Publications and Research Reports
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X. Ji, M. Einsiedler, P. M. D'Agostino, J. Herrmann, R. Müller, T. A. M. Gulder; A Chemo-Enzymatic Platform for Furanolide Synthesis and Functional Exploration; J. Am. Chem. Soc. 2025, 147, ASAP.
doi: 10.1021/jacs.5c08354 -
T. M. Milzarek, F. Gattwinkel, S. Š. Bogojević, D. Milivojević, S. Vojnović, T. A. M. Gulder, J. Nikodinovic-Runic; Total synthesis of a sorrentanone ester library and evaluation of its antimicrobial potential; Sci. Rep. 2025, 15, 23877.
doi: 10.1038/s41598-025-05360-y -
R. Zhu, X. Mo, T. Gulder, T. A. M. Gulder; Regioselective C–H Functionalization by the Combination of Enzymatic and Chemocatalytic Reactions in Water; Angew. Chem. Int. Ed. 2025, 64, e202504378.
doi: 10.1002/anie.202504378 -
T. A. M. Gulder, K. Lim; 40 Years of Natural Product Reports; Nat. Prod. Rep. 2025, 42, 647–648.
doi: 10.1039/D5NP90012C -
M. Hohmann, D. Iliasov, M. Larralde, W. Johannes, K.-P. Janßen, G. Zeller, T. Mascher, T. A. M. Gulder; Heterologous Expression of a Cryptic BGC from Bilophila sp. Provides Access to a Novel Family of Antibacterial Thiazoles; ACS Synth. Biol. 2025, 14, 967–978.
doi: 10.1021/acssynbio.5c00042 -
T. M. Milzarek, T. A. M. Gulder; The fungal natural product class of the sorbicillinoids: structures, bioactivities, biosynthesis, and synthesis; Nat. Prod. Rep. 2025, 42, 482–500.
doi: 10.1039/D4NP00059E -
J. K. Evers, A. Glöckle, M. Wiegand, S. Schuler, M. Einsiedler, T. A. M. Gulder; Heterologous Expression and Optimization of Fermentation Conditions for Recombinant Ikarugamycin Production; Biotechnol. Bioeng. 2025, 122, 974–982.
doi: 10.1002/bit.28919 -
A. Glöckle, S. Schuler, M. Einsiedler, T. A. M. Gulder; A plug-and-play system for polycyclic tetramate macrolactam production and functionalization; Microb. Cell Fact. 2025, 24, 13.
doi: 10.1186/s12934-024-02630-8 -
S. Schuler, M. Einsiedler, J. K. Evers, M. Malay, V. Uka, S. Schneider, T. A. M. Gulder; Expanding Polycyclic Tetramate Macrolactam (PoTeM) Core Structure Diversity by Chemo-Enzymatic Synthesis and Bioengineering; Angew. Chem. Int. Ed. 2025, 64, e202420335.
doi: 10.1002/anie.202420335
German Version: Erweiterung der Vielfalt der Kernstruktur von Polycyclischen Tetramsäure-Haltigen Makrolactamen (PoTeMs) durch Chemo-Enzymatische Synthese und Bio-Engineering; Angew. Chem. 2025, 137, e202420335.
doi: 10.1002/ange.202420335 -
M. Einsiedler, S. Š. Bogojević, D. Milivojević, S. Vojnović, M. K. Milčić, V. Maslak, A. Matura, T. A. M. Gulder, J. Nikodinović-Runić; Homophenylalanine-derived benzo[1,4]diazepine-2,5-diones are strong bacterial quorum sensing inhibitors; Org. Biomol. Chem. 2025, 23, 835–843.
doi: 10.1039/d4ob01734j -
A. Behnsen, G. Hertrampf, S. Vojnović, J. Nikodinović-Runić, T. A. M. Gulder; Synthesis and antibiotic potential of myxocoumarin-inspired chromene dione analogs; RSC Adv. 2024, 14, 35215–35219.
doi: 10.1039/D4RA05941G -
G. P. Schmartz, J. Rehner, ..., T. A. M. Gulder, ..., A. Keller; Decoding the diagnostic and therapeutic potential of microbiota using pan-body pan-disease microbiomics; Nat. Commun. 2024, 15, 8261.
doi: 10.1038/s41467-024-52598-7 -
X.-H. Mo, Q. Pu, T. Lübken, G.-H. Yu, M. Malay, P. M. D'Agostino, T. A. M. Gulder; Discovery and biosynthesis of non-canonical C16-terpenoids from Pseudomonas; Cell Chem. Biol. 2024, 31, 2128–2137.
doi: 10.1016/j.chembiol.2024.09.002 -
T. Ilić-Tomić, A. Kramar, M. Kostić, S. Vojnović, J. Milovanović, M. Petković, P. M. D'Agostino, T. A. M. Gulder, J. Nikodinović-Runić; Functionalization of silk with actinomycins from Streptomyces anulatus BV365 for biomedical applications; Front. Bioeng. Biotechnol. 2024, 12, 1466757.
