Research Focus
Working group: Tissue remodeling and Metabolism
Welcome to our research group dedicated to unraveling the complexities of tissue remodeling and metabolism, particularly in the context of Type 2 diabetes mellitus (T2DM). As the most prevalent metabolic disorder globally, T2DM has evolved from a focus on pancreatic function to a broader understanding of its impact on multiple organs and systems. This shift highlights the intricate interplay between various organs, which is crucial for maintaining human health and managing diseases.Our research emphasizes the importance of organ crosstalk, especially as the population ages and the prevalence of comorbidities rises. Conditions such as chronic kidney disease (CKD) frequently accompany T2DM, leading to significant cardiovascular complications. Patients with these conditions often face an increased risk of heart failure, primarily due to sudden cardiac death or ischemic heart disease. These issues are exacerbated by premature vascular aging, characterized by cardiovascular calcification, fibrosis, and hypertrophy. Understanding these shared pathophysiological pathways is essential for developing effective therapeutic strategies.
One of the major areas of our investigation is arterial calcification, a critical yet underexplored mechanism linked to cardiovascular diseases. This pathological process disrupts normal vascular function and is associated with poor clinical outcomes. We are particularly interested in how extracellular vesicles—tiny particles released by cells—play a pivotal role in mediating inter-organ communication and influencing metabolic homeostasis. Recent findings suggest that these vesicles can significantly regulate the formation of microcalcifications, which are crucial in the context of vascular and renal dysfunction.
Our multidisciplinary approach combines in vitro and in vivo studies with cutting-edge omics technologies to explore the molecular mechanisms underlying these processes. Our ultimate goal is to advance the understanding of fibro-calcific remodeling within the cardiovascular-renal-metabolic syndrome. By elucidating the biogenesis and functional roles of extracellular vesicles, we aim to uncover their potential as metabolic transport vehicles that facilitate organ communication during metabolic disorders. Furthermore, we are focused on the regulatory mechanisms governing smooth muscle cell metabolism and phenotype plasticity, which is vital for maintaining vascular health.
Through our research, we aspire to contribute to the development of innovative therapeutic approaches that address the complexities of metabolic disorders, ultimately improving patient outcomes and enhancing quality of life.
