Luca Bertinetti
From the time of my PhD, I have been interested in studying molecular structure and interactions at the interfaces of biological materials.
Biological materials are constituted by chemically fairly simple molecular/supramolecular building blocks which are assembled over several hierarchical levels. This organization across different scales, together with possible small changes in chemical composition, endow the tissues with a variety of functionalities for which, in the last decades, biological materials became source of inspiration. However, independent of their function, these materials have evolved to optimize their interactions with water and ions, as these are ubiquitous in biological tissues. In many cases, changes in water and ions concentration even induce materials’ responses that are fundamental to achieve the desired functionality. Prominent examples are passive actuation in plants, hydration dependent force generation in collagen and crystallization of amorphous calcium carbonate. One of my goals is to describe and understand, from the molecular level upward, the interplay of water structure and interactions, ions nature and properties, and the molecular/supramolecular structure of the components of natural materials. For this, I strive to describe the thermodynamic of these interactions and to understand the molecular mechanisms underlying the observed responses at the materials and tissues levels. Because of the various hierarchical levels of organization of biological materials, I have been developing (in collaboration with many groups and colleagues) in-situ, multi-technique approaches, allowing to obtain information from the molecular to the macroscopic level.
Because the physical chemistry of these interaction is fundamental also to the formation of biological materials, I lately I became more and more interested in describing and understanding the processes underlying tissues deposition. To this aim, I have been working to establish FIB/SEM based volume imaging, a technique that enables the imaging of three-dimensional volumes that are larger than typical eukaryotic cells with a voxel size down to 3-4 nm and in particular, Cryo-FIB/SEM, (i.e. FIB/SEM serial surface imaging in cryogenic conditions) that represents the most advanced method for tissue imaging in the quasi-native state.
In parallel, I’m highly involved in the development of 3D image processing, AI-based segmentation techniques and volume imaging analytical tools.
Professional career:
Since 2020 | Senior scientist at B CUBE, TUD, Germany |
2017 - 2020 | Group Leader of the ‘3D imaging of forming tissues’ group, Max Planck Institute for Colloids and Interfaces, Potsdam, Germany |
2010 - 2017 |
Independent researcher, Max Planck Institute for Colloids and Interfaces, Germany |
2006 - 2010 | Research technician, Department of Inorganic Physical and Materials’ Chemistry of the University of Torino, Italy |
2002 - 2006 |
PhD student and Postdoc, Institute of Science and Technology for Ceramics (ISTEC) of the National Research Council (CNR), Faenza, Italy |
Education:
2006 | PhD in Chemistry, Title: " Nanomaterials for biomedical applications: synthesis and surface characterization", Supervisor: Prof. Dr. G. Martra, University of Torino, Italy |
2001 |
Master in Materials Science, Thesis title: " From solvated atoms to nanoparticles: a study on hydrogenation catalysts", Supervisor: Prof. S. Coluccia, University of Torino, Italy |
2016
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Honeycomb Actuators Inspired by the Unfolding of Ice Plant Seed Capsules , 2 Nov 2016, 11, 11Electronic (full-text) versionResearch output: Contribution to journal > Research article
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The role of water on the structure and mechanical properties of a thermoplastic natural block co-polymer from squid sucker ring teeth , 2 Sep 2016, 11, 5, 055003Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Chemical, colloidal and mechanical contributions to the state of water in wood cell walls , 24 Aug 2016, 18, 083048Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Cooperative behavior of a sacrificial bond network and elastic framework in providing self-healing capacity in mussel byssal threads. , Jul 2016, 196Research output: Contribution to journal > Research article
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Inherent Role of Water in Damage Tolerance of the Prismatic Mineral–Organic Biocomposite in the Shell of Pinna Nobilis , 7 Jun 2016, 26, 21, p. 3663-3669, 7 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Nano-channels in the spider fang for the transport of Zn ions to cross-link His-rich proteins pre-deposited in the cuticle matrix. , Jun 2016, 46, 1, p. 30-38, 9 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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A vacuole-like compartment concentrates a disordered calcium phase in a key coccolithophorid alga , 14 Apr 2016, 7, 11228Electronic (full-text) versionResearch output: Contribution to journal > Research article
2015
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Osmotically driven tensile stress in collagen-based mineralized tissues , 1 Dec 2015, 52, p. 14-21, 8 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Mechanical homeostasis of a DOPA-enriched biological coating from mussels in response to metal variation , 6 Sep 2015, 12, 110, 20150466Electronic (full-text) versionResearch output: Contribution to journal > Research article
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Elastic response of mesoporous silicon to capillary pressures in the pores , 29 Jun 2015, 106, 26, 261901Electronic (full-text) versionResearch output: Contribution to journal > Research article