doi: 10.3389/fbioe.2024.1466757 -
M. Hohmann, J. F. Ohlrogge, T. A. M. Gulder; Biosynthesis of Brevinic Acid from Lawsone; Org. Biomol. Chem. 2024, 22, 7035–7038.
doi: 10.1039/D4OB01184H -
M. Einsiedler, K. Lamm, J. F. Ohlrogge, S. Schuler, I. J. Richter, T. Lübken, T. A. M. Gulder; Product Selectivity in Baeyer–Villiger Monooxygenase-Catalyzed Bacterial Alkaloid Core Structure Maturation; J. Am. Chem. Soc. 2024, 146, 16203–16212.
doi: 10.1021/jacs.4c04115 -
M. Hohmann, V. Brunner, W. Johannes, D. Schum, L. M. Carroll, T. Liu, D. Sasaki, J. Bosch, T. Clavel, S. A. Sieber, G. Zeller, M. Tschurtschenthaler, K.-P. Janßen, T. A. M. Gulder; Bacillamide D produced by Bacillus cereus from the mouse intestinal bacterial collection (miBC) is a potent cytotoxin in vitro; Commun. Biol. 2024, 7, 655.
doi: 10.1038/s42003-024-06208-3 -
J. I. Müller, T. A. M. Gulder; Chemoenzymatic total synthesis of sorbicillactone A; Commun. Chem. 2024, 7, 39.
doi: 10.1038/s42004-024-01126-1 -
G. Hertrampf, S. Vojnović, J. I. Müller, C. Merten, J. Nikodinović-Runić, T. A. M. Gulder; Synthesis, Stereochemical Determination, and Antimicrobial Evaluation of Myxocoumarin A; J. Org. Chem. 2023, 88, 14184–14188.
doi: 10.1021/acs.joc.3c01285 -
T. M. Milzarek, T. A. M. Gulder; Chemo-enzymatic total synthesis of the spirosorbicillinols; Commun. Chem. 2023, 6, 187.
doi: 10.1038/s42004-023-00996-1 -
T. M. Milzarek, M. Stevanović, D. Milivojević, Sandra Vojnović, D. Iliasov, D. Wolf, T. Mascher, J. Nikodinović-Runić, T. A. M. Gulder; Antibiotic Potential of the Ambigol Cyanobacterial Natural Product Class and Simplified Synthetic Analogs; ACS Infect. Dis. 2023, 9, 1941–1948.
doi: 10.1021/acsinfecdis.3c00232 -
M. Einsiedler, T. A. M. Gulder; Discovery of extended product structural space of the fungal dioxygenase AsqJ; Nat. Commun. 2023, 14, 3658.
doi: 10.1038/s41467-023-39111-2 -
X. Ouyang, P. M. D'Agostino, M. Wahlsten, E. Delbaje, J. Jokela, P. Permi, G. Gaiani, A. Poso, P. Bartos, T. A. M. Gulder, H. Koistinen and D. P. Fewer; Direct pathway cloning and expression of the radiosumin biosynthetic gene cluster; Org. Biomol. Chem. 2023, 21, 4893–4908.
doi: 10.1039/D3OB00385J - M. Stevanović, P. M. D'Agostino, M. Mojicević, T. A. M. Gulder, J. Nikodinović-Runić, S. Vojnović; Streptomyces sp. BV410: Interspecies cross‐talk for staurosporine production; J. Appl. Microbiol. 2022, 133, 2560–2568.
doi: 10.1111/jam.15726 - N. Eusébio, R. Castelo-Branco, D. Sousa, M. Preto, P. M. D'Agostino, T. A. M. Gulder, P. Leão; Discovery and heterologous expression of microginins from Microcystis aeruginosa LEGE 91341; ACS Synth. Biol. 2022, 11, 3493–3503.
doi: 10.1021/acssynbio.2c00389 - M. Stevanović, P. M. D'Agostino, M. Mojicević, T. A. M. Gulder, J. Nikodinović-Runic, S. Vojnović; Streptomyces sp. BV410: Interspecies cross-talk for staurosporine production; J. Appl. Microbiol. 2022, 133, 2560–2568.
doi: 10.1111/jam.15726 - P. M. D'Agostino, C. J. Seel, X. Ji, T. Gulder, T. A. M. Gulder; Biosynthesis of cyanobacterin, a paradigm for furanolide core structure assembly; Nat. Chem. Biol. 2022.
doi: 10.1038/s41589-022-01013-7 - K. D. Bauman, V. V. Shende, P. Yang-Ting Chen, D. B. B. Trivella, T. A. M. Gulder, S. Vellalath, D. Romo, B. S. Moore; Enzymatic assembly of the salinosporamide γ-lactam-β-lactone anticancer warhead; Nat. Chem. Biol. 2022.
doi: 10.1038/s41589-022-00993-w - G. Hertrampf, K. Kusserow, S. Vojnović, A. Pavić, J. I. Müller, J. Nikodinović-Runić, T. A. M. Gulder; Strong Antibiotic Activity of the Myxocoumarin Scaffold in vitro and in vivo; Chem. Eur. J. 2022, 28, e202200394.
