People
© Michael Kretzschmar
Department Chair
NameProf. A. Francis Stewart
Group Leader
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Visiting address:
Biotechnologisches Zentrum, Floor 1, Room 129 Tatzberg 47/49
01307 Dresden
Find the publications and for more information please look here.
Assistant to Group Leader
NameJuliane Wunderlich
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Biotechnologisches Zentrum, Floor 1, Room 130 Tatzberg 47/49
01307 Dresden
© Michael Kretzschmar
PostDoc
NameDr. Deepthi Ashokkumar
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Visiting address:
Biotechnologisches Zentrum, Floor 1, Room 102 Tatzberg 47/49
01307 Dresden
© Michael Kretzschmar
Predoc
NameRong Fan M.Sc.
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Visiting address:
Biotechnologisches Zentrum, Floor 1, Room 101 Tatzberg 47/49
01307 Dresden
© Michael Kretzschmar
Postdoc
NameDr. Andrea Kranz
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Visiting address:
Biotechnologisches Zentrum, Floor 1, Room 103 Tatzberg 47/49
01307 Dresden
CV
| 1994 | Diploma in Biology, Christian-Albrechts-Universität Kiel |
| 1995 | Research fellow, Laboratory of Prof. M. Kendall, Babraham Institute, Cambridge University, United Kingdom |
| 1999 | PhD, "The vascular system as a target for the Vascular Endothelial Growth Factor-A: A mediator for the physiologic and pathologic angiogenesis in human", Laboratory of Prof. J. Waltenberger, Universität Ulm |
| 1999-2000 | Postdoc, Laboratory of Prof. J. Waltenberger, Universität Ulm |
| 2001-2004 | Postdoc, Laboratory of Prof. T.N. Sato, University of Texas, Southwestern Medical Center Dallas |
| 2005 | Postdoc, Laboratory of Prof. T.N. Sato, Weill Medical College, Cornell University New York City |
| 2006-now | Postdoc, Laboratory of Prof. A.F. Stewart, Technische Universität Dresden, BIOTEC |
Scientific Awards
| 1995 | Scholarship of the Dr. Helmut Robert Memorial Foundation |
| 1998 | Ludolf-Krehl-Award of the Southwest-German Society for Internal Medicine |
| 1999 | Gotthard-Schettler-Award of the German Society for Arteriosclerosis-Research |
| 2000 | PhD-Award of the Society of the University Ulm |
Publications
Kranz, A. and Anastassiadis, K. (2020), "The role of SETD1A and SETD1B in development and disease" Biochim. Biophys. Acta Gene Regul. Mech., doi: 10.1016/j.bbagrm.2020.194578
Ashokkumar, D., Zhang, Q., Much, C., Bledau, A.S., Naumann, R., Alexopoulou, D., Dahl, A., Goveas, N., Fu, J., Anastassiadis, K., Stewart, A.F. and Kranz, A. (2020) "MLL4 is required after implantation whereas MLL3 becomes essential during late gestation" Development, 147(12), doi: 10.1242/dev.186999
Chen, Y., Jones, K.L., Anastassiadis, K., Kranz, A., Stewart, A.F., Grembecka, J., Meyerson, M. and Ernst, P. (2018) "Distinct pathways affected by Menin versus MLL1/MLL2 in MLL-rearranged Acute Myeloid Leukemia" Exp Hematol 69, 37 - 42
Schmidt, K., Zhang, Q., Tasdogan, A., Petzold, A., Dahl, A., Arneth, B.M., Slany, R., Fehling, H.J., Kranz, A., Stewart, A.F. and Anastassiadis, K. (2018) "The H3K4 methyltransferase Setd1b is essential for hematopoietic stem cell and progenitor cell homeostasis in mice" ELife, doi: 10.7554/eLife.27157
Arndt, K., Kranz, A., Fohgrub, J., Jolly, A., Bledau, A.S., Di Virgilio, M., Lesche, M., Dahl, A., Höfer, T., Stewart, A.F. and Waskow, C. (2018) "SETD1A protects HSCs from activation-induced functional decline in vivo" Blood 131(12), 1311 - 1324
