Study Centre Munich

Cushing's syndrome is a very rare hormonal disorder. It is caused by an overproduction of the body's own hormone cortisol (hypercortisolism), which is triggered by a tumor. To date, Cushing's syndrome has not been sufficiently researched and the care of patients worldwide is unsatisfactory. For this reason, the German Cushing's Disease Registry was founded in 2012 to better investigate the disease and improve treatment for patients. By participating in the "German Cushing's Registry", you are actively supporting research into Cushing's syndrome and helping to improve treatment of the disease in the long term.

Neuroendocrine tumors of the gastro-entero-pancreatic system as well as pituitary and hypothalamic masses and tumors of the adrenal glands are very rare diseases that originate in the digestive system, the pituitary gland or the adrenal glands and can either directly cause the release of hormones or influence the release of hormones. The effects and therefore also the clinical treatment of the diseases mentioned can vary greatly, depending on whether the tumor growth and / or the excess hormones are in the foreground and where in the body the tumor or the disease is located. The Network of Excellence for Neuroendocrine Tumors and Pituitary and Adrenal Diseases aims to systematically investigate the complaints, symptoms, treatment response, sequelae, prognosis and mortality of all these different neuroendocrine tumors.

In the European Network for the Study of Adrenal Tumors (ENS@T), specialist centers across Europe work together to investigate benign and malignant adrenal tumors. By comparing clinical data and examining tumor material or blood samples, differences in the development of these tumors and their clinical characteristics can be investigated, thereby indirectly improving the care of those affected.

The aim of this randomized, interventional study is to gain a better understanding of Cushing-associated myopathy and the effect of physical training on muscle function in this context. The intervention consists of an increase in physical activity, fitness and strength through an individualized training program. Patients with newly diagnosed Cushing's syndrome, a history of Cushing's syndrome, or metabolic syndrome will be included.

• Who: People with confirmed endogenous Cushing's syndrome (initial diagnosis or history), people with suspected hypercortisolism, people with mild autonomous cortisol secretion (MACS)
• What: Questionnaire survey (digital or in paper form)
• Time required: approx. 15-20 min

• Who: People with confirmed endogenous Cushing's syndrome (initial diagnosis or history), people with suspected hypercortisolism, people with mild autonomous cortisol secretion (MACS)
• What: Non-invasive examination of activity and sleep behavior
• Time required: Wearing an actigraph on the wrist for three weeks (similar to a wristwatch/fitness tracker, no location data is recorded)

• Who: People with confirmed endogenous Cushing's syndrome (initial diagnosis or recurrence), people with suspected hypercortisolism
• What: Questionnaire, saliva samples, hair samples if necessary
• Time required: Repeated saliva sample collection over three months, visit to outpatient clinic only required at the beginning and end of the study (i.e. twice in total)

Conn's syndrome (primary hyperaldosteronism) describes a disease of the adrenal glands in which there is an increased production of the endogenous hormone aldosterone. To date, Conn syndrome has not been sufficiently researched and the care of patients worldwide is unsatisfactory. For this reason, the German Conn Registry was founded to better investigate the disease and improve treatment for patients. By participating in the "German Conn Register", you are actively supporting research into Conn syndrome and helping to improve treatment of the disease in the long term.

In the European Network for the Study of Adrenal Tumors (ENS@T), specialist centers across Europe work together to investigate benign and malignant adrenal tumors. By comparing clinical data and examining tumor material or blood samples, differences in the development of these tumors and their clinical characteristics can be investigated, thereby indirectly improving the care of those affected.

In the European Network for the Study of Adrenal Tumors (ENS@T), specialist centers across Europe work together to investigate benign and malignant adrenal tumors. By comparing clinical data and examining tumor material or blood samples, differences in the development of these tumors and their clinical characteristics can be investigated, thereby indirectly improving the care of those affected.