doi: 10.1002/chem.202200394 - T. M. Milzarek, S. Schuler, A. Matura, T. A. M. Gulder; Evaluation of the Substrate Promiscuity of SorbC for the Chemo-Enzymatic Total Synthesis of Structurally Diverse Sorbicillinoids; ACS Catal. 2022, 12, 1898–1904.
doi: 10.1021/acscatal.1c05196 - H. Aldemir, S. Shu, F. Schaefers, H. Hong, R. Richarz, S. Harteis, M. Einsiedler, T. M. Milzarek, S. Schneider, T. A. M. Gulder; Carrier-Protein Free Enzymatic Biaryl Coupling in Arylomycin A2 Assembly and Structure of the Cytochrome P450 AryC; Chem. Eur. J. 2022, 28, e202104450.
doi: 10.1002/chem.202103389
This article was highlighted on the journal cover, see doi/10.1002/chem.202104450 - X.-H. Mo, T. A. M. Gulder; Biosynthetic strategies for tetramic acid formation; Nat. Prod. Rep. 2021, 38, 1555–1566.
doi: 10.1039/D0NP00099J - D. M. Kresna, L. Linares-Otoya, T. M. Milzarek, E. R. Duell, M. M. Moseni, U. Mettal, G. M. König, T. A. M. Gulder, T. F. Schäberle; In vitro Characterization of 3-Chloro-4-hydroxybenzoic Acid Building Block Formation in Ambigol Biosynthesis; Org. Biomol. Chem. 2021, 19, 2302–2311.
doi: 10.1039/D0QO00707B - M. Einsiedler, C. S. Jamieson, M. A. Maskeri, K. N. Houk, T. A. M. Gulder; Fungal Dioxygenase AsqJ Is Promiscuous and Bimodal: Substrate-Directed Formation of Quinolones versus Quinazolinones; Angew. Chem. Int. Ed. 2021, 60, 8297–8302.
doi: 10.1002/anie.202017086 - T. M. Milzarek, T. A. M. Gulder; Total Synthesis of the Ambigols – A Cyanobacterial Class of Polyhalogenated Natural Products; Org. Lett. 2021, 1, 102–106.
doi: 10.1021/acs.orglett.0c03784 - D. Wylensek, T. C. A. Hitch, ..., T. Liu, ... P. M. D'Agostino, ..., T. A. M. Gulder, J. Overmann, T. Clavel; A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity; Nat. Commun. 2020, 11, 6389.
doi: 10.1038/s41467-020-19929-w - B. S. Moore, T. A. M. Gulder; Enzymes in Natural Product Total Synthesis; Nat. Prod. Rep. 2020, 37, 1292–1293.
doi: 10.1039/D0NP90038A - E. R. Duell, T. M. Milzarek, M. E. Omari, L. J. Linares-Otoya, T. F. Schäberle, G. M. König, T. A. M. Gulder; Identification, Cloning, Expression and Functional Interrogation of the Biosynthetic Pathway of the Polychlorinated Triphenyls Ambigol A–C from Fischerella ambigua 108b; Org. Chem. Front. 2020, 7, 3193–3201.
doi: 10.1039/D0QO00707B - O. H. Abdelhafez, T. F. S. Ali, J. R. Fahim, S. Y. Desoukey, S. Ahmed, F. A. Behery, M. S. Kamel, T. A. M. Gulder, U. R. Abdelmohsen; Anti-Inflammatory Potential of Green Synthesized Silver Nanoparticles of the Soft Coral Nephthea Sp. Supported by Metabolomics Analysis and Docking Studies; Int. J. Nanomedicine 2020, 15, 5345–5360.
doi: 10.2147/IJN.S239513 - M. Mojicević, P. M. D'Agostino, A. Pavić, S. Vojnović, R. Senthamaraikannan, B. Vasiljević, T. A. M. Gulder, J. Nikodinović-Runić; Streptomyces sp. BV410 Isolate from Chamomile Rhizosphere Soil Efficiently Produces Staurosporine with Antifungal and Antiangiogenic Properties; MicrobiologyOpen 2020, 9, e986.
doi: 10.1002/mbo3.986 - A. Sib, T. M. Milzarek, A. Herrmann, L. Oubraham, J. I. Müller, A. Pichlmair, R. Brack-Werner, T. A. M. Gulder; Chemo-Enzymatic Total Synthesis of Sorbicatechol Structural Analogs and Evaluation of Their Anti-Viral Potential; ChemBioChem 2020, 21, 492–495.
doi: 10.1002/cbic.201900472 - Z. Qian, T. Bruhn, P. M. D'Agostino, A. Herrmann, M. Haslbeck, N. Antal, H.-P. Fielder, R. Brack-Werner, T. A .M. Gulder; Discovery of the Streptoketides by Direct Cloning and Rapid Heterologous Expression of a Cryptic PKS II Gene Cluster from Streptomyces sp. Tü6314; J. Org. Chem. 2019. 85, 664–673.
doi: 10.1021/acs.joc.9b02741 - T. M. Milzarek, M. Einsiedler, H. Aldemir, P. M. D'Agostino, J. K. Evers, G. Hertrampf, K. Lamm, M. Malay, A. Matura, J. I. Müller, T. A. M. Gulder; Bypassing Biocatalytic Substrates Limitations in Oxidative Dearomatization Reactions by Transient Substrate Mimicking; Org. Lett. 2019, 21, 4520–4524.