Hanna, C.W., Taudt, A., Huang, J., Gahurova, L., Kranz, A., Andrews, S., Dean, W., Stewart, A.F., Colomé-Tatché, M. and Kelsey, G. (2018) "MLL2 conveys transcription-independent H3K4 trimethylation in oocytes" Nat. Struct. Mol. Biol. 25(1), 73 - 82
Kerimoglu, C., Sakib, M.S., Jain, G., Benito, E., Burkhardt, S., Capece, V., Kaurani, L., Halder, R., Agís-Balboa, R.C., Stilling, R., Urbanke, H., Kranz, A., Stewart, A.F. and Fischer, A. (2017) "KMT2A and KMT2B mediate memory function by affecting distinct genomic regions" Cell Rep., 20(3), 538 - 548
Chen, Y., Anastassiadis, K., Kranz, A., Stewart, A.F., Arndt, K., Waskow, C., Yokoyama, A., Jones, K., Neff, T., Lee, Y. and Ernst P. (2017) "MLL2, not MLL1, plays a major role in sustaining MLL-rearranged accute myeloid leukemia" Cancer Cell 31(6), 755 - 770
Brici, D., Zhang, Q., Reinhardt, S., Dahl, A., Hartmann, H., Schmidt, K., Goveas, N., Huang, J., Gahurova, L., Kelsey, G., Anastassiadis, K., Stewart, A.F. and Kranz, A. (2017) "The histone 3 lysine 4 methyltransferase Set1b is a maternal effect gene required for the oogenic gene expression program" Development 144(14), 2606 - 2617
Baker, O., Tsurkan, S., Fu, J., Klink, B., Rump, A., Obst, M., Kranz, A., Schröck, E., Anastassiadis, K. and Stewart, A.F. (2017) "The contribution of homology arms to nuclease-assisted genome engineering" Nucl. Acids Res., 45(13), 8105 - 8115
Subramaniam, S., Erler, A., Fu, J., Kranz, A., Tang, J., Gopalswamy, M., Ramakrishnan, S., Keller, A., Grundmeier, G., Müller, D. Sattler, M. and Stewart, A.F. (2016) "DNA Annealing by Redβ is insufficient for homologous recombination and the additional requirements involve intra- and inter-molecular interactions" Sci. Rep. 6: 34525
Kantidakis, T., Saponaro, M., Mitter, R., Horswell, S., Kranz, A., Boeing, S., Aygün, O., Kelly, G.P., Matthews, N., Stewart, A., Stewart, A.F. and Svejstrup, J.Q. (2016) "Mutation of cancer driver MLL2 results in transcription stress and genome instability" Genes Dev. 30, 408 - 420
Bögershausen, N., Tsai, I. C., Pohl, E., Kiper, P. O., Beleggia, F., Percin, E. F., Keupp, K., Matchan, A., Milz, E., Alanay, Y., Kayserili, H., Liu, Y., Banka, S., Kranz, A., Zenker, M., Wieczorek, D., Elcioglu, N., Prontera, P., Lyonnet, S., Meitinger, T., Stewart, A. F., Donnai, D., Strom, T. M., Boduroglu, K., Yigit, G., Li, Y., Katsanis, N. and Wollnik, B. (2015). "RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome" J Clin Invest. 125(9), 3585 - 3599
Bledau, A. S., Schmidt, K., Neumann, K., Hill, U., Ciotta, G., Gupta, A., Torres, D. C., Fu, J., Kranz, A., Stewart, A. F. and Anastassiadis, K. (2014). "The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation" Development 141(5), 1022 - 1035
Denissov, S., Hofemeister, H., Marks, H., Kranz, A., Ciotta, G., Singh, S., Anastassiadis, K., Stunnenberg, H. G. and Stewart, A. F. (2014). "Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant" Development 141(3), 526 - 537
Kerimoglu, C., Agis-Balboa, R. C., Kranz, A., Stilling, R., Bahari-Javan, S., Benito-Garagorri, E., Halder, R., Burkhardt, S., Stewart, A. F. and Fischer, A. (2013). "Histone-methyltransferase MLL2 (KMT2B) is required for memory formation in mice" J Neurosci 33, 3452 - 3464
Marks, H., Kalkan, T., Menafra, R., Denissov, S., Jones, K., Hofemeister, H., Nichols, J., Kranz, A., Stewart, A. F., Smith, A. and Stunnenberg, H. G. (2012). "The transcriptional and epigenomic foundations of ground state pluripotency" Cell 149(3), 590 - 604
