Publications

  • Held,S., Erck,C., Kemppainen,S., Bleibaum,F., Giridhar,N.J., Feederle,R., Krenner,C., Juopperi,S.P., Calliari,A., Mentrup,T., Schröder,B., Dickson,D.W., Rauramaa,T., Petrucelli,L., Prudencio,M., Hiltunen,M., Lüningschrör,P., Capell,A., Damme,M. (2024) Physiological shedding and C-terminal proteolytic processing of TMEM106B. Cell Rep 44, 115107.

  • Contreras,W., Groenendyk,J., Gentzel,M., Schönberg,P., Buchholz,F., Michalak,M., Schröder,B., Mentrup,T. (2024) Selective regulation of aspartyl intramembrane protease activity by calnexin. Cell Mol Life Sci 81, 441.

  • Leinung,N., Mentrup,T., Hodzic,S., Schröder,B. (2024) Molecular and functional in vivo characterisation of murine Dectin-1 isoforms. Eur J Immunol 54, e2451092.

  • Maccioni,R., Travisan,C., Badman,J., Zerial,S., Wagener,A., Andrade-Talavera,Y., Picciau,F., Grassi,C., Chen,G., Lemoine,L., Fisahn,A., Jiang,R., Fluhrer,R., Mentrup,T., Schröder,B., Nilsson,P., and Tambaro,S. (2024) Signal Peptide Peptidase-Like 2b Modulates the Amyloidogenic Pathway and exhibits an Aβ-dependent expression in Alzheimer's Disease. Prog Neurobiol 235, 102585.

  • Mentrup,T., Leinung,N., Patel,M., Fluhrer,R., and Schröder,B. (2024)

    The role of SPP/SPPL intramembrane proteases in membrane protein homeostasis.

    FEBS J 291, 25-44.

  • Zhang,P., Chaldebas,M., Ogishi,M., Al Qureshah,F., Ponsin,K., Feng,Y., Rinchai,D., Milisavljevic,B., Han,J.E., Moncada-Vélez,M., Keles,S., Schröder,B., Stenson,P.D., Cooper,D.N., Cobat,A., Boisson,B., Zhang,Q., Boisson-Dupuis,S., Abel,L., and Casanova.J.L. (2023)

    Genome-wide detection of human intronic AG-gain variants located between splicing branchpoints and canonical splice acceptor sites. Proc Natl Acad Sci 120, e2314225120.

  • Hoeppner, S., Schröder, B., and Fluhrer,R. (2023)

    Structure and function of SPP/SPPL proteases: insights from biochemical evidence and predictive modeling. FEBS J 290, 5456-5474.

  • Leinung,N., Mentrup,T., Patel,M., Gallagher,T., and Schröder,B. (2023)

    Dynamic association of the intramembrane proteases SPPL2a/b and their substrates with tetraspanin-enriched microdomains. iScience 26, 107819.

  • Ballin,M., Griep,W., Patel,M., Karl,M., Mentrup,T., Rivera-Monroy,J., Foo,B., Schwappach,B., and Schröder,B. (2023)

    The intramembrane proteases SPPL2a and SPPL2b regulate the homeostasis of selected SNARE proteins. FEBS J 290, 2320-2337

  • Contreras,W., Wiesehöfer,C., Schreier,D., Leinung,N., Peche,P., Wennemuth,G., Gentzel,M., Schröder,B., and Mentrup,T. (2022)

    C11orf94/Frey is a key regulator for male fertility by controlling Izumo1 complex assembly.

    Sci Adc 8, eabo6049.

  • Mentrup,T., Stumpff-Niggemann,A.Y., Leinung,N., Schlosser,C., Schubert,K., Wehner,R., Tunger,A., Schatz,V., Neubert,P., Gradtke,A.C., Wolf,J., Rose-John,S., Saftig,P., Dalpke,A., Jantsch,J., Schmitz,M., Fluhrer,R., Jacobsen,I.D. and Schröder,B. (2022)

    Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis. Nat Comm 13: 1880.

  • Mentrup,T. and Schröder,B. (2022)

    Signal peptide peptidase-like 2 proteases: Regulatory switches or proteasome of the membrane?

    Biochim. Biophys. Acta Mol Cell Res 1869:119163.

  • Mentrup,T., Cabrera-Cabrera,F. and Schröder,B. (2021)

    Proteolytic regulation of the Lectin-like oxidised lipoprotein receptor LOX-1

    Front Cardiovasc Med 7: 594441.

