People

A. Francis Stewart (Group Leader)

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Department Chair

Prof. A. Francis Stewart

Group Leader, Seniorprofessor

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Biotechnology Center (BIOTEC)

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Besuchsadresse:

Biotechnologisches Zentrum, Floor 1, Room 129 Tatzberg 47/49

01307 Dresden

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fax Fax: +49 351 463-40143

Find the publications and for more information please look here.

Andrea Kranz (PostDoc)

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Postdoc

Dr. Andrea Kranz

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Biotechnology Center (BIOTEC)

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Besuchsadresse:

Biotechnologisches Zentrum, Floor 1, Room 103 Tatzberg 47/49

01307 Dresden

work Tel.
fax Fax: +49 351 463-40143

CV

1994	Diploma in Biology, Christian-Albrechts-Universität Kiel
1995	Research fellow, Laboratory of Prof. M. Kendall, Babraham Institute, Cambridge University, United Kingdom
1999	PhD, "The vascular system as a target for the Vascular Endothelial Growth Factor-A: A mediator for the physiologic and pathologic angiogenesis in human", Laboratory of Prof. J. Waltenberger, Universität Ulm
1999-2000	Postdoc, Laboratory of Prof. J. Waltenberger, Universität Ulm
2001-2004	Postdoc, Laboratory of Prof. T.N. Sato, University of Texas, Southwestern Medical Center Dallas
2005	Postdoc, Laboratory of Prof. T.N. Sato, Weill Medical College, Cornell University New York City
2006-now	Postdoc, Laboratory of Prof. A.F. Stewart, Technische Universität Dresden, BIOTEC

Scientific Awards

1995	Scholarship of the Dr. Helmut Robert Memorial Foundation
1998	Ludolf-Krehl-Award of the Southwest-German Society for Internal Medicine
1999	Gotthard-Schettler-Award of the German Society for Arteriosclerosis-Research
2000	PhD-Award of the Society of the University Ulm

Publications

Kranz, A. and Anastassiadis, K. (2020), "The role of SETD1A and SETD1B in development and disease" Biochim. Biophys. Acta Gene Regul. Mech., doi: 10.1016/j.bbagrm.2020.194578

Ashokkumar, D., Zhang, Q., Much, C., Bledau, A.S., Naumann, R., Alexopoulou, D., Dahl, A., Goveas, N., Fu, J., Anastassiadis, K., Stewart, A.F. and Kranz, A. (2020) "MLL4 is required after implantation whereas MLL3 becomes essential during late gestation" Development, 147(12), doi: 10.1242/dev.186999

Chen, Y., Jones, K.L., Anastassiadis, K., Kranz, A., Stewart, A.F., Grembecka, J., Meyerson, M. and Ernst, P. (2018) "Distinct pathways affected by Menin versus MLL1/MLL2 in MLL-rearranged Acute Myeloid Leukemia" Exp Hematol 69, 37 - 42

Schmidt, K., Zhang, Q., Tasdogan, A., Petzold, A., Dahl, A., Arneth, B.M., Slany, R., Fehling, H.J., Kranz, A., Stewart, A.F. and Anastassiadis, K. (2018) "The H3K4 methyltransferase Setd1b is essential for hematopoietic stem cell and progenitor cell homeostasis in mice" ELife, doi: 10.7554/eLife.27157

Arndt, K., Kranz, A., Fohgrub, J., Jolly, A., Bledau, A.S., Di Virgilio, M., Lesche, M., Dahl, A., Höfer, T., Stewart, A.F. and Waskow, C. (2018) "SETD1A protects HSCs from activation-induced functional decline in vivo" Blood 131(12), 1311 - 1324

Hanna, C.W., Taudt, A., Huang, J., Gahurova, L., Kranz, A., Andrews, S., Dean, W., Stewart, A.F., Colomé-Tatché, M. and Kelsey, G. (2018) "MLL2 conveys transcription-independent H3K4 trimethylation in oocytes" Nat. Struct. Mol. Biol. 25(1), 73 - 82

Kerimoglu, C., Sakib, M.S., Jain, G., Benito, E., Burkhardt, S., Capece, V., Kaurani, L., Halder, R., Agís-Balboa, R.C., Stilling, R., Urbanke, H., Kranz, A., Stewart, A.F. and Fischer, A. (2017) "KMT2A and KMT2B mediate memory function by affecting distinct genomic regions" Cell Rep., 20(3), 538 - 548

