Endocytosis and systems biology
The goal of this project (supported by the German "BMBF System Biology Initiative", in close cooperation with Prof. M. Zerial (Max Planck Institute of Molecular Cell biology and Genetics, Dresden) is to understand the molecular basis of biogenesis and function of endocytosis (endocytosis is the process by which eukaryotic cells internalize membrane components and other molecular complexes). By applying a combination of techniques from bioinformatics, biophysics and mathematics, we try to discover the regulation of transport at the molecular scale in the endocytotic pathway. Corresponding models are primarily based on (partial) differential equations.
Partners
Max-Planck-Institut für Physik komplexer Systeme, Dresden
Max-Planck-Institut für Molekulare Zellbiologie und Genetik, Dresden
ZIH Contact
Project Term
06/2008 - 03/2015
Funding
BMBF
Publications
- A.P. Kupinski, I. Raabe, M. Michel, D. Ail, L. Brusch, T. Weidemann, C. Bökel. Phosphorylation of the Smo tail is controlled by membrane localization and is dispensable for clustering. J. Cell Sci., 126, 20, 4684-4697, 2013. [Link]
- L. Foret, J.E. Dawson, R. Villaseñor, C. Collinet, A. Deutsch, L. Brusch, M. Zerial, Y. Kalaidzidis, F. Jülicher. A general theoretical framework to infer endosomal network dynamics from quantitative image analysis. Curr. Biol., 22, 15, 1381 - 1390, 2012. [Link]
- T. Nakakuki, M. R. Birtwistle, Y. Saeki, N. Yumoto, K. Ide, T. Nagashima, L. Brusch, B. A. Ogunnaike, M. Okada-Hatakeyama, B. N. Kholodenko. Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics. Cell, 141, 884-896, 2010. [Link]
- P. del Conte-Zerial, L. Brusch, J. Rink, C. Collinet, Y. Kalaidzidis, M. Zerial, A. Deutsch. Membrane identity and GTPase cascades regulated by toggle and cut-out switches. Mol. Syst. Biol., 4, 206, 2008. [Link]
- L. Brusch, A. Deutsch. The coherence of the vesicle theory of protein secretion. J. Theor. Biol., 252, 370-373, 2008. [Link]