  • Gradtke,A.C., Mentrup,T., Lehmann,C.H.K., Cabrera-Cabrera,F., Desel,C. Okakpu,D., Assmann, M., Dalpke,A., Schaible, U., Dudziak,D., and Schröder, B. (2021)
    Deficiency of the intramembrane protease SPPL2a alters anti-mycobacterial cytokine responses of dendritic cells. J Immunol 206, 164-180.

  • Mentrup,T., Cabrera-Cabrera,F., Fluhrer,R., and Schröder,B. (2020)
    Physiological functions of SPP/SPPL intramembrane proteases.
    Cell Mol Life Sci. 77, 2959-2979.

  • Niemeyer,J., Mentrup,T., Heidasch,R., Müller,S.A., Biswas,U., Meyer,R., Papadopoulou,A., Dederer,V., Haug-Kröper,M., Adamski,V., Lüllmann-Rauch,R., Bergmann,M., Mayerhofer,A., Saftig,P., Wennemuth,G., Jessberger,R., Fluhrer,R., Lichtenthaler, S.F., Lemberg,M., and Schröder,B. (2019)
    The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban. EMBO Rep 20, e46449.

  • Papadopoulou,A., Müller,S.A., Mentrup,T., Shmueli,M.D., Niemeyer,J., Haug-Kröper,M., von Blume,J., Mayerhofer,A., Feederle,R., Schröder,B., Lichtenthaler,S.F. and Fluhrer,R. (2019)
    Signal Peptide-Peptidase-Like 2c (SPPL2c impairs vesicular transport by cleavage of SNARE proteins. EMBO Rep 20, e46451.

