Process design for bioproduct synthesis of plant cells

The project contains the optimization of in vitro plant cell systems for selective production of metabolites and the transfer of these plant cells into bioreactors as submers cultures. The research worked is focused on following main objectives:

• Cultivation of Beta vulgaris hairy root cultures in different types of bioreactors (stirred tank, bubble column) and investigation of correlativ behaviour between processing parameters (aeration rate etc.), the physiological state of the cells, the biomass production and the betalaine biosynthesis; Scale-up for different reactor types
• Adaption of Harpagophytum procumbens hairy root cells (devil's claw) to submers cultivation; process transfer into different types of bioreactors (stirred tank, bubble column, temporery immersion system); investigation  of H. procumbens hairy root extracts from cultivation

Financing of the project:

EU, Marie Curie Programm

Contact:

Georgiev, Bley