doi: 10.1021/acs.orglett.9b01398 - Z. Qian, J. Antosch, J. Wiese, J. F. Imhoff, H. P. Fiedler, A. Pothig, T. A. M. Gulder; Structures and Biological Activities of Cycloheptamycin A and B; Org. Biomol. Chem. 2019, 17, 6595–6600.
doi: 10.1039/c9ob01261c - E. R. Duell, P. M. D'Agostino, N. Shapiro, T. Woyke, T. M. Fuchs, T. A. M. Gulder; Direct Pathway Cloning of the Sodorifen Biosynthetic Gene Cluster and Recombinant Generation of its Product in E. coli; Microb. Cell Fact. 2019, 18, 32.
doi: 10.1186/s12934-019-1080-6 -
J. I. Müller, K. Kusserow, G. Hertrampf, A. Pavić, J. Nikodinović-Runić, T. A. M. Gulder; Synthesis and Initial Biological Evaluation of Myxocoumarin B; Org. Biomol. Chem. 2019, 17, 1966–1969.
doi: 10.1039/C8OB02273A -
M. Mojicević, P. M. D'Agostino, J. Nikodinović-Runić, B. Vasiljević, T. A. M. Gulder , S. Vojnović; Antifungal Potential of Bacterial Rhizosphere Isolates Associated with Three Ethno-Medicinal Plants (Poppy, Chamomile, and Nettle); Int. Microbiol. 2019, 22, 343–353.
doi: 10.1007/s10123-019-00054-8 -
A. Sib, T. A. M. Gulder; Chemo-Enzymatic Total Synthesis of Oxosorbicillinol, Sorrentanone, Rezishanones B and C, Sorbicatechol A, Bisvertinolone and (+) - Epoxysorbicillinol; Angew. Chem. Int. Ed. 2018, 57, 14650–14653.
doi: 10.1002/anie.201802176
German Version: Chemo-enzymatische Totalsynthese von Oxosorbicillinol, Sorrentanon, Rezishanon B und C, Sorbicatechol A, Bisvertinolon und (+)-Epoxysorbicillinol; Angew. Chem. 2018, 130, 14861–14864.
doi: 10.1002/ange.201802176 -
S. S. El-Hawary, A. M. Sayed, R. Mohammed, M. A. Khanfar, M. E. Rateb, T. A. Mohammed, D. Hajjar, H. M. Hassan, T. A. M. Gulder, U. R. Abdelmohsen; New Pim-1 Kinase Inhibitor from the Co-Culture of Two Sponge-Associated Actinomycetes; Front. Chem. 2018, 6, 538.
doi: 10.3389/fchem.2018.00538 - P. M. D'Agostino, T. A. M. Gulder; Direct Pathway Cloning Combined with Sequence- and Ligation-Independent Cloning for Fast Biosynthetic Gene Cluster Refactoring and Heterologous Expression; ACS Synth. Biol. 2018, 7, 1702–1708.
doi: 10.1021/acssynbio.8b00151 - C. Greunke, E. R. Duell, P. M. D'Agostino, A. Glöckle, K. Lamm, T. A. M. Gulder; Direct Pathway Cloning (DiPaC) to Unlock Natural Product Biosynthetic Potential; Metab. Eng. 2018, 47, 334–345.
doi: 10.1016/j.ymben.2018.03.010 . - A. H. Ibrahim, E. Z. Attia, D. Hajjar, M. A. Anany, S. Y. Desoukey, M. A. Fouad, M. S. Camel, H. Wajant, T. A. M. Gulder, U. R. Abdelmohsen; New Cytotoxic Cyclic Peptides from the Marine Sponge-Associated Nocardiopsis sp. UR67; Mar. Drugs 2018, 16, 290.
doi: 10.3390/md16090290 - A. H. Ibrahim, S. Y. Desoukey, M. A. Fouad, M. S. Camel, T. A. M. Gulder, U. R. Abdelmohsen; Natural Product Potential of the Genus Nocardiopsis; Mar. Drugs 2018, 16, 147.
doi: 10.3390/md16050147 - A. Glöckle, T. A. M. Gulder; A Pericyclic Reaction Cascade in Leporine Biosynthesis; Angew. Chem. Int. Ed. 2018, 57, 2754–2756. doi: 10.1002/anie.201800629
German Version: Eine pericyclische Reaktionskaskade in der Leporin-Biosynthese; Angew. Chem. 2018, 130, 2802–2804. doi: 10.1002/ange.201800629 - A. Sib, T. A. M. Gulder; Stereoselective Total Synthesis of Bisorbicillinoid Natural Products by Enzymatic Oxidative Dearomatization/Dimerization; Angew. Chem. Int. Ed. 2017, 56, 12888–12891.
doi: 10.1002/anie.201705976 - H. Aldemir, T. A. M. Gulder; Expanding the Structural Space of Ribosomal Peptides: Autocatalytic N-Methylation in Omphalotin Biosynthesis; Angew. Chem. Int. Ed. 2017, 56, 13570–13572.