  • Mentrup,T., Theodorou,K., Cabrera-Cabrera,F., Helbig,A.O., Happ,K., Gijbels, M., Gradtke, A.C., Rabe,B., Fukumori, A., Steiner, H., Tholey,A., Fluhrer,R., Donners,M. and Schröder,B. (2019)
    Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis. J Exp Med 216, 807-830.
  • Kong,X.F., Martinez-Barricarte,R., Kennedy, J., Mele,F., Lazarov,T., Deenick,E.K., Ma,C.S., Breton,G., Lucero, K.B., Langlais,D., Bousfiha,A., Aytekin,C., Markle,J., Trouillet,C., Jabot-Hanin,F., Arlehamn,C.S.L., Rao,G., Picard,C., Lasseau,T., Latorre,D., Hambleton,S., Deswarte,C., Itan,Y., Abarca,K., Moraes-Vasconcelos,D., Ailal,F., Ikinciogullari,A., Dogu,F., Benhsaien,I., Sette,A., Abel,L., Boisson-Dupuis,S., Schröder,B., Nussenzweig,M.C., Liu,K., Geissmann,F., Tangye,S.G., Gros,P., Sallusto,F., Bustamante,J., Casanova, J.L. (2018)
    Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. Nat Immunol., 19, 973-985.
  • Mentrup,T., Loock,A.C., Fluhrer,R. and Schröder,B. (2017)
    Signal peptide peptidase and SPP-like proteases - possible therapeutic targets? Biochim. Biophys. Acta, 1864, 2169-2182.
  • Schneppenheim,J., Loock,A.C., Hüttl,S., Schweizer,M., Lüllmann-Rauch,R., Oberg,H.H., Arnold,P., Lehmann,C., Dudziak,D., Kabelitz,D., Lucius,R., Lennon-Duménil,A.M., Saftig,P., and Schröder,B. (2017)
    The influence of MHC class II on B cell defects induced by Invariant chain/CD74 N-terminal fragments. J. Immunol., 199, 172-185.
  • Mentrup,T., Fluhrer, R. and Schröder,B. (2017)
    Latest emerging functions of SPP/SPPL intramembrane proteases. Eur J Cell Biol, 96, 372-382.         
  • Schröder,B. and Saftig,P. (2016)
    Intramembrane proteolysis within lysosomes. Ageing Res Rev, 32, 51-64.           
  • Schröder,B. (2016)
    The multifaceted roles of the invariant chain CD74 - More than just a chaperone. Biochim. Biophys. Acta, 1863, 1269-1281                                              
  • Hüttl,S., Helfrich,F., Mentrup,T., Held,S., Fukumori,A., Steiner,H., Saftig,P., Fluhrer,R., and Schröder,B. (2016)
    Substrate determinants of Signal peptide peptidase-like 2a (SPPL2a)-mediated Intramembrane Proteolysis of the Invariant chain CD74. Biochem. J., 473, 1405-1422.
  • Hüttl,S., Kläsener,K., Schweizer,M., Schneppenheim,J., Oberg,H.H., Kabelitz,D., Reth,M., Saftig,P., and Schröder,B. (2015)
    Processing of CD74 by the intramembrane protease SPPL2a is critical for B cell receptor signaling in transitional B cells J. Immunol., 195, 1548-1563.                    
  • Mentrup,T., Häsler,R., Fluhrer,R., Saftig,P., and Schröder,B. (2015)
    A cell-based assay reveals nuclear translocation of intracellular domains released by SPPL proteases. Traffic, 16, 871-892.      
  • Kuhn,P.H., Voss,M., Haug-Kröper,M., Schröder,B., Schepers,U., Bräse,S., Haass,C., Lichtenthaler,S.F., and Fluhrer,R. (2015)
    Secretome analysis identifies novel signal peptide peptidase-like 3 (SPPL3) substrates and reveals a role of SPPL3 in multiple Golgi glycosylation pathways. Mol Cell Prot, 14, 1584-1598.
  • Voss,M., Künzel,U., Higel,F., Kuhn,P.H., Colombo,A., Fukumori,A., Haug-Kröper,M., Klier,B., Grammer,G., Seidl,A., Schröder,B., Obst,R., Steiner,H., Lichtenthaler,S.F., Haass,C., and Fluhrer,R. (2014)
    Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation. EMBO J, 33, 2809-2905.                            
  • Schneppenheim,J., Hüttl,S. Kruchen,A., Fluhrer,R. Müller,I., Saftig,P., Schneppenheim,R., Martin,C.L. and Schröder,B. (2014)
    Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells. Biochem Biophys Res Commun, 451, 48-53.                   
  • Schneppenheim,J., Hüttl,S., Mentrup,T, Lüllmann-Rauch,R., Rothaug,M., Engelke,M., Dittmann,K., Dressel,R., Araki,M., Araki,K., Wienands,J., Fluhrer,R., Saftig,P. and Schröder,B. (2014)
    The intramembrane proteases Signal-peptide-peptidase-like 2a/b have distinct functions in vivo. Mol Cell Biol, 34, 1398-1411.
  • Voss,M., Schröder,B. and Fluhrer,R.(2013)
    Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases. Biochim. Biophys. Acta, 1828, 2828-2839.            
  • Bronckers,A., Güneli,N., Lüllmann-Rauch,R., Schneppenheim,J., Moraru,A.P., Himmerkus,N., Bervoets,T.J., Fluhrer, R., Everts,V., Saftig,P. and Schröder,B. (2013) The intramembrane protease SPPL2A is critical for tooth enamel formation. J Bone Miner Res, 28, 1622-1630.             
  • Schwake,M., Schröder,B. and Saftig,P. (2013)
    Lysosomal Membrane Proteins and their central role in physiology. Traffic, 14, 739-748.                         
  • Schneppenheim,J., Dressel,R., Hüttl,S.,Lüllmann-Rauch,R., Engelke,M., Dittmann,K., Wienands,J., Eskelinen,E.L., Hermans-Borgmeyer,I., Fluhrer,R., Saftig,P., and Schröder,B. (2013)
    The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain. J. Exp. Med., 210, 41-58.
  • Voss,M., Fukumori,A., Kuhn, P.H., Künzel, U., Klier,B., Grammer,G., Haug-Kröper,M., Kremmer,E., Lichtenthaler,S., Steiner,H., Schröder,B., Haass,C., and Fluhrer,R. (2012)
    Foamy virus envelope protein is a substrate for signal peptide peptidase like-3 (SPPL3). J. Biol. Chem., 287 (52), 43401-43409.                  
  • Behnke,J., Schneppenheim,J., Koch-Nolte,F., Haag,F., Saftig,P., and Schröder,B. (2011)
    Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endsosomes by a tyrosine motif in ist C-terminal tail. FEBS Lett, 585, 2951-2957.          
  • Schröder,B., Wrocklage,C., Hasilik,A., and Saftig,P. (2010).
    The proteome of lysosomes. Proteomics 10, 4053-4076.                                                         
  • Schröder,B., Wrocklage,C., Pan,C., Jäger,R., Kösters,B., Schäfer,H., Elsässer,H.P., Mann,M., and Hasilik,A. (2007).
    Integral and Associated Lysosomal Membrane Proteins. Traffic 8, 1676-1686.

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Andrea Heinze
Last modified: Feb 19, 2025