Publications and Patents

Articles

  • Browne, W. M., Pettinger, J., Weckwerth, T., Purkiss, A., Lok, S. H., Penicaut, L., Ogrodowicz, R., Morar, R., Kunzelmann, S., Roustan, C., Bineva-Todd, G., Pieters, S., Zappacosta, F., Doherty, A. E., Oram, I., Quinlan, R., Redmond, J., Kjaer, S., House, D., Mouilleron, S., Bush, J. T., Schumann, B. A Synergistic Inhibitor Development Strategy Against Human UDP-Galactose-4-Epimerase. Angew. Chem. Int. Ed. (2026): e20304. Link

  • Li, Z., Chawla, H., Di Vagno, L., Cheallaigh, A. N., Critcher, M., Sammon, D., Gonzalez-Rodriguez, E., Briggs, D. C. Chung, N., Chang, V., Mahoney, K. E., Cioce, A., Bineva-Todd, G., Wang, P.-Y., Liu, Z.-C., Murphy, L. D., Chen, Y.-H., Narimatsu, Y., Miller, R. L., Willems, L. I., Malaker, S. A., Huang, M. L., Miller, G. J. Hohenester, E., Schumann, B. Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells. Nat. Chem. Biol. 2026, 22, 612–621. Link

  • Liu, Y., Pieters, S., Bineva-Todd, G., Sagiroglugil, M., Burnap, S. A., Hoddle, F., Cioce, A., Ohara, A., Bruemmer, K., Bertozzi, C. R., Polizzi, K., Struwe, W. B., Rovira, C., Schumann, B. Iterative Bump-and-hole engineering creates a bioorthogonal reporter for N-acetylglucosaminyl-transferase I. bioRxiv pre-print 2026. Link

  • Bineva-Todd, G., Schumann, B. Chemoenzymatic Synthesis and Purification of Bioorthogonally Tagged UDP-GlcNAc and UDP-GalNAc Analogues. Curr. Protoc. 2025, 5, e70277.  Link

  • Zafar, A., Schumann, B. Precision Probing of O-GalNAc Glycosylation Using Bump-and-Hole Engineering. Chimia 2025, 79, 146-151. Link

  • Peng, Z., Hodgson, K., Fisher, M., Mei, S., Orozco-Moreno, M., Cao, L., Kemp, M., Gatlin, W., Donald, L., Zeng, F., Lawson, M. A., Ungar, D., Sykes, D. B., Elliott, D. J., Peng, L., Schumann, B., Wang, N., Munkley, J. Siglec-engaging immunosuppressive sialoglycans are upregulated in prostate cancer and are targetable to suppress bone metastasis. bioRxiv 2025. Link

  • Fadda, E., Hevey, R., Schumann, B., Westerlind, U. Chemical Glycobiology. Beilstein J. Org. Chem. Editorial 2025, 21, 8–9. Link

  • Liu, Y. Bineva-Todd, G., Meek, R., Mazo, L., Piniello, B., Moroz, O., Begum, N., Ohara, A., Roustan, C., Tomita, S., Kjaer, S., Polizzi, K., Rovira, C., Davies, G. J., Schumann, B. A Bioorthogonal Precision Tool for human N-acetylglucosaminyltransferase V. J. Am. Chem. Soc. 2024, 146, 26707-26718. Link

  • Zafar, A., Sridhar, S., Bineva-Todd, G., Cioce, A., Abdulla, N., Chang, V., Malaker, S. A., Hewings, D. S., Schumann, B. Expanding the repertoire of GalNAc analogues for cell-specific bioorthogonal tagging of glycoproteins. RSC Chem. Biol. 2024, 22, 1002-1009. Link

  • Gonzalez-Rodriguez, E.*, Zol-Hanlon, M.*, Bineva-Todd, G.*, Marchesi, A.*, Skehel, M., Mahoney, K. E., Roustan, C., Borg, A., Di Vagno, L., Kjaer, S., Wrobel, A. G., Benton, D. J., Nawrath, P., Flitsch, S. L., Joshi, D., González-Ramírez, A. M., Wilkinson, K. A., Wilkinson, R. J., Hurtado-Guerrero, R., Malaker, S. A., Schumann, B. O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Contribute to the Mutational Trajectory in Variants of Concern. ACS Cent. Sci. 2023, 9, 393-404. Link

  • Cell Scientists to Watch - Ben Schumann. J. Cell Sci. 2023, 136. Link

  • What Time is it? Glycotime! FEBS Network 2023. Link

  • Sammon, D., Krueger, A., Busse-Wicher, M., Morgan, R. M., Haslam, S. M., Schumann, B., Briggs, D. C., Hohenester, E. Molecular mechanism of decision-making in glycosaminoglycan biosynthesis. Nat. Commun. 2023, 14. Link

  • Calle, B., Gonzalez-Rodriguez, E., Mahoney, K. E., Cioce, A., Bineva-Todd, G., Tastan, O. Y., Roustan, C., Flynn, H., Malaker, S. A., Schumann, B. Bump-and-hole engineering of human polypeptide N-acetylgalactosamine transferases to dissect their protein substrates and glycosylation sites in cells. STAR Protoc. 2023, 11, 101974.  Link

