FENABIUM II
Studies on the interactions of f-elements with biologically relevant structural motifs: Derivation of basic structure-activity principles for mobilization in the environment. „FENABIUM II“
Joint project, funded by the Federal Ministry of Education and Research (BMBF)
Funding area/measure: Nuclear safety research and radiation research
Project leader: Prof. Jan J. Weigand
Dr. M. Acker, Prof. E. Brunner, Prof. T. Henle, Prof. Jan J. Weigand
Faculty of Chemistry and Food Chemistry and Central Radionuclid Laboratory, TU Dresden
Prof. B. Kersting
Institut of Inorganic Chemistry, University Leipzig
Prof. T. Stumpf
Institute for Resource Ecology, Helmholtz Centre Dresden-Rossendorf
Based on the successful FENABIUM project, the joint project will investigate in detail structure-activity relationships between f-elements and known, biologically relevant structural motifs. With regard to the assessment of a spread of these elements in geo- and biosystems, especially after an accidental release, the entry of actinoids into the food chain is of particular relevance. In the joint project, bioinspired model compounds will be set up, the f-element complexes formed structurally characterised and their thermodynamic parameters determined in order to gain a fundamental understanding of the present interactions. Furthermore, studies are carried out on selected amino acids and peptide sequences as well as on food-relevant proteins. In focus are caseins, the most important group of milk proteins from a quantitative point of view. Based on the knowledge gained from the model ligands, a fundamental transfer of the findings to biological overall systems can take place.
Another important aspect of the joint project is the training and promotion of young scientists. In addition to the scientific qualification of the doctoral students directly involved in FENABIUM II, both at the project partners and during research stays of several months at cooperation partners in European and non-European countries, further measures such as summer schools and knowledge transfer in the form of a Radioecology Open Online Module (ROOM) are part of FENABIUM II.
Conveying period: 01.04.2023 - 31.03.2026
