The vertebrate limb contains various tissue types including bone, skin, nerves, muscle and blood vessels. After an injury these tissues respond to a plethora of signals driving repair and, in few animal species, regeneration. Our main goal is to understand how individual tissues respond to an injury to further understand their interaction during axolotl limb regeneration. The fine-tuned coordination of both, the individual tissue regeneration and the interaction with other tissue types could be the key for successful appendage regeneration. Moreover, we aim to find differences and similarities between axolotl and mammalian regeneration, in order to identify key components that promote or restrict regeneration in mammals.