Publication List
Original Papers
J. P. Joos, A. R. Saadatmand, C. Schnabel, I. Viktorinová, T. Brand, M. Kramer, S. Nattel, D. Dobrev, P. Tomancak, J. Backs, P. Kleinbongard, G. Heusch, K. Lorenz, E. Koch, S. Weber & A. El-Armouche. Ectopic expression of S28A-mutated Histone H3 modulates longevity, stress resistance and cardiac function in Drosophila. Sci. Rep. 2018 Feb 13. [Epub ahead of print]
Schwab DM, Tilemann L, Bauer R, Heckmann M, Jungmann A, Wagner M, Burgis J, Vettel C, Katus HA, El-Armouche A, Müller OJ. AAV-9 mediated phosphatase-1 inhibitor-1 overexpression improves cardiac contractility in unchallenged mice but is deleterious in pressure-overload. Gene Ther. 2018 Jan 19. [Epub ahead of print]
Rossmann J, Renner LD, Oertel R, El-Armouche A. Post-column infusion of internal standard quantification for liquid chromatography-electrospray ionization-tandem mass spectrometry analysis - Pharmaceuticals in urine as example approach. J Chromatogr A. 2018 Jan 2. pii: S0021-9673(18)30002-5.
Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Völkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Schäfer M, Sticht C, Maack C, Gretz N, Wagner M, El-Armouche A, Maier LS, Londoño JEC, Meder B, Freichel M, Gröne HJ, Most P, Müller OJ, Herzig S, Furlong EEM, Katus HA, Backs J. A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway. Nat Med. 2018 Jan;24(1):62-72
Ebner A, Kuerbis N, Brandt A, Zatschler B, Weinert S, Poitz DM, Ebner B, Augstein A, Wunderlich C, El-Armouche A, Strasser RH. Endothelial Nitric Oxide Synthase-Induced Hypertrophy and Vascular Dysfunction Contribute to the Left Ventricular Dysfunction in Caveolin-1-/- Mice. Can J Cardiol. 2017 Dec;33(12):1716-1724.
Perera RK, Fischer TH, Wagner M, Dewenter M, Vettel C, Bork NI, Maier LS, Conti M, Wess J, El-Armouche A, Hasenfuß G, Nikolaev VO. Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4. Sci Rep. 2017 Nov 9;7(1):15222.
Dewenter M, Neef S, Vettel C, Lämmle S, Beushausen C, Zelarayan LC, Katz S, von der Lieth A, Meyer-Roxlau S, Weber S, Wieland T, Sossalla S, Backs J, Brown JH, Maier LS, El-Armouche A (2017). Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure. Circ Heart Fail. 10(5):e003840
Weber S, Zeller M, Guan K, Wunder F, Wagner M and El-Armouche A (2017). PDE2 at the crossway between cAMP and cGMP signalling in the heart. Cell Signal. 38:76-84.
Vettel C, Lindner M, Dewenter M, Lorenz K, Schanbacher C, Riedel M, Lämmle S, Meinecke S, Mason FE, Sossalla S, Geerts A, Hoffmann M, Wunder F, Brunner FJ, Wieland T, Mehel H, Karam S, Lechene P, Leroy J, Vandecasteele G, Wagner M, Fischmeister R and El-Armouche A (2017). Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction. Circ Res. 120:120-132.
Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz CM, Neef S, Voigt N, Baczko I, Varro A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D and Wieland T (2017). Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure. Circulation. 135:881-897.
Al-Gburi S, Deussen A, Zatschler B, Weber S, Künzel S, El-Armouche A, Lorenz K, Cybularz M, Morawietz H and Kopaliani I (2017). Sex-difference in expression and function of beta-adrenoceptors in macrovessels: role of the endothelium. Basic Res Cardiol. 112:29.
Meyer-Roxlau S, Lämmle S, Opitz A, Kunzel S, Joos JP, Neef S, Sekeres K, Sossalla S, Schöndube F, Alexiou K, Maier LS, Dobrev D, Guan K, Weber S and El-Armouche A (2017). Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation. Basic Res Cardiol. 112:43.