  • Scott, E., Hodgson, K., Calle, B., Turner, H., Cheung, K., Bermudez, A., Marques, F., Pye, H., Yo, E. C., Islam, K., Oo, H. Z., McClurg, U. L., Wilson, L., Thomas, H., Frame, F. M., Orozco-Moreno, M., Bastian, K., Arredondo, H. M., Roustan, C., Gray, M. A., Kelly, L., Tolson, A., Mellor, E., Hysenaj, G., Goode, E. A., Garnham, R., Duxfield, A., Heavey, S., Stopka-Farooqui, U., Haider, A., Freeman, A., Singh, S., Johnston, E. W., Punwani, S., Knight, B., McCullagh, P., McGrath, J., Crundwell, M., Harries, L., Bogdan, D., Westaby, D., Fowler, G., Flohr, P., Yuan, W., Sharp, A., DeBono, J., Maitland, N., Wisnovsky, S., Bertozzi, C. R., Heer, R., Hurtado-Guerrero, R., Daugaard, M., Leivo, J., Whitaker, H., Pitteri, S., Wang, N., Elliott, D., Schumann, B., Munkley, J. Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth. Oncogene 2023, 42. Link

  • Pensinger, D., Fisher, A., Dobrila, H., Van Treuren, W., Gardner, J., Higginbottom, S., Carter, M., Schumann, B., Bertozzi, C. R., Anikst, V., Martin, C., Robilotti, E., Chow, J., Buck, R., Tompkins, L., Sonnenburg, J., Hryckowian, A. Butyrate differentiates permissiveness to Clostridioides difficile infection and influences growth of diverse C. difficile isolates. Infect. Immun. 2023, 91. Link

  • Kramer, J., Pratt, M., Schumann, B. Celebrating the Contributions of Carolyn Bertozzi to Bioorthogonal Chemistry and its Application to Glycoscience. Isr. J. Chem. 2023, e202300003. Link

  • Cioce, A., Calle, B., Rizou, T., Lowery, S. C., Bridgeman, V., Mahoney, K., Marchesi, A., Bineva-Todd, G., Flynn, H., Li, Z., Tastan, O. Y., Roustan, C., Soro-Barrio, P., Wood, T. M., Keenan, T., Both, P., Parmeggiani, F., Snijders, A., Skehel, M., Kjaer, S., Fascione, M. A., Bertozzi, C. R., Flitsch, S., Malaker, S.A., Malanchi, I., Schumann, B. Cell-specific Bioorthogonal Tagging of Glycoproteins. Nat. Commun. 2022, 13. Link

  • Jackson, E. G. Cutolo, G., Yang, B., Yarravarapu, N., Burns, M. W. N., Bineva-Todd, G., Roustan, C., Thoden, J. B., Lin-Jones, H. M., van Kuppevelt, T. H., Holden, H. M., Schumann, B., Kohler, J. J., Woo, C. M. and Pratt, M. R. 4‑Deoxy-4-fluoro-GalNAz (4FGalNAz) Is a Metabolic Chemical Reporter of O‑GlcNAc Modifications, Highlighting the Notable Substrate Flexibility of O‑GlcNAc Transferase. ACS Chem. Biol. 2022, 17, 159-170. Link

  • Calle, B.*, Bineva-Todd, G.*, Marchesi, A.*, Flynn, H., Ghirardello, M., Tastan, O. Y., Roustan, C., Choi, J., Galan, C. M., Schumann, B., Malaker, S. A. Benefits of chemical sugar modifications introduced by click chemistry for glycoproteomic analyses. J. Amer. Soc. Mass Spectrom. 2021, 32, 2366-2375. Link

  • Cioce, A., Malaker, S. A., Schumann, B. Generating Orthogonal Glycosyltransferase-Nucleotide Sugar Pairs as Next Generation Glycobiology Tools. Curr. Opin, Chem. Biol. 2021, 60, 66-78. Link

  • Cioce, A., Bineva-Todd, G., Agbay, A. J., Choi, J., Wood, T. M., Debets, M. F., Browne, W. M., Douglas, H. L., Roustan, C., Tastan, O. Y., Kjaer, S., Bush, J. T., Bertozzi, C. R., Schumann, B. Optimization of Metabolic Oligosaccharide Engineering with Ac4GalNAlk and Ac4GlcNAlk by an Engineered Pyrophosphorylase. ACS Chem. Biol. 2021, 16, 1961-1967. Link

  • Debets, M. F., Tastan, O. Y., Wisnovsky, S. P., Malaker, S. A, Angelis, N., Moeckl, L. K. R., Choi, J., Flynn, H., Wagner, L. J. S., Bineva-Todd, G., Antononopoulos, A., Cioce, A., Browne, W. M., Li, Z., Briggs, D. C., Douglas, H. L., Hess, G. T., Agbay, A., J., Roustan, C., Kjaer, S., Haslam, S., Snijders, A. P., Bassik, M. C., Moerner, W. E., Li, V. S. W., Bertozzi, C. R., Schumann, B. Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation. Proc. Natl. Acad. Sci. USA. 2020, 117, 25293-25301. Link