doi: 10.1002/anie.201708456
German Version: Erweiterung des Strukturraums ribosomaler Peptide: autokatalytische N-Methylierung in der Omphalotin-Biosynthese; Angew. Chem. 2017, 129, 13756–13758.
doi: 10.1002/ange.201708456 - C. Greunke, A. Glöckle, J. Antosch, T. A. M. Gulder; Biocatalytic Total Synthesis of Ikarugamycin; Angew. Chem. Int. Ed. 2017, 56, 4351–4355.
doi: 10.1002/anie.201611063
German Version: Biokatalytische Totalsynthese von Ikarugamycin; Angew. Chem. 2017, 129, 4416–4420.
doi: 10.1002/ange.201611063 - J. Wiese, H. Aldemir, R. Schmaljohann, T. A. M. Gulder, J. F. Imhoff; Asperin B, a Novel Inhibitor of the Protein Tyrosine Phosphatase 1B; Mar. Drugs 2017, 15, 191.
doi: 10.3390/md15060191 - K. Kusserow, T. A. M. Gulder; Complete Genome Sequence of Actinomadura Parvosata Subsp. Kistnae, A Rich Source of Novel Natural Product (Bio-)Chemistry; J. Genomics 2017, 5, 75–76.
doi: 10.7150/jgen.19673 - N. H. Shady, E. M. El-Hossary, A. Fouad, T. A. M. Gulder, M. S. Kamel, U. R. Abdelmohsen; Bioactive Natural Products of Marine Sponges from the Genus Hyrtios; Molecules 2017, 22, 781–801.
doi: 10.3390/molecules22050781 - J. Wiese, J. F. Imhoff, T. A. M. Gulder, A. Labes, R. Schmaljohann; Marine Fungi as Producers of Benzocoumarin, a New Class of Inhibitors of Glycogen-Synthase-Kinase 3β; Mar. Drugs. 2016, 14, 200.
doi: 10.3390/md14110200 - F. Schaefers, T. A. M. Gulder; Polyketide Biosynthesis in From Biosynthesis to Total Synthesis; John Wiley & Sons (Ed. A. L. Zografos), 2016.
doi: 10.1002 / 9781118754085.ch2 - J. Kundert, T. A. M. Gulder; Extending Polyketides Structural Diversity Using Engineered Carboxylase/Reductase Enzymes; Angew. Chem. Int. Ed. 2016, 55, 858–860.
doi: 10.1002/anie.201510402
German Version: Erweiterung der Strukturvielfalt von Polyketiden durch Einsatz modifizierter Carboxylase/Reduktase-Enzyme; Angew. Chem. 2016, 128, 868–870.
doi: 10.1002/ange.201510402 - C. Greunke, J. Antosch, T. A. M. Gulder; Promiscuous hydroxylases for the functionalization of polycyclic tetramate macrolactams – conversion of ikarugamycin to butremycin; Chem. Commun. 2015, 51, 5334–5336.
doi: 10.1039/c5cc00843c - H. Aldemir, S. Kohlhepp, T. Gulder, T. A. M. Gulder; On the Structure of a Putative Fluorinated Natural Product from Streptomyces sp. TC1; J. Nat. Prod. 2014, 77, 2331–2334.
doi: 10.1021/np500643g - T. Gulder, T. A. M. Gulder; Chemistry in Stereo: The 49th Bürgenstock Conference; Angew. Chem. Int. Ed. 2014, 53, 9418–9420.
doi: 10.1002/anie.201406309
German Version: Chemie in Stereo: die 49. Bürgenstock-Konferenz; Angew. Chem. 2014, 126, 9572–9574.
doi: 10.1002/ange.201406309 - H. Aldemir, R. Richarz, T. A. M. Gulder; The Biocatalytic Repertoire of Natural Biaryl Formation; Angew. Chem. Int. Ed. 2014, 53, 8286–8293.
doi: 10.1002/anie.201401075
German Version: Das biokatalytische Repertoire natürlicher Biarylbildung; Angew. Chem. 2014, 126, 8426–8433.
doi: 10.1002/ange.201401075 - J. Antosch, F. Schaefers, T. A. M. Gulder; Heterologous Reconstitution of Ikarugamycin Biosynthesis in E. coli; Angew. Chem. Int. Ed. 2014, 53, 3011–3014.
doi: 10.1002/anie.201310641
German Version: Heterologe Rekonstitution der Ikarugamycin-Biosynthese in E. coli; Angew. Chem. 2014, 126, 3055–3058. - T. Gulder, T. A. M. Gulder; Biosynthese im Reagenzglas; Nachr. Chem. 2014, 62, 1081–1084.
doi: 10.1002/nadc.201490379 - T. Gulder, T. A. M. Gulder; Hydrofunktionalisierung mit unüblicher Regioselektivität; Nachr. Chem. 2014, 62, 869–872.
doi: 10.1002/nadc.201490290 - T. Gulder, T. A. M. Gulder; Ein Sesquiterpen gegen das Vergessen; Nachr. Chem. 2014, 62, 765–768.