Chen, Y., Anastassiadis, K., Kranz, A., Stewart, A.F., Arndt, K., Waskow, C., Yokoyama, A., Jones, K., Neff, T., Lee, Y. and Ernst P. (2017) "MLL2, not MLL1, plays a major role in sustaining MLL-rearranged accute myeloid leukemia" Cancer Cell 31(6), 755 - 770

Brici, D., Zhang, Q., Reinhardt, S., Dahl, A., Hartmann, H., Schmidt, K., Goveas, N., Huang, J., Gahurova, L., Kelsey, G., Anastassiadis, K., Stewart, A.F. and Kranz, A. (2017) "The histone 3 lysine 4 methyltransferase Set1b is a maternal effect gene required for the oogenic gene expression program" Development 144(14), 2606 - 2617

Baker, O., Tsurkan, S., Fu, J., Klink, B., Rump, A., Obst, M., Kranz, A., Schröck, E., Anastassiadis, K. and Stewart, A.F. (2017) "The contribution of homology arms to nuclease-assisted genome engineering" Nucl. Acids Res., 45(13), 8105 - 8115

Subramaniam, S., Erler, A., Fu, J., Kranz, A., Tang, J., Gopalswamy, M., Ramakrishnan, S., Keller, A., Grundmeier, G., Müller, D. Sattler, M. and Stewart, A.F. (2016) "DNA Annealing by Redβ is insufficient for homologous recombination and the additional requirements involve intra- and inter-molecular interactions" Sci. Rep. 6: 34525

Kantidakis, T., Saponaro, M., Mitter, R., Horswell, S., Kranz, A., Boeing, S., Aygün, O., Kelly, G.P., Matthews, N., Stewart, A., Stewart, A.F. and Svejstrup, J.Q. (2016) "Mutation of cancer driver MLL2 results in transcription stress and genome instability" Genes Dev. 30, 408 - 420

Bögershausen, N., Tsai, I. C., Pohl, E., Kiper, P. O., Beleggia, F., Percin, E. F., Keupp, K., Matchan, A., Milz, E., Alanay, Y., Kayserili, H., Liu, Y., Banka, S., Kranz, A., Zenker, M., Wieczorek, D., Elcioglu, N., Prontera, P., Lyonnet, S., Meitinger, T., Stewart, A. F., Donnai, D., Strom, T. M., Boduroglu, K., Yigit, G., Li, Y., Katsanis, N. and Wollnik, B. (2015). "RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome" J Clin Invest. 125(9), 3585 - 3599

Bledau, A. S., Schmidt, K., Neumann, K., Hill, U., Ciotta, G., Gupta, A., Torres, D. C., Fu, J., Kranz, A., Stewart, A. F. and Anastassiadis, K. (2014). "The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation" Development 141(5), 1022 - 1035

Denissov, S., Hofemeister, H., Marks, H., Kranz, A., Ciotta, G., Singh, S., Anastassiadis, K., Stunnenberg, H. G. and Stewart, A. F. (2014). "Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant" Development 141(3), 526 - 537

Kerimoglu, C., Agis-Balboa, R. C., Kranz, A., Stilling, R., Bahari-Javan, S., Benito-Garagorri, E., Halder, R., Burkhardt, S., Stewart, A. F. and Fischer, A. (2013). "Histone-methyltransferase MLL2 (KMT2B) is required for memory formation in mice" J Neurosci 33, 3452 - 3464

Marks, H., Kalkan, T., Menafra, R., Denissov, S., Jones, K., Hofemeister, H., Nichols, J., Kranz, A., Stewart, A. F., Smith, A. and Stunnenberg, H. G. (2012). "The transcriptional and epigenomic foundations of ground state pluripotency" Cell 149(3), 590 - 604

Anastassiadis, K., Glaser, S., Kranz, A., Bernhardt, K. and Stewart, A. F. (2010). "A practical summary of site-specific recombination, conditional mutagenesis, and tamoxifen induction of CreERT2" Methods Enzymol 477, 109-23

