Publikationen

  • Witt A, Mateska I, Palladini A, Sinha A, Wölk M, Harauma A, Bechmann N, Pamporaki C, Dahl A, Rothe M, Kopaliani I, Adolf C, Riester A, Wielockx B, Bornstein SR, Kroiss M, Peitzsch M, Moriguchi T, Fedorova M, Grzybek M, Chavakis T, Mirtschink P, Alexaki. Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland. Sci Adv. 2023 Jul 21;9(29):eadf6710. doi: 10.1126/sciadv.adf6710. Epub 2023 Jul 21.
  • Subramanian P, Gargani S, Palladini A, Chatzimike M, Grzybek M, Peitzsch M, Papanastasiou AD, Pyrina I, Ntafis V, Gercken B, Lesche M, Petzold A, Sinha A, Nati M, Thangapandi VR, Kourtzelis I, Andreadou M, Witt A, Dahl A, Burkhardt R, Haase R, Domingues AMJ, Henry I, Zamboni N, Mirtschink P, Chung KJ, Hampe J, Coskun Ü, Kontoyiannis DL, Chavakis T. The RNA binding protein human antigen R is a gatekeeper of liver homeostasis. Hepatology. 2022;75:881-897. doi: 10.1002/hep.32153.
  • Ansarullah, Jain C, Far FF, Homberg S, Wißmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenländer L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Müller TD, Meier M, Tschöp MH, Coskun Ü, Lickert H. Inceptor counteracts insulin signalling in β-cells to control glycaemia. Nature. 2021;590:326-331. doi: 10.1038/s41586-021-03225-8.
  • Trautenberg LC, Prince E, Maas C, Beier N, Honold F, Grzybek M#, Brankatschk M#. Selective Phosphorylation of Akt/Protein-Kinase B Isoforms in Response to Dietary Cues. Front Cell Dev Biol. 2019;7:206. doi: 10.3389/fcell.2019.00206.
  • Backman M, Flenkenthaler F, Blutke A, Dahlhoff M, Ländström E, Renner S, Philippou-Massier J, Krebs S, Rathkolb B, Prehn C, Grzybek M, Coskun Ü, Rothe M, Adamski J, de Angelis MH, Wanke R, Fröhlich T, Arnold GJ, Blum H, Wolf E. Multiomics insights into functional alterations of the liver in insulin-deficient diabetes mellitus. Mol Metab. 2019; 26:30-44. doi: 10.1016/j.molmet.2019.05.011.
  • Grzybek M, Palladini A, Alexaki VI, Surma MA, Simons K, Chavakis T, Klose C, Coskun Ü. Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics. Mol Metab. 2019;22:12-20. doi: 10.1016/j.molmet.2019.01.009.
  • Kourtzelis I, Li X, Mitroulis I, Grosser D, Kajikawa T, Wang B, Grzybek M, von Renesse J, Czogalla A, Troullinaki M, Ferreira A, Doreth C, Ruppova K, Chen LS, Hosur K, Lim JH, Chung KJ, Grossklaus S, Tausche AK, Joosten LAB, Moutsopoulos NM, Wielockx B, Castrillo A, Korostoff JM, Coskun Ü, Hajishengallis G, Chavakis T. DEL-1 promotes macrophage efferocytosis and clearance of inflammation. Nat Immunol. 2019;20(1):40-49. doi: 10.1038/s41590-018-0249-1.
  • Brankatschk M, Gutmann T, Knittelfelder O, Palladini A, Prince E, Grzybek M, Brankatschk B, Shevchenko A, Coskun Ü, Eaton S. A Temperature-Dependent Switch in Feeding Preference Improves Drosophila Development and Survival in the Cold. Dev Cell. 2018;47(2):257-259. doi: 10.1016/j.devcel.2018.10.010.
  • Gutmann T, Kim KH, Grzybek M, Walz T, Coskun Ü. Visualization of ligand- induced transmembrane signaling in the full-length human insulin receptor. J Cell Biol. 2018;217(5):1643-1649. doi: 10.1083/jcb.201711047.
  • Toepfner N, Herold C, Otto O, Rosendahl P, Jacobi A, Kräter M, Stächele J, Menschner L, Herbig M, Ciuffreda L, Ranford-Cartwright L, Grzybek M, Coskun Ü, Reithuber E, Garriss G, Mellroth P, Henriques-Normark B, Tregay N, Suttorp M, Bornhäuser M, Chilvers ER, Berner R, Guck J. Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood. Elife. 2018;7:e29213. doi: 10.7554/eLife.29213.