Neef S, Heijman J, Otte K, Dewenter M, Saadatmand AR, Meyer-Roxlau S, Antos CL, Backs J, Dobrev D, Wagner M, Maier LS and El-Armouche A (2017). Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity. Naunyn Schmiedebergs Arch Pharmacol. 390:857-862.
Wagner M and El-Armouche A (2016). Off-label-drug-use: Scientific evidence counts. Dtsch Med Wochenschr. 141:307.
Wagner M, Mehel H, Fischmeister R and El-Armouche A (2016). Phosphodiesterase 2: anti-adrenergic friend or hypertrophic foe in heart disease? Naunyn Schmiedebergs Arch Pharmacol. 389:1139-1141.
Weber S, Meyer-Roxlau S and El-Armouche A (2016). Role of protein phosphatase inhibitor-1 in cardiac beta adrenergic pathway. J Mol Cell Cardiol. 101:116-126.
Swain L, Kesemeyer A, Meyer-Roxlau S, Vettel C, Zieseniss A, Güntsch A, Jatho A, Becker A, Nanadikar MS, Morgan B, Dennerlein S, Shah AM, El-Armouche A, Nikolaev VO and Katschinski DM (2016). Redox Imaging Using Cardiac Myocyte-Specific Transgenic Biosensor Mice. Circ Res. 119:1004-1016.
Richter K, Barthel A, Bornstein SR, El-Armouche A and Wagner M. PCSK9 Inhibitors - the magic bullet for LDL cholesterol reduction? (2016). Dtsch Med Wochenschr. 141:863-9.
Jordan J, El-Armouche A, Hanefeld M, Bornstein SR and Birkenfeld AL (2016). Comment on Ferrannini et al. CV Protection in the EMPA-REG OUTCOME Trial: A "Thrifty Substrate" Hypothesis. Diabetes Care. 39:e224-e225.
Herschel T, El-Armouche A and Weber S. Monoclonal antibodies, overview and outlook of a promising therapeutic option (2016). Dtsch Med Wochenschr. 141:1390-4.
Dewenter M, Wagner M and El-Armouche A. (2016) LATITUDE-TIMI: is there still hope for anti-inflammatory therapy in acute myocardial infaction? J Thorac Dis. 8:E1047-E1049.
García-Martín R, Alexaki VI, Qin N, Rubín de Celis MF, Economopoulou M, Ziogas A, Gercken B, Kotlabova K, Phieler J, Ehrhart-Bornstein M, Bornstein SR, Eisenhofer G, Breier G, Blüher M, Hampe J, El-Armouche A, Chatzigeorgiou A, Chung KJ, Chavakis T (2015) Adipocyte-Specific Hypoxia-Inducible Factor 2α Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation. Mol Cell Biol 36:376-93.
Godier-Furnemont AFG, Tiburcy M, Wagner E, Dewenter M, Lämmle S, El-Armouche A, Lehnart SE, Vunjak-Novakovic Gordana, Zimmermann WH (2015) Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation.Biomaterials In press.
Perera RK, Sprenger JU, Steinbrecher JH, Hübscher D, Lehnart SE, Abesser M, Schuh K,El-Armouche A, Nikolaev VO (2015) Microdomain Switch of cGMP-Regulated Phosphodiesterases Leads to ANP-Induced Augmentation of β-Adrenoceptor-Stimulated Contractility in Early Cardiac Hypertrophy. Circ Res 116:1304-11.
Friedrich FW, Sotoud H, Geertz B, Weber S, Flenner F, Reischmann S, Eschenhagen T, Carrier L, El-Armouche A (2015) I-1-deficiency negatively impacts survival in a cardiomyopathy mouse model. IJC Heart & Vasc 8:87-94.
Sotoud H, Borgmeyer U, Schulze C, El-Armouche A, Eschenhagen T (2015)Development of phosphatase inhibitor-1 peptides acting as indirect activators of phosphatase 1. N-S Arch Pharmacol 388:283-93.