Kranz, A., Fu, J., Duerschke, K., Weidlich, S., Naumann, R., Stewart, A. F. and Anastassiadis, K. (2010). "An improved Flp deleter mouse in C57Bl/6 based on Flpo recombinase" Genesis 48(8), 512 - 520

Glaser, S., Lubitz, S., Loveland, K. L., Ohbo, K., Robb, L., Schwenk, F., Seibler, J., Roellig, D., Kranz, A., Anastassiadis, K. and Stewart, A. F. (2009). "The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis" Epigenetics Chromatin 2: 5

Hooper, A. T., Butler, J. M., Nolan, D. J., Kranz, A., Iida, K., Kobayashi, M., Kopp, H. G., Shido, K., Petit, I., Yanger, K., James, D., Witte, L., Zhu, Z., Wu, Y., Pytowski, B., Rosenwaks, Z., Mittal, V., Sato, T. N. and Rafii, S. (2009). "Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells" Cell Stem Cell 4(3), 263 - 274

Stadler, N., Eggermann, J., Voo, S., Kranz, A. and Waltenberger, J. (2007). "Smoking-induced monocyte dysfunction is reversed by vitamin C supplementation in vivo" Arterioscler Thromb Vasc Biol 27(1), 120 - 126.

Autiero, M., Waltenberger, J., Communi, D., Kranz, A., Moons, L., Lambrechts, D., Kroll, J., Plaisance, S., De Mol, M., Bono, F., Kliche, S., Fellbrich, G., Ballmer-Hofer, K., Maglione, D., Mayr-Beyrle, U., Dewerchin, M., Dombrowski, S., Stanimirovic, D., Van Hummelen, P., Dehio, C., Hicklin, D. J., Persico, G., Herbert, J. M., Communi, D., Shibuya, M., Collen, D., Conway, E. M. and Carmeliet, P. (2003). "Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1" Nat Med 9(7), 936 - 943

von Degenfeld, G., Raake, P., Kupatt, C., Lebherz, C., Hinkel, R., Gildehaus, F. J., Munzing, W., Kranz, A., Waltenberger, J., Simoes, M., Schwaiger, M., Thein, E. and Boekstegers, P. (2003). "Selective pressure-regulated retroinfusion of fibroblast growth factor-2 into the coronary vein enhances regional myocardial blood flow and function in pigs with chronic myocardial ischemia" J Am Coll Cardiol 42(6), 1120 - 1128

Kranz, A., Rau, C., Kochs, M. and Waltenberger, J. (2000). "Elevation of vascular endothelial growth factor-A serum levels following acute myocardial infarction. Evidence for its origin and functional significance" J Mol Cell Cardiol 32(1), 65 - 72

Waltenberger, J., Lange, J. and Kranz, A. (2000). "Vascular endothelial growth factor-A-induced chemotaxis of monocytes is attenuated in patients with diabetes mellitus: A potential predictor for the individual capacity to develop collaterals" Circulation 102(2), 185 - 190

Kranz, A., Mattfeldt, T. and Waltenberger, J. (1999). "Molecular mediators of tumor angiogenesis: enhanced expression and activation of vascular endothelial growth factor receptor KDR in primary breast cancer" Int J Cancer 84(3), 293 - 298

Kranz, A., Mayr, U., Frank, H. and Waltenberger, J. (1999). "The coronary endothelium: a target for vascular endothelial growth factor. Human coronary artery endothelial cells express functional receptors for vascular endothelial growth factor in vitro and in vivo" Lab Invest 79, 985 - 991

Waltenberger, J., Kranz, A. and Beyer, M. (1999). "Neovascularization in the human heart is associated with expression of VEGF-A and its receptors Flt-1 (VEGFR-1) and KDR (VEGFR-2). Results from cardiomyopexy in ischemic cardiomyopathy" Angiogenesis 3(4), 345 - 351.

Head, G. M., Mentlein, R., Kranz, A., Downing, J. E. and Kendall, M. D. (1997). "Modulation of dye-coupling and proliferation in cultured rat thymic epithelium by factors involved in thymulin secretion" J Anat 191(3), 355 - 365

Kranz, A., Kendall, M. D. and von Gaudecker, B. (1997). "Studies on rat and human thymus to demonstrate immunoreactivity of calcitonin gene-related peptide, tyrosine hydroxylase and neuropeptide Y" J Anat 191(3), 441 - 450