou, A. ; Samus, M. ; Tran, N. ; Zacharowski, K. ; Chavakis, T. ; Bornstein, S.R. Characterization of the LPS-induced inflammation of the adrenal gland in mice. Mol. Cell. Endocrinol. 371, 228-235 (2013)
Klotzsche-von Ameln, A. ; Prade, I. ; Grosser, M. ; Kettelhake, A. ; Rezaei, M. ; Chavakis, T. ; Flamme, I. ; Wielockx, B. ; Breier, G. PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-α. Mol. Cancer Res. 11, 1337-1348 (2013)
Kopprasch, S. ; Bornstein, S.R. ; Schwarz, P.E. ; Bergmann, S. ; Julius, U. ; Graessler, J. Single whole blood dextran sulfate adsorption favorably affects systemic oxidative balance in lipoprotein apheresis patients. Atherosclerosis 14, 157-160 (2013)
Korten, S. ; Brunssen, C. ; Poitz, D.M. ; Großklaus, S. ; Brux, M. ; Schnittler, H.J. ; Strasser, R.H. ; Bornstein, S.R. ; Morawietz, H. ; Goettsch, W. Impact of Hey2 and COUP-TFII on genes involved in arteriovenous differentiation in primary human arterial and venous endothelial cells. Basic Res. Cardiol. 108:362 (2013)
Krautz, C. ; Wolk, S. ; Steffen, A. ; Knoch, K.P. ; Ceglarek, U. ; Thiery, J. ; Bornstein, S. ; Saeger, H.-D. ; Solimena, M. ; Kersting, S. Effects of immunosuppression on alpha and beta cell renewal in transplanted mouse islets. Diabetologia 56, 1596-1604 (2013)
Kumashiro, N. ; Beddow, S.A. ; Vatner, D.F. ; Majumdar, S.K. ; Cantley, J.L. ; Guebre-Egziabher, F. ; Fat, I. ; Guigni, B. ; Jurczak, M.J. ; Birkenfeld, A.L. ; Kahn, M. ; Perler, B.K. ; Puchowicz, M.A. ; Manchem, V.P. ; Bhanot, S. ; Still, C.D. ; Gerhard, G.S. ; Petersen, K.F. ; Cline, G.W. ; Shulman, G.I. ; Samuel, V.T. Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance. Diabetes 62, 2183-2194 (2013)
Lamounier-Zepter, V. ; Look, C. ; Ehrhart-Bornstein, M. ; Bornstein, S.R. ; Fischer, S. ; Julius, U. Lipoprotein apheresis reduces adipocyte fatty acid-binding protein serum levels. Atherosclerosis 14, 129-134 (2013)
Langer, H.F. ; Chavakis, T. Platelets and neurovascular inflammation. Thromb. Haemost. 110, 888-893 (2013)
Lee, H.S. ; Briese, T. ; Winkler, C. ; Rewers, M. ; Bonifacio, E. ; Hyoty, H. ; Pflueger, M. ; Simell, O. ; She, J.X. ; Hagopian, W. ; Lernmark, A. ; Akolkar, B. ; Krischer, J.P. ; Ziegler, A.-G. ; TEDDY Study Group Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes. Diabetologia 56, 1705-1711 (2013)
Leinster, D.A. ; Colom, B. ; Whiteford, J.R. ; Ennis, D.P. ; Lockley, M. ; McNeish, I.A. ; Aurrand-Lions, M. ; Chavakis, T. ; Imhof, B.A. ; Balkwill, F.R. ; Nourshargh, S. Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer. FASEB J. 27, 4244-4253 (2013)
Lin, Z. ; Tian, H. ; Lam, K.S. ; Lin, S. ; Hoo, R.C. ; Konishi, M. ; Itoh, N. ; Wang, Y. ; Bornstein, S.R. ; Xu, A. ; Li, X. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab. 17, 779-789 (2013)
Löffler, M.G. ; Birkenfeld, A.L. ; Philbrick, K.M. ; Belman, J.P. ; Habtemichael, E.N. ; Booth, C.J. ; Castorena, C.M. ; Choi, C.S. ; Jornayvaz, F.R. ; Gassaway, B.M. ; Lee, H.Y. ; Cartee, G.D. ; Philbrick, W. ; Shulman, G.I. ; Samuel, V.T. ; Bogan, J.S. Enhanced fasting glucose turnover in mice with disrupted action of TUG protein in skeletal muscle. J. Biol. Chem. 288, 20135-20150 (2013)
Ludwig, B. ; Reichel, A. ; Steffen, A. ; Zimerman, B. ; Schally, A.V. ; Block, N.L. ; Colton, C.K. ; Ludwig, S. ; Kersting, S. ; Bonifacio, E. ; Solimena, M. ; Gendler, Z. ; Rotem, A. ; Barkai, U. ; Bornstein, S.R. Transplantation of human islets without immunosuppression. Proc. Natl. Acad. Sci. U.S.A. 110, 19054-19058 (2013)
