The further development of digitalization is a central strategic goal of the TUD. The Support Center Digitalization (SCD), started its work on 1 January 2024 under the responsibility of the CDIO. The SCD supports TUD members as a central point of contact, for example in questions relating to security aspects, digital administration and central IT support.

The interactive science lab, an interdisciplinary team at CIDS, is planning interactive exhibition modules that feature prototypes and demonstrators of current research from CIDS combined with historical objects from university collections.

Since 2019, the Center for Scalable Data Analytics and Artificial Intelligence - ScaDS.AI Dresden/Leipzig - extends the research program of the national competence center for Big Data, ScaDS, founded in 2014. With its research, ScaDS.AI bridges the gap between the efficient use of mass data and advanced AI and addresses new methods for machine learning, knowledge management and efficient data handling. Furthermore, ScaDS.AI develops service-oriented solutions and cooperates with a variety of application partners from science and industry.

As scientific institution of the TUD, the Center for Information Services and High Performance Computing (ZIH) is responsible for the IT infrastructure of the university. It operates the central IT infrastructure services as well as servers and it is a competence center for high-performance computing. In addition, as an interdisciplinary center, it supports the university's schools in all IT-relevant areas. To support these tasks, ZIH carries out research and development work and is closely networked nationally and internationally with scientific institutions and partners from industry and business.

The Center for Synergy of Systems (SynoSys) focuses on research in „Interdisciplinary Digital Science for Healthy Human Development“ for complex systems. SynoSys investigates emergence, self-organization and swarm intelligence in heterogeneous, complex, collective adaptive human-nature-technical systems like robots in medicine, neural systems or social groups. Using digital research methods, it investigates how research results can be transferred between different disciplines.

The Center for Open Digital Innovation and Participation (CODIP) researches digital media as tools for teaching, learning, research and other contexts of activity, but also in everyday social life, succeeding the Media Center. It focuses on the consequences of digitization for innovation processes, the testing of digital research infrastructures and the demand-oriented design of digital tools. Simultaneously, CODIP trains young scientists and is a promoter of research results around digital transformation and barrier-free participation with methods of Open / Citizen Science for the TUD and research partners worldwide.

The Department of Speculative Transformation (DST) bundles TUD's technology-oriented research and development with a human-centered, sustainable, and socially reflective orientation. Based on interdisciplinary research fields in engineering, mathematics and natural sciences, humanities, and social sciences, as well as construction and environment, the DST addresses societal challenges and issues at the intersection of humans, technology, society and the environment. It integrates ethical, social, ecological, legal, economic, and user-specific concerns into innovation and change processes.

The Center for Advanced Modeling and Simulation (CAMS) combines the activities in the field of method, theory and software development for computational modeling and numerical simulation in different application areas. Based on research projects of the professorships of Scientific Computing and Applied Mathematics, Fluid Mechanics, Materials Science and Nanotechnology, and Scientific Computing in Systems Biology, CAMS creates an innovative platform for simulations at the highest level.

The Living Labs Computer Science Saxony (LICOSS) are an open, interdisciplinary department designed for interacting with the outside world, researching the cross-sectional fields of Mixed-Reality Systems and Cyber-Physical Systems and demonstrating them to the public in open experimental environments (Living Labs).