Neuber C, Uebeler J, Schulze T, Sotoud H, El-Armouche A, Eschenhagen T (2014)Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes. J Pharmacol Exp Ther 9:e98893.
Zafiriou MP, Noack C, Unsöld B, Didie M, Pavlova E, Fischer HJ, Reichardt HM, Bergmann MW, El-Armouche A, Zimmermann WH, Zelarayan LC (2014) Erythropoietin responsive cardiomyogenic cells contribute to heart repair post myocardial infarction. Stem Cells 32:2480-91.
Haj Slimane Z, Bedioune I, Lechêne P, Varin A, Lefebvre F, Mateo P, Domergue-Dupont V, Dewenter M, Richter W, Conti M, El-Armouche A, Zhang J, Fischmeister R, Vandecasteele G (2014) Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes. Cardiovasc Res 102:97-106.
Vettel C, Lämmle S, Ewens S, Cevirgen C, Emons J, Ongherth A, Dewenter M, Lindner D, Westermann D, Nikolaev VO, Lutz S, Zimmermann WH, El-Armouche A (2014) PDE2-mediated cAMP hydrolysis accelerates cardiac fibroblast to myofibroblast conversion and is antagonized by exogenous activation of cGMP signaling pathways. Am J Physiol Heart Circ Physiol 306:H1246-52.
Neuber C, Müller OJ, Hansen FC, Eder A, Witten A, Rühle F, Stoll M, Katus HA, Eschenhagen T, El-Armouche A (2014) Paradoxical Effects on Force Generation after Efficient β1-Adrenoceptor Knockdown in Reconstituted Heart Tissue. J Pharmacol Exp Ther 349:39-46.
Unsöld B, Kaul A, Sbroggiò M, Schubert C, Regitz-Zagrosek V, Brancaccio M, Damilano F, Hirsch E, van Bilsen M, Munts C, Sipido K, Bito V, Detre E, Wagner NM, Schäfer K, Seidler T, Vogt J, Neef S, Bleckmann A, Maier LS, Balligand JL, Bouzin C, Ventura Clapier R, Garnier A, Eschenhagen T, El-Armouche A, Knöll R, Tarone G, Hasenfuß G (2013) Melusin protects from cardiac rupture and improves functional remodeling after myocardial infarction. Cardiovas Res 101:97-107.
Vettel C, Hottenrott M, Spindler R, Benck U, Schnuelle P, Tsagogiorgas C, Krämer BK, Hoeger S, El-Armouche A, Wieland T, Yard BA (2013) Dopamine and lipophilic derivates protect cardiomyocytes against cold preservation injury. J Pharmacol Exp Ther 348:77-85.
Schwoerer AP, Neef S, Broichhausen I, Jacubeit J, Tiburcy M, Wagner M, Biermann D, Didié M, Vettel C, Maier LS, Zimmermann WH, Carrier L, Eschenhagen T, Volk T, El-Armouche A, Ehmke H (2013) Enhanced Ca(2+) influx through cardiac L-type Ca(2+) channels maintains the systolic Ca (2+) transient in early cardiac atrophy induced by mechanical unloading Pflugers Arch 465:1763-73.
Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier L, Leroy J, Varin A, Lefebvre F, Eschenhagen T, Nattel S, Dobrev D, Zimmermann WH, Nikolaev V, Vandecasteele G, Fischmeister R*, El-Armouche A* (2013) Phoshodiesterase-2 is upregulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes. J Am Coll Cardiol 62:1596–606. *shared senior-authorship
Didié M, Biermann D, Buchert R, Hess A, Wittköpper K, Christalla P, Döker S, Jebran F, Schöndube F, Reichenspurner H, El-Armouche A*, Zimmermann WH* (2013) Preservation of left ventricular function and morphology in volume-loaded versus volume-unloaded heterotopic heart transplants Am J Physiol Heart Circ Physiol 305:H533-41. *shared senior-authorship
Sotoud H, Gribbon P, Ellinger B, Reinshagen J, Boknik P, El-Armouche A*, Eschenhagen T* (2013) Development of a Colorimetric and a Fluorescence Phosphatase-Inhibitor Assay Suitable for Drug Discovery Approaches J Biomol Screen 18:899-909. *shared senior-authorship
Neef S, Sag CM, Daut M, Bäumer H, Grefe C, El-Armouche A, Desantiago J, Pereira L, Bers DM, Backs J, Maier LS (2013) While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKIIδ-KO mice.J Mol Cell Cardiol 59:107-116.