  • Mitroulis I, Ruppova K, Wang B, Chen LS, Grzybek M, Grinenko T, Eugster A, Troullinaki M, Palladini A, Kourtzelis I, Chatzigeorgiou A, Schlitzer A, Beyer M, Joosten LAB, Isermann B, Lesche M, Petzold A, Simons K, Henry I, Dahl A, Schultze JL, Wielockx B, Zamboni N, Mirtschink P, Coskun Ü, Hajishengallis G, Netea MG, Chavakis T. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell. 2018;172(1-2):147-161.e12. doi:10.1016/j.cell.2017.11.034.
  • Blutke A, Renner S, Flenkenthaler F, Backman M, Haesner S, Kemter E, Ländström E, Braun-Reichhart C, Albl B, Streckel E, Rathkolb B, Prehn C, Palladini A, Grzybek M, Krebs S, Bauersachs S, Bähr A, Brühschwein A, Deeg CA, De Monte E, Dmochewitz M, Eberle C, Emrich D, Fux R, Groth F, Gumbert S, Heitmann A, Hinrichs A, Keßler B, Kurome M, Leipig-Rudolph M, Matiasek K, Öztürk H, Otzdorff C, Reichenbach M, Reichenbach HD, Rieger A, Rieseberg B, Rosati M, Saucedo MN, Schleicher A, Schneider MR, Simmet K, Steinmetz J, Übel N, Zehetmaier P, Jung A, Adamski J, Coskun Ü, Hrabě de Angelis M, Simmet C, Ritzmann M, Meyer-Lindenberg A, Blum H, Arnold GJ, Fröhlich T, Wanke R, Wolf E. The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes. Mol Metab. 2017;6(8):931-940. doi: 10.1016/j.molmet.2017.06.004.
  • Rissanen S*, Grzybek M*, Orłowski A, Róg T, Cramariuc O, Levental I, Eggeling C, Sezgin E, Vattulainen I. Phase Partitioning of GM1 and Its Bodipy-Labeled Analog Determine Their Different Binding to Cholera Toxin. Front Physiol. 2017;8:252. doi: 10.3389/fphys.2017.00252.
  • Stefanko A, Thiede C, Ehninger G, Simons K, Grzybek M#. Lipidomic approach for stratification of acute myeloid leukemia patients. PLoS One. 2017;12(2):e0168781. doi: 10.1371/journal.pone.0168781.
  • Beutel O, Roder F, Birkholz O, Rickert C, Steinhoff HJ, Grzybek M, Coskun Ü, Piehler J. Two-Dimensional Trap for Ultrasensitive Quantification of Transient Protein Interactions. ACS Nano. 2015;9(10):9783-91. doi:10.1021/acsnano.5b02696.
  • Luisoni S, Suomalainen M, Boucke K, Tanner LB, Wenk MR, Guan XL, Grzybek M, Coskun Ü, Greber UF. Co-option of Membrane Wounding Enables Virus Penetration into Cells. Cell Host Microbe. 2015;18(1):75-85. doi:10.1016/j.chom.2015.06.006.
  • Podkalicka J, Biernatowska A, Majkowski M, Grzybek M, Sikorski AF. MPP1 as a Factor Regulating Phase Separation in Giant Plasma Membrane-Derived Vesicles. Biophys J. 2015;108(9):2201-11. doi: 10.1016/j.bpj.2015.03.017.
  • Sezgin E, Gutmann T, Buhl T, Dirkx R, Grzybek M, Coskun Ü, Solimena M, Simons K, Levental I, Schwille P. Adaptive lipid packing and bioactivity in membrane domains. PLoS One. 2015;10(4):e0123930. doi:10.1371/journal.pone.0123930.
  • Kaszuba K, Grzybek M*, Orłowski A, Danne R, Róg T, Simons K, Coskun Ü, Vattulainen I. N-Glycosylation as determinant of epidermal growth factor receptor conformation in membranes. Proc Natl Acad Sci U S A. 2015;112(14):4334-9. doi: 10.1073/pnas.1503262112.
  • Lenoir M, Grzybek M, Majkowski M, Rajesh S, Kaur J, Whittaker SB, Coskun Ü, Overduin M. Structural basis of dynamic membrane recognition by trans-Golgi network specific FAPP proteins. J Mol Biol. 2015;427(4):966-981. doi:10.1016/j.jmb.2014.12.023.
  • Gerl MJ, Sachsenheimer T, Grzybek M, Coskun U, Wieland FT, Brügger B. Analysis of transmembrane domains and lipid modified peptides with matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. Anal Chem. 2014;86(8):3722-6. doi: 10.1021/ac500446z.
