Publications of the PLID

Here you can find all articles of PLID scientists that were published within the last 5 years. By law we are prevented from posting the pdf files of recent publications on our website.
Please contact us directly if you are interested in a reprint. Thank you.

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Featured Publications

Better efficacy of an orally available GLP-1 agonist compared to DPP-IV inhibitor

With the participation of researchers from the PLID, a GLP-1 receptor agonist in the form of tablets could for the first time be compared with the most common second-line therapy of T2D, a DPP-IV inhibitor. The results of the PIONEER-3 trial have now been published in the renowned journal ´Journal of the American Medical Association (JAMA)´.

Publikation_Grzybek_AdiposeTissueLipidomics

New shotgun lipidomics method for molecular profiling of adipose tissue

Scientists from PLID, University Hospital Carl Gustav Carus and Lipotype GmbH joined their forces and developed a new shotgun lipidomics method for the molecular profiling of brown and white adipose tissue.

How a protein promotes the healing of inflammation

Inflammatory processes are a natural defense reaction of the immune system against pathogens. If they get out of control, they can however lead to diseases themselves. The protein DEL-1, is a central actor that ensures that excessive inflammation subsides. Scientists from the Medical Faculty Carl Gustav Carus of the TU Dresden and the National Center for Tumor Diseases Dresden (NCT/UCC), together with an international team of researchers, were able to demonstrate the importance and basic function of this protein.

How the insulin receptor works

Scientists at PLID have found out how cells react to insulin. It was previously known that insulin transmits a signal through receptors on the cell surface, however the Coskun group was now able to observe a change in the shape of the receptors.

Largest collection of islet cells reveals new diabetes genes

A collaborative study has identified a novel cluster of dysregulated genes in the pancreatic islets of patients with type 2 diabetes. The study is part of the EU-Innovative Medicine Initiative (IMI) research consortium IMIDIA.

Rainbow colors reveal cell history

Dr. Nikolay Ninov and his group developed a system called “Beta-bow”, which allows the history of β-cells to be traced by genetic bar-coding and multicolor imaging.

Pancreas lineage allocation and specification

Sphingosine-1-phosphate has a key role in mouse pancreas progenitor survival and the generation of the endocrine and acinar lineages. S1p signaling promotes endocrine specification by stabilizing YAP and attenuating Notch signaling.

Recent Publications

Here you can find the 10 latest publications of our institute. If you are looking for older publications, please follow the link below to our publications form 2013 until today.

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Protein Methyltransferase Inhibition Decreases Endocrine Specification Through the Upregulation of Aldh1b1 Expression. Giannios I, Serafimidis I, Anastasiou V, Pezzolla D, Lesche M, Andree C, Bickle M, Gavalas A. Stem Cells. 2019 Jan 25. doi: 10.1002/stem.2979. [Epub ahead of print]
Nerve growth factor regulates endothelial cell survival and pathological retinal angiogenesis. Troullinaki M, Alexaki VI, Mitroulis I, Witt A, Klotzsche-von Ameln A, Chung KJ, Chavakis T, Economopoulou M. J Cell Mol Med. 2019 Jan 24. doi: 10.1111/jcmm.14002. [Epub ahead of print]
Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families. Hippich M, Beyerlein A, Hagopian WA, Krischer JP, Vehik K, Knoop J, Winker C, Toppari J, Lernmark Å, Rewers MJ, Steck AK, She JX, Akolkar B, Robertson CC, Onengut-Gumuscu S, Rich SS, Bonifacio E, Ziegler AG; TEDDY Study Group. Diabetes. 2019 Jan 17. pii: db180882. doi: 10.2337/db18-0882. [Epub ahead of print]
Short-term antidepressant treatment has long-lasting effects, and reverses stress-induced decreases in bone features in rats. Lee SH, Mastronardi CA, Li RW, Paz-Filho G, Dutcher EG, Lewis MD, Vincent AD, Smith PN, Bornstein SR, Licinio J, Wong ML. Transl Psychiatry. 2019 Jan 16;9(1):10. doi: 10.1038/s41398-018-0351-z.
53BP1 Deficiency Promotes Pathological Neovascularization in Proliferative Retinopathy. Troullinaki M, Garcia-Martin R, Sprott D, Klotzsche-von Ameln A, Grossklaus S, Mitroulis I, Chavakis T, Economopoulou M. Thromb Haemost. 2019 Jan 8. doi: 10.1055/s-0038-1676966. [Epub ahead of print]
Immunometabolic Crosstalk: An Ancestral Principle of Trained Immunity? Penkov S, Mitroulis I, Hajishengallis G, Chavakis T. Trends Immunol. 2019 Jan;40(1):1-11. doi: 10.1016/j.it.2018.11.002. Epub 2018 Nov 29. Review.
Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection. Delgadillo-Silva LF, Tsakmaki A, Akhtar N, Franklin ZJ, Konantz J, Bewick GA, Ninov N. Dis Model Mech. 2019 Jan 23;12(1). pii: dmm036004. doi: 10.1242/dmm.036004.
Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress. Steenblock C, Rubin de Celis MF, Delgadillo Silva LF, Pawolski V, Brennand A, Werdermann M, Berger I, Santambrogio A, Peitzsch M, Andoniadou CL, Schally AV, Bornstein SR. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):12997-13002. doi: 10.1073/pnas.1814072115. Epub 2018 Dec 4.
Reference intervals for LC-MS/MS measurements of plasma free, urinary free and urinary acid-hydrolyzed deconjugated normetanephrine, metanephrine and methoxytyramine. Eisenhofer G, Peitzsch M, Kaden D, Langton K, Mangelis A, Pamporaki C, Masjkur J, Geroula A, Kurlbaum M, Deutschbein T, Beuschlein F, Prejbisz A, Bornstein SR, Lenders JWM. Clin Chim Acta. 2019 Mar;490:46-54. doi: 10.1016/j.cca.2018.12.019. Epub 2018 Dec 17.
Reprint of: Blood Sugar Regulation for Cardiovascular Health Promotion and Disease Prevention: JACC Health Promotion Series. Schwarz PEH, Timpel P, Harst L, Greaves CJ, Ali MK, Lambert J, Weber MB, Almedawar MM, Morawietz H. J Am Coll Cardiol. 2018 Dec 11;72(23 Pt B):3071-3086. doi: 10.1016/j.jacc.2018.10.026. Review.