Didié M, Christalla P, Rubart M, Muppala V, Döker S, Unsöld B, El-Armouche A, Rau T, Eschenhagen T, Schwoerer AP, Ehmke H, Schumacher U, Fuchs S, Lange C, Becker A, Wen T, Scherschel JA, Soonpaa MH, Yang T, Lin Q, Zenke M, Han DW, Schöler HR, Rudolph C, Steinemann D, Schlegelberger B, Kattman S, Witty A, Keller G, Field LJ, Zimmermann WH (2013) Parthenogenetic Stem Cells for Tissue Engineered Heart Repair. J Clin Invest 123:1285-98.
Renger A, Zafiriou MP, Noack C, Pavlova E, Becker A, Sharkova K, Bergmann MW, El-Armouche A, Zimmermann WH, Zelarayán LC (2013) The four and a half LIM-domain (FHL) 2 controls early cardiac cell commitment and expansion via regulating ß-catenin-dependent transcription Stem Cells 31:928-40.
Vettel C, Wittig K, Vogt A, Wuertz CM, El-Armouche A, Lutz S, Wieland T (2012) A novel player in cellular hypertrophy: Gi/PI3K-dependent activation of the RacGEF TIAM-1 is required for a1-adrenoceptor induced hypertrophy in neonatal rat cardiomyocytes. J Mol Cell Cardiol 53:165-75.
Unsöld B, Schotola H, Jacobshagen C, Seidler T, Sossalla S, Emons J, Klede S, Knöll R, Guan K, El-Armouche A, Linke WA, Kögler H, Hasenfuß G (2012) Age-dependent changes in contractile function and passive elastic properties of myocardium from mice lacking muscle LIM protein. Eur J Heart Fail 14:430-7.
Hölscher M, Schäfer K, Krull S, Farhat K, Hesse A, Silter M, Lin Y, Pichler B, Thistlethwaite P, El-Armouche A, Maier LS, Katschinski DM, Zieseniss, A (2012) Unfavorable consequences of chronic cardiac HIF-1a stabilization. Cardiovas Res 94:77-86.
Tiburcy M, Zhang J, Didié M, Boy O, Christalla P, Doeker S, Naito H, Karikkineth BC, El-Armouche A, Grimm M, Nose M, Eschenhagen T, Zieseniss A, Katschinksi D, Hamdani N, Linke WA, Yin X, Mayr M, Zimmermann WH. (2011) Terminal Differentiation, Advanced Organotypic Maturation, and Modeling of Hypertrophic Growth in Engineered Heart Tissue. Circ Res 109:1105-14.
El-Armouche A, Wittköpper K, Fuller W, Howie J, Shattock MJ, Pavlovic D (2011) Phospholemman-dependent regulation of the cardiac Na/K-ATPase activity is modulated by inhibitor-1 sensitive type-1 phosphatase. FASEB J 25:4467-75.
El-Armouche A, Ouchi N, Tanaka K, Doros G, Wittköpper K, Schulze T, Eschenhagen T, Walsh K, Sam F (2011) Follistatin-like 1 in chronic systolic heart failure–a marker of Left Ventricular Remodeling. Circ Heart Fail 4:621-7.
Tsuji Y, Hojo M, Voigt N, El-Armouche A, Inden Y, Murohara T, Dobrev D, Nattel S, Kodama I, Kamiya K (2011) Ca2+-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm. Circulation 123: 2192-203
El-Armouche A, Schwoerer AP, Neuber C, Emmons J, Biermann D, Christalla T, Grundhoff A, Eschenhagen T, Zimmermann WH, Ehmke H (2011) Common microRNA signatures in cardiac hypertrophic and atrophic remodeling induced by changes in hemodynamic load. Plos One 5:e14263.