doi: 10.1002/nadc.201490256 - T. Gulder, T. A. M. Gulder; H als Abgangsgruppe; Nachr. Chem. 2014, 62, 534–537.
doi: 10.1002/nadc.201490162 - T. Gulder, T. A. M. Gulder; Enantioselektive Fluorocyclisierungen; Nachr. Chem. 2014, 62, 39–42.
doi: 10.1002/nadc.201490011 - T. A. M. Gulder, S. Neff, T. Schütz, T. Winkler, R. Gees, B. Böhlendorf; The Myxocoumarins A and B from Stigmatella aurantiaca strain MYX-030; Beilstein J. Org. Chem. 2013, 9, 2579–2585.
doi: 10.3762/bjoc.9.293 - M. Yu, K. Tang, J. Liu, X. Shi, T. A. M. Gulder, X.-H. Zhang; Genome Analysis of Pseudoalteromonas flavipulchra JG1 Reveals Various Survival Advantages in Marine Environment; BMC Genomics 2013, 14, 707.
doi: 10.1186/1471-2164-14-707 - A. Kampa, A. N. Gagunashvili, T. A. M. Gulder, C. Daolio, M. Godejohann, V. Miao, J. Piel, Ó. S. Andrésson; Metagenomic natural product discovery in lichen provides evidence for a family of biosynthetic pathways in diverse symbioses; Proc. Natl. Acad. Sci. USA 2013, 110, 3129–3137.
doi: 10.1073/pnas.1305867110 - T. A. M. Gulder, R. Richarz; Nature’s Chemical Treasure Trove – Biodiversity and Pharmaceuticals in Biodiversity: Concept and Value, Routledge: London, 2013.
- T. A. M. Gulder, M. F. Freeman, J. Piel; The Catalytic Diversity of Multimodular Polyketide Synthases: Natural Product Biosynthesis Beyond Textbook Assembly Rules; Top. Curr. Chem. 2013, 1–53.
doi: 10.1007/128_2010_113 - T. A. M. Gulder, H. Hong, J. Correa, E. Egereva, J. Wiese, J. F. Imhoff, H. Gross; Isolation, Structure Elucidation and Total Synthesis of Lajollamide A from the Marine Fungus Asteromyces cruciatus; Mar. Drugs 2012, 10, 2912.
doi: 10.3390/md10122912 - K. Yamanaka, K. S. Ryan, T. A. M. Gulder, C. C. Hughes, B. S. Moore; Flavoenzyme-Catalyzed Atropo-Selective N,C-Bipyrrole Homocoupling in Marinopyrrole Biosynthesis; J. Am. Chem. Soc. 2012, 134, 12434–12437.
doi: 10.1021/ja305670f - A. Lechner, A. S. Eustaquio, T. A. M. Gulder, M. Hafner, B. S. Moore; Selective Overproduction of the Proteasome Inhibitor Salinosporamide A via Precursor Pathway Regulation; Chem. Biol. 2011, 18, 1527–1536.
doi: 10.1016/j.chembiol.2011.10.014 - S. M. Pimentel-Elardo, V. Buback, T. A. M. Gulder, T. S. Bugni, J. Reppart, G. Bringmann, C. M. Ireland, T. Schirmeister, U. Hentschel; New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities; Mar. Drugs 2011, 9, 1682–1697.
doi: 10.3390/md9101682 - G. Bringmann, T. A. M. Gulder, T. Gulder; Asymmetric Synthesis of (M)-2-Hydroxymethyl-1-(2-hydroxy-4,6-dimethylphenyl)naphthalene via a Configurationally Unstable Biaryl Lactone - Discussion Addendum; Org. Synth. 2011, 88, 70–78.
doi: 10.15227/orgsyn.088.0070 - M. C. Wilson, S. J. Nam, T. A. M. Gulder, C. Kauffman, P. Jensen, W. Fenical, B. S. Moore; Structure and Biosynthesis of the Marine Streptomycete Ansamycin Ansalactam A and Its Distinctive Branched Chain Polyketide Extender Unit; J. Am. Chem. Soc. 2011, 133, 1971–1977.
doi: 10.1021/ja109226s - G. Bringmann, T. Gulder, T. A. M. Gulder, M. Breuning; Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products; Chem. Rev. 2011, 111, 563–639.
doi: 10.1021/cr100155e - T. A. M. Gulder, B. S. Moore; The Salinosporamide Natural Product Family: Potent 20S Proteasome Inhibitors as Potential Cancer Chemotherapeutics; Angew. Chem. Int. Ed. 2010, 49, 9346–9367.
doi: 10.1002/anie.201000728
German Version: Salinosporamid-Naturstoffe: potente Inhibitoren des 20S-Proteasoms als vielversprechende Krebs-Chemotherapeutika; Angew. Chem. 2010, 9534–9556.
doi: 10.1002/ange.201000728 - A. A. Roberts, K. S. Ryan, B. S. Moore, T. A. M. Gulder; Total (Bio)Synthesis: Strategies of Nature and of Chemists; Top. Curr. Chem. 2010, 297, 149–203. doi: 10.1007/128_2010_79
- M. C. Wilson, T. A. M. Gulder, M. Taifo, B. S. Moore; Shared Biosynthesis of the Saliniketals and Rifamycins in Salinispora arenicola is Controlled by the sare1259-Encoded Cytochrome P450; J. Am. Chem. Soc. 2010, 132, 12757–12765.
