Research Groups & Publications
SPP2389 has united highly skilled and multidisciplinary groups that will bring to the table expertise, novelty and experience to understand and unveil the bacterial multicellularity traits and emergent functions. Thus, the program covers different perspectives of bacterial multicellularity, such as studies in colonies and biofilms, filamentous microorganisms, and the medical context of multicellularity.
Methods
Single-cell RNA sequencing of multicellular communities
Prof Dr Susanne Häußler
Resolving bacterial collectives on the single-cell level with flow cytometry, cell sorting, and multi-omics data science - Z-PROJECT
Prof Dr Susann Müller, Prof Dr Christian Müller
Biofilms and Colonies
How do biofilms heal their wounds?
Prof Dr Liraz Chai, Prof Dr Vasily Zaburdaev
Cannibalism in Bacillus subtilis colonies: Role of programmed cell death in shaping and functionalizing differentiated multicellular populations
Prof Dr Klaus Dreisewerd, Prof Dr Thorsten Mascher
Form-function relationships in the development of Bacillus subtilis fruiting bodies
Dr Ilka Bischofs, PD Dr Karl Rohr
Non-hereditary, contact-dependent molecular exchange as a prerequisite for bacterial multicellularity
Prof Dr Sigal Ben-Yehuda, Prof Dr Boris Macek
Large-scale extracellular matrix architecture and tissue-like morphogenesis as emerging properties of bacterial multicellularity
Prof Dr Regine Hengge
Altruistic suicide in multicellular clusters of bacteria causes and consequences
Prof Dr Alexander Grünberger, Prof Dr Christian Kost
Collective membrane potential dynamics in bacterial colonies
Prof Dr Berenike Maier
Quantifying the Link Between Architectural Integrity and Adaptive Potential in Developing Biofilms
Prof Dr Oskar Hallatschek
Filaments
Ca2+ signalling in cyanobacteria multicellularity: unravelling the network of the Ca2+ sensor CSE
Dr Khaled Selim
Cause and consequences of multicellularity in Streptomyces
Prof Dr Natalia Tschowri, Prof Dr Daniel Rozen
Early Determinants of Heterocyst Differentiation in Multicellular Cyanobacteria
Prof Dr Rolf Backofen, Prof Dr Wolfgang Hess
Medical Context of Multicellularity
Antibiotic tolerance of biofilms emerging from multicellular effects of antibiotic efflux
Prof Dr Rosalind J Allen, Dr Frank Schreiber
Cooperative pathogenicity of enteropathogenic E. coli within mucosa-attached microcolonies
Dr Aline Dupont, Dr Emmanuel Saliba, Prof Dr Markus Sauer
Function of Small basic protein (Sbp) in Staphylococcus epidermidis biofilm matrix assembly: molecular mechanisms and spatio-temporal patterning
Prof Dr Holger Rohde
Mechanisms underlying emergence of antibiotic tolerance of Vibrio cholerae biofilms
Prof Dr Knut Drescher, Prof Dr Kai Papenfort
The impact of Streptokinase on biofilm heterogeneity of group G streptococci
Prof Dr Michael Lalk, Prof Dr Nikolai Siemens