Seifert Lab: Bioinformatics Core Unit
The fast progress in the development of experimental technologies enables to measure molecular data of complex diseases with unprecedented detail. The analysis of such heterogeneous data sets requires specific bioinformatics tools to disentangle the complex interplay of different regulatory layers associated with disease-causing processes.
The Bioinformatics Core Unit offers bioinformatics consulting and supports the analysis of molecular high-throughput data. We further develop innovative bioinformatics and systems biology methods for the integrative analysis of molecular high-throughput data.
Service and research focus
- Analysis of microarray and sequencing data
- Development of network-based methods and probabilistic models for the integrative analysis of heterogeneous molecular high-throughput data
- Identification of molecular alterations of astrocytoma and oligodendroglioma development
- Comparative analysis of brain and non-brain metastases of melanomas
- Molecular characterization of subgroups of T-cell prolymphocytic leukemia
- Transmembrane receptors and their impact on therapy resistance of head and neck cancer
Projects
-
ERANET-PLL — Implementation of (epi)genetic and metabolic networks in the targeting of T-cell prolymphocytic leukemia (BMBF, EU)
- Junior Associations MelBrainSys — Model-based prediction and experimental validation of novel therapeutic interventions for melanoma brain metastases (BMBF)
- MelBrainNet — Identification and validation of proteins and signaling pathways associated with therapy resistance of melanoma brain metastases (Translational Research Grant in Precision Oncology, NCT)
- Transmembrane receptors in focal adhesions — Identification of therapy resistance mechanisms and their deactivation in combination with radiochemotherapy (Deutsche Krebshilfe e.V.)
Group leader
© Michael Seifert
Group leader
NameMr PD Dr. rer. nat. habil. Michael Seifert
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Members of the research group
© Felix Broghammer
Research fellow (external: OncoRay)
NameMr Felix Broghammer M.Sc.
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© Konrad Gruetzmann
Research fellow
NameMr Dr. rer. nat. Konrad Grützmann
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© Theresa Kraft
Research fellow
NameMs Theresa Kraft M.Sc.
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Research fellow
NameMr Dr. rer. nat. Nathan Mikhaylenko
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© Lisa Schöne
Research fellow (external: NCT)
NameMs Lisa Schöne M.Sc.
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© Marc-Christoph Wagner
Research fellow
NameMr Marc-Christoph Wagner M.Sc.
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Students (MD/ Ph.D. students, student assistants)
© Annemarie Schwarz
MD student
NameMs Annemarie Schwarz
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MD student
NameMs Lisa Sturm
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Former staff members
MD student
NameMr Josef Gladitz
Else-Kröner-Stiftung
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© Chris Lauber
Research fellow
NameMr Dr. Chris Lauber
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student assistant
NameMs Olena Maiakovska B.Sc.
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student assistant
NameMr Assad Majid B.Sc.
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Ph.D. student
NameMr Adrian Ortiz Cervantes M.Sc.
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© Pirasteh Pahlavan
Research fellow (external: NCT)
NameMs Dr. rer. nat. Pirasteh Pahlavan
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