Wittköpper K, Fabritz L, Neef S, Ort K, Grefe C, Unsöld B, Kirchhoff P, Maier LS, Hasenfuß G, Dobrev D, Eschenhagen T*, El-Armouche A* (2010) Constitutively active inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging. J Clin Invest 120:617-26 (Selected for Faculty of 1000 Biology). *shared senior-authorship
l-Armouche A, Wahab A, Wittköpper K, Schulze T, Böttcher F, Pohlmann L, King SB, Dumond JF, Gerloff C, Böger RH, Eschenhagen T, Carrier L, Donzelli S (2010) The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and β-adrenergically desensitized ventricular myocytes. Biochem Biophys Res Commun 402:340-4.
Sossalla S, Fluschnik N, Schotola H, Ort KR, Neef S, Schulte T, Wittköpper K, Renner A, Schmitto JD, Gummert J, El-Armouche A, Hasenfuss G, Maier LS (2010) Inhibition of Elevated Ca2+/Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium. Circ Res 107:1150-61.
Duncker DJ, Boontje NM, Merkus D, Versteilen A, Krysiak J, Mearini G, El-Armouche A, Lamberts R, Carrier L, Walker LA, Linke WA, Stienen GJ, van der Velden J (2009) Prevention of myofilament dysfunction by beta-blocker therapy in post-infarct remodeling. Circ Heart Fail 2:233-42.
Schmechel A, Grimm M, El-Armouche A, Höppner G, Schwoerer AP, Ehmke H, Eschenhagen T (2009) Treatment with atorvastatin partially protects the rat heart from harmful catecholamine effects. Cardiovasc Res 80:396-406.
Greiser M, Neuberger HP, Harks E, El-Armouche A, Boknik P, de Haan S, Verheyen F, Verheule S, Schmitz W, Ravens U, Nattel S, Allessie MA, Dobrev D, Schotten U (2009) Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV-block-induced atrial dilatation and atrial fibrillation. J Mol Cell Cardiol 46:385-94.
Schwoerer P, Neuber C, Schmechel A, Mearini G, Boknik P, Schmitz W, Ehmke H, Eschenhagen T, El-Armouche A (2008) Mechanical unloading of the heart involves marked changes in the protein kinase-phosphatase balance. J Mol Cell Cardiol 45:846-52.
Zhang J, Zhang MH, Sears CE, Emanuel K, Redwood C, El-Armouche A, Kranias EG, Casadei B (2008) Reduced phospholamban phosphorylation is associated with impaired relaxation in left ventricular myocytes from nNOS deficient mice. Circ Res 102:242-9.
El-Armouche A, F Degenhardt, K Wittkoepper, I Melnychenko, F Weinberger, M Didie, M Peeck, WH Zimmermann, T Eschenhagen (2008) Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy.Cardiovasc Res 80:396-406.
Schwörer A, Melnychenko I, Goltz D, Hedinger N, Broichhausen I, El-Armouche A, Eschenhagen T, Volk T, Ehmke H (2008) Unloaded rat hearts in vivo express a hypertrophic phenotype of cardiac repolarization. J Mol Cell Cardiol 45:633-41.
Grote-Wessels S, Baba HA, Boknik P, El-Armouche A, Fabritz L, Gillmann HJ, Kucerova D, Matus M, Müller FU, Neumann J, Schmitz M, Stümpel F, Theilmeier G, Wohlschlaeger J, Schmitz W, Kirchhefer U (2008) Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload Cardiovasc Res 79:464-71.
Pohlmann L, Kröger I, Vignier N, Schlossarek S, Krämer E, Coirault C, El-Armouche A, Winegard S, Eschenhagen T, Carrier L (2007) Cardiac myosin-binding protein C is required for complete relaxation in intact myocytes. Circ Res 101: 928-38.
