Publications of the PLID

Here you can find all articles of PLID scientists that were published within the last 5 years. By law we are prevented from posting the pdf files of recent publications on our website.
Please contact us directly if you are interested in a reprint. Thank you.

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Featured Publications

How insulin interacts with its receptor

One goal of modern diabetes research is to improve the effect of therapeutic insulin on the body. In a new study, the researchers have now solved a critical part of the puzzle by showing how insulin interacts with its receptor at a second binding site.

Graphical Abstract Binger et al.2019 PNAS

International research team identified new important player in insulin homeostasis

Researchers from La Trobe University in Australia and the PLID have identified that the protein Atp6ap2 is essential for the correct functioning of pancreatic beta cells. When this protein was switched off in the beta cells of mice their blood glucose levels dramatically increased.

Metabolically phenotyped surgical patients represent a novel and complementary source of pancreatic tissue for diabetes research

Contemporary research of beta cell biology in context of type-2 diabetes is based mainly on the long-standing technique for isolation of the pancreatic islets of Langerhans. Scientists of the PLID developed a new approach to isolate islets from snap frozen surgical specimens donated by metabolically phenotyped pancreatectomized patients. A new review article published in “Molecular Metabolism” explains how this platform may represent a paradigmatic shift for the study of human islets and diabetes research.

Widespread disease diabetes: Why do beta cells refuse to release insulin?

Researchers from PLID together with colleagues from Imperial College London and other research institutes from the UK, Canada and Italy have observed amazing cell interactions: The beta cells of the pancreas work as highly-connected clusters, known as islets, and their responses to rising blood glucose levels are coordinated by small teams of “leader cells”. To show that, the research teams developed an innovative imaging technique which allowed them to observe beta cells’ hierarchical relationship in live animals including in zebrafish and mouse.

New drug reduces risk of death in patients with type 2 diabetes

In Germany, about one in ten people suffer from diabetes and diabetes patients still die two to three times more frequently from cardiovascular diseases such as heart attacks and strokes. Newly developed drugs for diabetes therapy are therefore expected to reduce the number of cardiovascular deaths. Scientists from the PLID have, together with international colleagues, investigated for the first time whether semaglutide in tablet form leads to a reduction in cardiovascular events. An international, randomized double-blind study with 3,183 participants was therefore conducted in 21 countries in parallel.

Better efficacy of an orally available GLP-1 agonist compared to DPP-IV inhibitor

With the participation of researchers from the PLID, a GLP-1 receptor agonist in the form of tablets could for the first time be compared with the most common second-line therapy of T2D, a DPP-IV inhibitor. The results of the PIONEER-3 trial have now been published in the renowned journal ´Journal of the American Medical Association (JAMA)´.

Publikation_Grzybek_AdiposeTissueLipidomics

New shotgun lipidomics method for molecular profiling of adipose tissue

Scientists from PLID, University Hospital Carl Gustav Carus and Lipotype GmbH joined their forces and developed a new shotgun lipidomics method for the molecular profiling of brown and white adipose tissue.

How a protein promotes the healing of inflammation

Inflammatory processes are a natural defense reaction of the immune system against pathogens. If they get out of control, they can however lead to diseases themselves. The protein DEL-1, is a central actor that ensures that excessive inflammation subsides. Scientists from the Medical Faculty Carl Gustav Carus of the TU Dresden and the National Center for Tumor Diseases Dresden (NCT/UCC), together with an international team of researchers, were able to demonstrate the importance and basic function of this protein.

How the insulin receptor works

Scientists at PLID have found out how cells react to insulin. It was previously known that insulin transmits a signal through receptors on the cell surface, however the Coskun group was now able to observe a change in the shape of the receptors.

Largest collection of islet cells reveals new diabetes genes

A collaborative study has identified a novel cluster of dysregulated genes in the pancreatic islets of patients with type 2 diabetes. The study is part of the EU-Innovative Medicine Initiative (IMI) research consortium IMIDIA.

Rainbow colors reveal cell history

Dr. Nikolay Ninov and his group developed a system called “Beta-bow”, which allows the history of β-cells to be traced by genetic bar-coding and multicolor imaging.

Pancreas lineage allocation and specification

Sphingosine-1-phosphate has a key role in mouse pancreas progenitor survival and the generation of the endocrine and acinar lineages. S1p signaling promotes endocrine specification by stabilizing YAP and attenuating Notch signaling.

Recent Publications

Here you can find the 10 latest publications of our institute. If you are looking for older publications, please follow the link below to our publications form 2013 until today.