Magro, M.G. ; Solimena, M. Regulation of β-cell function by RNA-binding proteins. Mol. Metab. 2, 348-355 (2013)
Maliga, Z. ; Junqueira, M. ; Toyoda, Y. ; Ettinger, A. ; Mora-Bermudez, F. ; Klemm, R.W. ; Vasilj, A. ; Guhr, E. ; Ibarlucea-Benitez, I. ; Poser, I. ; Bonifacio, E. ; Huttner, W.B. ; Shevchenko, A. ; Hyman, A.A. A genomic toolkit to investigate kinesin and myosin motor function in cells. Nat. Cell Biol. 15, 325-334 (2013)
Marciniak, A. ; Selck, C. ; Friedrich, B. ; Speier, S. Mouse pancreas tissue slice culture facilitates long-term studies of exocrine and endocrine cell physiology in situ. PLoS ONE 8:e78706 (2013)
Monti, P. ; Brigatti, C. ; Krasmann, M. ; Ziegler, A.-G. ; Bonifacio, E. Concentration and activity of the soluble form of the interleukin-7 receptor α in type I diabetes identifies an interplay between hyperglycemia and immune function. Diabetes 62, 2500-2508 (2013)
Morawietz, H. ; Goettsch, W. ; Brux, M. ; Reimann, M. ; Bornstein, S.R. ; Julius, U. ; Ziemssen, T. Lipoprotein apheresis of hypercholesterolemic patients mediates vasoprotective gene expression in human endothelial cells. Atherosclerosis 14, 107-113 (2013)
Müller, G. ; Parfentyeva, E. ; Olschewsky, J. ; Bornstein, S.R. ; Schwarz, P.E. Assessment of small fiber neuropathy to predict future risk of type 2 diabetes. Prim. Care Diabetes 7, 269-273 (2013)
Müller, G. ; Weser, G. ; Schwarz, P.E. The European perspective of diabetes prevention: The need for individualization of diabetes prevention. J. Endocrinol. Invest. 36, 352-357 (2013)
Neufeld, T.P. ; Ludwig, B. ; Barkai, U. ; Weir, G.C. ; Colton, C.K. ; Evron, Y. ; Balyura, M. ; Yavriyants, K. ; Zimermann, B. ; Azarov, D. ; Maimon, S. ; Shabtay, N. ; Rozenshtein, T. ; Lorber, D. ; Steffen, A. ; Willenz, U. ; Bloch, K. ; Vardi, P. ; Taube, R. ; de Vos, P. ; Lewis, E.C. ; Bornstein, S.R. ; Rotem, A. The efficacy of an immunoisolating membrane system for islet xenotransplantation in minipigs. PLoS ONE 8:e70150 (2013)
Ninov, N. ; Hesselson, D. ; Gut, P. ; Zhou, A. ; Fidelin, K. ; Stainier, D.Y. Metabolic regulation of cellular plasticity in the pancreas. Curr. Biol. 23, 1242-1250 (2013)
Palm, W. ; Swierczynska, M.M. ; Kumari, V. ; Ehrhart-Bornstein, M. ; Bornstein, S.R. ; Eaton, S. Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals. PLoS Biol. 11:e1001505 (2013)
Pamporaki, C. ; Därr, R. ; Bursztyn, M. ; Glöckner, S. ; Bornstein, S.R. ; Lenders, J.W. ; Pacak, K. ; Krinner, A. ; Eisenhofer, G. Plasma-free vs deconjugated metanephrines for diagnosis of phaeochromocytoma. Clin. Endocrinol. 79, 476-483 (2013)
Petrowski, K. ; Wintermann, G.B. ; Schaarschmidt, M. ; Bornstein, S.R. ; Kirschbaum, C. Blunted salivary and plasma cortisol response in patients with panic disorder under psychosocial stress. Int. J. Psychophysiol. 88, 35-39 (2013)
Petzold, C. ; Riewaldt, J. ; Watts, D. ; Sparwasser, T. ; Schallenberg, S. ; Kretschmer, K. Foxp3+ regulatory T cells in mouse models of type 1 diabetes. J. Diabetes Res. 2013:940710 (2013)
Phieler, J. ; Chung, K.-J. ; Chatzigeorgiou, A. ; Klotzsche-von Ameln, A. ; Garcia-Martin, R. ; Sprott, D. ; Moisidou, M. ; Tzanavari, T. ; Ludwig, B. ; Baraban, E. ; Ehrhart-Bornstein, M. ; Bornstein, S.R. ; Mziaut, H. ; Solimena, M. ; Karalis, K.P. ; Economopoulou, M. ; Lambris, J.D. ; Chavakis, T. The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance. J. Immunol. 191, 4367-4374 (2013)
Phieler, J. ; Garcia-Martin, R. ; Lambris, J.D. ; Chavakis, T. The role of the complement system in metabolic organs and metabolic diseases. Semin. Immunol. 25, 47-53 (2013)
