MulticellML - Standardising the exchange of multicellular models in computational systems medicine
New insights into multicellular processes in tissues and organs, like tissue regeneration, can be gained using spatially resolved modelling and simulation. Correspondingly, many international Systems Medicine projects, including those at ZIH, are developing spatially resolved multicellular models and new simulation software. However, the exchange, reproducibility and archiving of spatially resolved multicellular models among different projects with different software tools is currently hampered by the lack of an appropriate and fully declarative model definition language for this model class.
Portion of a declarative xml-description for a multicellular model
The project MulticellML aims at developing an infrastructure for the exchange of spatially resolved multicellular models among projects of the e:Med-network and beyond. The project plans to combine the established data management framework FAIRDOMhub/SEEK with a fully declarative model description language for spatially resolved multicellular models.
Partners
HITS gGmbH, Heidelberg
Helmholtz-Zentrum für Infektionsforschung GmbH, Braunschweig
ZIH Contact
Duration
01/2018 - 12/2019
Funding
BMBF (01ZX1707A)
Publications
J. Starruß, W. de Back, L. Brusch, A. Deutsch.Morpheus: a user-friendly modeling environment for multiscale and multicellular systems biology.Bioinformatics30,1331,2014.