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Kahl S, Gancheva S, Straßburger K, Herder C, Machann J, Katsuyama H, Kabisch S, Henkel E, Kopf S, Lagerpusch M, Kantartzis K, Kupriyanova Y, Markgraf D, van Gemert T, Knebel B, Wolkersdorfer MF, Kuss O, Hwang JH, Bornstein SR, Kasperk C, Stefan N, Pfeiffer A, Birkenfeld AL, Roden M.
Empagliflozin Effectively Lowers Liver Fat Content in Well-Controlled Type 2 Diabetes: A Randomized, Double-Blind, Phase 4, Placebo-Controlled Trial.
Diabetes Care. 2020 Feb;43(2):298-305. doi: 10.2337/dc19-0641. Epub 2019 Sep 20. PubMed PMID: 31540903.
Troullinaki M, Chen LS, Witt A, Pyrina I, Phieler J, Kourtzelis I, Chmelar J, Sprott D, Gercken B, Koutsilieris M, Chavakis T, Chatzigeorgiou A.
Robo4-mediated pancreatic endothelial integrity decreases inflammation and islet destruction in autoimmune diabetes.
FASEB J. 2020 Jan 9. doi: 10.1096/fj.201900125RR. [Epub ahead of print] PubMed PMID: 31916652.
Gutmann T, Schäfer IB, Poojari C, Brankatschk B, Vattulainen I, Strauss M, Coskun Ü.
Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain.
J Cell Biol. 2020 Jan 6;219(1). pii: e201907210. doi:10.1083/jcb.201907210. PubMed PMID: 31727777.
Knoop J, Eugster A, Gavrisan A, Lickert R, Sedlmeier EM, Dietz S, Lindner A, Warncke K, Hummel N, Ziegler AG, Bonifacio E.
Maternal Type 1 Diabetes Reduces Autoantigen-Responsive CD4(+) T Cells in Offspring.
Diabetes. 2020 Jan 2. pii:db190751. doi: 10.2337/db19-0751. [Epub ahead of print] PubMed PMID: 31896551.
Mziaut H, Henniger G, Ganss K, Hempel S, Wolk S, McChord J, Chowdhury K, Ravassard P, Knoch KP, Krautz C, Weitz J, Grützmann R, Pilarsky C, Solimena M, Kersting S.
MiR-132 controls pancreatic beta cell proliferation and survival through Pten/Akt/Foxo3 signaling.
Mol Metab. 2020 Jan;31:150-162. doi:10.1016/j.molmet.2019.11.012. Epub 2019 Nov 22. PubMed PMID: 31918917; PubMed Central PMCID: PMC6928290.
Schumann T, König J, Henke C, Willmes DM, Bornstein SR, Jordan J, Fromm MF, Birkenfeld AL.
Solute Carrier Transporters as Potential Targets for the Treatment of Metabolic Disease.
Pharmacol Rev. 2020 Jan;72(1):343-379. doi:10.1124/pr.118.015735. Review. PubMed PMID: 31882442.
Bonifacio E, Achenbach P.
Birth and coming of age of islet autoantibodies.
Clin Exp Immunol. 2019 Dec;198(3):294-305. doi: 10.1111/cei.13360. Epub 2019 Sep 12. Review. PubMed PMID: 31397889; PubMed Central PMCID: PMC6857083.
Goldman O, Puchinsky D, Durlacher K, Sancho R, Ludwig B, Kugelmeier P, Heller C, Kunicher N, Bornstein SR, Treves AJ.
Lung Based Engineered Micro-Pancreas Sustains Human Beta Cell Survival and Functionality.
Horm Metab Res. 2019 Dec;51(12):805-811. doi: 10.1055/a-1041-3305. Epub 2019 Dec 11. PubMed PMID: 31826275.
Angelini G, Gissey LC, Del Corpo G, Giordano C, Cerbelli B, Severino A, Manco M, Basso N, Birkenfeld AL, Bornstein SR, Genco A, Mingrone G, Casella G.
New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery.
Sci Rep. 2019 Nov 21;9(1):17315. doi: 10.1038/s41598-019-53702-4. PubMed PMID: 31754142; PubMed Central PMCID: PMC6872729.
Fuchs YF, Sharma V, Eugster A, Kraus G, Morgenstern R, Dahl A, Reinhardt S, Petzold A, Lindner A, Löbel D, Bonifacio E.
Gene Expression-Based Identification of Antigen-Responsive CD8(+) T Cells on a Single-Cell Level.
Front Immunol. 2019 Nov 6;10:2568. doi: 10.3389/fimmu.2019.02568. eCollection 2019. PubMed PMID: 31781096; PubMed Central PMCID: PMC6851025.