Seifert Lab: Bioinformatics Core Unit
The fast progress in the development of experimental technologies enables to measure molecular data of complex diseases with unprecedented detail. The analysis of such heterogeneous data sets requires specific bioinformatics tools to disentangle the complex interplay of different regulatory layers associated with disease-causing processes.
The Bioinformatics Core Unit offers bioinformatics consulting and supports the analysis of molecular high-throughput data. We further develop innovative bioinformatics and systems biology methods for the integrative analysis of molecular high-throughput data.
Service and research focus
- Analysis of microarray and sequencing data
- Development of network-based methods and probabilistic models for the integrative analysis of heterogeneous molecular high-throughput data
- Identification of molecular alterations of astrocytoma and oligodendroglioma development
- Comparative analysis of brain and non-brain metastases of melanomas
- Molecular characterization of subgroups of T-cell prolymphocytic leukemia
- Transmembrane receptors and their impact on therapy resistance of head and neck cancer
Projects
-
ERANET-PLL — Implementation of (epi)genetic and metabolic networks in the targeting of T-cell prolymphocytic leukemia (BMBF, EU)
- Junior Associations MelBrainSys — Model-based prediction and experimental validation of novel therapeutic interventions for melanoma brain metastases (BMBF)
- MelBrainNet — Identification and validation of proteins and signaling pathways associated with therapy resistance of melanoma brain metastases (Translational Research Grant in Precision Oncology, NCT)
- Transmembrane receptors in focal adhesions — Identification of therapy resistance mechanisms and their deactivation in combination with radiochemotherapy (Deutsche Krebshilfe e.V.)
Group leader
© Michael Seifert
Group leader
NameMr Dr. rer. nat. Michael Seifert
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- work Tel.
- +49 351 458-6056
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- +49 351 458-7222
Members of the research group
© Felix Broghammer
Research fellow (external: OncoRay)
NameMr Felix Broghammer M.Sc.
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- +49 351 458-6060
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- +49 351 458-7222
© Theresa Kraft
Research fellow
NameMs Theresa Kraft M.Sc.
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- work Tel.
- +49 351 458-6055
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- +49 351 458-7222
Research fellow
NameMr Dipl. Biol. Nathan Mikhaylenko
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- work Tel.
- +49 351 458-6063
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- +49 351 458-7222
© Pirasteh Pahlavan
Research fellow (external: NCT)
NameMs Dr. rer. nat. Pirasteh Pahlavan
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- work Tel.
- +49 351 458-6228
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- +49 351 458-7222
© Lisa Schöne
Research fellow (external: NCT)
NameMs Lisa Schöne M.Sc.
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- +49 351 458-6060
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- +49 351 458-7222
Students (MD/ Ph.D. students, student assistants)
MD student
NameMr Josef Gladitz
Else-Kröner-Stiftung
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- +49 351 458-6060
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- +49 351 458-7222
© Annemarie Schwarz
MD student
NameMs Annemarie Schwarz
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- +49 351 458-6060
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- +49 351 458-7222
Former staff members
© Chris Lauber
Research fellow
NameMr Dr. Chris Lauber
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- +49 351 458-6055
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- +49 351 458-7222
student assistant
NameMs Olena Maiakovska B.Sc.
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- work Tel.
- +49 351 458-6060
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- +49 351 458-7222
student assistant
NameMr Assad Majid B.Sc.
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- work Tel.
- +49 351 458-6060
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- +49 351 458-7222
Ph.D. student
NameMr Adrian Ortiz Cervantes M.Sc.
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- work Tel.
- +49 351 458-6230
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- +49 351 458-7222
Student assistant
NameMr Michael Rank
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