doi: 10.1021/ja105891a - A. Ponte-Sucre, T. Gulder, T. A. M. Gulder, G. Vollmers, A. Stich, G. Bringmann, H. Moll; Alterations to the Structure of Leishmania major Induced by N-Arylisoquinolines Correlate with Compound Accumulation and Disposition; J. Med. Microbiol. 2010, 59, 69–75.
doi: 10.1099/jmm.0.014241-0 - M. Nett, T. A. M. Gulder, A. J. Kale, C. C. Hughes, B. S. Moore; Function-Oriented Biosynthesis of ß-Lactone Proteasome Inhibitors in Salinispora tropica; J. Med. Chem. 2009, 52, 6163–6167.
doi: 10.1021/jm901098m - T. A. M. Gulder, B. S. Moore; Chasing the Treasures of the Sea – Bacterial Marine Natural Products; Curr. Opin. Microbiol. 2009, 12, 252–260.
doi: 10.1016/j.mib.2009.05.002 - G. Bringmann, T. A. M. Gulder, A. Hamm, M. Goodfellow, H.-P. Fiedler; Multiple Convergence in Polyketide Biosynthesis: a Third Folding Mode to the Anthraquinone Chrysophanol; Chem. Commun. 2009, 6810–6812.
doi: 10.1039/B910501H - G. Bringmann, A. Irmer, D. Feineis, T. A. M. Gulder, H.-P. Fiedler, Convergence in the Biosynthesis of Acetogenic Natural Products from Plants, Fungi, and Bacteria; Phytochemistry 2009, 70, 1776–1786.
doi: 10.1016/j.phytochem.2009.08.019 - G. Bringmann, D. C. G. Götz, T. A. M. Gulder, T. H. Gehrke, T. Bruhn, T. Kupfer, K. Radacki, H. Braunschweig, A. Heckmann, C. Lambert; Axially Chiral ß,ß'-Bisporphyrins: Synthesis and Configurational Stability Tuned by the Central Metals; J. Am. Chem. Soc. 2008, 130, 17821–17825.
doi: 10.1021/ja8055886 - S. M. Pimentel-Elardo, T. A. M. Gulder, U. Hentschel, G. Bringmann; Cebulactams A1 and A2, New Macrolactams Isolated from Saccharopolyspora cebuensis, the First Obligate Marine Strain of the Genus Saccharopolyspora; Tetrahedron Lett. 2008, 49, 6889–6892. doi: 10.1016/j.tetlet.2008.09.094
- H.-P. Fiedler, A. Dieter, T. A. M. Gulder, I. Kajahn, A. Hamm, R. Brown, A. L. Jones, M. Goodfellow, W. E. G. Müller, G. Bringmann; Genoketides A1 and A2, New Octaketides and Biosynthetic Intermediates of Chrysophanol Produced by Streptomyces sp. AK 671; J. Antibiot. 2008, 61, 464–473.
doi: 10.1038/ja.2008.63 - G. Bringmann, T. A. M. Gulder, M. Reichert, T. Gulder; The Online Assignment of the Absolute Configuration of Natural Products: HPLC-CD in Combination with Quantum Chemical CD Calculations; Chirality 2008, 20, 628–642.
doi: 10.1002/chir.20557 - A. Goel, F. V. Singh, V. Kumar, M. Reichert, T. A. M. Gulder, G. Bringmann; Synthesis, Optical Resolution, and Configurational Assignment of Novel Axially Chiral Quateraryls; J. Org. Chem. 2007, 72, 7765–7768.
doi: 10.1021/jo071097b - G. Bringmann, T. A. M. Gulder, G. Lang, S. Schmitt, R. Schmitt, J. Wiese, K. Nagel, J. F. Imhoff; Large-Scale Biotechnological Production of the Antileukemic Alkaloid Sorbicillactone A; Mar. Drugs 2007, 5, 23–30.
doi: 10.3390/md502023 - G. Bringmann, Y. Haagen, T. A. M. Gulder, T. Gulder, L. Heide; Biosynthesis of the Isoprenoid Moieties of Furanonaphthoquinone I and Endophenazine A in Streptomyces cinnamonensis DSM 1042; J. Org. Chem. 2007, 72, 4198–4204.
doi: 10.1021/jo0703404 - A. Charchoglyan, A. Abrahamyan, I. Fujii, Z. Boubakir, T. A. M. Gulder, T. M. Kutchan, H. Vardapetyan, G. Bringmann, Y. Ebizuka, L. Beerhues; Differential Accumulation of Hyperforin and Secohyperforin in Hypericum perforatum Tissue Cultures; Phytochemistry 2007, 68, 2670–2677.
doi: 10.1016/j.phytochem.2007.06.004 - X. Yang, T. A. M. Gulder, M. Reichert, C. Tang, C. Ke, Y. Ye, G. Bringmann; Parvestimins A–D, Novel Dimeric Phenylethyl Benzoquinones from Stemona parviflora Wright; Tetrahedron 2007, 63, 4688–4694.
