Research Groups & Publications
SPP2389 has united highly skilled and multidisciplinary groups that will bring to the table expertise, novelty and experience to understand and unveil the bacterial multicellularity traits and emergent functions. Thus, the program covers different perspectives of bacterial multicellularity, such as studies in colonies and biofilms, filamentous microorganisms, and the medical context of multicellularity.
Methods
Single-cell RNA sequencing of multicellular communities
Prof. Dr. Susanne Häußler
Resolving bacterial collectives on the single-cell level with flow cytometry, cell sorting, and multi-omics data science - Z-PROJECT
Prof. Dr. Susann Müller, Prof. Dr. Christian Müller
Biofilms and Colonies
How do biofilms heal their wounds?
Prof. Dr. Liraz Chai, Prof. Dr. Vasily Zaburdaev
Cannibalism in Bacillus subtilis colonies: Role of programmed cell death in shaping and functionalizing differentiated multicellular populations
Prof. Dr. Klaus Dreisewerd, Prof. Dr. Thorsten Mascher
Form-function relationships in the development of Bacillus subtilis fruiting bodies
Dr. Ilka Bischofs, Prof. Dr. Karl Rohr
Non-hereditary, contact-dependent molecular exchange as a prerequisite for bacterial multicellularity
Prof. Dr. Sigal Ben-Yehuda, Prof. Dr. Boris Macek
Large-scale extracellular matrix architecture and tissue-like morphogenesis as emerging properties of bacterial multicellularity
Prof. Dr. Regine Hengge
Altruistic suicide in multicellular clusters of bacteria causes and consequences
Prof. Dr. Alexander Grünberger, Prof. Dr. Christian Kost
Collective membrane potential dynamics in bacterial colonies
Prof. Dr. Berenike Maier
Quantifying the Link Between Architectural Integrity and Adaptive Potential in Developing Biofilms
Prof. Dr. Oskar Hallatschek
Filaments
Ca2+ signalling in cyanobacteria multicellularity: unravelling the network of the Ca2+ sensor CSE
Dr. Khaled Selim
Cause and consequences of multicellularity in Streptomyces
Prof. Dr. Natalia Tschowri, Prof. Dr. Daniel Rozen
Early Determinants of Heterocyst Differentiation in Multicellular Cyanobacteria
Prof. Dr. Rolf Backofen, Prof. Dr. Wolfgang Hess
Medical Context of Multicellularity
Antibiotic tolerance of biofilms emerging from multicellular effects of antibiotic efflux
Prof. Dr. Rosalind J Allen, Dr. Frank Schreiber
Cooperative pathogenicity of enteropathogenic E. coli within mucosa-attached microcolonies
Dr. Aline Dupont, Dr. Emmanuel Saliba, Prof. Dr. Markus Sauer
Function of Small basic protein (Sbp) in Staphylococcus epidermidis biofilm matrix assembly: molecular mechanisms and spatio-temporal patterning
Prof. Dr. Holger Rohde
Mechanisms underlying emergence of antibiotic tolerance of Vibrio cholerae biofilms
Prof. Dr. Knut Drescher, Prof. Dr. Kai Papenfort
The impact of Streptokinase on biofilm heterogeneity of group G streptococci
Prof. Dr. Michael Lalk, Prof. Dr. Nikolai Siemens