Publikationen

Klotzsche-von Ameln A, Sprott D, Harnessing retinal phagocytes to combat pathological neovascularization in ischemic retinopathies? Pflugers Arch. 2022 Jun; 474(6):575-590. doi: 10.1007/s00424-022-02695-7. PMID: 35524802

Khedr S, Klotzsche-von Ameln A, Khedr M, Elsayed MH, Sudha T, Mousa SA, Deussen A, Martin M. Characterization of tryptophan-containing dipeptides for anti-angiogenic effects. Acta Physiol (Oxf). 2020 Sep 7: e13556. doi: 10.1111/apha.13556. PMID: 32894635

Korovina I, Neuwirth A, Sprott D, Troullinaki M, Poitz DM, Deussen A, Klotzsche-von Ameln A. Myeloid SOCS3 Deficiency Regulates Angiogenesis via Enhanced Apoptotic Endothelial Cell Engulfment. J Innate Immun. 2019 Oct 1:1-9. doi: 10.1159/000502645. PMID: 31574508

Sprott D, Poitz DM, Korovina I, Ziogas A, Phieler J, Chatzigeorgiou A, Mitroulis I, Deussen A, Chavakis T, Klotzsche-von Ameln A. Endothelial-Specific Deficiency of ATG5 (Autophagy Protein 5) Attenuates Ischemia-Related Angiogenesis. Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1137-1148. doi: 10.1161/ATVBAHA.119.309973. PMID: 31070476

Troullinaki M, Alexaki VI, Mitroulis I, Witt A, Klotzsche-von Ameln A, Chung KJ, Chavakis T, Economopoulou M. Nerve growth factor regulates endothelial cell survival and pathological retinal angiogenesis. J Cell Mol Med. 2019 Apr;23(4):2362-2371. doi: 10.1111/jcmm.14002. PMID: 30680928

Troullinaki M, Garcia-Martin R, Sprott D, Klotzsche-von Ameln A, Grossklaus S, Mitroulis I, Chavakis T, Economopoulou M. 53BP1 Deficiency Promotes Pathological Neovascularization in Proliferative Retinopathy. Thromb Haemost. 2019 Mar;119(3):439-448. doi: 10.1055/s-0038-1676966. PMID: 30620991

Korovina I, Neuwirth A, Sprott D, Weber S, Sardar Pasha SPB, Gercken B, Breier G, El-Armouche A, Deussen A, Karl MO, Wielockx B, Chavakis T, Klotzsche-von Ameln A. Hematopoietic hypoxia-inducible factor 2α deficiency ameliorates pathological retinal neovascularization via modulation of endothelial cell apoptosis. FASEB J. 2019 Feb;33(2):1758-1770. doi: 10.1096/fj.201800430R. PMID: 30156910

Klotzsche - von Ameln A, Cremer S, Hoffmann J, Schuster P, Khedr S, Korovina I, Troulinaki M, Neuwirth A, Sprott D, Chatzigeorgiou A, Economopoulou M, Orlandi A, Hain A, Zeiher AM, Deussen A, Hajishengallis G, Dimmeler S, Chavakis T, Emmanouil Chavakis. Endogenous developmental endothelial locus-1 limits ischemia-related angiogenesis by blocking inflammation. Thromb Haemost. 2017 Jun 2;117(6):1150-1163. doi: 10.1160/TH16-05-0354. PMID: 28447099

Kourtzelis I, Kotlabova K, Lim JH, Mitroulis I, Ferreira A, Chen LS, Gercken B, Steffen A, Kemter E, Klotzsche-von Ameln A, Waskow C, Hosur K, Chatzigeorgiou A, Ludwig B, Wolf E, Hajishengallis G, Chavakis T. Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation. Thromb Haemost. 2016 Apr;115(4):781-8. doi: 10.1160/TH15-05-0429. PMID: 26676803

Economopoulou M, Avramovic N, Klotzsche-von Ameln A, Korovina I, Sprott D, Samus M, Gercken B, Troullinaki M, Grossklaus S, Funk RH, Li X, Imhof BA, Orlova VV, Chavakis T. Endothelial-specific deficiency of Junctional Adhesion Molecule-C promotes vessel normalisation in proliferative retinopathy. Thromb Haemost. 2015 Nov 25;114(6):1241-9. doi: 10.1160/TH15-01-0051. PubMed PMID: 26311310.