Piemonti, L. ; Everly, M.J. ; Maffi, P. ; Scavini, M. ; Poli, F. ; Nano, R. ; Cardillo, M. ; Melzi, R. ; Mercalli, A. ; Sordi, V. ; Lampasona, V. ; Espadas de Arias, A. ; Scalamogna, M. ; Bosi, E. ; Bonifacio, E. ; Secchi, A. ; Terasaki, P.I. Alloantibody and autoantibody monitoring predicts islet transplantation outcome in human type 1 diabetes. Diabetes 62, 1656-1664 (2013)
Reichel, A. ; Rietzsch, H. ; Ludwig, B. ; Röthig, K. ; Moritz, A. ; Bornstein, S.R. Self-adjustment of insulin dose using graphically depicted self-monitoring of blood glucose measurements in patients with type 1 diabetes mellitus. J. Diabetes Sci. Technol. 7, 156-162 (2013)
Reimann, M. ; Julius, U. ; Bornstein, S.R. ; Fischer, S. ; Reichmann, H. ; Rüdiger, H. ; Ziemssen, T. Regular lipoprotein apheresis maintains residual cardiovascular and microvascular function in patients with advanced atherosclerotic disease. Atherosclerosis 14, 135-141 (2013)
Ringers, J. ; van der Torren, C.R. ; van de Linde, P. ; van der Boog, P.J. ; Mallat, M.J. ; Bonifacio, E. ; Roep, B.O. ; de Fijter, J.W. Pretransplantation GAD-autoantibody status to guide prophylactic antibody induction therapy in simultaneous pancreas and kidney transplantation. Transplantation 96, 745-752 (2013)
Ritter, P.S. ; Kretschmer, K. ; Pfennig, A. ; Soltmann, B. Disturbed sleep in bipolar disorder is related to an elevation of IL-6 in peripheral monocytes. Med. Hypotheses 81, 1031-1033 (2013)
Saha, S. ; Graessler, J. ; Bornstein, S.R. ; Schwarz, P.E. ; Kopprasch, S. Stimulation of phagocyte adhesion to endothelial cells by modified VLDL and HDL requires scavenger receptor BI. Mol. Cell. Biochem. 383, 21-28 (2013)
Saha, S. ; Schwarz, P.E. ; Bergmann, S. ; Bornstein, S.R. ; Graessler, J. ; Kopprasch, S. Circulating very-low-density lipoprotein from subjects with impaired glucose tolerance accelerates adrenocortical cortisol and aldosterone synthesis. Horm. Metab. Res. 45, 169-172 (2013)
Schatz, U. ; Arneth, B. ; Siegert, G. ; Siegels, D. ; Fischer, S. ; Julius, U. ; Bornstein, S.R. Iron deficiency and its management in patients undergoing lipoprotein apheresis. Comparison of two parenteral iron formulations. Atherosclerosis 14, 115-122 (2013)
Schöfl, C. ; Franz, H. ; Grussendorf, M. ; Honegger, J. ; Jaursch-Hancke, C. ; Mayr, B. ; Schopohl, J. Long-term outcome in patients with acromegaly: Analysis of 1344 patients from the German Acromegaly Register. Eur. J. Endocrinol. 168, 39-47 (2013)
Schubert, U. ; Schmid, J. ; Lehmann, S. ; Zhang, X.Y. ; Morawietz, H. ; Block, N.L. ; Kanczkowski, W. ; Schally, A.V. ; Bornstein, S.R. ; Ludwig, B. Transplantation of pancreatic islets to adrenal gland is promoted by agonists of growth-hormone-releasing hormone. Proc. Natl. Acad. Sci. U.S.A. 110, 2288-2293 (2013)
Schwarz, P.E. ; Gallein, G. ; Ebermann, D. ; Müller, A. ; Lindner, A. ; Rothe, U. ; Nebel, I.T. ; Müller, G. Global Diabetes Survey - an annual report on quality of diabetes care. Diabetes Res. Clin. Pract. 100, 11-18 (2013)
Shin, J.T. ; Hosur, K.B. ; Pyaram, K. ; Jotwani, R. ; Liang, S. ; Chavakis, T. ; Hajishengallis, G. Expression and function of the homeostatic molecule Del-1 in endothelial cells and the periodontal tissue. Clin. Dev. Immunol. 2013:617809 (2013)
Singh, R.P. ; Franke, K. ; Kalucka, J. ; Mamlouk, S. ; Muschter, A. ; Gembarska, A. ; Grinenko, T. ; Willam, C. ; Naumann, R. ; Anastassiadis, K. ; Stewart, A.F. ; Bornstein, S.R. ; Chavakis, T. ; Breier, G. ; Waskow, C. ; Wielockx, B. HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress. Blood 121, 5158-5166 (2013)