El-Armouche A, Gocht F, Jäckel E, Wittköpper K, Peeck M, Eschenhagen T (2007) Long-term beta-adrenergic stimulation leads to downregulation of protein phosphatase inhibitor-1 in the heart. Eur J Heart Fail 9:1077-80.
El-Armouche A, Singh J, Naito H, Wittköpper K, Didie M, Laatsch A, Zimmermann WH, Eschenhagen T (2007) Adenovirus-delivered short hairpin RNA targeting PKCα improves contractile function in reconstituted heart tissue. J Mol Cell Cardiol 43:371-6.
El-Armouche A, Pohlmann L, Schlossarek S, Starbatty J, Yeh YH, Nattel S, Dobrev D, Eschenhagen T, Carrier L (2007) Decreased phosphorylation levels of cardiac myosin binding protein-C in human and experimental heart failure. J Mol Cell Cardiol 43:223-9.
Grimm M, El-Armouche A, Zang R, Anderson ME, Eschenhagen T (2007) Reduced contractile response to alpha1-adrenergic stimulation in atria from mice with chronic cardiac calmodulin kinase II inhibition. J Mol Cell Cardiol 42:643-52.
El-Armouche A, Boknik P, Eschenhagen T, Carrier L, Knaut M, Ravens U, Dobrev D (2006) Molecular determinants of altered Ca2+-handling in human chronic atrial fibrillation.Circulation 114:670-80.
Sahin B, Shu H, Fernandez J, El-Armouche A, J Molkentin JD, Nairn AC, Bibb JA (2006) Phosphorylation of protein phosphatase inhibitor-1 by protein kinase C. J Biol Chem 281:24322-35.
El-Armouche A, Bednorz A, Pamminger T, Ditz D., Didié M, Dobrev D, Eschenhagen T (2006) Role of calcineurin and protein phosphatase-2A in the regulation of phosphatase inhibitor-1 in cardiac myocytes. Biochem Biophys Res Commun 346:700-6.
Grimm M, Mahnecke N, Soja F, El-Armouche A, Haas P, Treede H, Reichenspurner H, Eschenhagen T (2006) The MLCK-Mediated α1-Adrenergic Inotropic Effect in Atrial Myocardium is Negatively Modulated by PKCε Signaling. Br J Pharmacol 148:991-1000.
El-Armouche A, Pamminger T, Ditz D, Zolk O, Eschenhagen T (2004) Decreased protein and phosphorylation level of the protein phosphatase inhibitor-1 in failing human hearts.Cardiovasc Res 6:87-93.
El-Armouche A, Jäckel E, Boheler KR, Boknik P, Hertle B, Neumann J, Eschenhagen T (2004) Ouabain treatment is associated with upregulation of phosphatase inhibitor-1 and Na+/Ca(2+)-exchanger and beta-adrenergic sensitization in rat hearts. Biochem Biophys Res Commun 318:219-26.
El-Armouche A, Rau T, Zolk O, Ditz D, Pamminger T, Zimmermann W-H, Jäckel E, Harding SE, Boknik P, Neumann J, Eschenhagen T (2003) Evidence for phosphatase inhibitor-1 playing an amplifier role in b-adrenergic signaling. FASEB J 17:437-39.
Zolk O, Marx M, Jäckel E, El-Armouche A, Eschenhagen T (2003) b-Adrenergic stimulation induces cardiac ankyrin repeat protein expression: Involvement of protein kinase A and calmodulin-dependent kinase. Cardiovasc Res 59:563-72.
Wiechert S, EI-Armouche A, Rau T, Zimmermann W-H, Eschenhagen T (2003) 24-h Langendorff-perfused neonatal rat heart to study the impact of adenoviral gene transfer.Am J Physiol Heart Circ Physiol 285:907-14.
Zolk O, Quattek J, Seeland U, El-Armouche A, Eschenhagen T, Böhm M (2002) Activation of the cardiac endothelin system in left ventricular hypertrophy before onset of heart failure in TG(mREN2)27 rats. Cardiovasc Res 53:363-71.