  • Czogalla A, Grzybek M, Jones W, Coskun U. Validity and applicability of membrane model systems for studying interactions of peripheral membrane proteins with lipids. Biochim Biophys Acta. 2014;1841(8):1049-59. doi:10.1016/j.bbalip.2013.12.012.
  • Toporkiewicz M, Grzybek M, Meissner J, Michalczyk I, Dubielecka PM, Korycka J, Seweryn E, Sikorski AF. Release of an ~55kDa fragment containing the actin-binding domain of β-spectrin by caspase-8 during FND-induced apoptosis depends on the presence of protein 4.1. Arch Biochem Biophys. 2013;535(2):205-13. doi: 10.1016/j.abb.2013.03.009.
  • Orłowski A, Grzybek M, Bunker A, Pasenkiewicz-Gierula M, Vattulainen I, Männistö PT, Róg T. Strong preferences of dopamine and l-dopa towards lipid head group: importance of lipid composition and implication for neurotransmitter metabolism. J Neurochem. 2012;122(4):681-90. doi:10.1111/j.1471-4159.2012.07813.x.
  • Sezgin E, Levental I, Grzybek M, Schwarzmann G, Mueller V, Honigmann A, Belov VN, Eggeling C, Coskun U, Simons K, Schwille P. Partitioning, diffusion, and ligand binding of raft lipid analogs in model and cellular plasma membranes. Biochim Biophys Acta. 2012 Jul;1818(7):1777-84. doi:10.1016/j.bbamem.2012.03.007.
  • Kaiser HJ, Surma MA, Mayer F, Levental I, Grzybek M, Klemm RW, Da Cruz S, Meisinger C, Müller V, Simons K, Lingwood D. Molecular convergence of bacterial and eukaryotic surface order. J Biol Chem. 2011;286(47):40631-7. doi:10.1074/jbc.M111.276444.
  • Wolny M, Grzybek M, Bok E, Chorzalska A, Lenoir M, Czogalla A, Adamczyk K, Kolondra A, Diakowski W, Overduin M, Sikorski AF. Key amino acid residues of ankyrin-sensitive phosphatidylethanolamine/phosphatidylcholine-lipid binding site of βI-spectrin. PLoS One. 2011;6(6):e21538. doi:10.1371/journal.pone.0021538.
  • Levental I, Grzybek M, Simons K. Raft domains of variable properties and compositions in plasma membrane vesicles. Proc Natl Acad Sci U S A. 2011;108(28):11411-6. doi: 10.1073/pnas.1105996108.
  • Coskun Ü, Grzybek M*, Drechsel D, Simons K. Regulation of human EGF receptor by lipids. Proc Natl Acad Sci U S A. 2011;108(22):9044-8. doi:10.1073/pnas.1105666108.
  • Lingwood D, Binnington B, Róg T, Vattulainen I, Grzybek M, Coskun U, Lingwood CA, Simons K. Cholesterol modulates glycolipid conformation and receptor activity. Nat Chem Biol. 2011;7(5):260-2. doi:10.1038/nchembio.551.
  • Levental I, Lingwood D, Grzybek M, Coskun U, Simons K. Palmitoylation regulates raft affinity for the majority of integral raft proteins. Proc Natl Acad Sci U S A. 2010;107(51):22050-4. doi: 10.1073/pnas.1016184107.
  • Mishra R, Grzybek M, Niki T, Hirashima M, Simons K. Galectin-9 trafficking regulates apical-basal polarity in Madin-Darby canine kidney epithelial cells. Proc Natl Acad Sci U S A. 2010;107(41):17633-8. doi:10.1073/pnas.1012424107.
  • Kolondra A, Lenoir M, Wolny M, Czogalla A, Overduin M, Sikorski AF, Grzybek M#. The role of hydrophobic interactions in ankyrin-spectrin complex formation. Biochim Biophys Acta. 2010;1798(11):2084-9. doi:10.1016/j.bbamem.2010.07.024.
  • Levental I, Grzybek M, Simons K. Greasing their way: lipid modifications determine protein association with membrane rafts. Biochemistry. 2010;49(30):6305-16. doi: 10.1021/bi100882y.
  • Lenoir M, Coskun U, Grzybek M, Cao X, Buschhorn SB, James J, Simons K, Overduin M. Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains. EMBO Rep. 2010;11(4):279-84. doi: 10.1038/embor.2010.28.
  • Kamal MM, Mills D, Grzybek M, Howard J. Measurement of the membrane curvature preference of phospholipids reveals only weak coupling between lipid shape and leaflet curvature. Version 2. Proc Natl Acad Sci U S A. 2009;106(52):22245-50. doi: 10.1073/pnas.0907354106.