Stalder, T. ; Kirschbaum, C. ; Alexander, N. ; Bornstein, S.R. ; Gao, W. ; Miller, R. ; Stark, S. ; Bosch, J.A. ; Fischer, J.E. Cortisol in hair and the metabolic syndrome. J. Clin. Endocrinol. Metab. 98, 2573-2580 (2013)
Sturm, D. ; Marselli, L. ; Ehehalt, F. ; Richter, D. ; Distler, M. ; Kersting, S. ; Grützmann, R. ; Bokvist, K. ; Froguel, P. ; Liechti, R. ; Jörns, A. ; Meda, P. ; Baretton, G.B. ; Saeger, H.-D. ; Schulte, A.M. ; Marchetti, P. ; Solimena, M. Improved protocol for laser microdissection of human pancreatic islets from surgical specimens. J. Vis. Exp. 71:e50231 (2013)
Swierczynska, M.M. ; Lamounier-Zepter, V. ; Bornstein, S.R. ; Eaton, S. Lipoproteins and Hedgehog signalling - possible implications for the adrenal gland function. Eur. J. Clin. Invest. 43, 1178-1183 (2013)
Taseva, K. ; Fischer, S. ; Passauer, J. ; Weiss, N. ; Bornstein, S.R. ; Julius, U. Factors inducing cardiovascular events in patients treated by lipoprotein apheresis. Atherosclerosis 14, 45-50 (2013)
Tausche, A.K. ; Gehrisch, S. ; Panzner, I. ; Winzer, M. ; Range, U. ; Bornstein, S.R. ; Siegert, G. ; Wunderlich, C. ; Aringer, M. A 3-day delay in synovial fluid crystal identification did not hinder the reliable detection of monosodium urate and calcium pyrophosphate crystals. J. Clin. Rheumatol. 19, 241-245 (2013)
Toker, A. ; Engelbert, D. ; Garg, G. ; Polansky, J.K. ; Floess, S. ; Miyao, T. ; Baron, U. ; Düber, S. ; Geffers, R. ; Giehr, P. ; Schallenberg, S. ; Kretschmer, K. ; Olek, S. ; Walter, J. ; Weiss, S. ; Hori, S. ; Hamann, A. ; Huehn, J. Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus. J. Immunol. 190, 3180-3188 (2013)
Toporkiewicz, M. ; Grzybek, M. ; Meissner, J. ; Michalczyk, I. ; Dubielecka, P.M. ; Korycka, J. ; Seweryn, E. ; Sikorski, A.F. Release of an ~55kDa fragment containing the actin-binding domain of β-spectrin by caspase-8 during FND-induced apoptosis depends on the presence of protein 4.1. Arch. Biochem. Biophys. 535, 205-213 (2013)
Tsourdi, E. ; Barthel, A. ; Rietzsch, H. ; Reichel, A. ; Bornstein, S.R. Current aspects in the pathophysiology and treatment of chronic wounds in diabetes mellitus. Biomed Res. Int. 2013:385641 (2013)
Ullmann, E. ; Barthel, A. ; Licinio, J. ; Petrowski, K. ; Bornstein, S.R. ; Strauß, B. Increased rate of depression and psychosomatic symptoms in Jewish migrants from the post-Soviet-Union to Germany in the 3rd generation after the Shoa. Transl. Psychiatry 3:e241 (2013)
von Dryander, M. ; Fischer, S. ; Passauer, J. ; Müller, G. ; Bornstein, S.R. ; Julius, U. Differences in the atherogenic risk of patients treated by lipoprotein apheresis according to their lipid pattern. Atherosclerosis 14, 39-44 (2013)
Willmes, D.M. ; Birkenfeld, A.L. The role of INDY in metabolic regulation. Comp. Struc. Biotech. J. 6:e201303020 (2013)
Ziegler, A.-G. ; Rewers, M. ; Simell, O. ; Simell, T. ; Lempainen, J. ; Steck, A. ; Winkler, C. ; Ilonen, J. ; Veijola, R. ; Knip, M. ; Bonifacio, E. ; Eisenbarth, G.S. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 309, 2473-2479 (2013)
Ziegler, C.G. ; Ullrich, M. ; Schally, A.V. ; Bergmann, R. ; Pietzsch, J. ; Gebauer, L. ; Gondek, K. ; Qin, N. ; Pacak, K. ; Ehrhart-Bornstein, M. ; Eisenhofer, G. ; Bornstein, S.R. Anti-tumor effects of peptide analogs targeting neuropeptide hormone receptors on mouse pheochromocytoma cells. Mol. Cell. Endocrinol. 371, 189-194 (2013)