May 27, 2021; Talk
V. Faria: Olfactory induced desensitization in patients with migraine
Department of Psychology, Uppsala University, Uppsala, Sweden;
Center for Pain and the Brain, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Abstract
Migraines are a leading cause of disability and suffering worldwide. However, migraines remain poorly defined at an anatomic and pathophysiologic level. Imaging patients with migraine provides a window to migraine related central nervous system alterations, allowing a better understanding of the neurological underpinnings behind this challenging chronic pain disorder.
Traditional pharmacological migraine therapies may have unsatisfactory efficacy or can be poorly tolerated which might lead to complications. Nowadays, pain therapy treatments are increasingly relying on new nonpharmacological therapeutic strategies that might offer promising areas of development. The use of odors, has gradually received more attention in pain management. Nevertheless, there are virtually no imaging studies investigating olfactory processing in migraine patients and the therapeutic and neural impact of olfactory training in migraineurs.
Forty female patients (age between 18-55) with migraine with aura will be recruited to engage the olfactory training program. Thirty-two females will be scanned before and after the olfactory training, during the interictal period. Twenty age-matched female healthy participants will also be recruited and will also engage the olfactory training program. Sixteen healthy females will be scanned before and after the olfactory training.
We aim to evaluate the psychophysical as well as the neurofunctional and the neuroanatomical changes during olfactory, trigeminal, and emotional stimuli processing before and after a 3-month structured olfactory training program.
https://tu-dresden.zoom.us/j/85768789320?pwd=bHorMjBFaDRYUC9FcGhna3lFSFduUT09
Meeting-ID: 857 6878 9320
Passcode: fMRI2021%