Weber GF, Chousterman BG, He S, Fenn AM, Nairz M, Anzai A, Brenner T, Uhle F, Iwamoto Y, Robbins CS, Noiret L, Maier SL, Zönnchen T, Rahbari NN, Schölch S, Klotzsche-von Ameln A, Chavakis T, Weitz J, Hofer S, Weigand MA, Nahrendorf M, Weissleder R, Swirski FK. Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis. Science. 2015 Mar 13;347(6227):1260-5. doi: 10.1126/science.aaa4268. PubMed PMID: 25766237.

Chatzigeorgiou A, Chung KJ, Garcia-Martin R, Alexaki VI, Klotzsche-von Ameln A, Phieler J, Sprott D, Kanczkowski W, Tzanavari T, Bdeir M, Bergmann S, Cartellieri M, Bachmann M, Nikolakopoulou P, Androutsellis-Theotokis A, Siegert G, Bornstein SR, Muders MH, Boon L, Karalis KP, Lutgens E, Chavakis T. Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation. Hepatology. 2014 Oct;60(4):1196-210. doi: 10.1002/hep.27233. PMID: 24845056

Chatzigeorgiou A, Seijkens T, Zarzycka B, Engel D, Poggi M, van den Berg S, van den Berg S, Soehnlein O, Winkels H, Beckers L, Lievens D, Driessen A, Kusters P, Biessen E, Garcia-Martin R, Klotzsche-von Ameln A, Gijbels M, Noelle R, Boon L, Hackeng T, Schulte KM, Xu A, Vriend G, Nabuurs S, Chung KJ, Willems van Dijk K, Rensen PC, Gerdes N, de Winther M, Block NL, Schally AV, Weber C, Bornstein SR, Nicolaes G, Chavakis T, Lutgens E. Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc Natl Acad Sci US A. 2014 Feb 18;111(7):2686-91. doi: 10.1073/pnas.1400419111. Erratum in: Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4644. PubMed PMID: 24492375.

Klotzsche-von Ameln A, Prade I, Grosser M, Kettelhake A, Rezaei M, Chavakis T, Flamme I, Wielockx B, Breier G. PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-α. Mol Cancer Res. 2013 Nov;11(11):1337-48. doi: 10.1158/1541-7786.MCR-13-0201. PubMed PMID: 24048703.

Phieler J, Chung KJ, Chatzigeorgiou A, Klotzsche-von Ameln A, Garcia-Martin R, Sprott D, Moisidou M, Tzanavari T, Ludwig B, Baraban E, Ehrhart-Bornstein M, Bornstein SR, Mziaut H, Solimena M, Karalis KP, Economopoulou M, Lambris JD, Chavakis T. The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance. J Immunol. 2013 Oct 15;191(8):4367-74. doi: 10.4049/jimmunol.1300038. Epub 2013 Sep 16. PMID: 24043887

Zhang F, Li Y, Tang Z, Kumar A, Lee C, Zhang L, Zhu C, Klotzsche-von Ameln A, Wang B, Gao Z, Zhang S, Langer HF, Hou X, Jensen L, Ma W, Wong W, Chavakis T, Liu Y, Cao Y, Li X. Proliferative and survival effects of PUMA promote angiogenesis. Cell Rep. 2012 Nov 29;2(5):1272-85. doi: 10.1016/j.celrep.2012.09.023. PubMed PMID: 23122957.

Klotzsche-von Ameln A, Muschter A, Heimesaat MM, Breier G, Wielockx B. HIF prolyl hydroxylase-2 inhibition diminishes tumor growth through matrix metalloproteinase-induced TGFβ activation. Cancer Biol Ther. 2012 Feb 15;13(4):216-23. doi: 10.4161/cbt.13.4.18830. PubMed PMID: 22354010.

Klotzsche-von Ameln A, Muschter A, Mamlouk S, Kalucka J, Prade I, Franke K, Rezaei M, Poitz DM, Breier G, Wielockx B. Inhibition of HIF prolyl hydroxylase-2 blocks tumor growth in mice through the antiproliferative activity of TGFβ. Cancer Res. 2011 May 1;71(9):3306-16. doi: 10.1158/0008-5472.CAN-10-3838. PubMed PMID: 21436457.