Anastassiadis, K., Glaser, S., Kranz, A., Bernhardt, K. and Stewart, A. F. (2010). "A practical summary of site-specific recombination, conditional mutagenesis, and tamoxifen induction of CreERT2" Methods Enzymol 477, 109-23
Kranz, A., Fu, J., Duerschke, K., Weidlich, S., Naumann, R., Stewart, A. F. and Anastassiadis, K. (2010). "An improved Flp deleter mouse in C57Bl/6 based on Flpo recombinase" Genesis 48(8), 512 - 520
Glaser, S., Lubitz, S., Loveland, K. L., Ohbo, K., Robb, L., Schwenk, F., Seibler, J., Roellig, D., Kranz, A., Anastassiadis, K. and Stewart, A. F. (2009). "The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis" Epigenetics Chromatin 2: 5
Hooper, A. T., Butler, J. M., Nolan, D. J., Kranz, A., Iida, K., Kobayashi, M., Kopp, H. G., Shido, K., Petit, I., Yanger, K., James, D., Witte, L., Zhu, Z., Wu, Y., Pytowski, B., Rosenwaks, Z., Mittal, V., Sato, T. N. and Rafii, S. (2009). "Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells" Cell Stem Cell 4(3), 263 - 274
Stadler, N., Eggermann, J., Voo, S., Kranz, A. and Waltenberger, J. (2007). "Smoking-induced monocyte dysfunction is reversed by vitamin C supplementation in vivo" Arterioscler Thromb Vasc Biol 27(1), 120 - 126.
Autiero, M., Waltenberger, J., Communi, D., Kranz, A., Moons, L., Lambrechts, D., Kroll, J., Plaisance, S., De Mol, M., Bono, F., Kliche, S., Fellbrich, G., Ballmer-Hofer, K., Maglione, D., Mayr-Beyrle, U., Dewerchin, M., Dombrowski, S., Stanimirovic, D., Van Hummelen, P., Dehio, C., Hicklin, D. J., Persico, G., Herbert, J. M., Communi, D., Shibuya, M., Collen, D., Conway, E. M. and Carmeliet, P. (2003). "Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1" Nat Med 9(7), 936 - 943
von Degenfeld, G., Raake, P., Kupatt, C., Lebherz, C., Hinkel, R., Gildehaus, F. J., Munzing, W., Kranz, A., Waltenberger, J., Simoes, M., Schwaiger, M., Thein, E. and Boekstegers, P. (2003). "Selective pressure-regulated retroinfusion of fibroblast growth factor-2 into the coronary vein enhances regional myocardial blood flow and function in pigs with chronic myocardial ischemia" J Am Coll Cardiol 42(6), 1120 - 1128
Kranz, A., Rau, C., Kochs, M. and Waltenberger, J. (2000). "Elevation of vascular endothelial growth factor-A serum levels following acute myocardial infarction. Evidence for its origin and functional significance" J Mol Cell Cardiol 32(1), 65 - 72
Waltenberger, J., Lange, J. and Kranz, A. (2000). "Vascular endothelial growth factor-A-induced chemotaxis of monocytes is attenuated in patients with diabetes mellitus: A potential predictor for the individual capacity to develop collaterals" Circulation 102(2), 185 - 190
Kranz, A., Mattfeldt, T. and Waltenberger, J. (1999). "Molecular mediators of tumor angiogenesis: enhanced expression and activation of vascular endothelial growth factor receptor KDR in primary breast cancer" Int J Cancer 84(3), 293 - 298
Kranz, A., Mayr, U., Frank, H. and Waltenberger, J. (1999). "The coronary endothelium: a target for vascular endothelial growth factor. Human coronary artery endothelial cells express functional receptors for vascular endothelial growth factor in vitro and in vivo" Lab Invest 79, 985 - 991
Waltenberger, J., Kranz, A. and Beyer, M. (1999). "Neovascularization in the human heart is associated with expression of VEGF-A and its receptors Flt-1 (VEGFR-1) and KDR (VEGFR-2). Results from cardiomyopexy in ischemic cardiomyopathy" Angiogenesis 3(4), 345 - 351.