Reviews and Book Chapters
Wagner M, El-Armouche A (2016) Off-label-drug-use: Scientific evidence counts. Deut Med Wochenschr 141:307.
Weber S, Meyer-Roxlau S, Wagner M, Dobrev D, El-Armouche A (2015) Counteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein Phosphatases. Front Pharmacol 6:270.
Dewenter M, Vetter C, El-Armouche A (2015) Kardiales Remodelling als therapeutisches Ziel. DGK connexi. 4:9-11.
Wagner M, Weber S, El-Armouche A (2015) Linking superinhibitory PLB mutations to CaMKII activation: a new arrhythmogenic mechanism in genetic DCM? Cardiovasc Res 107:5-6.
Dewenter M, Vettel C, El-Armouche A (2014) The Janus face of BNP therapy in chronic heart failure – beneficial effects unmasked by beta blockers? Heart 100:819-20.
Döker S, Dewenter M, El-Armouche A (2014) Tofacitinib. Aktuel Rheumatol 39: 399-404.(0.1 /0.1)
Döker S, Dewenter M, El-Armouche A (2014) Tofacitinib. Deut Med Wochenschr 138:39-42.
Heijman J, Dewenter M, El-Armouche A*, Dobrev D* (2013) Function and regulation of serine/threonine phosphatases in the healthy and diseased heart. J Mol Cell Cardiol 64:90-8. *shared senior-authorship.
Dewenter M, Vettel C, El-Armouche A (2013) Losmapimod. Deut Med Wochenschr 138:39-42.
Christalla P, Dewenter M, El-Armouche A (2012) Effectiveness and safety of varenicline for smoking cessation. Deut Med Wochenschr 137:940-4.
Wittköpper K, Dobrev D, Eschenhagen T, El-Armouche A (2011) Phosphatase-1-inhibitor-1 in physiological and pathological beta-adrenergic signaling? Cardiovasc Res 91:392-401.
Wittköpper K, Emons J, El-Armouche A (2011) Febuxostat. Deut Med Wochenschr 136:1270-4.
Christalla P, Wittköpper K, El-Armouche A (2011) Febuxostat a new drug for treatment of gout: Increased cardiovascular risk in gout patients? Der Kardiologe 5:45-50.
Wittköpper K, Eschenhagen T, El-Armouche A (2010) Phosphatase-1-inhibitor-1: amplifier or attenuator of catecholaminergic stress? Basic Res Cardiol 105:569-71.
El-Armouche A, Eschenhagen T (2009) Beta-adrenergic stimulation and myocardial function in the failing heart. Heart Fail Rev 14:225-41.
Wittköpper K, El-Armouche A, Eschenhagen T (2008) Olanzapin Deut Med Wochenschr133:1958-62. (0.5 /0.5) El-Armouche A, Eschenhagen T (2007) Stellenwert von Dopamin in der modernen Intensivmedizin. Dtsch Med Wochenschr 132:2654.
El-Armouche A, Rau T, Eschenhagen T (2007) Herzklappenfehler durch Parkinsonmedikamente? Deut Med Wochenschr 132:5.
Zimmermann W-H, Melnychenko I, Didie M, El-Armouche A, Eschenhagen T (2005) Engineering heart tissue for in vitro and in vivo studies; Editor: Dhein S, Mohr F.W., Delmar M., Springer Verlag Berlin Heidelberg.
El-Armouche A, Rau T, Zolk O, Eschenhagen T (2003) Inhibitory G-proteins and their role in desensitization of the adenylyl cyclase pathway in heart failure. Cardiovasc Res 60:478-87.
El-Armouche A, Zolk O, Eschenhagen T (2003) Citalopram Deut Med Wochenschr 128:2253-6.
Zolk O, El-Armouche A, Eschenhagen T (2001) Arzneimittelwechselwirkungen für die Praxis. Welche Kombinationen sind tabu? Deut Med Wochenschr 143:24-32.