Research

Fields of research

• Degradation under flowing liquids
  • Bioreactors / Flow chambers
  • Dynamic interactions between medium and biomaterial

• Biomimetic mineral formation
• Bioresponsive materials and composites
• Composite/hybrid materials for bone replacement
  • Phosphate prestructured gelatin mineralized with calcium and strontium (PPGC+S) for treatment of osteoporotic altered bone

• Compact materials and porous scaffolds
• Sol-gel process under defined climatic conditions
• Mechanical testing
• Atomic force microscopy, electron microscopy, fluorescence microscopy
• Cultivation of stem cells for tissue engineering
• Bone remodeling, osteoblasts, osteoclasts

DFG-Projekt (Nahost-Kooperationsprogramm)

Crustacean bifunctional proteins in mineralized exoskeleton – a model for biomimetic injectable bone substitutes

The focus of the project is on the production and selection of recombinant proteins and their use in chitin gels in the context of bone regeneration. We have focused on basic research into the influence of crustacean proteins on mineralization. Initial binding analyses and investigations of the mineralization-mediating properties in a special chamber are planned. The long-standing cooperation between BGU and TUD has already proven the added value of the interdisciplinary approach. In the future, these bifunctional proteins could be an innovative component of an injectable bone substitute.

Duration: 2024-2027

Principal investigator: - TU Dresden: Dr. Benjamin Kruppke

Principal investigator:  - Ben Gurion Universität (Israel): Prof. Amir Sagi

Project number: 538923079

EUTOPIA Connected Community

Agile in Biomechanics

We are working in the Connected Community "Agile in Biomechanics" together with a group of scientists, including Maurizio Busacca from the Università Ca' Foscari Venezia, Richard King from the University Hospitals Coventry & Warwickshire, Arnab Palit from the University of Warwick, Bulcsú Sándor and Zoltán Bálint from the Babes-Bolyai University in Cluj-Napoca and Bart Jansen from the Vrije Universiteit Brussel. Together, they are implementing the new teaching concept "Agile project management with Scrum" at CC. Students learn agile methods and apply them in practical projects. This concept requires and promotes independent work in accordance with research-based learning principles and addresses the new possibilities of artificial intelligence and additive manufacturing in research and teaching. Interdisciplinary expertise is integrated through collaboration with partners from the EUTOPIA network, and the projects are iteratively improved and adapted in an agile manner in regular presentations to stakeholders. The aim is to transfer this teaching concept to other areas and promote cooperation between different universities.

Duration: 2024-2027

Principal investigator: Dr. Benjamin Kruppke & Prof. Hans-Peter Wiesmann

AGEO e.V.-Project

Electron microscopic interfacial analysis for systematization of short fiber reinforcement of calcium phosphate cements

Duration: 2023-2025

Principal investigator: Dr. Benjamin Kruppke

Funded by the Arbeitsgemeinschaft für Elektronenoptik e.V.

DFG-Project

Resorbable Biopolymer Filaments for Drug Release in Gingival Pockets for Adjuvant Periodontitis Treatment

Periodontitis is a chronic disease caused by inflammatory reactions to biofilm in the periodontal pocket. Our interdisciplinary project aims to develop biodegradable threads for the local release of antibacterial substances subgingivally. Dentists, microbiologists and material scientists will work together to create a suitable material base and test the efficacy in a modified flow chamber. The threads should release relevant amounts of antiseptic and antibiotic therapeutics for up to 10 days without damaging the surrounding tissue. This model is intended to simulate the in vivo situation and provide the basis for time-efficient clinical translation.

Duration: 2022-2024

Principal investigator: Dr. Benjamin Kruppke

Project number: 495284435

DFG-Project

Osteoclast activation by radiolytic degradation of organic/inorganic double hybrid materials (DHM) for controlled enhanced degradation of bone substitute materials

The starting point for this research project is supercritical bone defects that need to be treated with a biomaterial to enable complete regeneration of bone tissue. Such biomaterials have to meet a variety of requirements, which can often only be fulfilled by combining different materials in a composite material. This raises the question of how these components are present on different size scales, i.e. whether they follow a hierarchical structure (similar to bone), which would increase the degrees of freedom for adaptation to the target tissue. Following such a structure, important properties such as mechanical strength, degradation and resorbability, bone cell stimulation, etc. could be separated from or coupled with each other.

Duration: 2022-2024

Principal investigator: Dr. Benjamin Kruppke

Project number: 497439310

BMBF-Project

Bioinspired production of Artificial Enamel by in-situ nano-mineralization. (ArtEnamel)

Duration: 1 Jahr (from 10.2021)

Principal investigator: Dr. Benjamin Kruppke

Researcher: Dr.-Ing. Christiane Heinemann

DFG Project

Investigating the synergistic effects of spatially resolved biochemical, physicochemical, and physical key stimuli to generate biomimetic niches in perfusion bioreactor and their proficiency to derive large bone-like constructs.

GEPRIS

Duration: 3 Years (from 07.2021)

Principal investigator: Dr. Benjamin Kruppke

Researcher: Dipl.-Ing. Franziska Alt

DFG Project

Collaborative Research Center/Transregio 79 " Materials for Tissue Regeneration within Systemically Altered Bone "

Materials for Tissue Regeneration within Systemically Altered Bone

Subproject M3: Composite based on collagen, silica and calcium phosphate for bone replacement

GEPRIS

Duration: 8+1 Years

Principal investigator: Dr. Thomas Hanke and Dr. Benjamin Kruppke (from 2018)