Karl Group
The MOKALAB investigates mechanisms of neurodegeneration in the human retina, and its regenerative potential. We are particularly interested in age-related macular degeneration (AMD), one of the most common causes of vision loss worldwide. With the help of human retinal organoids and cell systems, we hope to contribute to new therapeutic strategies to prevent vision loss and to restore retinal cell, structure and function.
© Manuela Völkner, Mike Karl (mokalab, CRTD)
Our Research
Our goals are to decipher and manipulate mechanisms that control the fate of retinal cells throughout their life. Specifically, we want to find new ways to prevent neuronal cell loss and to restore defects in neural structure and cells. We study the human and mouse retina, an approachable part of the nervous system, to decipher basic mechanisms of neurodegeneration as well as its regenerative potential. We develop human cell and organoid systems and apply them to reproduce pathologic processes – with the ultimate aims to identify new potential therapeutic approaches and targets to prevent neurodegenerative diseases, and to restore them.
Our current overall objectives are to develop human stem cell derived neural organoid and cell systems, specifically for the retina, to apply these to understand mechanisms of neuronal degeneration and regeneration, and thereby to find new therapeutic strategies for a broad patient spectrum, particularly, age-related macular degeneration (AMD).
Curious? Contact us!
If you have any questions regarding our research or if your are interested in a scientific collaboration please contact us.
© CRTD/Franziska Clauß
Group Leader
NameProf. Dr. Mike O. Karl
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