Head, G. M., Mentlein, R., Kranz, A., Downing, J. E. and Kendall, M. D. (1997). "Modulation of dye-coupling and proliferation in cultured rat thymic epithelium by factors involved in thymulin secretion" J Anat 191(3), 355 - 365
Kranz, A., Kendall, M. D. and von Gaudecker, B. (1997). "Studies on rat and human thymus to demonstrate immunoreactivity of calcitonin gene-related peptide, tyrosine hydroxylase and neuropeptide Y" J Anat 191(3), 441 - 450
© Michael Kretzschmar
Technician
NameSusan Schneider Dipl. Biol.
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Visiting address:
Biotechnologisches Zentrum, Floor 1, Room 101 Tatzberg 47/49
01307 Dresden
CV
| 2004-now | Technician, Genomics, BIOTEC, Technische Universität Dresden |
| 2002-2003 | Scientific associate, Laboratory of S.H. Park Department of Pathology, Seoul National University College of Medicine, Korea. |
| 2002 | Diploma in Biology, Technische Universität Dresden Laboratory of Prof. Dr. G. Rödel, "Untersuchungen zur molekularen Organisation des mitochondrialen Abc1p bei der Hefe Saccharomyces cerevisae mit der Blue native polyacrylamid gelelectrophoresis" |
Publications
Duryagina, R., Anastassiadis, K., Maitz, M., Gramm, S., Schneider, S., Wobus, M., Thieme, S., Brenner, S., Werner, C. and Bornhäuser, M. (2014). "Cellular reporter systems for high-throughput-screening of interactions between bioactive matrices and human mesenchymal stromal cells" Tissue Eng Part C Methods 20(10), 828 - 837
Duryagina, R., Thieme, S., Anastassiadis, K., Werner, C., Schneider, S., Wobus, M., Brenner, S. and Bornhäuser, M. (2013). "Overexpression of Jagged-1 and its intracellular domain in human mesenchymal stromal cells differentially affect the interaction with hematopoietic stem and progenitor cells" Stem Cells Dev 22, 2736 - 2750.
Gross, F., Ring, M. W., Perlova, O., Fu, J., Schneider, S., Gerth, K., Kuhlmann, S., Stewart, A. F., Zhang, Y. and Muller, R. (2006). "Metabolic engineering of Pseudomonas putida for methylmalonyl-CoA biosynthesis to enable complex heterologous secondary metabolite formation" Chem Biol 13(12), 1253 - 1264.
Sarov, M., Schneider, S., Pozniakovski, A., Roguev, A., Ernst, S., Zhang, Y., Hyman, A. A. and Stewart, A. F. (2006). "A recombineering pipeline for functional genomics applied to Caenorhabditis elegans" Nat Methods 3, 839 - 844.