  • Zol-Hanlon, M. I., Schumann, B. Open Questions in Chemical Glycobiology. Commun. Chem., 2020, 3. Link

  • Schumann, B., Malaker, S. A., Wisnovsky, S. P., Debets, M. F., Agbay, A. J., Fernandez, D., Wagner, L. J. S., Lin, L., Li, Z., Choi, J., Fox, D., Peh, J., Gray, M. A., Pedram, K., Kohler, J. J., Mrksich, M., Bertozzi, C. R. Bump-and-hole engineering identifies specific substrates of glycosyltransferases in living cells. Mol. Cell. 2020, 78, 824-834. Link Cover art; highlighted in Mol. Cell.

  • Choi, J., Wagner, L. J. S., Timmermans, S. B. P. E., Malaker, S. A., Schumann, B., Gray, M. A., Debets, M. F., Takashima, M., Gehring, J., Bertozzi, C. R. Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs. J. Am. Chem. Soc. 2019, 141, 13442-13453. Link

  • Kaplonek, P., Khan, N., Reppe, K., Schumann, B., Emmadi, M., Lisboa, M. P., Xu, F.-F., Calow, A. D. J., Parameswarappa, S. G., Witzenrath, M., Pereira, C. L., Seeberger, P. H. Improving Vaccines Against Streptococcus pneumoniae Using Synthetic Glycans. Proc. Natl. Acad. Sci. U. S. A. 2018, 115, 13353-13358. Link

  • Schumann, B., Reppe, K., Kaplonek, P., Wahlbrink, A., Anish, C., Witzenrath, M., Pereira, C. L., Seeberger, P. H. Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Against Streptococcus pneumoniae Serotype 1. ACS Cent. Sci., 2018, 4, 357-361 Link

  • Qin, C., Schumann, B., Zou, X., Pereira, C. L., Tian, G., Hu, J., Seeberger, P. H., Yin, J. Total Synthesis of a Densely Functionalized Plesiomonas shigelloides Serotype 51 Aminoglycoside Trisaccharide Antigen. J. Am. Chem. Soc., 2018, 140, 3120-3127. Link

  • Schumann, B., Hahm, H. S., Parameswarappa, S. G., Reppe, K., Wahlbrink, A., Govindan, S., Kaplonek, P., Pirofski, L., Witzenrath, M., Anish, C., Pereira, C. L., Seeberger, P. H. A Semisynthetic Streptococcus pneumoniae Serotype 8 Glycoconjugate Vaccine. Sci. Transl. Med., 2017, 9, eaaf5347. Link

  • Schumann, B.*, Parameswarappa, S. G.*, Lisboa, M. P., Kottari, N., Guidetti, F., Pereira, C. L., Seeberger, P. H. Nucleophile-directed Stereocontrol over Glycosylations using Geminal Difluorinated Nucleophiles., Angew. Chem. Int. Ed., 2016, 55, 14431-14434. Link

  • Anish, C.*, Schumann, B.*, Pereira, C. L., Seeberger, P. H. Chemical Biology Approaches to Designing Defined Carbohydrate Vaccines. Chem. Biol., 2014, 21, 38-50. Link

  • Schumann, B., Pragani, R., Anish, C., Pereira, C. L., Seeberger, P. H. Synthesis of Conjugation-ready Zwitterionic Oligosaccharides by Chemoselective Thioglycoside Activation. Chem. Sci., 2014, 5, 1992-2002. Link

  • Schumann, B., Anish, C., Pereira, C. L., Seeberger, P. H. Carbohydrate Vaccines. In Biotherapeutics: Recent Developments using Chemical and Molecular Biology. Royal Society of Chemistry, London. 2013, 68-104. Link

  • Dimmer, K. S., Papić, D., Schumann, B., Sperl, D., Krumpe, K., Walther, D. M., Rapaport, D. A Crucial Role for Mim2 in the Biogenesis of Mitochondrial Outer Membrane Proteins. J. Cell Sci., 2012, 125, 3464-3473. Link

Patents

Parameswarappa, S. G., Khan, N., Lisboa, M. P., Schumann, B., Pereira, C. L., Seeberger, P. H. Pneumococcal Polysaccharide-protein Conjugate Composition. European Patent Application No. EP 16 179 133.0, 2016.

Schumann, B., Parameswarappa, S. G., Hahm, H. S., Govindan, S., Anish, C., Pereira, C. L., Seeberger, P. H. Synthetic Vaccines against Streptococcus pneumoniae Serotype 8. European Patent Application No. EP 14 186 597.2, 2014.

Schumann, B., Anish, C., Pereira, C. L., Seeberger, P. H. Synthetic Vaccines against Streptococcus pneumoniae. European Patent Application No. EP 13 196 568.3, 2013.

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Benjamin Schumann
Last modified: Apr 23, 2026