  • Dubielecka PM, Grzybek M*, Kolondra A, Jaźwiec B, Draga A, Aleksandrowicz P, Kołodziejczyk M, Serwotka A, Dolińska-Krajewska B, Warchoł J, Kuliczkowski K, Sikorski AF. Aggregation of spectrin and PKCtheta is an early hallmark of fludarabine/mitoxantrone/dexamethasone-induced apoptosis in Jurkat T and HL60 cells. Mol Cell Biochem. 2010;339(1-2):63-77. doi:10.1007/s11010-009-0370-4.
  • Cao X, Coskun U, Rössle M, Buschhorn SB, Grzybek M, Dafforn TR, Lenoir M, Overduin M, Simons K. Golgi protein FAPP2 tubulates membranes. Proc Natl Acad Sci U S A. 2009;106(50):21121-5. doi: 10.1073/pnas.0911789106
  • Grzybek M, Kubiak J, Łach A, Przybyło M, Sikorski AF. A raft-associated species of phosphatidylethanolamine interacts with cholesterol comparably to sphingomyelin. A Langmuir-Blodgett monolayer study. PLoS One. 2009;4(3):e5053. doi: 10.1371/journal.pone.0005053.
  • Kolondra A, Grzybek M, Chorzalska A, Sikorski AF. The 22.5 kDa spectrin-binding domain of ankyrinR binds spectrin with high affinity and changes the spectrin distribution in cells in vivo. Protein Expr Purif. 2008;60(2):157-64. doi: 10.1016/j.pep.2008.04.002.
  • Diakowski W, Grzybek M, Sikorski AF. Protein 4.1, a component of the erythrocyte membrane skeleton and its related homologue proteins forming the protein 4.1/FERM superfamily. Folia Histochem Cytobiol. 2006;44(4):231-48.
  • Dubielecka PM, Trusz A, Diakowski W, Grzybek M, Chorzalska A, Jaźwiec B, Lisowski M, Jezierski A, Sikorski AF. Mitoxantrone changes spectrin-aminophospholipid interactions. Mol Membr Biol. 2006;23(3):235-43. doi:10.1080/09687860600601643.
  • Grzybek M, Chorzalska A, Bok E, Hryniewicz-Jankowska A, Czogalla A, Diakowski W, Sikorski AF. Spectrin-phospholipid interactions. Existence of multiple kinds of binding sites? Chem Phys Lipids. 2006;141(1-2):133-41.doi: 10.1016/j.chemphyslip.2006.02.008.
  • Grzybek M, Kolondra A, Sikorski A. Q10 and its analogues - Promising compounds in the fight with various disorders. Agro Food Industry Hi-Tech 2006;17(6) 14-16.
  • Grzybek M, Kozubek A, Dubielecka P, Sikorski AF. Rafts--the current picture. Folia Histochem Cytobiol. 2005;43(1):3-10.
  • Sroda K, Rydlewski J, Langner M, Kozubek A, Grzybek M, Sikorski AF. Repeated injections of PEG-PE liposomes generate anti-PEG antibodies. Cell Mol Biol Lett. 2005;10(1):37-47.
  • Grzybek M, Stebelska K, Wyrozumska P, Grieb P, Langner M, Jaszewski A, Jezierski A, Sikorski AF. ESR and monolayer study of the localization of coenzyme Q10 in artificial membranes Gen Physiol Biophys 2005; 24(4) 449-460.
  • Stebelska K, Wyrozumska P, Grzybek M, Sikorski AF. Characterization and medical applications of liposome constructions. Adv Clin Exp Med 2002; 11(2) 229-242.
  • Grzybek M, Wyrozumska P, Stebelska K, Sikorski AF. Prodrugs and their formulations. Medycyna Weterynaryjna 2002; 58(6) 420-425.

Book Chapters:

  • Wyrozumska P, Stebelska K, Grzybek M, Grieb P, Langner M, Jaszewski A, Jezierski A, Sikorski AF. Synthetic vectors for genetic drug delivery. Springer Netherlands, (2006), 139-174
  • Sikorski A, Czogalla A, Hryniewicz-Jankowska A, Bok E, Plazuk E, Diakowski W, Chorzalska A, Kolondra A, Langner M, Grzybek M. Interactions of Erythroid and Nonerythroid Spectrins and Other Membrane-Skeletal Proteins with Lipid Mono- and Bilayers, Elsevier, (2008)
  • Grzybek M, Gutmann T, Coskun Ü; Functional role of membrane lipids in EGF receptor dynamics and regulation. CRC Press, (2014), 41-58

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Elena Wiederhold
Letzte Änderung: 29.08.2023