The immune system is the body's defense mechanism, safeguarding us against foreign substances and pathogens such as helminths, bacteria, and viruses. However, a combination of genetic, epigenetic, and environmental factors can sometimes cause the immune system to malfunction. This can lead to autoimmune diseases like rheumatoid arthritis and inflammatory bowel disease, or hypersensitivity reactions such as allergic asthma. These chronic conditions necessitate lifelong medication adjustments for patients, imposing substantial health and economic burdens on both individuals and society.
Our research aims to explore cellular and molecular signaling pathways that contribute to misguided immune responses, leveraging this knowledge to promote the resolution of chronic diseases and restore tissue homeostasis.