External Links
ChemBio Probes
Avoid: PAINS and low-quality probes; lousy/missing controls (experiments & compounds).
* Baell PAINS 2014 / 2017; Schapira controls 2021; Derek Lowe (1, 2); NCB15
* EU OpenScreen and SGC Chemical Probes: on- and off-targets, control compounds
* ChemicalProbes.org curated database (excludes the bad compounds)
* NIH Guide: avoiding aggregation, fluorescence / absorbance, or reactivity
* Just next door: the world-leading TU Dresden Dye Collection for inspiration!
ChemBio
* NIH Bio Assays with Chem Probes (viability 2D/ spheroids; in vivo; PK/ADME)
* OTS Chemical Fluorophore spectra; Arizona Fluorophore Spectra; RGB converter
* Fluorescent Protein Database, Mol Probes Handbook, UCSF FP Visualiser & List
* TS Group Chemistry Lab Book info pages.
* PDB; Michelangelo PDB Visualiser; and SGC pre-processed PDB structures.
* Proteins: ExPASy portal; UniProt sequences & info; SwissModel; String.
* Redox resources at US SfRBM; SfRR Europe.
Chemistry
* Herbert Mayr's Farewell to the Hard/Soft Acid/Base Rationale for Reactivity
* Hans Reich's Org Chem Databank of Everything; the FOCUS Org Chem database
* Chemistry By Design, OrgSyn, the Organic Chemistry Portal / Total Syntheses
* It's Not Voodoo chemistry site; Schlenk Line Survival Guide
* Name Reactions; 100 Top Mechanisms; Mayr/Ofial Nuc/Elec database
* In the Pipeline, OrgPrepDaily/Milkshake, Organiclinks, PubChem (in beta)
* Onward Learning: BACON Bio&Chem website (Neil Garg et al); Christmann links
Biological Databases and Files; Microscopy & Image Processing
* The JCS Cell Science at a Glance page
* Leica LAS X free image evaluation software for Windows; Zeiss has similar
* Antibody Search Engine, Cheap Bio Reagents
* Human Protein Atlas, CRISPR (Addgene), diagnostics,
* Widefield & Confocal Introduction: Combs 2010
* Confocal How-to: Olympus / Marder lab / Nikon; acquisition & image quality
Find your Science
* PDF compression & manipulation tools
* DOI and shortDOI (bookmarklets in the subpage); ORCID
* Reaxys, SciFinder, Google Scholar, Google Patent
* Reference Resolver to jump to any article (extensions)
* T1P Link Shortener; GigaMove File Transfer; When2Meet meeting scheduler
Tools for UV-Vis, Energy, λ ↔︎ RGB, Graphics, Fonts,...
* Free a|e UV-Vis/Fluo spectral analysis/cleaning software (Win only)
* RGB calculator and Relative Brightness table; Colour-Wavelength Loci for RGB
* Energy Converter 1; Energy Converter 2, with wavelengths; Rayleigh scatter
* NounProject icons; Servier Medical graphics for bio (animals, cells, organelles etc)
Chemistry Reference/Properties
* Evans' pKa; Bordwell pKa; BDEs; Mayr Reactivity Database and Posters
* Structure Resolver (ChemDraw script); eMolecules search (ChemDraw script)
* How-To: reverse-phase purification/TLC
* Screening: NIH DTP; Stanford Guide & PAINS list; cApp handler; ChemAxon
* Chemicalize: powerful chemical property calculator (use ChemAxon to register)
* GAMESS, NMRpredict, Lab Insurance
# Know a good Synthetic Equivalents page? Let me know!
Pharmacological Databases and Files
* CancerRXGene and NCI60 cell line screening data for reference compounds
* IUPHAR Guide to Pharmacology
* DrugBank, ChEMBL, ChemicalProbes
* ADMET Predictor, East China UST Pharmacy Dept
* Top 150 Drugs, 2013-2014 and Njardason Top Pharma Posters