CMCB Life Sciences Seminar: Irina Solovei, LMU München

Title: „Understanding functional genome architecture through unusual nuclear arrangements“

Host: Tomohisa Toda (DZNE)

Abstract:

On the seminar, I am going to discuss two unusual nuclear arrangements of heterochromatin and euchromatin, both contributing to our understanding of the general principles of the functional genome organization within the cell nucleus.

The study of abnormally inverted rod nuclei helped to unravel mechanisms of heterochromatin tethering to the nuclear envelope, principles of euchromatin-heterochromatin segregation and the importance of the conventional nuclear architecture.

The study of unusually highly upregulated long genes allowed to dismiss model of transcription factories and demonstrated the organization of expressed genes in Transcription Loops formed via mechanisms universal for eukaryotic transcription.