doi 10.1016/j.tet.2007.03.093 - G. Bringmann, T.F. Noll, T. A. M. Gulder, M. Grüne, M. Dreyer, C. Wilde, F. Pankewitz, M. Hilker, G. D. Payne, A. L. Jones, M. Goodfellow, H.-P. Fiedler; Different Polyketide Folding Modes Converge to an Identical Molecular Architecture; Nat. Chem. Biol. 2006, 2, 429–433.
doi: 10.1038/nchembio805 - G. Bringmann, T. Gulder, T. A. M. Gulder; Asymmetric Synthesis of Biaryls by the ‘Lactone Method’ in Asymmetric Synthesis - The Essentials (Eds. M. Christmann, S. Bräse); Wiley VCH-Verlag: Weinheim, 2006, 246–250.
- G. Bringmann, S. Rüdenauer, D. C. G. Götz, T. A. M. Gulder, M. Reichert; Axially chiral Directly β,β-Linked Bisporphyrins: Synthesis and Stereostructure; Org. Lett. 2006, 8, 4743–4746.
doi: 10.1021/ol061812o - M. Scheuermayer, T. A. M. Gulder, G. Bringmann, U. Hentschel; Rubritalea marina gen. nov., sp. nov., a Marine Representative of the Phylum 'Verrucomicrobia', Isolated from a Sponge (Porifera); Int. J. Syst. Evol. Microbiol. 2006, 56, 2119–2124.
doi: 10.1099/ijs.0.64360-0 - A. Aiello, M. D’Esposito, E. Fattorusso, M. Menna, W. E. G. Müller, S. Perović-Ottstadt, H. Tsuruta, T. A. M. Gulder, G. Bringmann; Daminin, a Bioactive Pyrrole Alkaloid from the Mediterranean Sponge Axinella damicornis; Tetrahedron 2005, 61, 7266–7270.
doi: 10.1016/j.tet.2005.05.025 - G. Bringmann, G. Lang, T. A. M. Gulder, H. Tsuruta, J. Mühlbacher, K. Maksimenka, S. Steffens, K. Schaumann, R. Stöhr, J. Wiese, J. F. Imhoff, S. Perović-Ottstadt, O. Boreiko, W.E.G. Müller; The First Sorbicillinoid Alkaloids, the Antileukemic Sorbicillactones A and B, from a Sponge-Derived Penicillium chrysogenum Strain; Tetrahedron 2005, 61, 7252–7265.
doi: 10.1016/j.tet.2005.05.026 - G. Bringmann, T. A. M. Gulder, K. Maksimenka, D. Kuckling, W. Tochtermann; A Borderline Case Between Meso and Stable C1: An Axially Chiral, Yet Configurationally Semi-Stable Biphenyl with Two Oppositely Configured [10]Paracyclophane Portions; Tetrahedron 2005, 61, 7241–7246.
doi: 10.1016/j.tet.2005.05.027 - G. Bringmann, G. Lang, K. Maksimenka, A. Hamm, T. A. M. Gulder, A. Dieter, A. T. Bull, J. E. M. Stach, N. Kocher, W. E. G. Müller, H.-P. Fiedler; Gephyromycin, the First Bridged Angucyclinone, from Streptomyces griseus Strain NTK 14; Phytochemistry 2005, 66, 1366–1373.
doi: 10.1016/j.phytochem.2005.04.010
Patents
- Aspernigrin B und Aspernigrin-B-Derivate, Verfahren zu ihrer Herstellung, sie enthaltende Arzneimittel und deren Verwendung; G. Bringmann, K. Maksimenka, T. A. M. Gulder, K. Schaumann, S. Perović-Ottstadt, W. E. G. Müller, J. Hiort, R. Ebel, P. Proksch; Deutsches Patent DE 10 2004 002 884 A1, 25.10.2007.
- Verfahren zur Herstellung von Sorbicillacton A; G. Bringmann, G. Lang, T. A. M. Gulder, K. Schaumann, W. E. G. Müller, S. Perović-Ottstadt, R. Stöhr, J. Wiese, R. Schmaljohann, J. F. Imhoff; Deutsches Patent DE 10 2004 004 901 B4, 5.1.2006.
- Sorbifuranone, Sorbivineton, Sorbivinetol und Derivate dieser Verbindungen, Verfahren zu ihrer Herstellung, sie enthaltende Arzneimittel und deren Verwendung; G. Bringmann, G. Lang, T. A. M. Gulder, K. Schaumann, S. Steffens, W. E. G. Müller, S. Perović-Ottstadt, J. F. Imhoff; Deutsche Patentoffenlegung DE 10 2004 005 106 A1, 18.8.2005.
- Method for Producing Sorbicillactone A ; G. Bringmann, G. Lang, T. A. M. Gulder , K. Schaumann, W. E. G. Müller, S. Perović-Ottstadt, R. Stoehr, J. Wiese, R. Schmaljohann, J. F. Imhoff; International Patent Disclosure WO2005 / 072711 A2, 11.8.2005.